Commentary in light of current findings on Roode et al., Developmental Biology (2012) Human hypoblast formation is not dependent on FGF signalling
Dev Biol. 2024 Apr 25;512:11-12. doi: 10.1016/j.ydbio.2024.04.007. Online ahead of print.NO ABSTRACTPMID:38677582 | DOI:10.1016/j.ydbio.2024.04.007 (Source: Developmental Biology)
Source: Developmental Biology - April 27, 2024 Category: Biology Authors: Austin Smith Jennifer Nichols Source Type: research
Commentary in light of current findings on Roode et al., Developmental Biology (2012) Human hypoblast formation is not dependent on FGF signalling
Dev Biol. 2024 Apr 25;512:11-12. doi: 10.1016/j.ydbio.2024.04.007. Online ahead of print.NO ABSTRACTPMID:38677582 | DOI:10.1016/j.ydbio.2024.04.007 (Source: Developmental Biology)
Source: Developmental Biology - April 27, 2024 Category: Biology Authors: Austin Smith Jennifer Nichols Source Type: research
Commentary in light of current findings on Roode et al., Developmental Biology (2012) Human hypoblast formation is not dependent on FGF signalling
Dev Biol. 2024 Apr 25:S0012-1606(24)00102-7. doi: 10.1016/j.ydbio.2024.04.007. Online ahead of print.NO ABSTRACTPMID:38677582 | DOI:10.1016/j.ydbio.2024.04.007 (Source: Developmental Biology)
Source: Developmental Biology - April 27, 2024 Category: Biology Authors: Austin Smith Jennifer Nichols Source Type: research
Commentary in light of current findings on Roode et al., Developmental Biology (2012) Human hypoblast formation is not dependent on FGF signalling
Dev Biol. 2024 Apr 25:S0012-1606(24)00102-7. doi: 10.1016/j.ydbio.2024.04.007. Online ahead of print.NO ABSTRACTPMID:38677582 | DOI:10.1016/j.ydbio.2024.04.007 (Source: Developmental Biology)
Source: Developmental Biology - April 27, 2024 Category: Biology Authors: Austin Smith Jennifer Nichols Source Type: research
Influence of DNA-methylation at multiple stages of limb chondrogenesis
This study investigates how the DNA methylation environment affects cell fate divergence during the early chondrogenic events. Our research has shown for the first time that inhibiting DNA methylation in interdigital tissue with 5-azacytidine results in the formation of an ectopic digit. This discovery suggested that DNA methylation dynamics could regulate the fate of cells between chondrogenesis and cell death during autopod development. Our in vitro findings indicate that DNA methylation at the early stages of chondrogenesis is integral in regulating condensation by controlling cell adhesion and proapoptotic genes. As a ...
Source: Developmental Biology - April 24, 2024 Category: Biology Authors: Mario Alberto Perez-Maldonado Ximena Alexandra Gonz ález-González Jes ús Chimal-Monroy Jessica Cristina Mar ín-Llera Source Type: research
Influence of DNA-methylation at multiple stages of limb chondrogenesis
This study investigates how the DNA methylation environment affects cell fate divergence during the early chondrogenic events. Our research has shown for the first time that inhibiting DNA methylation in interdigital tissue with 5-azacytidine results in the formation of an ectopic digit. This discovery suggested that DNA methylation dynamics could regulate the fate of cells between chondrogenesis and cell death during autopod development. Our in vitro findings indicate that DNA methylation at the early stages of chondrogenesis is integral in regulating condensation by controlling cell adhesion and proapoptotic genes. As a ...
Source: Developmental Biology - April 24, 2024 Category: Biology Authors: Mario Alberto Perez-Maldonado Ximena Alexandra Gonz ález-González Jes ús Chimal-Monroy Jessica Cristina Mar ín-Llera Source Type: research
Influence of DNA-methylation at multiple stages of limb chondrogenesis
This study investigates how the DNA methylation environment affects cell fate divergence during the early chondrogenic events. Our research has shown for the first time that inhibiting DNA methylation in interdigital tissue with 5-azacytidine results in the formation of an ectopic digit. This discovery suggested that DNA methylation dynamics could regulate the fate of cells between chondrogenesis and cell death during autopod development. Our in vitro findings indicate that DNA methylation at the early stages of chondrogenesis is integral in regulating condensation by controlling cell adhesion and proapoptotic genes. As a ...
Source: Developmental Biology - April 24, 2024 Category: Biology Authors: Mario Alberto Perez-Maldonado Ximena Alexandra Gonz ález-González Jes ús Chimal-Monroy Jessica Cristina Mar ín-Llera Source Type: research
Normal table of embryonic development in the Anji salamander Hynobius amjiensis (Hynobiidae)
Dev Biol. 2024 Apr 20;511:84-91. doi: 10.1016/j.ydbio.2024.04.005. Online ahead of print.ABSTRACTWe established a normal embryonic development table for the Anji salamander Hynobius amjiensis, a critically endangered tailed amphibian of the family Hynobiidae with a very limited distribution in East China, following the standards set by the early developmental table of vertebrates. Put together 32 embryonic stages for the Anji salamander was defined. The total embryonic period from oviposition to hatching is approximately 30 days at 9 °C. Stages 1-16 represent early development from cleavage to neurulation. Stages 17-32 re...
Source: Developmental Biology - April 22, 2024 Category: Biology Authors: Zhihao Cao Ruiyang Guo Zhengyuan Fang Zhiwen Wang Yang Liu Longhui Lin Xiang Ji Source Type: research
Normal table of embryonic development in the Anji salamander Hynobius amjiensis (Hynobiidae)
Dev Biol. 2024 Apr 20:S0012-1606(24)00100-3. doi: 10.1016/j.ydbio.2024.04.005. Online ahead of print.ABSTRACTWe established a normal embryonic development table for the Anji salamander Hynobius amjiensis, a critically endangered tailed amphibian of the family Hynobiidae with a very limited distribution in East China, following the standards set by the early developmental table of vertebrates. Put together 32 embryonic stages for the Anji salamander was defined. The total embryonic period from oviposition to hatching is approximately 30 days at 9 °C. Stages 1 to 16 represent early development from cleavage to neurulation. ...
Source: Developmental Biology - April 22, 2024 Category: Biology Authors: Zhihao Cao Ruiyang Guo Zhengyuan Fang Zhiwen Wang Yang Liu Longhui Lin Xiang Ji Source Type: research
Dyrk1a is required for craniofacial development in Xenopus laevis
This study is the first to provide insight into why craniofacial birth defects might arise in humans with variants of DYRK1A.PMID:38621649 | DOI:10.1016/j.ydbio.2024.04.004 (Source: Developmental Biology)
Source: Developmental Biology - April 15, 2024 Category: Biology Authors: H Katherine Johnson Stacey E Wahl Fatmata Sesay Larisa Litovchick Amanda Jg Dickinson Source Type: research
Dyrk1a is required for craniofacial development in Xenopus laevis
This study is the first to provide insight into why craniofacial birth defects might arise in humans with variants of DYRK1A.PMID:38621649 | DOI:10.1016/j.ydbio.2024.04.004 (Source: Developmental Biology)
Source: Developmental Biology - April 15, 2024 Category: Biology Authors: H Katherine Johnson Stacey E Wahl Fatmata Sesay Larisa Litovchick Amanda Jg Dickinson Source Type: research
Dyrk1a is required for craniofacial development in Xenopus laevis
This study is the first to provide insight into why craniofacial birth defects might arise in humans with variants of DYRK1A.PMID:38621649 | DOI:10.1016/j.ydbio.2024.04.004 (Source: Developmental Biology)
Source: Developmental Biology - April 15, 2024 Category: Biology Authors: H Katherine Johnson Stacey E Wahl Fatmata Sesay Larisa Litovchick Amanda Jg Dickinson Source Type: research
Dyrk1a is required for craniofacial development in Xenopus laevis
This study is the first to provide insight into why craniofacial birth defects might arise in humans with variants of DYRK1A.PMID:38621649 | DOI:10.1016/j.ydbio.2024.04.004 (Source: Developmental Biology)
Source: Developmental Biology - April 15, 2024 Category: Biology Authors: H Katherine Johnson Stacey E Wahl Fatmata Sesay Larisa Litovchick Amanda Jg Dickinson Source Type: research
A new atlas to study embryonic cell types in Xenopus
Dev Biol. 2024 Apr 11:S0012-1606(24)00098-8. doi: 10.1016/j.ydbio.2024.04.003. Online ahead of print.ABSTRACTThis paper introduces a single-cell atlas for pivotal developmental stages in Xenopus, encompassing gastrulation, neurulation, and early tailbud. Notably surpassing its predecessors, the new atlas enhances gene mapping, read counts, and gene/cell type nomenclature. Leveraging the latest Xenopus tropicalis genome version, alongside advanced alignment pipelines and machine learning for cell type assignment, this release maintains consistency with previous cell type annotations while rectifying nomenclature issues. Emp...
Source: Developmental Biology - April 13, 2024 Category: Biology Authors: Kseniya Petrova Maksym Tretiakov Aleksandr Kotov Anne H Monsoro-Burq Leonid Peshkin Source Type: research
TATA-binding associated factors have distinct roles during early mammalian development
Dev Biol. 2024 Apr 7;511:53-62. doi: 10.1016/j.ydbio.2024.04.002. Online ahead of print.ABSTRACTEarly embryonic development is a finely orchestrated process that requires precise regulation of gene expression coordinated with morphogenetic events. TATA-box binding protein-associated factors (TAFs), integral components of transcription initiation coactivators like TFIID and SAGA, play a crucial role in this intricate process. Here we show that disruptions in TAF5, TAF12 and TAF13 individually lead to embryonic lethality in the mouse, resulting in overlapping yet distinct phenotypes. Taf5 and Taf12 mutant embryos exhibited a...
Source: Developmental Biology - April 9, 2024 Category: Biology Authors: Xinjian Doris He Shelby Phillips Kaito Hioki Prabin Dhangada Majhi Courtney Babbitt Kimberly D Tremblay Leonid A Pobezinsky Jesse Mager Source Type: research
