Circulating Immune Cells Predict Prognosis and Clinical Response to Chemotherapy in Cholangiocarcinoma
CONCLUSION: The relationship between circulating immune cells with prognosis and chemotherapy response in patients with CCA highlights their potential application as an indicator of CCA prognosis and stratification of chemotherapy response.PMID:38698750 | DOI:10.2174/0109298673296618240424095548 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - May 3, 2024 Category: Chemistry Authors: Huina Shi Zhaosheng Li Mingchen Zhu Source Type: research
Probiotics for Inflammatory Bowel Disease; A Deep Dive into Their Impact on Disease Course and Associated Health Risks
In conclusion, we recommend probiotics as an adjuvant therapeutic option for IBD therapy for ulcerative colitis; however, their role in Crohn's disease needs further research.PMID:38693730 | DOI:10.2174/0109298673314861240429072352 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - May 2, 2024 Category: Chemistry Authors: Wassan Nori Mohammed Hassan Methaq Mueen Al-Kaabi Nabeeha Najatee Akram Mustafa Ali Kassim Kassim Alexandru Cosmin Pantazi Source Type: research
Recent Synthesis of Nucleoside Phosphonate Analogs Using Olefin Cross-metathesis
Curr Med Chem. 2024 Apr 30. doi: 10.2174/0109298673280546240106123000. Online ahead of print.ABSTRACTNucleotide analogs known as acyclic and cyclic nucleoside phosphonates (ANPs and CNPs, respectively) have a variety of biological properties, including antibacterial, antiviral, antiparasitic, antineoplastic, and immunomodulatory. A strong reaction that has emerged in the last several decades has fundamentally changed our knowledge of the chemistry of nucleoside phosphonates. In particular, Olefin cross-metathesis (CM) has been a potent and practical synthesis route to produce functionalized olefins from essential alkene pr...
Source: Current Medicinal Chemistry - May 2, 2024 Category: Chemistry Authors: Joon Hee Hong Source Type: research
Synthesis, In Silico Prediction, and In Vitro Evaluation of Anti-tumor Activities of Novel 4'-Hydroxybiphenyl-4-carboxylic Acid Derivatives as EGFR Allosteric Site Inhibitors
CONCLUSION: Compound S4 is a promising EGFR tyrosine kinase allosteric inhibitor that warrants further research.PMID:38693732 | DOI:10.2174/0109298673305163240427065543 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - May 2, 2024 Category: Chemistry Authors: Wurood A Shihab Ammar A Razzak Kubba Lubna H Tahtamouni Khaled M Saleh Mai F AlSakhen Sana I Kanaan Abdulrahman M Saleh Salem R Yasin Source Type: research
Probiotics for Inflammatory Bowel Disease; A Deep Dive into Their Impact on Disease Course and Associated Health Risks
In conclusion, we recommend probiotics as an adjuvant therapeutic option for IBD therapy for ulcerative colitis; however, their role in Crohn's disease needs further research.PMID:38693730 | DOI:10.2174/0109298673314861240429072352 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - May 2, 2024 Category: Chemistry Authors: Wassan Nori Mohammed Hassan Methaq Mueen Al-Kaabi Nabeeha Najatee Akram Mustafa Ali Kassim Kassim Alexandru Cosmin Pantazi Source Type: research
Recent Synthesis of Nucleoside Phosphonate Analogs Using Olefin Cross-metathesis
Curr Med Chem. 2024 Apr 30. doi: 10.2174/0109298673280546240106123000. Online ahead of print.ABSTRACTNucleotide analogs known as acyclic and cyclic nucleoside phosphonates (ANPs and CNPs, respectively) have a variety of biological properties, including antibacterial, antiviral, antiparasitic, antineoplastic, and immunomodulatory. A strong reaction that has emerged in the last several decades has fundamentally changed our knowledge of the chemistry of nucleoside phosphonates. In particular, Olefin cross-metathesis (CM) has been a potent and practical synthesis route to produce functionalized olefins from essential alkene pr...
Source: Current Medicinal Chemistry - May 2, 2024 Category: Chemistry Authors: Joon Hee Hong Source Type: research
Synthesis, In Silico Prediction, and In Vitro Evaluation of Anti-tumor Activities of Novel 4'-Hydroxybiphenyl-4-carboxylic Acid Derivatives as EGFR Allosteric Site Inhibitors
CONCLUSION: Compound S4 is a promising EGFR tyrosine kinase allosteric inhibitor that warrants further research.PMID:38693732 | DOI:10.2174/0109298673305163240427065543 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - May 2, 2024 Category: Chemistry Authors: Wurood A Shihab Ammar A Razzak Kubba Lubna H Tahtamouni Khaled M Saleh Mai F AlSakhen Sana I Kanaan Abdulrahman M Saleh Salem R Yasin Source Type: research
Multiomics Analysis of Disulfidptosis Patterns and Integrated Machine Learning to Predict Immunotherapy Response in Lung Adenocarcinoma
CONCLUSION: Our research introduces an innovative prognostic risk model predicated upon disulfidptosis genes for patients afflicted with Lung Adenocarcinoma (LUAD). This model proficiently forecasts the survival rates and therapeutic outcomes for LUAD patients, thereby delineating the high-risk population with distinctive immune cell infiltration and a state of immunosuppression. Furthermore, NAPSA can inhibit the proliferation and invasion capabilities of LUAD cells, thereby identifying new molecules for clinical targeted therapy.PMID:38685772 | DOI:10.2174/0109298673313281240425050032 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Junzhi Liu Huimin Li Nannan Zhang Qiuping Dong Zheng Liang Source Type: research
Polymeric Molecular Envelope Technology for Improved Therapeutics Efficacy: A Review
Curr Med Chem. 2024 Apr 29. doi: 10.2174/0109298673290370240425092350. Online ahead of print.ABSTRACTThe review explores the enhancement of therapeutic efficacy through the innovative use of polymeric molecular envelope technology (MET). It delves into the diverse methods employed to achieve superior therapeutic outcomes, shedding light on strategies for improving drug delivery and bioavailability. MET is a promising approach to improve the solubility and bioavailability of poorly water-soluble drugs. This technology involves the use of a molecular envelope of cyclic oligosaccharides called cyclodextrins, which is a supram...
Source: Current Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Jigar Vyas Nensi Raytthatha Bhupendra G Prajapati Sudarshan Singh Source Type: research
Molecular Mechanisms and Roles of MiR-136-5p in Human Cancer and Other Disorders
CONCLUSION: The current review aims to elucidate the role of miR-136-5p in both cancer progression and non-cancerous disorders, emphasizing dysregulated signaling pathways. It also sheds light on the potential of this miRNA as a prognostic biomarker in cancer, offering valuable insights and directions for future research.PMID:38685774 | DOI:10.2174/0109298673283936240215110627 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Xiaoling Chen Ting Lu Ying Zheng Zhiyong Lin Chaoqi Liu Ding Yuan Chengfu Yuan Source Type: research
Does Eta Protein Differentiate Rheumatoid Arthritis from Psoriatic Arthritis?
CONCLUSION: Eta protein levels are higher in the serum of RA patients than PsA and are associated with joint erosion. Eta protein may be a potential biomarker in the differential diagnosis of RA and PsA. It may represent a possible therapeutic step in the pathophysiological pathways in the development of joint erosion.PMID:38685775 | DOI:10.2174/0109298673295359240422115759 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Ahmet Kor Kevser Orhan Y üksel Maraş Esra F ırat Oğuz Mehtap Kal çık Unan Gamze Dilek Şükran Erten Kemal Nas Source Type: research
Multiomics Analysis of Disulfidptosis Patterns and Integrated Machine Learning to Predict Immunotherapy Response in Lung Adenocarcinoma
CONCLUSION: Our research introduces an innovative prognostic risk model predicated upon disulfidptosis genes for patients afflicted with Lung Adenocarcinoma (LUAD). This model proficiently forecasts the survival rates and therapeutic outcomes for LUAD patients, thereby delineating the high-risk population with distinctive immune cell infiltration and a state of immunosuppression. Furthermore, NAPSA can inhibit the proliferation and invasion capabilities of LUAD cells, thereby identifying new molecules for clinical targeted therapy.PMID:38685772 | DOI:10.2174/0109298673313281240425050032 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Junzhi Liu Huimin Li Nannan Zhang Qiuping Dong Zheng Liang Source Type: research
Polymeric Molecular Envelope Technology for Improved Therapeutics Efficacy: A Review
Curr Med Chem. 2024 Apr 29. doi: 10.2174/0109298673290370240425092350. Online ahead of print.ABSTRACTThe review explores the enhancement of therapeutic efficacy through the innovative use of polymeric molecular envelope technology (MET). It delves into the diverse methods employed to achieve superior therapeutic outcomes, shedding light on strategies for improving drug delivery and bioavailability. MET is a promising approach to improve the solubility and bioavailability of poorly water-soluble drugs. This technology involves the use of a molecular envelope of cyclic oligosaccharides called cyclodextrins, which is a supram...
Source: Current Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Jigar Vyas Nensi Raytthatha Bhupendra G Prajapati Sudarshan Singh Source Type: research
Molecular Mechanisms and Roles of MiR-136-5p in Human Cancer and Other Disorders
CONCLUSION: The current review aims to elucidate the role of miR-136-5p in both cancer progression and non-cancerous disorders, emphasizing dysregulated signaling pathways. It also sheds light on the potential of this miRNA as a prognostic biomarker in cancer, offering valuable insights and directions for future research.PMID:38685774 | DOI:10.2174/0109298673283936240215110627 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Xiaoling Chen Ting Lu Ying Zheng Zhiyong Lin Chaoqi Liu Ding Yuan Chengfu Yuan Source Type: research
Does Eta Protein Differentiate Rheumatoid Arthritis from Psoriatic Arthritis?
CONCLUSION: Eta protein levels are higher in the serum of RA patients than PsA and are associated with joint erosion. Eta protein may be a potential biomarker in the differential diagnosis of RA and PsA. It may represent a possible therapeutic step in the pathophysiological pathways in the development of joint erosion.PMID:38685775 | DOI:10.2174/0109298673295359240422115759 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Ahmet Kor Kevser Orhan Y üksel Maraş Esra F ırat Oğuz Mehtap Kal çık Unan Gamze Dilek Şükran Erten Kemal Nas Source Type: research
