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Pharmacological and Therapeutic Potential of Berbamine: A Potent Alkaloid from Genus Berberis
Curr Top Med Chem. 2024 Apr 29. doi: 10.2174/0115680266289292240420062705. Online ahead of print.ABSTRACTBerbamine (Ber) is an active medicinal bisbenzylisoquinoline alkaloid, which is usually obtained from different plants of the genus Berberis (family Berberidaceae) and is used to cure various disorders in traditional Chinese and Ayurvedic systems of medicine. Numerous in-vitro and in-vivo studies revealed the apoptotic and cytotoxic potential of Ber against different cell lines (SMMC-7721, A549, MDA-MB-231, and K562) by upregulating pro-apoptotic (Bax, p53) and downregulating anti-apoptotic (Bcl-2, survivin) proteins. O...
Source: Current Topics in Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Gulzar Muhammad Muhammad Ajaz Hussain Zahid Shafiq Adnan Ashraf Umer Shafique Ajmal Khan Asaad Khalid Javid Hussain Ahmed Al-Harrasi Source Type: research

Neuroprotective Role of Phytoconstituents-based Nanoemulsion for the Treatment of Alzheimer's Disease
Curr Top Med Chem. 2024 Apr 25. doi: 10.2174/0115680266296001240327090111. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is the most prevalent form of neurodegenerative disorder (ND), affecting more than 44 million individuals globally as of 2023. It is characterized by cognitive dysfunction and an inability to perform daily activities. The progression of AD is associated with the accumulation of amyloid beta (Aβ), the formation of neurofibrillary tangles (NFT), increased oxidative stress, neuroinflammation, mitochondrial dysfunction, and endoplasmic reticulum stress. Presently, various phytomedicines and their b...
Source: Current Topics in Medicinal Chemistry - April 27, 2024 Category: Chemistry Authors: Sukriti Vishwas Bushra Bashir Devendra Birla Nikhil Khandale Motamarri Venkata Naga Lalitha Chaitanya Dinesh Kumar Chellappan Gaurav Gupta Poonam Negi Kamal Dua Sachin Kumar Singh Source Type: research

A New Approach to Melanoma Treatment: microRNAs
Curr Top Med Chem. 2024 Apr 25. doi: 10.2174/0115680266291290240417081544. Online ahead of print.ABSTRACTAlthough immunotherapy and targeted therapy have radically changed melanoma treatment, the development of resistance and reduction of patient responses are still significant problems. Small molecule inhibitors are needed to overcome this situation, and biomarkers that can estimate whether patients will reply to existing treatments need to be developed. miRNAs are involved in diverse processes such as tumor development, tumor progression, metastasis, and invasion. While some miRNAs act as tumor suppressors, others may be...
Source: Current Topics in Medicinal Chemistry - April 27, 2024 Category: Chemistry Authors: Suleyman Ilhan Ferdi Oguz Harika Atmaca Source Type: research

The Current Landscape in the Development of Small-molecule Modulators Targeting Sphingosine-1-phosphate Receptors to Treat Neurodegenerative Diseases
This study provides a concise overview of sphingolipid metabolism, the mechanism by which S1P receptors are af-fected, and the structural characteristics of several small molecule S1P modulators, with a particu-lar focus on their structure-activity connections.PMID:38676503 | DOI:10.2174/0115680266288509240422112839 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - April 27, 2024 Category: Chemistry Authors: Sidharth Sankar Kar Soumya Ranjan Gharai Sujit Kumar Sahu V Ravichandiran Sharada Prasanna Swain Source Type: research

Antioxidative and Anti-inflammatory Effects of Plant-derived Hypoglycemic Medicines: An In vivo/In vitro Systematic Review
CONCLUSION: Our findings showed that the application of different plant-derived hypoglycemic treatments in animal models improved diabetes and its complications, as well as modulated concomitant inflammatory and oxidative stress biomarkers. These findings suggest that plant-based antidiabetic medicines and food supplements have the potential to manage diabetes and its complications.PMID:38644706 | DOI:10.2174/0115680266295032240415064750 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - April 22, 2024 Category: Chemistry Authors: Mohammad Sadegh Adel-Mehraban Ozra Tabatabaei-Malazy Azadeh Manayi Sudabeh Alatab Shahrzad Mohseni Saeed Ebrahimi Fana Pooria Asili Roodabeh Bahramsoltani Fataneh Esmaeili Bayan Azizi Source Type: research

The Gold Standard Diagnosis of Schizophrenia is Counterproductive: Towards Quantitative Research and Diagnostic Algorithmic Rules (RADAR) and their Derived Qualitative Distinct Classes
Curr Top Med Chem. 2024 Apr 19. doi: 10.2174/0115680266295129240415120646. Online ahead of print.ABSTRACTRecently, we developed Research and Diagnostic Algorithm Rules (RADAR) to assess the clinical and pathway features of mood disorders. The aims of this paper are to review a) the methodology for developing continuous RADAR scores that describe the clinical and pathway features of schizophrenia, and b) a new method to visualize the clinical status of patients and the pathways implicated in RADAR graphs. We review how to interpret clinical RADAR scores, which serve as valuable tools for monitoring the staging of illness, l...
Source: Current Topics in Medicinal Chemistry - April 22, 2024 Category: Chemistry Authors: Michael Maes Source Type: research

Navigating the Alzheimer's Treatment Landscape: Unraveling Amyloid-Beta Complexities and Pioneering Precision Medicine Approaches
Curr Top Med Chem. 2024 Apr 19. doi: 10.2174/0115680266295495240415114919. Online ahead of print.ABSTRACTA variety of cutting-edge methods and good knowledge of the illness's complex causes are causing a sea change in the field of Alzheimer's Disease (A.D.) research and treatment. Precision medicine is at the vanguard of this change, where individualized treatment plans based on genetic and biomarker profiles give a ray of hope for customized therapeutics. Combination therapies are becoming increasingly popular as a way to address the multifaceted pathology of Alzheimer's by simultaneously attacking Aβ plaques, tau tangle...
Source: Current Topics in Medicinal Chemistry - April 22, 2024 Category: Chemistry Authors: Mohsina Patwekar Faheem Patwekar Shahzad Khan Rohit Sharma Dileep Kumar Source Type: research