Size effect of mesoporous silica nanoparticles on regulating the immune effect of oral influenza split vaccine
Colloids Surf B Biointerfaces. 2024 Apr 16;238:113920. doi: 10.1016/j.colsurfb.2024.113920. Online ahead of print.ABSTRACTMucosal immunization is a powerful weapon against viral infection. In this paper, large pore mesoporous silica nanoparticles (LMSN) with different particle sizes were synthesized for loading influenza split vaccine (SV) to explore the effect of nanoparticle sizes on mucosal immunization and adjuvant efficacy. Interestingly, it was found that among the three particle sizes of nanoparticles, only LMSN-M with around 250 nm could significantly enhance the mucosal immune effect of SV, possessing adjuvant eff...
Source: Colloids and Surfaces - April 30, 2024 Category: Biotechnology Authors: Zhu Liu Hongyan Lu Shi Li Bin Liu Qinfu Zhao Yikun Gao Yuling Mao Jinghai Zhang Siling Wang Source Type: research
Glycerophospholipid polyunsaturation modulates resveratrol action on biomimetic membranes
Colloids Surf B Biointerfaces. 2024 Apr 16;238:113922. doi: 10.1016/j.colsurfb.2024.113922. Online ahead of print.ABSTRACTThe phytoalexin resveratrol has received increasing attention for its potential to prevent oxidative damages in human organism. To shed further light on molecular mechanisms of its interaction with lipid membranes we study resveratrol influence on the organisation and mechanical properties of biomimetic lipid systems composed of synthetic phosphatidylcholines with mixed aliphatic chains and different degree of unsaturation at sn-2 position (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, POPC, and 1-p...
Source: Colloids and Surfaces - April 28, 2024 Category: Biotechnology Authors: Victoria Vitkova Rusina Hazarosova Iva Valkova Albena Momchilova Galya Staneva Source Type: research
Glycerophospholipid polyunsaturation modulates resveratrol action on biomimetic membranes
Colloids Surf B Biointerfaces. 2024 Apr 16;238:113922. doi: 10.1016/j.colsurfb.2024.113922. Online ahead of print.ABSTRACTThe phytoalexin resveratrol has received increasing attention for its potential to prevent oxidative damages in human organism. To shed further light on molecular mechanisms of its interaction with lipid membranes we study resveratrol influence on the organisation and mechanical properties of biomimetic lipid systems composed of synthetic phosphatidylcholines with mixed aliphatic chains and different degree of unsaturation at sn-2 position (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, POPC, and 1-p...
Source: Colloids and Surfaces - April 28, 2024 Category: Biotechnology Authors: Victoria Vitkova Rusina Hazarosova Iva Valkova Albena Momchilova Galya Staneva Source Type: research
Genetically encoded biocompatible anti-coagulant protein-coated coronary artery stents drive endothelialization
Colloids Surf B Biointerfaces. 2024 Apr 8;238:113908. doi: 10.1016/j.colsurfb.2024.113908. Online ahead of print.ABSTRACTIn response to the critical demand for advancements in coronary artery stents, this study addresses the challenges associated with arterial recoil and restenosis post-angioplasty and the imperative to encourage rapid re-endothelialization for minimizing thrombosis risks. We employed an innovative approach inspired by mussel adhesion, incorporating placental anticoagulant protein (AnnexinV) on stent design. The introduction of a post-translationally modified catecholic amino acid L-3,4-dihydroxyphenylalan...
Source: Colloids and Surfaces - April 27, 2024 Category: Biotechnology Authors: Pandurangan Suryalakshmi Ashokraj Sundarapandian Jebakumar Mercyjayapriya Mohandass Pachaiyappan Prem Suresh Sisila Valappil Mayilvahanan Aarthy Niraikulam Ayyadurai Source Type: research
High throughput microfluidics-based synthesis of PEGylated liposomes for precise size control and efficient drug encapsulation
Colloids Surf B Biointerfaces. 2024 Apr 22;238:113926. doi: 10.1016/j.colsurfb.2024.113926. Online ahead of print.ABSTRACTThe low scalability and reproducibility of existing synthesis methods have hindered the translation of liposome nanoparticles as carriers for targeted drug delivery from conventional laboratory techniques to mass production. To this end, in this study, we present a high-throughput microfluidics-based approach for the synthesis of PEGylated liposomes with a primary focus on achieving precise size control and efficient encapsulation of hydrophobic drug molecules. In this platform, liposomes were self-asse...
Source: Colloids and Surfaces - April 27, 2024 Category: Biotechnology Authors: Shima Akar Somayeh Fardindoost Mina Hoorfar Source Type: research
Legume protein fermented by lactic acid bacteria: Specific enzymatic hydrolysis, protein composition, structure, and functional properties
Colloids Surf B Biointerfaces. 2024 Apr 24;238:113929. doi: 10.1016/j.colsurfb.2024.113929. Online ahead of print.ABSTRACTIn recent years, with increasing emphasis on healthy, green, and sustainable consumption concepts, plant-based foods have gained popularity among consumers. As widely sourced plant-based raw materials, legume proteins are considered sustainable and renewable alternatives to animal proteins. However, legume proteins have limited functional properties, which hinder their application in food products. LAB fermentation is a relatively natural processing method that is safer than chemical/physical modificati...
Source: Colloids and Surfaces - April 27, 2024 Category: Biotechnology Authors: Qiwei Du Hang Li Maolin Tu Zhen Wu Tao Zhang Jianhua Liu Yuting Ding Xiaoqun Zeng Daodong Pan Source Type: research
Genetically encoded biocompatible anti-coagulant protein-coated coronary artery stents drive endothelialization
Colloids Surf B Biointerfaces. 2024 Apr 8;238:113908. doi: 10.1016/j.colsurfb.2024.113908. Online ahead of print.ABSTRACTIn response to the critical demand for advancements in coronary artery stents, this study addresses the challenges associated with arterial recoil and restenosis post-angioplasty and the imperative to encourage rapid re-endothelialization for minimizing thrombosis risks. We employed an innovative approach inspired by mussel adhesion, incorporating placental anticoagulant protein (AnnexinV) on stent design. The introduction of a post-translationally modified catecholic amino acid L-3,4-dihydroxyphenylalan...
Source: Colloids and Surfaces - April 27, 2024 Category: Biotechnology Authors: Pandurangan Suryalakshmi Ashokraj Sundarapandian Jebakumar Mercyjayapriya Mohandass Pachaiyappan Prem Suresh Sisila Valappil Mayilvahanan Aarthy Niraikulam Ayyadurai Source Type: research
High throughput microfluidics-based synthesis of PEGylated liposomes for precise size control and efficient drug encapsulation
Colloids Surf B Biointerfaces. 2024 Apr 22;238:113926. doi: 10.1016/j.colsurfb.2024.113926. Online ahead of print.ABSTRACTThe low scalability and reproducibility of existing synthesis methods have hindered the translation of liposome nanoparticles as carriers for targeted drug delivery from conventional laboratory techniques to mass production. To this end, in this study, we present a high-throughput microfluidics-based approach for the synthesis of PEGylated liposomes with a primary focus on achieving precise size control and efficient encapsulation of hydrophobic drug molecules. In this platform, liposomes were self-asse...
Source: Colloids and Surfaces - April 27, 2024 Category: Biotechnology Authors: Shima Akar Somayeh Fardindoost Mina Hoorfar Source Type: research
Legume protein fermented by lactic acid bacteria: Specific enzymatic hydrolysis, protein composition, structure, and functional properties
Colloids Surf B Biointerfaces. 2024 Apr 24;238:113929. doi: 10.1016/j.colsurfb.2024.113929. Online ahead of print.ABSTRACTIn recent years, with increasing emphasis on healthy, green, and sustainable consumption concepts, plant-based foods have gained popularity among consumers. As widely sourced plant-based raw materials, legume proteins are considered sustainable and renewable alternatives to animal proteins. However, legume proteins have limited functional properties, which hinder their application in food products. LAB fermentation is a relatively natural processing method that is safer than chemical/physical modificati...
Source: Colloids and Surfaces - April 27, 2024 Category: Biotechnology Authors: Qiwei Du Hang Li Maolin Tu Zhen Wu Tao Zhang Jianhua Liu Yuting Ding Xiaoqun Zeng Daodong Pan Source Type: research
Synthesis of calix (4) resorcinarene based amphiphilic macrocycle as an efficient nanocarrier for Amphotericin-B to enhance its oral bioavailability
In this study, we designed and synthesized a new supramolecular amphiphilic macrocycle to serve as an efficient nanocarrier, achieved by treating 4-hydroxybenzaldehyde with 1-bromotetradecane. The derivatized product was subsequently treated with resorcinol to cyclize, resulting in the formation of a calix(4)-resorcinarene-based supramolecular amphiphilic macrocycle. The synthesized macrocycle and intermediate products were characterized using mass spectrometry, IR, and 1H NMR spectroscopic techniques. The amphotericin-B (Amph-B)-loaded and unloaded amphiphiles were screened for biocompatibility studies, vesicle formation,...
Source: Colloids and Surfaces - April 26, 2024 Category: Biotechnology Authors: Imdad Ali Amjad Ali Li Guo Samiullah Burki Jawad Ur Rehman Mahmood Fazal Naushad Ahmad Sarzamin Khan Carlos A T Toloza Muhammad Raza Shah Source Type: research
Structural and tribological studies on the interaction of porcine gastric mucin with non- and cationic-modified β-lactoglobulins
This study demonstrates a unique and successful approach to intensify the interaction between BLG and mucins, which is meaningful for a broad range of disciplines, including food science, macromolecular interactions, and biolubrication etc.PMID:38669751 | DOI:10.1016/j.colsurfb.2024.113924 (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - April 26, 2024 Category: Biotechnology Authors: Hadi Asgharzadeh Shirazi Seunghwan Lee Saif Ullah Kristoffer Almdal Source Type: research
Synthesis of calix (4) resorcinarene based amphiphilic macrocycle as an efficient nanocarrier for Amphotericin-B to enhance its oral bioavailability
In this study, we designed and synthesized a new supramolecular amphiphilic macrocycle to serve as an efficient nanocarrier, achieved by treating 4-hydroxybenzaldehyde with 1-bromotetradecane. The derivatized product was subsequently treated with resorcinol to cyclize, resulting in the formation of a calix(4)-resorcinarene-based supramolecular amphiphilic macrocycle. The synthesized macrocycle and intermediate products were characterized using mass spectrometry, IR, and 1H NMR spectroscopic techniques. The amphotericin-B (Amph-B)-loaded and unloaded amphiphiles were screened for biocompatibility studies, vesicle formation,...
Source: Colloids and Surfaces - April 26, 2024 Category: Biotechnology Authors: Imdad Ali Amjad Ali Li Guo Samiullah Burki Jawad Ur Rehman Mahmood Fazal Naushad Ahmad Sarzamin Khan Carlos A T Toloza Muhammad Raza Shah Source Type: research
Structural and tribological studies on the interaction of porcine gastric mucin with non- and cationic-modified β-lactoglobulins
This study demonstrates a unique and successful approach to intensify the interaction between BLG and mucins, which is meaningful for a broad range of disciplines, including food science, macromolecular interactions, and biolubrication etc.PMID:38669751 | DOI:10.1016/j.colsurfb.2024.113924 (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - April 26, 2024 Category: Biotechnology Authors: Hadi Asgharzadeh Shirazi Seunghwan Lee Saif Ullah Kristoffer Almdal Source Type: research
Synergistic antibacterial effect and mechanism between Cu < sub > 2 < /sub > O nanoparticles and quaternary ammonium salt in moisture-curable acrylic coatings
Colloids Surf B Biointerfaces. 2024 Apr 12;238:113914. doi: 10.1016/j.colsurfb.2024.113914. Online ahead of print.ABSTRACTCombining with various antibacterial mechanisms is the preferred strategy to fabricate coatings with effective antibacterial performance. Herein, Cu2O nanoparticles and dimethyloctadecyl [3-(trimethoxysilyl) propyl] ammonium chloride, a kind of quaternary ammonium salt (QAS), were simultaneously incorporated into a moisture-curable acrylic resin in order to achieve both contact-killing and release-killing abilities for antibacterial coatings. The surface morphology, surface composition and basic propert...
Source: Colloids and Surfaces - April 25, 2024 Category: Biotechnology Authors: Haofeng Xiao Shuxue Zhou Source Type: research
Exploring the antifungal potential of Annona muricata leaf extract-loaded hydrogel in treating vulvovaginal candidiasis
This study presents an innovative hydrogel formulation containing the ethanolic extract from A. muricata leaves designed to control C. albicans in an in vivo model of vulvovaginal candidiasis. Here, we report the development, thermal, physicochemical and rheological characterization of a Carbopol®-based hydrogel containing A. muricata extract. Furthermore, we evaluated its activity in a vulvovaginal candidiasis in vivo model. Thermal analyses indicated that the addition of the extract increased the polymer-polymer and polymer-solvent interactions.Rheological analysis showed a decrease in the viscosity and elasticity of th...
Source: Colloids and Surfaces - April 25, 2024 Category: Biotechnology Authors: Lara Melo Campos Ari S érgio de Oliveira Lemos Priscila de Lima Paula Vin ícius Novaes da Rocha Marcelo Gonzaga de Freitas Ara újo Guilherme Diniz Tavares Thais Nogueira Barradas Wesley William Gon çalves Nascimento Angelo M ácio Leite Denadai Luiz F Source Type: research
