Genetic variations in immune mediators and prostate cancer risk: A field synopsis with Bayesian calculations
CONCLUSION: In conclusion, this current Bayesian revaluation showed that the rs1143627 and the rs1946518 polymorphisms in the IL1B and IL18 genes, respectively, were noteworthy biomarker candidates for PCa risk.PMID:38696882 | DOI:10.1016/j.cyto.2024.156630 (Source: Cytokine)
Source: Cytokine - May 2, 2024 Category: Molecular Biology Authors: Matheus Santos Freire Andr é Victor de Oliveira Monteiro Tayane Moura Martins M árcia Socorro Silva Lima Duarte Antonio Carlos Lima Alessandro Luiz Ara újo Bentes Leal Felipe Rodolfo Pereira da Silva Jos é Fernando Marques Barcellos Source Type: research
Epstein-Barr virus-encoded BART9 and BART15 miRNAs are elevated in exosomes of cerebrospinal fluid from relapsing-remitting multiple sclerosis patients
Cytokine. 2024 Apr 30;179:156624. doi: 10.1016/j.cyto.2024.156624. Online ahead of print.ABSTRACTEpstein-Barr virus (EBV) infection is approved as the main environmental trigger of multiple sclerosis (MS). In this path, we quantified ebv-miR-BART9-3p and ebv-miR-BART15 in exosomes of cerebrospinal fluid (CSF) of untreated relapsing-remitting MS (RRMS) patients in comparison with the control group. Interestingly, patients displayed significant upregulation of ebv-miR-BART9-3p (18.4-fold) and ebv-miR-BART15 (3.1-fold) expression in CSF exosomes. Moreover, the expression levels of hsa-miR-21-5p and hsa-miR-146a-5p were found ...
Source: Cytokine - May 1, 2024 Category: Molecular Biology Authors: Mina Mohammadinasr Soheila Montazersaheb Vahid Hosseini Houman Kahroba Mahnaz Talebi Ommoleila Molavi Hormoz Ayromlou Mohammad Saeid Hejazi Source Type: research
The role of innate lymphoid cells in systemic lupus erythematosus
Cytokine. 2024 Apr 28;179:156623. doi: 10.1016/j.cyto.2024.156623. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is a connective tissue disorder that affects various body systems. Both the innate and adaptive immunity contribute to the onset and progression of SLE. The main mechanism of SLE is an excessive immune response of immune cells to autoantigens, which leads to systemic inflammation and inflammation-induced organ damage. Notably, a subset of innate immune cells known as innate lymphoid cells (ILCs) has recently emerged. ILCs are pivotal in the early stages of infection; participate in immune resp...
Source: Cytokine - April 30, 2024 Category: Molecular Biology Authors: Yong Chen Xiaotian Gu Kunyu Cao Miao Tu Wan Liu Jiyu Ju Source Type: research
The role of innate lymphoid cells in systemic lupus erythematosus
Cytokine. 2024 Apr 28;179:156623. doi: 10.1016/j.cyto.2024.156623. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is a connective tissue disorder that affects various body systems. Both the innate and adaptive immunity contribute to the onset and progression of SLE. The main mechanism of SLE is an excessive immune response of immune cells to autoantigens, which leads to systemic inflammation and inflammation-induced organ damage. Notably, a subset of innate immune cells known as innate lymphoid cells (ILCs) has recently emerged. ILCs are pivotal in the early stages of infection; participate in immune resp...
Source: Cytokine - April 30, 2024 Category: Molecular Biology Authors: Yong Chen Xiaotian Gu Kunyu Cao Miao Tu Wan Liu Jiyu Ju Source Type: research
The role of innate lymphoid cells in systemic lupus erythematosus
Cytokine. 2024 Apr 28;179:156623. doi: 10.1016/j.cyto.2024.156623. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is a connective tissue disorder that affects various body systems. Both the innate and adaptive immunity contribute to the onset and progression of SLE. The main mechanism of SLE is an excessive immune response of immune cells to autoantigens, which leads to systemic inflammation and inflammation-induced organ damage. Notably, a subset of innate immune cells known as innate lymphoid cells (ILCs) has recently emerged. ILCs are pivotal in the early stages of infection; participate in immune resp...
Source: Cytokine - April 30, 2024 Category: Molecular Biology Authors: Yong Chen Xiaotian Gu Kunyu Cao Miao Tu Wan Liu Jiyu Ju Source Type: research
Resveratrol has neuroprotective effects and plays an anti-inflammatory role through Dectin-1/p38 pathway in Aspergillus fumigatus keratitis
CONCLUSION: These evidences revealed that RES could exert antifungal effects on A. fumigatus and ameliorate FK through suppressing the Dectin-1/p38 MAPK pathway to down-regulate IL-1β, IL-6, etc. expression and play protective effect on corneal nerves.PMID:38678810 | DOI:10.1016/j.cyto.2024.156626 (Source: Cytokine)
Source: Cytokine - April 28, 2024 Category: Molecular Biology Authors: Weilin Diao Min Yin Yinghe Qi Yudong Fu Lingwen Gu Jing Lin Lina Zhang Nan Jiang Qian Wang Yuwei Wang Wendan Yi Menghui Chi Cui Li Guiqiu Zhao Source Type: research
Resveratrol has neuroprotective effects and plays an anti-inflammatory role through Dectin-1/p38 pathway in Aspergillus fumigatus keratitis
CONCLUSION: These evidences revealed that RES could exert antifungal effects on A. fumigatus and ameliorate FK through suppressing the Dectin-1/p38 MAPK pathway to down-regulate IL-1β, IL-6, etc. expression and play protective effect on corneal nerves.PMID:38678810 | DOI:10.1016/j.cyto.2024.156626 (Source: Cytokine)
Source: Cytokine - April 28, 2024 Category: Molecular Biology Authors: Weilin Diao Min Yin Yinghe Qi Yudong Fu Lingwen Gu Jing Lin Lina Zhang Nan Jiang Qian Wang Yuwei Wang Wendan Yi Menghui Chi Cui Li Guiqiu Zhao Source Type: research
Circulating cytokines levels and osteoarthritis: A Mendelian randomization study
CONCLUSIONS: Our MR analysis provides suggestive evidence of causal relationships between circulating cytokines and growth factors levels and OA, providing new insights into the etiology of OA.PMID:38677184 | DOI:10.1016/j.cyto.2024.156625 (Source: Cytokine)
Source: Cytokine - April 27, 2024 Category: Molecular Biology Authors: Jiale Xie Xianjie Wan Mingyi Yang Hui Yu Jinrong Hao Ke Xu Jiachen Wang Peng Xu Source Type: research
Association between CBL gene polymorphism and susceptibility of microscopic polyangiitis in a Chinese population: A case-control analysis
CONCLUSION: The genetic polymorphism of CBL had a potential association with the risk of MPA and clinical treatment effects in Guangxi population in China.PMID:38669907 | DOI:10.1016/j.cyto.2024.156596 (Source: Cytokine)
Source: Cytokine - April 26, 2024 Category: Molecular Biology Authors: Liu Liu Yan Zhu Jingjing Lan Liepeng Chu Wei Li Chao Xue Source Type: research
IL-23 regulation of myeloid cell biology during inflammation
We report that endogenous IL-23 was required for maximal macrophage activation by zymosan as determined by pro-inflammatory cytokine production, including a dramatic upregulation of granulocyte-colony stimulating factor (G-CSF). Furthermore, both IL-23p19 genetic deletion and neutralization in zymosan-induced peritonitis (ZIP) led to a specific reduction in the neutrophil numbers, as well as a reduction in the G-CSF levels in exudate fluids. We conclude that endogenous IL-23 can contribute significantly to macrophage activation during an inflammatory response, mostly likely via an autocrine/paracrine mechanism; of note, en...
Source: Cytokine - April 26, 2024 Category: Molecular Biology Authors: Kevin M-C Lee Tanya Lupancu Leon Chang Carl L Manthey Martha Zeeman Anne M Fourie John A Hamilton Source Type: research
Association between CBL gene polymorphism and susceptibility of microscopic polyangiitis in a Chinese population: A case-control analysis
CONCLUSION: The genetic polymorphism of CBL had a potential association with the risk of MPA and clinical treatment effects in Guangxi population in China.PMID:38669907 | DOI:10.1016/j.cyto.2024.156596 (Source: Cytokine)
Source: Cytokine - April 26, 2024 Category: Molecular Biology Authors: Liu Liu Yan Zhu Jingjing Lan Liepeng Chu Wei Li Chao Xue Source Type: research
IL-23 regulation of myeloid cell biology during inflammation
We report that endogenous IL-23 was required for maximal macrophage activation by zymosan as determined by pro-inflammatory cytokine production, including a dramatic upregulation of granulocyte-colony stimulating factor (G-CSF). Furthermore, both IL-23p19 genetic deletion and neutralization in zymosan-induced peritonitis (ZIP) led to a specific reduction in the neutrophil numbers, as well as a reduction in the G-CSF levels in exudate fluids. We conclude that endogenous IL-23 can contribute significantly to macrophage activation during an inflammatory response, mostly likely via an autocrine/paracrine mechanism; of note, en...
Source: Cytokine - April 26, 2024 Category: Molecular Biology Authors: Kevin M-C Lee Tanya Lupancu Leon Chang Carl L Manthey Martha Zeeman Anne M Fourie John A Hamilton Source Type: research
Diagnostic accuracy and cellular origin of pleural fluid CXCR3 ligands for tuberculous pleural effusion
CONCLUSIONS: Pleural CXCL9 and CXCL11 are potential diagnostic markers for TPE, but their diagnostic accuracy is compromised in elderly patients. CXCL9 and CXCL11 can promote the migration of peripheral Th cells, thus representing a therapeutic target for the treatment of TPE.PMID:38663252 | DOI:10.1016/j.cyto.2024.156618 (Source: Cytokine)
Source: Cytokine - April 25, 2024 Category: Molecular Biology Authors: Zhi Yan Jian-Xun Wen Yan Niu Ting-Wang Jiang Jin-Hong Huang Hong Chen Qi Chen Ya-Fei Wang Li Yan Zhi-De Hu Wen-Qi Zheng Source Type: research
Diagnostic accuracy and cellular origin of pleural fluid CXCR3 ligands for tuberculous pleural effusion
CONCLUSIONS: Pleural CXCL9 and CXCL11 are potential diagnostic markers for TPE, but their diagnostic accuracy is compromised in elderly patients. CXCL9 and CXCL11 can promote the migration of peripheral Th cells, thus representing a therapeutic target for the treatment of TPE.PMID:38663252 | DOI:10.1016/j.cyto.2024.156618 (Source: Cytokine)
Source: Cytokine - April 25, 2024 Category: Molecular Biology Authors: Zhi Yan Jian-Xun Wen Yan Niu Ting-Wang Jiang Jin-Hong Huang Hong Chen Qi Chen Ya-Fei Wang Li Yan Zhi-De Hu Wen-Qi Zheng Source Type: research
Immune profiles of MCP-1 with M tb antigens and recombinant cytokines stimulation in tuberculosis
In conclusion, the study determined the differential expression and production of MCP-1 with M tb antigens and recombinant cytokines. Further, cohort studies are required to study these interaction to identify the high risk individuals, which might help for TB control.PMID:38648681 | DOI:10.1016/j.cyto.2024.156622 (Source: Cytokine)
Source: Cytokine - April 22, 2024 Category: Molecular Biology Authors: Ashwini Pullagurla Bhagyalaxmi Rapolu Shazia Ahmad Sumanlatha Gaddam Source Type: research
