Four-Leaf Clover Shape Agglomerate Keratoacanthomas: A Case Report
Clin Cosmet Investig Dermatol. 2024 Apr 24;17:921-924. doi: 10.2147/CCID.S453734. eCollection 2024.ABSTRACTKeratoacanthoma (KA) is a papule, plaque, or nodule in an exposed area, with a crater-like horn plug in the center. Multiple KAs are rare disorders, especially when the lesions are agglomerated together. Herein, we report a case of 65-year-old man who presented with four red nodules of different sizes on the right side of the chest. The lesions were clustered, with central keratotic cores, similar in appearance to a four-leaf clover. The nodules were completely removed by excisional surgery and the diagnosis of Agglom...
Source: Clinical, Cosmetic and Investigational Dermatology - May 3, 2024 Category: Dermatology Authors: Dingbin Yang Yu Mao Lu Peng Shuqiong Huang Lijun Zhou Changqiang Li Source Type: research

A Frequent Diagnostic Pitfall: Dermatological Clinical Features and Pathological Results in Diagnosing Pagetoid Squamous Cell Carcinoma in situ (Case Series)
In this study, three patients underwent pathological routine and auxiliary immunohistochemical (IHC) examination and were ultimately diagnosed with pagetoid SCC in situ - a different diagnosis from the initial clinical assessment. All three patients received a complete resection of the skin mass. After follow-up, as of June 2023, the patients had no tumour recurrence or metastasis. Pagetoid SCC in situ is a particular type of SCC in situ that has no specific features in clinical manifestations, gross diagnosis or histopathological sections. The final diagnosis depends on IHC staining. Pagetoid SCC in situ expresses EMA, CK...
Source: Clinical, Cosmetic and Investigational Dermatology - May 3, 2024 Category: Dermatology Authors: Sheng-Kai Wang Jia-Wei Cai Yu Zhang Ya-Jing Lin Yi-Hui Yang Source Type: research

Dermatology Consultation in the Geriatrics Department of a Tertiary Hospital in China: A Retrospective Study of 178 Patients
CONCLUSION: This study summarized the reasons for dermatology consultations for geriatric inpatients and found that dermatitis/eczema and infectious diseases were the common types of diseases consulted. The findings of this study contribute to the enhanced comprehension and management of dermatological conditions in hospitalized patients by geriatricians, as well as facilitating more efficient diagnosis and treatment by dermatologists.PMID:38699408 | PMC:PMC11063470 | DOI:10.2147/CCID.S461156 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - May 3, 2024 Category: Dermatology Authors: Lingyun Du Zhiqiang Cao Changyu Han Jingjing Wei Mingming Li Chunhong Zhang Source Type: research

Causal Association Between Diabetes, Body Mass Index and Lichen Sclerosus: A Bidirectional Two-Sample Mendelian Randomization Analysis
CONCLUSION: This MR analysis demonstrated no significant causal relationship between DM and BMI with LS in both directions, which contradicts previous observational studies reporting a positive association. Potential confounding factors may contribute to previously observed associations, and further research is necessary.PMID:38689755 | PMC:PMC11060172 | DOI:10.2147/CCID.S450399 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - May 1, 2024 Category: Dermatology Authors: Lin Liu Qiuli Zhang Jianmin Chang Kun Yang Source Type: research

Successful Treatment of Cutaneous Protothecosis Due to < em > Prototheca wickerhamii < /em > with Terbinafine
This report documents a case involving an 82-year-old male with Protothecosis. Histopathological analysis revealed granulomatous inflammation in the dermis, exhibiting necrotic features and hosting numerous non-budding spherical organisms. These organisms were positively stained using methenamine silver and periodic acid-Schiff stains, confirming identification as P. wickerhamii after validation through tissue culture and sequencing procedures. Initially, the patient received oral itraconazole at a dosage of 200 mg daily, accompanied by topical 1% naftifine-0.25% ketoconazole cream for a duration of 4 weeks, resulting in s...
Source: Clinical, Cosmetic and Investigational Dermatology - May 1, 2024 Category: Dermatology Authors: Yue Chen Aili Gao Yanan Ke Xin Zhou Li Lin Sha Lu Yumei Liu Source Type: research

Causal Association Between Diabetes, Body Mass Index and Lichen Sclerosus: A Bidirectional Two-Sample Mendelian Randomization Analysis
CONCLUSION: This MR analysis demonstrated no significant causal relationship between DM and BMI with LS in both directions, which contradicts previous observational studies reporting a positive association. Potential confounding factors may contribute to previously observed associations, and further research is necessary.PMID:38689755 | PMC:PMC11060172 | DOI:10.2147/CCID.S450399 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - May 1, 2024 Category: Dermatology Authors: Lin Liu Qiuli Zhang Jianmin Chang Kun Yang Source Type: research

Successful Treatment of Cutaneous Protothecosis Due to < em > Prototheca wickerhamii < /em > with Terbinafine
This report documents a case involving an 82-year-old male with Protothecosis. Histopathological analysis revealed granulomatous inflammation in the dermis, exhibiting necrotic features and hosting numerous non-budding spherical organisms. These organisms were positively stained using methenamine silver and periodic acid-Schiff stains, confirming identification as P. wickerhamii after validation through tissue culture and sequencing procedures. Initially, the patient received oral itraconazole at a dosage of 200 mg daily, accompanied by topical 1% naftifine-0.25% ketoconazole cream for a duration of 4 weeks, resulting in s...
Source: Clinical, Cosmetic and Investigational Dermatology - May 1, 2024 Category: Dermatology Authors: Yue Chen Aili Gao Yanan Ke Xin Zhou Li Lin Sha Lu Yumei Liu Source Type: research

Causal Association Between Diabetes, Body Mass Index and Lichen Sclerosus: A Bidirectional Two-Sample Mendelian Randomization Analysis
CONCLUSION: This MR analysis demonstrated no significant causal relationship between DM and BMI with LS in both directions, which contradicts previous observational studies reporting a positive association. Potential confounding factors may contribute to previously observed associations, and further research is necessary.PMID:38689755 | PMC:PMC11060172 | DOI:10.2147/CCID.S450399 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - May 1, 2024 Category: Dermatology Authors: Lin Liu Qiuli Zhang Jianmin Chang Kun Yang Source Type: research

Successful Treatment of Cutaneous Protothecosis Due to < em > Prototheca wickerhamii < /em > with Terbinafine
This report documents a case involving an 82-year-old male with Protothecosis. Histopathological analysis revealed granulomatous inflammation in the dermis, exhibiting necrotic features and hosting numerous non-budding spherical organisms. These organisms were positively stained using methenamine silver and periodic acid-Schiff stains, confirming identification as P. wickerhamii after validation through tissue culture and sequencing procedures. Initially, the patient received oral itraconazole at a dosage of 200 mg daily, accompanied by topical 1% naftifine-0.25% ketoconazole cream for a duration of 4 weeks, resulting in s...
Source: Clinical, Cosmetic and Investigational Dermatology - May 1, 2024 Category: Dermatology Authors: Yue Chen Aili Gao Yanan Ke Xin Zhou Li Lin Sha Lu Yumei Liu Source Type: research

Lactic Acid Chemical Peeling in Skin Disorders
Clin Cosmet Investig Dermatol. 2024 Apr 23;17:901-909. doi: 10.2147/CCID.S455700. eCollection 2024.ABSTRACTLactic acid is the most widely occurring natural organic acid in nature. It not only exhibits mild and safe properties but also possesses multiple physiological activities, such as antibacterial effects, immune regulation, and promotion of wound healing, making it one of the most popular chemical peeling agents. Chemical peels are commonly used in the field of aesthetic dermatology as a non-invasive therapeutic approach. This research aims to provide valuable references for clinical dermatologists by summarizing the c...
Source: Clinical, Cosmetic and Investigational Dermatology - April 29, 2024 Category: Dermatology Authors: Xiaoyue Feng Jianli Shang Zhengping Gu Xingyi Luo Yong Chen Youting Liu Source Type: research

Relationship Between Family History and Quality of Life in Patients with Psoriasis: A Cross-Sectional Study from China
CONCLUSION: PASI and PEST play a chain mediating role in the relationship between family history and DLQI in patients with plaque psoriasis, and high levels of BSA increase the ability of family history to positively predict PASI in plaque psoriasis, thereby affecting the patient's QoL.PMID:38660588 | PMC:PMC11042476 | DOI:10.2147/CCID.S453078 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - April 25, 2024 Category: Dermatology Authors: Fan Jiang Lingyi Lu Sihan Wang Feng Yuan Lu Cao Suling Xu Bingjiang Lin Source Type: research