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Albiflorin Inhibits Advanced Glycation End Products-Induced ROS and MMP-1 Expression in Gingival Fibroblasts
CONCLUSION: Albiflorin exhibited protective effects against AGEs-induced oxidative stress and inflammation in gingival fibroblasts, highlighting its potential as a therapeutic agent for periodontitis in diabetic patients. The modulation of the NF-κB and Nrf2 pathways by albiflorin provides insight into its mechanism of action.PMID:38685787 | DOI:10.2174/011574888X302174240420165019 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - April 30, 2024 Category: Stem Cells Authors: Linlin Gao Wenqi Fu Yanyan Liu Lili Fan Shiwei Liu Nan Zhang Source Type: research

Exosomes from MicroRNA-125b-Modified Adipose-Derived Stem Cells Promote Wound Healing of Diabetic Foot Ulcers
CONCLUSION: ADSCs-Exo promoted wound healing of DFU rats, especially when overexpressing miR-125b.PMID:38659271 | DOI:10.2174/011574888X287173240415050555 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - April 25, 2024 Category: Stem Cells Authors: Enqi Guo Liang Wang Jianlong Wu Qiang Chen Source Type: research

Unlocking the Potential of Induced Pluripotent Stem Cells in Revolutionizing Cancer Therapy
This article highlights the potential of iPSC- based NK cells and dendritic cells for immunotherapy and delves into the role of iPSC-based mesenchymal cells in targeted therapy. The potential of iPSC-derived organoids as a vital tool for disease modeling and drug discovery has been showcased, and the importance of iPSC-based cancer vaccines is also emphasized. The ongoing clinical trials of iPSC-based cancer treatment have also been highlighted. Though much work remains to be done to implicate these iPSC-based therapeutic options from research labs to clinics and hospitals, ongoing studies and clinical/translational follow...
Source: Current Stem Cell Research and Therapy - April 17, 2024 Category: Stem Cells Authors: Amrita Mondal Ankita Talukdar Rizwanul Haque Source Type: research

Outcomes of Patients with Heavily Pretreated Relapsed/Refractory Multiple Myeloma Receiving Salvage Cytotoxic Therapy with Supportive Stem Cell Boost
CONCLUSION: This data allow clinicians to appropriately implement and inform patients of the therapeutic uses and clinical outcomes of stem cell boost in patients with multiply relapsed/refractory MM.PMID:38584546 | DOI:10.2174/011574888X287532240325041249 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - April 8, 2024 Category: Stem Cells Authors: Ayrton Bangolo Samir Oza Ronit Slotky Aimee Chappell David Siegel Harsh Parmar Noa Biran David H Vesole Pooja Phull Source Type: research