DNA methylation and type 2 diabetes: a systematic review
DNA methylation influences gene expression and function in the pathophysiology of type 2 diabetes mellitus (T2DM). Mapping of T2DM-associated DNA methylation could aid early detection and/or therapeutic treatm... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 16, 2024 Category: Research Authors: Nikhil Nadiger, Jyothisha Kana Veed, Priyanka Chinya Nataraj and Arpita Mukhopadhyay Tags: Review Source Type: research
Machine learning unveils an immune-related DNA methylation profile in germline DNA from breast cancer patients
There is an unmet need for precise biomarkers for early non-invasive breast cancer detection. Here, we aimed to identify blood-based DNA methylation biomarkers that are associated with breast cancer. (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 15, 2024 Category: Research Authors: Ning Yuan Lee, Melissa Hum, Guek Peng Tan, Ai Choo Seah, Pei-Yi Ong, Patricia T. Kin, Chia Wei Lim, Jens Samol, Ngiap Chuan Tan, Hai-Yang Law, Min-Han Tan, Soo-Chin Lee, Peter Ang and Ann S. G. Lee Tags: Research Source Type: research
DNA methylation signatures of youth-onset type 2 diabetes and exposure to maternal diabetes
Youth-onset type 2 diabetes (T2D) is physiologically distinct from adult-onset, but it is not clear how the two diseases differ at a molecular level. In utero exposure to maternal type 2 diabetes (T2D) is know... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 13, 2024 Category: Research Authors: Ola E. Salama, Nikho Hizon, Melissa Del Vecchio, Kurt Kolsun, Mario A. Fonseca, David T. S. Lin, Oscar Urtatiz, Julia L. MacIsaac, Michael S. Kobor, Elizabeth A. C. Sellers, Vernon W. Dolinsky, Allison B. Dart, Meaghan J. Jones and Brandy A. Wicklow Tags: Research Source Type: research
Hyper-physiologic mechanical cues, as an osteoarthritis disease-relevant environmental perturbation, cause a critical shift in set points of methylation at transcriptionally active CpG sites in neo-cartilage organoids
Osteoarthritis (OA) is a complex, age-related multifactorial degenerative disease of diarthrodial joints marked by impaired mobility, joint stiffness, pain, and a significant decrease in quality of life. Among... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 10, 2024 Category: Research Authors: Niek G. C. Bloks, Amanda Dicks, Zainab Harissa, Rob G. H. H. Nelissen, Ghazaleh Hajmousa, Yolande F. M. Ramos, Rodrigo Coutinho de Almeida, Farshid Guilak and Ingrid Meulenbelt Tags: Research Source Type: research
Decitabine as epigenetic priming with CLAG induce improved outcome of relapsed or refractory acute myeloid leukemia in children
Decitabine (DAC), a DNA methyltransferase inhibitor, has shown efficacy combined with chemotherapy for relapsed or refractory (R/R) acute myeloid leukemia (AML) in adults, but less is known about its efficacy ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 9, 2024 Category: Research Authors: Na Zhang, Hong Li, Dan Wang, Zhen Wang, Jia-Shi Zhu, Kai Chen, Hui Jiang, Jing-Bo Shao and Cheng Cai Tags: Research Source Type: research
Epigenetics of the non-coding RNA nc886 across blood, adipose tissue and skeletal muscle in offspring exposed to diabetes in pregnancy
Diabetes in pregnancy is associated with increased risk of long-term metabolic disease in the offspring, potentially mediated by in utero epigenetic variation. Previously, we identified multiple differentially... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 7, 2024 Category: Research Authors: Line Hjort, Sandra Stokholm Bredgaard, Eleonora Manitta, Irene Marques, Anja Elaine S ørensen, David Martino, Louise Groth Grunnet, Louise Kelstrup, Azadeh Houshmand-Oeregaard, Tine Dalsgaard Clausen, Elisabeth Reinhardt Mathiesen, Sjurdur Frodi Olsen, R Tags: Research Source Type: research
Novel 14q32.2 paternal deletion encompassing the whole DLK1 gene associated with Temple syndrome
Temple syndrome (TS14) is a rare imprinting disorder caused by maternal UPD14, imprinting defects or paternal microdeletions which lead to an increase in the maternal expressed genes and a silencing the patern... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 7, 2024 Category: Research Authors: Neus Baena, David Monk, Cinthia Aguilera, Mario F. Fraga, Agust ín F. Fernández, Elisabeth Gabau, Raquel Corripio, Nuria Capdevila, Juan Pablo Trujillo, Anna Ruiz and Miriam Guitart Tags: Research Source Type: research
Genome- and epigenome-wide association studies identify susceptibility of CpG sites and regions for metabolic syndrome in a Korean population
While multiple studies have investigated the relationship between metabolic syndrome (MetS) and its related traits (fasting glucose, triglyceride, HDL cholesterol, blood pressure, waist circumference) and DNA ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 29, 2024 Category: Research Authors: Ho-Sun Lee, Boram Kim and Taesung Park Tags: Research Source Type: research
Correction: Improvements in lung function following vitamin C supplementation to pregnant smokers are associated with buccal DNA methylation at 5 years of age
(Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 25, 2024 Category: Research Authors: Lyndsey E. Shorey-Kendrick, Cindy T. McEvoy, Kristin Milner, Julia Harris, Julie Brownsberger, Robert S. Tepper, Byung Park, Lina Gao, Annette Vu, Cynthia D. Morris and Eliot R. Spindel Tags: Correction Source Type: research
DNA methylation of imprint control regions associated with Alzheimer ’s disease in non-Hispanic Blacks and non-Hispanic Whites
The objective of this study was to determine whether aberrant methylation at imprint control... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 25, 2024 Category: Research Authors: Sebnem E. Cevik, David A. Skaar, Dereje D. Jima, Andy J. Liu, Truls Østbye, Heather E. Whitson, Randy L. Jirtle, Cathrine Hoyo and Antonio Planchart Tags: Research Source Type: research
Evaluating the link between DIO3-FA27 promoter methylation, biochemical indices, and heart failure progression
Heart failure (HF) is a disease that poses a serious threat to individual health, and DNA methylation is an important mechanism in epigenetics, and its role in the occurrence and development of the disease has... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 24, 2024 Category: Research Authors: Yan Qi, Xiangchao Meng, Jing Li, Aoyue He, Jie Hao, Xu Zhao, Ruonan Zhao, Rongrong Chen and Rongqiang Zhang Tags: Research Source Type: research
Discovery and technical validation of high-performance methylated DNA markers for the detection of cervical lesions at risk of malignant progression in low- and middle-income countries
Cervical cancer remains a leading cause of death, particularly in developing countries. WHO screening guidelines recommend human papilloma virus (HPV) detection as a means to identify women at risk of developi... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 20, 2024 Category: Research Authors: Mary Jo Fackler, Madison Pleas, Youran Li, Anushri Soni, Deyin Xing, Leslie Cope, Syed Ali, Quang Van Le, Chu Van Nguyen, Han Thi Pham, Long Minh Duong, Eunice Vanden Berg, Reubina Wadee, Pamela Michelow, Wenlong Carl Chen, Maureen Joffe & hellip; Tags: Research Source Type: research
DNMT1/miR-152-3p/SOS1 signaling axis promotes self-renewal and tumor growth of cancer stem-like cells derived from non-small cell lung cancer
This study aimed to elucidate the underlying mechanism involving the DNMT1/miR-... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 15, 2024 Category: Research Authors: Qing Yuan, Rubo Wang, Xiang Li, Fei Sun, Jiazhi Lin, Zhimin Fu and Jiansong Zhang Tags: Research Source Type: research
Polycomb repressive complex 2 and its core component EZH2: potential targeted therapeutic strategies for head and neck squamous cell carcinoma
The polycomb group (PcG) comprises a set of proteins that exert epigenetic regulatory effects and play crucial roles in diverse biological processes, ranging from pluripotency and development to carcinogenesis... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 10, 2024 Category: Research Authors: Yuxi Cheng, Zhengzheng Song, Xiaodan Fang and Zhangui Tang Tags: Review Source Type: research
Meta-analysis of epigenetic aging in schizophrenia reveals multifaceted relationships with age, sex, illness duration, and polygenic risk
The study of biological age acceleration may help identify at-risk individuals and reduce the rising global burden of age-related diseases. Using DNA methylation (DNAm) clocks, we investigated biological aging... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 8, 2024 Category: Research Authors: Anil P. S. Ori, Loes M. Olde Loohuis, Jerry Guintivano, Eilis Hannon, Emma Dempster, David St. Clair, Nick J. Bass, Andrew McQuillin, Jonathan Mill, Patrick F. Sullivan, Rene S. Kahn, Steve Horvath and Roel A. Ophoff Tags: Research Source Type: research
