Time to switch gears: how long noncoding RNAs function as epigenetic regulators in Apicomplexan parasites
Curr Opin Microbiol. 2024 Apr 29;79:102484. doi: 10.1016/j.mib.2024.102484. Online ahead of print.ABSTRACTLong noncoding RNAs (lncRNA) are emerging as important regulators of gene expression in eukaryotes. In recent years, a large repertoire of lncRNA were discovered in Apicomplexan parasites and were implicated in several mechanisms of gene expression, including marking genes for activation, contributing to the formation of subnuclear compartments and organization, regulating the deposition of epigenetic modifications, influencing chromatin and chromosomal structure and manipulating host gene expression. Here, we aim to u...
Source: Current Opinion in Microbiology - April 30, 2024 Category: Microbiology Authors: Vera Mitesser Karina Simantov Ron Dzikowski Source Type: research
Bacterial synthase-dependent exopolysaccharide secretion: a focus on cellulose
Curr Opin Microbiol. 2024 Apr 29;79:102476. doi: 10.1016/j.mib.2024.102476. Online ahead of print.ABSTRACTBacterial biofilms are a prevalent multicellular life form in which individual members can undergo significant functional differentiation and are typically embedded in a complex extracellular matrix of proteinaceous fimbriae, extracellular DNA, and exopolysaccharides (EPS). Bacteria have evolved at least four major mechanisms for EPS biosynthesis, of which the synthase-dependent systems for bacterial cellulose secretion (Bcs) represent not only key biofilm determinants in a wide array of environmental and host-associat...
Source: Current Opinion in Microbiology - April 30, 2024 Category: Microbiology Authors: Petya V Krasteva Source Type: research
PII-like signaling proteins: a new paradigm in orchestrating cellular homeostasis
Curr Opin Microbiol. 2024 Apr 27;79:102453. doi: 10.1016/j.mib.2024.102453. Online ahead of print.ABSTRACTMembers of the PII superfamily are versatile, multitasking signaling proteins ubiquitously found in all domains of life. They adeptly monitor and synchronize the cell's carbon, nitrogen, energy, redox, and diurnal states, primarily by binding interdependently to adenyl-nucleotides, including charged nucleotides (ATP, ADP, and AMP) and second messengers such as Cyclic adenosine monophosphate, Cyclic di-adenosine monophosphate, and S-adenosylmethionine-AMP (SAM-AMP). These proteins also undergo a variety of posttranslati...
Source: Current Opinion in Microbiology - April 28, 2024 Category: Microbiology Authors: Khaled A Selim Vikram Alva Source Type: research
PII-like signaling proteins: a new paradigm in orchestrating cellular homeostasis
Curr Opin Microbiol. 2024 Apr 27;79:102453. doi: 10.1016/j.mib.2024.102453. Online ahead of print.ABSTRACTMembers of the PII superfamily are versatile, multitasking signaling proteins ubiquitously found in all domains of life. They adeptly monitor and synchronize the cell's carbon, nitrogen, energy, redox, and diurnal states, primarily by binding interdependently to adenyl-nucleotides, including charged nucleotides (ATP, ADP, and AMP) and second messengers such as Cyclic adenosine monophosphate, Cyclic di-adenosine monophosphate, and S-adenosylmethionine-AMP (SAM-AMP). These proteins also undergo a variety of posttranslati...
Source: Current Opinion in Microbiology - April 28, 2024 Category: Microbiology Authors: Khaled A Selim Vikram Alva Source Type: research
PII-like signaling proteins: a new paradigm in orchestrating cellular homeostasis
Curr Opin Microbiol. 2024 Apr 27;79:102453. doi: 10.1016/j.mib.2024.102453. Online ahead of print.ABSTRACTMembers of the PII superfamily are versatile, multitasking signaling proteins ubiquitously found in all domains of life. They adeptly monitor and synchronize the cell's carbon, nitrogen, energy, redox, and diurnal states, primarily by binding interdependently to adenyl-nucleotides, including charged nucleotides (ATP, ADP, and AMP) and second messengers such as Cyclic adenosine monophosphate, Cyclic di-adenosine monophosphate, and S-adenosylmethionine-AMP (SAM-AMP). These proteins also undergo a variety of posttranslati...
Source: Current Opinion in Microbiology - April 28, 2024 Category: Microbiology Authors: Khaled A Selim Vikram Alva Source Type: research
Phage transmission strategies: are phages farming their host?
Curr Opin Microbiol. 2024 Apr 26;79:102481. doi: 10.1016/j.mib.2024.102481. Online ahead of print.ABSTRACTExtensive coevolution has led to utterly intricate interactions between phages and their bacterial hosts. While both the (short-term) intracellular molecular host-subversion mechanisms during a phage infection cycle and the (long-term) mutational arms race between phages and host cells have traditionally received a lot of attention, there has been an underestimating neglect of (mid-term) transmission strategies by which phages manage to cautiously spread throughout their host population. However, recent findings unders...
Source: Current Opinion in Microbiology - April 27, 2024 Category: Microbiology Authors: Yorben Casters Leonard E B äcker Kevin Broux Abram Aertsen Source Type: research
Transcript tinkering: RNA modifications in protozoan parasites
Curr Opin Microbiol. 2024 Apr 24;79:102477. doi: 10.1016/j.mib.2024.102477. Online ahead of print.ABSTRACTApicomplexan and trypanosomatid parasites have evolved a wide range of post-transcriptional processes that allow them to replicate, differentiate, and transmit within and among multiple different tissue, host, and vector environments. In this review, we highlight the recent advances that point toward the regulatory potential of RNA modifications in mediating these processes on the coding and noncoding transcriptome throughout the life cycle of protozoan parasites. We discuss the recent technical advancements enabling t...
Source: Current Opinion in Microbiology - April 25, 2024 Category: Microbiology Authors: Tiziano Vignolini Justine E C Couble Gr égory R G Doré Sebastian Baumgarten Source Type: research
Transcript tinkering: RNA modifications in protozoan parasites
Curr Opin Microbiol. 2024 Apr 24;79:102477. doi: 10.1016/j.mib.2024.102477. Online ahead of print.ABSTRACTApicomplexan and trypanosomatid parasites have evolved a wide range of post-transcriptional processes that allow them to replicate, differentiate, and transmit within and among multiple different tissue, host, and vector environments. In this review, we highlight the recent advances that point toward the regulatory potential of RNA modifications in mediating these processes on the coding and noncoding transcriptome throughout the life cycle of protozoan parasites. We discuss the recent technical advancements enabling t...
Source: Current Opinion in Microbiology - April 25, 2024 Category: Microbiology Authors: Tiziano Vignolini Justine E C Couble Gr égory R G Doré Sebastian Baumgarten Source Type: research
Transcript tinkering: RNA modifications in protozoan parasites
Curr Opin Microbiol. 2024 Apr 24;79:102477. doi: 10.1016/j.mib.2024.102477. Online ahead of print.ABSTRACTApicomplexan and trypanosomatid parasites have evolved a wide range of post-transcriptional processes that allow them to replicate, differentiate, and transmit within and among multiple different tissue, host, and vector environments. In this review, we highlight the recent advances that point toward the regulatory potential of RNA modifications in mediating these processes on the coding and noncoding transcriptome throughout the life cycle of protozoan parasites. We discuss the recent technical advancements enabling t...
Source: Current Opinion in Microbiology - April 25, 2024 Category: Microbiology Authors: Tiziano Vignolini Justine E C Couble Gr égory R G Doré Sebastian Baumgarten Source Type: research
Cell wall synthesizing complexes in Mycobacteriales
Curr Opin Microbiol. 2024 Apr 22;79:102478. doi: 10.1016/j.mib.2024.102478. Online ahead of print.ABSTRACTMembers of the order Mycobacteriales are distinguished by a characteristic diderm cell envelope, setting them apart from other Actinobacteria species. In addition to the conventional peptidoglycan cell wall, these organisms feature an extra polysaccharide polymer composed of arabinose and galactose, termed arabinogalactan. The nonreducing ends of arabinose are covalently linked to mycolic acids (MAs), forming the immobile inner leaflet of the highly hydrophobic MA membrane. The contiguous outer leaflet of the MA membra...
Source: Current Opinion in Microbiology - April 23, 2024 Category: Microbiology Authors: Fabian M Meyer Marc Bramkamp Source Type: research
Cell wall synthesizing complexes in Mycobacteriales
Curr Opin Microbiol. 2024 Apr 22;79:102478. doi: 10.1016/j.mib.2024.102478. Online ahead of print.ABSTRACTMembers of the order Mycobacteriales are distinguished by a characteristic diderm cell envelope, setting them apart from other Actinobacteria species. In addition to the conventional peptidoglycan cell wall, these organisms feature an extra polysaccharide polymer composed of arabinose and galactose, termed arabinogalactan. The nonreducing ends of arabinose are covalently linked to mycolic acids (MAs), forming the immobile inner leaflet of the highly hydrophobic MA membrane. The contiguous outer leaflet of the MA membra...
Source: Current Opinion in Microbiology - April 23, 2024 Category: Microbiology Authors: Fabian M Meyer Marc Bramkamp Source Type: research
Renal implications of coronavirus disease 2019: insights into viral tropism and clinical outcomes
Curr Opin Microbiol. 2024 Apr 13;79:102475. doi: 10.1016/j.mib.2024.102475. Online ahead of print.ABSTRACTIn recent years, multiple coronaviruses have emerged, with the latest one, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing a global pandemic. Besides respiratory symptoms, some patients experienced extrapulmonary effects, such as cardiac damage or renal injury, indicating the broad tropism of SARS-CoV-2. The ability of the virus to effectively invade the renal cellular environment can eventually cause tissue-specific damage and disease. Indeed, patients with severe coronavirus disease 2019 exhibit...
Source: Current Opinion in Microbiology - April 14, 2024 Category: Microbiology Authors: Valentin A B ärreiter Toni L Meister Source Type: research
Neuroinvasion and neurotropism of severe acute respiratory syndrome coronavirus 2 infection
In conclusion, SARS-CoV-2 can infect numerous cells within the peripheral and central nervous system, provoke inflammatory responses, and induce neuropathological changes.PMID:38615394 | DOI:10.1016/j.mib.2024.102474 (Source: Current Opinion in Microbiology)
Source: Current Opinion in Microbiology - April 14, 2024 Category: Microbiology Authors: Michelle Jagst Lilli Pottk ämper Andr é Gömer Kalliopi Pitarokoili Eike Steinmann Source Type: research
Renal implications of coronavirus disease 2019: insights into viral tropism and clinical outcomes
Curr Opin Microbiol. 2024 Apr 13;79:102475. doi: 10.1016/j.mib.2024.102475. Online ahead of print.ABSTRACTIn recent years, multiple coronaviruses have emerged, with the latest one, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing a global pandemic. Besides respiratory symptoms, some patients experienced extrapulmonary effects, such as cardiac damage or renal injury, indicating the broad tropism of SARS-CoV-2. The ability of the virus to effectively invade the renal cellular environment can eventually cause tissue-specific damage and disease. Indeed, patients with severe coronavirus disease 2019 exhibit...
Source: Current Opinion in Microbiology - April 14, 2024 Category: Microbiology Authors: Valentin A B ärreiter Toni L Meister Source Type: research
Neuroinvasion and neurotropism of severe acute respiratory syndrome coronavirus 2 infection
In conclusion, SARS-CoV-2 can infect numerous cells within the peripheral and central nervous system, provoke inflammatory responses, and induce neuropathological changes.PMID:38615394 | DOI:10.1016/j.mib.2024.102474 (Source: Current Opinion in Microbiology)
Source: Current Opinion in Microbiology - April 14, 2024 Category: Microbiology Authors: Michelle Jagst Lilli Pottk ämper Andr é Gömer Kalliopi Pitarokoili Eike Steinmann Source Type: research
