Plasma levels of Sirtuin 7 are decreased in patients with essential hypertension
CONCLUSION: Plasma levels of SIRT7 are decreased in patients with essential hypertension, implying its potential as a biomarker for diagnosing essential hypertension..PMID:38679273 | DOI:10.1016/j.clinbiochem.2024.110766 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 28, 2024 Category: Biochemistry Authors: Ying Liu Ying Guo Ning Wang Zhaojie Dong Xiaoyan Yang Qian Liu Guohong Wang Mingzhao Qin Jiawei Song Jing Li Li Xu Ying Dong Jiuchang Zhong Source Type: research
Plasma levels of Sirtuin 7 are decreased in patients with essential hypertension
CONCLUSION: Plasma levels of SIRT7 are decreased in patients with essential hypertension, implying its potential as a biomarker for diagnosing essential hypertension.PMID:38679273 | DOI:10.1016/j.clinbiochem.2024.110766 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 28, 2024 Category: Biochemistry Authors: Ying Liu Ying Guo Ning Wang Zhaojie Dong Xiaoyan Yang Qian Liu Guohong Wang Mingzhao Qin Jiawei Song Jing Li Li Xu Ying Dong Jiuchang Zhong Source Type: research
Plasma levels of Sirtuin 7 are decreased in patients with essential hypertension
CONCLUSION: Plasma levels of SIRT7 are decreased in patients with essential hypertension, implying its potential as a biomarker for diagnosing essential hypertension.PMID:38679273 | DOI:10.1016/j.clinbiochem.2024.110766 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 28, 2024 Category: Biochemistry Authors: Ying Liu Ying Guo Ning Wang Zhaojie Dong Xiaoyan Yang Qian Liu Guohong Wang Mingzhao Qin Jiawei Song Jing Li Li Xu Ying Dong Jiuchang Zhong Source Type: research
A validated method for simultaneous quantification of four antiretrovirals in dried blood spot and plasma using LC-MS/MS: Application to efavirenz therapeutic drug monitoring in pregnant patients
CONCLUSIONS: The method was successfully applied to quantify efavirenz in DBS samples obtained from HIV-1 infected pregnant volunteers under antiretroviral therapy. The concentrations of efavirenz in DBS and plasma were comparable according to Passing-Bablok regression and Bland-Altman analysis.PMID:38649089 | DOI:10.1016/j.clinbiochem.2024.110765 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 22, 2024 Category: Biochemistry Authors: Maira Ludna Duarte Aurylanne Mikaelle Brand ão Silva Jos é Wellithom Viturino da Silva Davi Pereira Santana Whocely Victor de Castro Luiz Cl áudio Arraes de Alencar Danilo C ésar Galindo Bedor Leila Bastos Leal Source Type: research
A validated method for simultaneous quantification of four antiretrovirals in dried blood spot and plasma using LC-MS/MS: Application to efavirenz therapeutic drug monitoring in pregnant patients
CONCLUSIONS: The method was successfully applied to quantify efavirenz in DBS samples obtained from HIV-1 infected pregnant volunteers under antiretroviral therapy. The concentrations of efavirenz in DBS and plasma were comparable according to Passing-Bablok regression and Bland-Altman analysis.PMID:38649089 | DOI:10.1016/j.clinbiochem.2024.110765 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 22, 2024 Category: Biochemistry Authors: Maira Ludna Duarte Aurylanne Mikaelle Brand ão Silva Jos é Wellithom Viturino da Silva Davi Pereira Santana Whocely Victor de Castro Luiz Cl áudio Arraes de Alencar Danilo C ésar Galindo Bedor Leila Bastos Leal Source Type: research
A validated method for simultaneous quantification of four antiretrovirals in dried blood spot and plasma using LC-MS/MS: Application to efavirenz therapeutic drug monitoring in pregnant patients
CONCLUSIONS: The method was successfully applied to quantify efavirenz in DBS samples obtained from HIV-1 infected pregnant volunteers under antiretroviral therapy. The concentrations of efavirenz in DBS and plasma were comparable according to Passing-Bablok regression and Bland-Altman analysis.PMID:38649089 | DOI:10.1016/j.clinbiochem.2024.110765 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 22, 2024 Category: Biochemistry Authors: Maira Ludna Duarte Aurylanne Mikaelle Brand ão Silva Jos é Wellithom Viturino da Silva Davi Pereira Santana Whocely Victor de Castro Luiz Cl áudio Arraes de Alencar Danilo C ésar Galindo Bedor Leila Bastos Leal Source Type: research
A validated method for simultaneous quantification of four antiretrovirals in dried blood spot and plasma using LC-MS/MS: Application to efavirenz therapeutic drug monitoring in pregnant patients
CONCLUSIONS: The method was successfully applied to quantify efavirenz in DBS samples obtained from HIV-1 infected pregnant volunteers under antiretroviral therapy. The concentrations of efavirenz in DBS and plasma were comparable according to Passing-Bablok regression and Bland-Altman analysis.PMID:38649089 | DOI:10.1016/j.clinbiochem.2024.110765 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 22, 2024 Category: Biochemistry Authors: Maira Ludna Duarte Aurylanne Mikaelle Brand ão Silva Jos é Wellithom Viturino da Silva Davi Pereira Santana Whocely Victor de Castro Luiz Cl áudio Arraes de Alencar Danilo C ésar Galindo Bedor Leila Bastos Leal Source Type: research
Primer Part 1 - Preparing a laboratory quality improvement project
Clin Biochem. 2024 Apr 16:110764. doi: 10.1016/j.clinbiochem.2024.110764. Online ahead of print.ABSTRACTQuality in laboratory medicine encompasses multiple components related to total quality management, including quality control (QC), quality assurance (QA), quality indicators, and quality improvement (QI). Together, they contribute to minimizing errors (pre-analytical, analytical, or post-analytical) in clinical service delivery and improving process appropriateness and efficiency. In contrast to static quality benchmarks (QC, QA, quality indicators), the QI paradigm is a continuous approach to systemic process improveme...
Source: Clinical Biochemistry - April 18, 2024 Category: Biochemistry Authors: Mary Kathryn Bohn Roy Augustin Lucas Chartier Luke Devine Samik Doshi Leanne Ginty Elliot Lass Felix Leung William Mundle Graeme Nimmo Alyson Sandy Kelly Shillington Amanda Simon Amanda Steiman Ahmed Taher Cindy Tang Friesner Cristina Zanchetta Jennifer T Source Type: research
Primer Part 1 - Preparing a laboratory quality improvement project
Clin Biochem. 2024 Apr 16:110764. doi: 10.1016/j.clinbiochem.2024.110764. Online ahead of print.ABSTRACTQuality in laboratory medicine encompasses multiple components related to total quality management, including quality control (QC), quality assurance (QA), quality indicators, and quality improvement (QI). Together, they contribute to minimizing errors (pre-analytical, analytical, or post-analytical) in clinical service delivery and improving process appropriateness and efficiency. In contrast to static quality benchmarks (QC, QA, quality indicators), the QI paradigm is a continuous approach to systemic process improveme...
Source: Clinical Biochemistry - April 18, 2024 Category: Biochemistry Authors: Mary Kathryn Bohn Roy Augustin Lucas Chartier Luke Devine Samik Doshi Leanne Ginty Elliot Lass Felix Leung William Mundle Graeme Nimmo Alyson Sandy Kelly Shillington Amanda Simon Amanda Steiman Ahmed Taher Cindy Tang Friesner Cristina Zanchetta Jennifer T Source Type: research
Methods and reagent-lot comparisons by regression analysis: sample size considerations
CONCLUSIONS: While some software is available to calculate joint confidence regions in real-life analyses, shifting this testing method into the mainstream will require a greater number of software developers incorporating the necessary code into their regression programs. The computer program used to conduct this study is freely available and can be used to model any laboratory test.PMID:38631810 | DOI:10.1177/00045632241252006 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 17, 2024 Category: Biochemistry Authors: William Sadler Source Type: research
New solutions to old problems: A practical approach to identify samples with intravenous fluid contamination in clinical laboratories
CONCLUSIONS: The proposed algorithm identified true contamination with low false flagging rates in tertiary care urban hospital laboratories. Retrospective and prospective analysis suggest the algorithm is suitable for implementation in clinical laboratories to identify samples with possible IV fluid contamination for further investigation.PMID:38615787 | DOI:10.1016/j.clinbiochem.2024.110763 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 14, 2024 Category: Biochemistry Authors: Ashley Newbigging Natalie Landry Miranda Brun Dustin Proctor Michelle Parker Carmen Zimmer Laurel Thorlacius Joshua E Raizman Albert K Y Tsui Source Type: research
New solutions to old problems: A practical approach to identify samples with intravenous fluid contamination in clinical laboratories
CONCLUSIONS: The proposed algorithm identified true contamination with low false flagging rates in tertiary care urban hospital laboratories. Retrospective and prospective analysis suggest the algorithm is suitable for implementation in clinical laboratories to identify samples with possible IV fluid contamination for further investigation.PMID:38615787 | DOI:10.1016/j.clinbiochem.2024.110763 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 14, 2024 Category: Biochemistry Authors: Ashley Newbigging Natalie Landry Miranda Brun Dustin Proctor Michelle Parker Carmen Zimmer Laurel Thorlacius Joshua E Raizman Albert K Y Tsui Source Type: research
Salivary testosterone changes during oral glucose tolerance tests in overweight and obese men - postprandial or circadian variation?
CONCLUSIONS: SalT decreased postprandially. A concomitant decrease in serum cortisol, prolactin and TSH reflecting diurnal variation offers an alternative explanation for the decrease in SalT independent of food consumption. Further studies are required to determine whether morning temporal changes in SalT are related to food consumption or circadian rhythm or both.PMID:38591370 | DOI:10.1177/00045632241249087 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 9, 2024 Category: Biochemistry Authors: Jonathan Fenn Henry Gill Lauren Starbrook Loretta Theresa Ford Hayley Sharrod-Cole Tejas Kalaria Clare Ford Rousseau Gama Source Type: research
Improvement of point of care testing (POCT) device for accurate whole blood glucose measurement in early neonates
CONCLUSION: The study showed that the point-of-care testing device could be improved to allow for accurate whole-blood glucose measurements in the early neonatal period.PMID:38591468 | DOI:10.1177/00045632241249034 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 9, 2024 Category: Biochemistry Authors: Kosuke Koyano Makoto Arioka Yasuhiro Nakao Aya Morimoto Masashiro Sugino Hirosuke Morita Shinji Nakamura Sonoko Kondo Yukihiko Konishi Saneyuki Yasuda Takashi Kusaka Source Type: research
Salivary testosterone changes during oral glucose tolerance tests in overweight and obese men - postprandial or circadian variation?
CONCLUSIONS: SalT decreased postprandially. A concomitant decrease in serum cortisol, prolactin and TSH reflecting diurnal variation offers an alternative explanation for the decrease in SalT independent of food consumption. Further studies are required to determine whether morning temporal changes in SalT are related to food consumption or circadian rhythm or both.PMID:38591370 | DOI:10.1177/00045632241249087 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 9, 2024 Category: Biochemistry Authors: Jonathan Fenn Henry Gill Lauren Starbrook Loretta Theresa Ford Hayley Sharrod-Cole Tejas Kalaria Clare Ford Rousseau Gama Source Type: research
