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Effect of Novel Inflammatory Biomarkers on Adverse Outcomes in Patients with Interstitial Lung Disease and Pneumonia: A Multicenter Retrospective Cohort Study
CONCLUSION: To some extent, SII levels exhibit correlations with the clinical manifestations in patients grappling with interstitial lung disease complicated by pneumonia. Notably, a high SII level is an independent predictor for an unfavorable prognosis in these patients. Nevertheless, these findings warrant further validation through prospective cohort studies.PMID:38698751 | DOI:10.2174/0113862073286907240308095907 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - May 3, 2024 Category: Chemistry Authors: Wenmei Bai Yide Wang Fengsen Li Source Type: research

miRNAs Influence m6A RNA Methylation through FTO and IGF2BP2 in Pressure Overload-Induced Heart Failure
CONCLUSION: miR-23b-3p and let-7b-5p are identified as potential regulators of RNA methylation in heart failure, acting via FTO and IGF2BP2, offering new insights into the role of miRNA-mediated RNA methylation and its potential therapeutic avenues for heart failure.PMID:38693740 | DOI:10.2174/0113862073316437240426071022 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - May 2, 2024 Category: Chemistry Authors: Yuanqi Wang Linghao Xu Md Sakibur Rahman Tapu Tiantian Jiao Xueqi Lin Wei Song Liang Wang Lindong Nie Jing Cheng Lijian Xing Qi Zhang Jiming Li Source Type: research

Deciphering the Pharmacological Mechanisms of Wen-Jing-Zhi-Tong Decoction in Treating Primary Dysmenorrhea by UPLC-Q-ExactiveOrbitrap-MS/MS with GC-MS and Network Pharmacology
CONCLUSION: This study provides the first comprehensive analysis of the key compounds, targets, and pathways of WJZTD, laying a solid foundation for future pharmacological studies on PDM. The anti-nociceptive and anti-inflammatory effect may be attributed to the downregulation of the BDNF/TrkB/ERK/CREB signaling pathway.PMID:38693741 | DOI:10.2174/0113862073308798240425115006 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - May 2, 2024 Category: Chemistry Authors: Xiaotian Yang Yajie Qin Huifang Zhou Source Type: research

Uncovering the Role of Anmeidan against Atherosclerosis from Integrated Network Pharmacology and Pharmacological Experiments
CONCLUSIONS: This study confirmed that AMD could treat AS by regulating lipid metabolism and preliminarily explored the related mechanism. These findings provide new ideas for the treatment of AS with TCM.PMID:38676497 | DOI:10.2174/0113862073281925240417062009 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 27, 2024 Category: Chemistry Authors: Yuting Zheng Jianxiang Wang Chengcheng Pan Jihong Song Xingyue Li Wenjing Ta Wen Lu Source Type: research

Ethnobotanical Significance, Phytopharmacology, and Toxicological Profile of Limonia acidissima L. (Rutaceae): A Review
Comb Chem High Throughput Screen. 2024 Apr 25. doi: 10.2174/0113862073285538240417051928. Online ahead of print.ABSTRACTMedicinal plants play a crucial role in traditional medicine, where they are extensively employed by traditional physicians for treating a wide array of ailments. Limonia acidissima (Linn), commonly known as the Wood apple and belonging to the Rutaceae family, is widely cultivated in countries, such as Pakistan, India, and Sri Lanka. The various parts of Limonia acidissima, including its roots, leaves, fruits, stem, and even the whole plant, have been traditionally used in the treatment of numerous condit...
Source: Combinatorial Chemistry and High Throughput Screening - April 27, 2024 Category: Chemistry Authors: Satyajit Mohanty Ashok Pattnaik Source Type: research

Mogroside V Promotes Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells from Diabetic Mice by Altering MicroRNA Profiles
CONCLUSION: MV significantly enhances the viability and osteogenic differentiation of BMSCs under diabetic conditions. The alteration of miRNA profiles provides a foundation for further research into the regulatory role of miRNAs and MV in this process.PMID:38676499 | DOI:10.2174/0113862073299904240416114653 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 27, 2024 Category: Chemistry Authors: Yicai Luo Zhimao Ye Cuiping Li Le Hong Hao Li Source Type: research

To Explore Potential Inhibitors Against Various Enzymatic Targets of Human African Trypanosomiasis
Comb Chem High Throughput Screen. 2024 Apr 25. doi: 10.2174/0113862073293708240416113543. Online ahead of print.ABSTRACTSynthetic drugs currently prescribed for the treatment of Human African Trypanosomiasis (HAT) are non-specific, toxic, demand extended therapeutic regimes and are of varying efficacy. Along with the challenging demographic and socio-economic hurdles, the everincreasing risk of drug resistance is another major problem to be addressed. Cysteine protease, Heat shock proteins (HSP-90), Trypanothione reductase (TR), Farnesyl diphosphate synthase, Glucose-6-phosphate dehydrogenase, UP-4-galactose epimerase, and...
Source: Combinatorial Chemistry and High Throughput Screening - April 27, 2024 Category: Chemistry Authors: Sayandeep Brahma Susmita Moitra Soumya Ranjan Bagchi Asmita Samadder Sisir Nandi Source Type: research

Targeted Drug Nanodelivery and Immunotherapy for Combating Tumor Resistance
Comb Chem High Throughput Screen. 2024 Apr 25. doi: 10.2174/0113862073296206240416060154. Online ahead of print.ABSTRACTChemotherapy resistance is a common cause of tumor treatment failure. Various molecular responses, such as increased expression of efflux transporter proteins, including Pglycoprotein (P-gp), changes in the tumor microenvironment (TME), the role of platelets, and the effects of cancer stem cells (CSCs), can lead to drug resistance. Through extensive research on the mechanisms of drug resistance, more effective anti-resistance drugs and therapeutic approaches are being developed. This review explores drug ...
Source: Combinatorial Chemistry and High Throughput Screening - April 27, 2024 Category: Chemistry Authors: Yun Liu Xinyu Sun Chen Wei Shoudong Guo Chunxiao Song Jiangyu Zhang Jingkun Bai Source Type: research

The NeuroProtect Formula: A Preventive Approach to AD Targeting the HIF-1/PI3K-AKT Signaling Pathway Evaluated through In Vivo, In Vitro, and Network Pharmacology Approaches
CONCLUSION: Our findings suggest that NP exhibits neuroprotective effects during the early stages of AD, positioning it as a potential candidate for AD prevention. The NP formula may exert its preventive effects through the HIF-1/PI3K-AKT signaling pathway, with mTOR identified as a key target.PMID:38676511 | DOI:10.2174/0113862073311518240416070410 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 27, 2024 Category: Chemistry Authors: Haiyan Li Qian Hua Shuo Cheng Xiaoge Liu Qingyuan Cai Jiani Zhang Tiantian Peng Jiao Li Chunxiang Wang Chengbang Liang Yu Shi Xu Wang Yan Tan Source Type: research

Exploring the Causal Effects of Gut Microbiota on Diabetic Nephropathy: A Two-Sample Mendelian Randomization Study
CONCLUSION: This study confirms the causal effects of gut microbiota on diabetic nephropathy. Identifying the risk and protective factors within the gut microbiota for diabetic nephropathy offers fresh insights and novel approaches for preventing and treating this condition.PMID:38676512 | DOI:10.2174/0113862073311197240425073859 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 27, 2024 Category: Chemistry Authors: Kai Chen Xu Wang Zhihao Shang Qingyue Li Wenqiang Yao Shaobo Guo Yingting Guan Source Type: research