Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives
CNS Neurosci Ther. 2024 May;30(5):e14715. doi: 10.1111/cns.14715.ABSTRACTGliomas are the most common primary tumors of the central nervous system, with glioblastoma multiforme (GBM) having the highest incidence, and their therapeutic efficacy depends primarily on the extent of surgical resection and the efficacy of postoperative chemotherapy. The role of the intracranial blood-brain barrier and the occurrence of the drug-resistant gene O6-methylguanine-DNA methyltransferase have greatly limited the efficacy of chemotherapeutic agents in patients with GBM and made it difficult to achieve the expected clinical response. In r...
Source: CNS Neuroscience and Therapeutics - May 6, 2024 Category: Neuroscience Authors: Jiyuan Liu Fan Yang Jinqu Hu Xiuchun Zhang Source Type: research
Identification of the circRNA-miRNA-mRNA network for treating methamphetamine-induced relapse and behavioral sensitization with cannabidiol
CONCLUSIONS: This study constructed the ceRNAs network for the first time, revealing the potential mechanism of CBD in treating METH-induced CPP reinstatement and behavioral sensitization, thus advancing the application of CBD in METH use disorders.PMID:38702929 | PMC:PMC11069028 | DOI:10.1111/cns.14737 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2024 Category: Neuroscience Authors: Liu Liu Chan Wang Haowei Wang Lin Miao Tong Xie Yunqing Tian Xiaodong Li Yizhen Huang Xiaofeng Zeng Bofeng Zhu Source Type: research
Plasma exosomes impair microglial degradation of α-synuclein through V-ATPase subunit V1G1
CONCLUSION: Pathogenic protein accumulation is a key feature of PD, and compromised V-type ATPase dysfunction might participate in PD pathogenesis. Moreover, V1G1 overexpression protects against neuronal toxicity in an MPTP-based PD mouse model, which may provide opportunities to develop novel therapeutic interventions for PD treatment.PMID:38702933 | PMC:PMC11069054 | DOI:10.1111/cns.14738 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2024 Category: Neuroscience Authors: Yunna Li Yiming Wang Liang Kou Sijia Yin Xiaosa Chi Yadi Sun Jiawei Wu Zongjie Jin Qiulu Zhou Wenkai Zou Tao Wang Yun Xia Source Type: research
Correlation between desynchrony of hippocampal neural activity and hyperlocomotion in the model mice of schizophrenia and therapeutic effects of aripiprazole
CONCLUSIONS: These results suggest that the disruption of neural coordination may underly the neuropathological mechanism for hyperlocomotion of SZ.PMID:38702935 | PMC:PMC11069053 | DOI:10.1111/cns.14739 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2024 Category: Neuroscience Authors: Xueru Wang Zijie Li Shihui Kuai Xuejiao Wang Jingyu Chen Yanping Yang Ling Qin Source Type: research
Integrated analysis of single cell-RNA sequencing and Mendelian randomization identifies lactate dehydrogenase B as a target of melatonin in ischemic stroke
CONCLUSION: Our study identifies LDHB as a novel biomarker for ischemic stroke via combining the sc RNA-seq and MR analysis.PMID:38702940 | PMC:PMC11069049 | DOI:10.1111/cns.14741 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2024 Category: Neuroscience Authors: Fei Shi Guiyun Zhang Jinshi Li Liang Shu Cong Yu Dabin Ren Yisong Zhang Ping Zheng Source Type: research
Identification of the circRNA-miRNA-mRNA network for treating methamphetamine-induced relapse and behavioral sensitization with cannabidiol
CONCLUSIONS: This study constructed the ceRNAs network for the first time, revealing the potential mechanism of CBD in treating METH-induced CPP reinstatement and behavioral sensitization, thus advancing the application of CBD in METH use disorders.PMID:38702929 | DOI:10.1111/cns.14737 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2024 Category: Neuroscience Authors: Liu Liu Chan Wang Haowei Wang Lin Miao Tong Xie Yunqing Tian Xiaodong Li Yizhen Huang Xiaofeng Zeng Bofeng Zhu Source Type: research
Plasma exosomes impair microglial degradation of α-synuclein through V-ATPase subunit V1G1
CONCLUSION: Pathogenic protein accumulation is a key feature of PD, and compromised V-type ATPase dysfunction might participate in PD pathogenesis. Moreover, V1G1 overexpression protects against neuronal toxicity in an MPTP-based PD mouse model, which may provide opportunities to develop novel therapeutic interventions for PD treatment.PMID:38702933 | DOI:10.1111/cns.14738 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2024 Category: Neuroscience Authors: Yunna Li Yiming Wang Liang Kou Sijia Yin Xiaosa Chi Yadi Sun Jiawei Wu Zongjie Jin Qiulu Zhou Wenkai Zou Tao Wang Yun Xia Source Type: research
Correlation between desynchrony of hippocampal neural activity and hyperlocomotion in the model mice of schizophrenia and therapeutic effects of aripiprazole
CONCLUSIONS: These results suggest that the disruption of neural coordination may underly the neuropathological mechanism for hyperlocomotion of SZ.PMID:38702935 | DOI:10.1111/cns.14739 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2024 Category: Neuroscience Authors: Xueru Wang Zijie Li Shihui Kuai Xuejiao Wang Jingyu Chen Yanping Yang Ling Qin Source Type: research
Integrated analysis of single cell-RNA sequencing and Mendelian randomization identifies lactate dehydrogenase B as a target of melatonin in ischemic stroke
CONCLUSION: Our study identifies LDHB as a novel biomarker for ischemic stroke via combining the sc RNA-seq and MR analysis.PMID:38702940 | DOI:10.1111/cns.14741 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2024 Category: Neuroscience Authors: Fei Shi Guiyun Zhang Jinshi Li Liang Shu Cong Yu Dabin Ren Yisong Zhang Ping Zheng Source Type: research
Identification of the circRNA-miRNA-mRNA network for treating methamphetamine-induced relapse and behavioral sensitization with cannabidiol
CONCLUSIONS: This study constructed the ceRNAs network for the first time, revealing the potential mechanism of CBD in treating METH-induced CPP reinstatement and behavioral sensitization, thus advancing the application of CBD in METH use disorders.PMID:38702929 | DOI:10.1111/cns.14737 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2024 Category: Neuroscience Authors: Liu Liu Chan Wang Haowei Wang Lin Miao Tong Xie Yunqing Tian Xiaodong Li Yizhen Huang Xiaofeng Zeng Bofeng Zhu Source Type: research
Plasma exosomes impair microglial degradation of α-synuclein through V-ATPase subunit V1G1
CONCLUSION: Pathogenic protein accumulation is a key feature of PD, and compromised V-type ATPase dysfunction might participate in PD pathogenesis. Moreover, V1G1 overexpression protects against neuronal toxicity in an MPTP-based PD mouse model, which may provide opportunities to develop novel therapeutic interventions for PD treatment.PMID:38702933 | DOI:10.1111/cns.14738 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2024 Category: Neuroscience Authors: Yunna Li Yiming Wang Liang Kou Sijia Yin Xiaosa Chi Yadi Sun Jiawei Wu Zongjie Jin Qiulu Zhou Wenkai Zou Tao Wang Yun Xia Source Type: research
Correlation between desynchrony of hippocampal neural activity and hyperlocomotion in the model mice of schizophrenia and therapeutic effects of aripiprazole
CONCLUSIONS: These results suggest that the disruption of neural coordination may underly the neuropathological mechanism for hyperlocomotion of SZ.PMID:38702935 | DOI:10.1111/cns.14739 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2024 Category: Neuroscience Authors: Xueru Wang Zijie Li Shihui Kuai Xuejiao Wang Jingyu Chen Yanping Yang Ling Qin Source Type: research
Integrated analysis of single cell-RNA sequencing and Mendelian randomization identifies lactate dehydrogenase B as a target of melatonin in ischemic stroke
CONCLUSION: Our study identifies LDHB as a novel biomarker for ischemic stroke via combining the sc RNA-seq and MR analysis.PMID:38702940 | DOI:10.1111/cns.14741 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 4, 2024 Category: Neuroscience Authors: Fei Shi Guiyun Zhang Jinshi Li Liang Shu Cong Yu Dabin Ren Yisong Zhang Ping Zheng Source Type: research
The changing of α5-GABAA receptors expression and distribution participate in sevoflurane-induced learning and memory impairment in young mice
CONCLUSION: Dysregulated α5-GABAAR expression and distribution contributes to sevoflurane-induced partial long-term learning and memory impairment, which lays the foundation for elucidating the underlying mechanisms in future studies.PMID:38698533 | DOI:10.1111/cns.14716 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 3, 2024 Category: Neuroscience Authors: Shengran Wang Sixuan Wang Zhun Wang Jinpeng Dong Mengxue Zhang Yongan Wang Jianyu Wang Beichen Jia Yuan Luo Yiqing Yin Source Type: research
The changing of α5-GABAA receptors expression and distribution participate in sevoflurane-induced learning and memory impairment in young mice
CONCLUSION: Dysregulated α5-GABAAR expression and distribution contributes to sevoflurane-induced partial long-term learning and memory impairment, which lays the foundation for elucidating the underlying mechanisms in future studies.PMID:38698533 | DOI:10.1111/cns.14716 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 3, 2024 Category: Neuroscience Authors: Shengran Wang Sixuan Wang Zhun Wang Jinpeng Dong Mengxue Zhang Yongan Wang Jianyu Wang Beichen Jia Yuan Luo Yiqing Yin Source Type: research
