Therapeutic Effects of Melatonin in the Regulation of Ferroptosis: A Review of Current Evidence
Curr Drug Targets. 2024 May 3. doi: 10.2174/0113894501284110240426074746. Online ahead of print.ABSTRACTFerroptosis is implicated in the pathogenesis of multiple diseases, including neurodegenerative diseases, cardiovascular diseases, kidney pathologies, ischemia-reperfusion injury, and cancer. The current review article highlights the involvement of ferroptosis in traumatic brain injury, acute kidney damage, ethanol-induced liver injury, and PM2.5-induced lung injury. Melatonin, a molecule produced by the pineal gland and many other organs, is well known for its anti- aging, anti-inflammatory, and anticancer properties an...
Source: Current Drug Targets - May 6, 2024 Category: Drugs & Pharmacology Authors: Mohammad Hossein Pourhanifeh Azam Hosseinzadeh Fereshteh Koosha Russel J Reiter Saeed Mehrzadi Source Type: research
Effect of Rotenone on the Neurodegeneration among Different Models
Curr Drug Targets. 2024 May 2. doi: 10.2174/0113894501281496231226070459. Online ahead of print.ABSTRACTRotenone is a naturally occurring plant product used as an insecticide, pesticide and piscicide. It is lipophilic in nature and can cross the blood-brain barrier and induce the degeneration of neurons. It inhibits the mitochondrial respiratory chain complex I and stops the transfer of electrons. It induces ROS generation, which impairs mitochondrial activity. Rotenone is a toxic agent which causes the death of neurons. The present review describes the effect of rotenone on neurodegeneration with an emphasis on behavioral...
Source: Current Drug Targets - May 3, 2024 Category: Drugs & Pharmacology Authors: Iqra Subhan Yasir Hasan Siddique Source Type: research
Effect of Rotenone on the Neurodegeneration among Different Models
Curr Drug Targets. 2024 May 2. doi: 10.2174/0113894501281496231226070459. Online ahead of print.ABSTRACTRotenone is a naturally occurring plant product used as an insecticide, pesticide and piscicide. It is lipophilic in nature and can cross the blood-brain barrier and induce the degeneration of neurons. It inhibits the mitochondrial respiratory chain complex I and stops the transfer of electrons. It induces ROS generation, which impairs mitochondrial activity. Rotenone is a toxic agent which causes the death of neurons. The present review describes the effect of rotenone on neurodegeneration with an emphasis on behavioral...
Source: Current Drug Targets - May 3, 2024 Category: Drugs & Pharmacology Authors: Iqra Subhan Yasir Hasan Siddique Source Type: research
Effect of Rotenone on the Neurodegeneration among Different Models
Curr Drug Targets. 2024 May 2. doi: 10.2174/0113894501281496231226070459. Online ahead of print.ABSTRACTRotenone is a naturally occurring plant product used as an insecticide, pesticide and piscicide. It is lipophilic in nature and can cross the blood-brain barrier and induce the degeneration of neurons. It inhibits the mitochondrial respiratory chain complex I and stops the transfer of electrons. It induces ROS generation, which impairs mitochondrial activity. Rotenone is a toxic agent which causes the death of neurons. The present review describes the effect of rotenone on neurodegeneration with an emphasis on behavioral...
Source: Current Drug Targets - May 3, 2024 Category: Drugs & Pharmacology Authors: Iqra Subhan Yasir Hasan Siddique Source Type: research
Chitosan-Based Nanocarriers for Pulmonary and Intranasal Drug Delivery Systems: A Comprehensive Overview of their Applications
Curr Drug Targets. 2024 Apr 26. doi: 10.2174/0113894501301747240417103321. Online ahead of print.ABSTRACTThe optimization of respiratory health is important, and one avenue for achieving this is through the application of both Pulmonary Drug Delivery System (PDDS) and Intranasal Delivery (IND). PDDS offers immediate delivery of medication to the respiratory system, providing advantages, such as sustained regional drug concentration, tunable drug release, extended duration of action, and enhanced patient compliance. IND, renowned for its non-invasive nature and swift onset of action, presents a promising path for advancemen...
Source: Current Drug Targets - April 27, 2024 Category: Drugs & Pharmacology Authors: Wasan Alwahsh Shariza Sahudin Hatim Alkhatib Mohammad F Bostanudin Mohammad Alwahsh Source Type: research
Chitosan-Based Nanocarriers for Pulmonary and Intranasal Drug Delivery Systems: A Comprehensive Overview of their Applications
Curr Drug Targets. 2024 Apr 26. doi: 10.2174/0113894501301747240417103321. Online ahead of print.ABSTRACTThe optimization of respiratory health is important, and one avenue for achieving this is through the application of both Pulmonary Drug Delivery System (PDDS) and Intranasal Delivery (IND). PDDS offers immediate delivery of medication to the respiratory system, providing advantages, such as sustained regional drug concentration, tunable drug release, extended duration of action, and enhanced patient compliance. IND, renowned for its non-invasive nature and swift onset of action, presents a promising path for advancemen...
Source: Current Drug Targets - April 27, 2024 Category: Drugs & Pharmacology Authors: Wasan Alwahsh Shariza Sahudin Hatim Alkhatib Mohammad F Bostanudin Mohammad Alwahsh Source Type: research
Chitosan-Based Nanocarriers for Pulmonary and Intranasal Drug Delivery Systems: A Comprehensive Overview of their Applications
Curr Drug Targets. 2024 Apr 26. doi: 10.2174/0113894501301747240417103321. Online ahead of print.ABSTRACTThe optimization of respiratory health is important, and one avenue for achieving this is through the application of both Pulmonary Drug Delivery System (PDDS) and Intranasal Delivery (IND). PDDS offers immediate delivery of medication to the respiratory system, providing advantages, such as sustained regional drug concentration, tunable drug release, extended duration of action, and enhanced patient compliance. IND, renowned for its non-invasive nature and swift onset of action, presents a promising path for advancemen...
Source: Current Drug Targets - April 27, 2024 Category: Drugs & Pharmacology Authors: Wasan Alwahsh Shariza Sahudin Hatim Alkhatib Mohammad F Bostanudin Mohammad Alwahsh Source Type: research
Chitosan-Based Nanocarriers for Pulmonary and Intranasal Drug Delivery Systems: A Comprehensive Overview of their Applications
Curr Drug Targets. 2024 Apr 26. doi: 10.2174/0113894501301747240417103321. Online ahead of print.ABSTRACTThe optimization of respiratory health is important, and one avenue for achieving this is through the application of both Pulmonary Drug Delivery System (PDDS) and Intranasal Delivery (IND). PDDS offers immediate delivery of medication to the respiratory system, providing advantages, such as sustained regional drug concentration, tunable drug release, extended duration of action, and enhanced patient compliance. IND, renowned for its non-invasive nature and swift onset of action, presents a promising path for advancemen...
Source: Current Drug Targets - April 27, 2024 Category: Drugs & Pharmacology Authors: Wasan Alwahsh Shariza Sahudin Hatim Alkhatib Mohammad F Bostanudin Mohammad Alwahsh Source Type: research
Magnetomorph: The Future of Targeted Drug Delivery
Curr Drug Targets. 2024 Apr 18. doi: 10.2174/0113894501309729240414081308. Online ahead of print.NO ABSTRACTPMID:38639288 | DOI:10.2174/0113894501309729240414081308 (Source: Current Drug Targets)
Source: Current Drug Targets - April 19, 2024 Category: Drugs & Pharmacology Authors: Ashutosh Kumar Ghanshyam Das Gupta Manish Kumar Source Type: research
Transcending Molecules: Paving the Way from Lab to Life in Drug Transport Innovation
Curr Drug Targets. 2024 Apr 18. doi: 10.2174/0113894501305312240414073623. Online ahead of print.NO ABSTRACTPMID:38639289 | DOI:10.2174/0113894501305312240414073623 (Source: Current Drug Targets)
Source: Current Drug Targets - April 19, 2024 Category: Drugs & Pharmacology Authors: Abhishek Verma Abhishek Chauhan Ankit Awasthi Source Type: research
Magnetomorph: The Future of Targeted Drug Delivery
Curr Drug Targets. 2024 Apr 18. doi: 10.2174/0113894501309729240414081308. Online ahead of print.NO ABSTRACTPMID:38639288 | DOI:10.2174/0113894501309729240414081308 (Source: Current Drug Targets)
Source: Current Drug Targets - April 19, 2024 Category: Drugs & Pharmacology Authors: Ashutosh Kumar Ghanshyam Das Gupta Manish Kumar Source Type: research
Transcending Molecules: Paving the Way from Lab to Life in Drug Transport Innovation
Curr Drug Targets. 2024 Apr 18. doi: 10.2174/0113894501305312240414073623. Online ahead of print.NO ABSTRACTPMID:38639289 | DOI:10.2174/0113894501305312240414073623 (Source: Current Drug Targets)
Source: Current Drug Targets - April 19, 2024 Category: Drugs & Pharmacology Authors: Abhishek Verma Abhishek Chauhan Ankit Awasthi Source Type: research
Magnetomorph: The Future of Targeted Drug Delivery
Curr Drug Targets. 2024 Apr 18. doi: 10.2174/0113894501309729240414081308. Online ahead of print.NO ABSTRACTPMID:38639288 | DOI:10.2174/0113894501309729240414081308 (Source: Current Drug Targets)
Source: Current Drug Targets - April 19, 2024 Category: Drugs & Pharmacology Authors: Ashutosh Kumar Ghanshyam Das Gupta Manish Kumar Source Type: research
Transcending Molecules: Paving the Way from Lab to Life in Drug Transport Innovation
Curr Drug Targets. 2024 Apr 18. doi: 10.2174/0113894501305312240414073623. Online ahead of print.NO ABSTRACTPMID:38639289 | DOI:10.2174/0113894501305312240414073623 (Source: Current Drug Targets)
Source: Current Drug Targets - April 19, 2024 Category: Drugs & Pharmacology Authors: Abhishek Verma Abhishek Chauhan Ankit Awasthi Source Type: research
Magnetomorph: The Future of Targeted Drug Delivery
Curr Drug Targets. 2024 Apr 18. doi: 10.2174/0113894501309729240414081308. Online ahead of print.NO ABSTRACTPMID:38639288 | DOI:10.2174/0113894501309729240414081308 (Source: Current Drug Targets)
Source: Current Drug Targets - April 19, 2024 Category: Drugs & Pharmacology Authors: Ashutosh Kumar Ghanshyam Das Gupta Manish Kumar Source Type: research
