Cochrane Database of Systematic Reviews This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Autologous platelet-rich plasma for assisted reproduction
CONCLUSIONS: We are uncertain about the effect of intrauterine or intraovarian administration of PRP on outcomes of assisted reproduction technology in infertile women. The pooled results should be interpreted with caution. Only one of the 12 included studies was judged at low risk of bias. Other limitations of the included trials were failure to report live birth, poor reporting of methods, lack of prospective protocol registration, low precision due to the small number of enrolled participants, indirectness due to the specific subpopulations and settings studied, and insufficient or absent safety data.PMID:38682756 | PMC...
Source: Cochrane Database of Systematic Reviews - April 29, 2024 Category: General Medicine Authors: Dennis Vaidakis Michail Papapanou Charalampos S Siristatidis Source Type: research

Psychosocial and medication interventions to stop or reduce alcohol consumption during pregnancy
CONCLUSIONS: Brief psychosocial interventions may increase the rate of continuous abstinence among pregnant women who report alcohol use during pregnancy. Further studies should be conducted to investigate the efficacy and safety of psychosocial interventions and other treatments (e.g. medications) for women with AUD. These studies should provide detailed information on alcohol use before and during pregnancy using consistent measures such as the number of drinks per drinking day. When heterogeneous populations are recruited, more detailed information on alcohol use during pregnancy should be provided to allow future syste...
Source: Cochrane Database of Systematic Reviews - April 29, 2024 Category: General Medicine Authors: Silvia Minozzi Ludovico Ambrosi Rosella Saulle Seilin S Uhm Mishka Terplan Julia Ma Sinclair Roberta Agabio Source Type: research

Angiotensin-converting-enzyme inhibitors and angiotensin receptor blockers for preventing the progression of diabetic kidney disease
CONCLUSIONS: ACEi or ARB may make little or no difference to all-cause and cardiovascular death compared to placebo or no treatment in people with diabetes and kidney disease but may prevent kidney failure. ARB may prevent the doubling of SCr and the progression from microalbuminuria to macroalbuminuria compared with a placebo or no treatment. Despite the international guidelines suggesting not combining ACEi and ARB treatment, the effects of ACEi or ARB monotherapy compared to dual therapy have not been adequately assessed. The limited data availability and the low quality of the included studies prevented the assessment ...
Source: Cochrane Database of Systematic Reviews - April 29, 2024 Category: General Medicine Authors: Patrizia Natale Suetonia C Palmer Sankar D Navaneethan Jonathan C Craig Giovanni Fm Strippoli Source Type: research

Appendectomy versus antibiotic treatment for acute appendicitis
CONCLUSIONS: Antibiotics may be associated with higher rates of unsuccessful treatment for 76 per 1000 people, although differences may not be clinically significant. It is uncertain if antibiotics increase length of hospital stay by half a day. Antibiotics may reduce wound infections. A third of the participants initially treated with antibiotics required subsequent appendectomy or two-thirds avoided surgery within one year, but the evidence is very uncertain. There were too few data from the included studies to comment on major complications.PMID:38682788 | PMC:PMC11057219 | DOI:10.1002/14651858.CD015038.pub2 (Source: Co...
Source: Cochrane Database of Systematic Reviews - April 29, 2024 Category: General Medicine Authors: Brett Doleman Siv Fonnes Jon N Lund Hannah Boyd-Carson Hannah Javanmard-Emamghissi Susan Moug Marianne Hollyman Gillian Tierney Samson Tou John P Williams Source Type: research

Autologous platelet-rich plasma for assisted reproduction
CONCLUSIONS: We are uncertain about the effect of intrauterine or intraovarian administration of PRP on outcomes of assisted reproduction technology in infertile women. The pooled results should be interpreted with caution. Only one of the 12 included studies was judged at low risk of bias. Other limitations of the included trials were failure to report live birth, poor reporting of methods, lack of prospective protocol registration, low precision due to the small number of enrolled participants, indirectness due to the specific subpopulations and settings studied, and insufficient or absent safety data.PMID:38682756 | DOI...
Source: Cochrane Database of Systematic Reviews - April 29, 2024 Category: General Medicine Authors: Dennis Vaidakis Michail Papapanou Charalampos S Siristatidis Source Type: research

Appendectomy versus antibiotic treatment for acute appendicitis
CONCLUSIONS: Antibiotics may be associated with higher rates of unsuccessful treatment for 76 per 1000 people, although differences may not be clinically significant. It is uncertain if antibiotics increase length of hospital stay by half a day. Antibiotics may reduce wound infections. A third of the participants initially treated with antibiotics required subsequent appendectomy or two-thirds avoided surgery within one year, but the evidence is very uncertain. There were too few data from the included studies to comment on major complications.PMID:38682788 | DOI:10.1002/14651858.CD015038.pub2 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - April 29, 2024 Category: General Medicine Authors: Brett Doleman Siv Fonnes Jon N Lund Hannah Boyd-Carson Hannah Javanmard-Emamghissi Susan Moug Marianne Hollyman Gillian Tierney Samson Tou John P Williams Source Type: research

Unlocking the power of global collaboration: building a stronger evidence ecosystem together
Cochrane Database Syst Rev. 2024 Apr 16;4(4):ED000166. doi: 10.1002/14651858.ED000166.NO ABSTRACTPMID:38623686 | PMC:PMC11019402 | DOI:10.1002/14651858.ED000166 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - April 16, 2024 Category: General Medicine Authors: Zoe Jordan Vivian Welch Karla Soares-Weiser Source Type: research

Unlocking the power of global collaboration: building a stronger evidence ecosystem together
Cochrane Database Syst Rev. 2024 Apr 16;4:ED000166. doi: 10.1002/14651858.ED000166.NO ABSTRACTPMID:38623686 | DOI:10.1002/14651858.ED000166 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - April 16, 2024 Category: General Medicine Authors: Zoe Jordan Vivian Welch Karla Soares-Weiser Source Type: research