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Progress toward universal health coverage in Vietnam: Evidence on dispensing trends of diabetes medications from 2015 to 2021
Addressing the increasing prevalence of non-communicable diseases (NCDs) is a public health priority, which has been included in the United Nations ’ Sustainable Development Goal (SDG). The four major NCDs, cardiovascular disease (CVD), cancers, chronic respiratory diseases, and diabetes, accounted for 12 million deaths in the Western Pacific region in 2019 [1]. Type-2 diabetes mellitus (T2DM), a major NCD, has been considered an epidemic of the 21st century [2]. According to the latest report of the International Diabetes Federation (IDF) released in 2021, the prevalence of diabetes mellitus (DM) around the globe was 10...
Source: Diabetes Research and Clinical Practice - May 4, 2024 Category: Endocrinology Authors: Anh Kim Dang, Binh Ngan Vu, Toi Phung Lam, Thanh Kim Thi Ho, Anh Kieu Thi Nguyen, Huong Thi Le, Abdullah A. Mamun, Dung Phung, Phong K. Thai Source Type: research

MASLD/MASH and type 2 diabetes: two sides of the same coin? From single PPAR to pan-PPAR agonists
Type 2 diabetes (T2D) and metabolic dysfunction-associated steatotic liver disease (MASLD), mainly related to nutrition and lack of physical activity, are both very common conditions, share several disease pathways and clinical manifestations, and increasingly co-occur with disease progression. Insulin resistance is an upstream node in the biology of both conditions and triggers liver parenchymal injury, inflammation and fibrosis. Peroxisome proliferator-activated receptor (PPAR) nuclear transcription factors are master regulators of energy homeostasis - insulin signaling in liver, adipose and skeletal muscle tissue - and ...
Source: Diabetes Research and Clinical Practice - April 30, 2024 Category: Endocrinology Authors: Michael P. Cooreman, Luisa Vonghia, Sven M. Francque Source Type: research

Real-world sex differences in type 2 diabetes patients treated with GLP-1 receptor agonists
Sex differences are important determinants of health, and, as such, are relevant to personalized approaches to patient care. Sex-specific biological factors can influence the pathophysiology of type 2 diabetes (T2DM) complications as well as the pharmacodynamics and pharmacokinetics of the medications used in the treatment of persons with T2DM [1,2]. Therefore, it is plausible that different pharmacological strategies might have a different effectiveness in men and women. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 30, 2024 Category: Endocrinology Authors: Sara Piccini, Giuseppe Favacchio, Emanuela Morenghi, Gherardo Mazziotti, Andrea G. A. Lania, Marco Mirani Source Type: research

Association between continuous glucose monitoring metrics and clinical outcomes in adults with type 1 diabetes in a real-world setting
As a surrogate marker for long-term complications of diabetes, glycated hemoglobin (HbA1c) is the “gold standard” metric used by clinicians in the management of people with diabetes [1–4]. However, as HbA1c is indicative of average glycemic control over approximately 2–4 months [2,4], it does not reflect fluctuations in blood glucose levels (i.e., glycemic variability). Glycemic variab ility is directly associated with micro- and macrovascular complications of diabetes [5,6], as well as short-term risks of hypoglycemia [6,7]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 30, 2024 Category: Endocrinology Authors: Robert Brett McQueen, Magaly Perez-Nieves, G. Todd Alonso, Ludi Fan, Emily R. Hankosky, Viral N. Shah, Yuer Yan, Samuel L. Ellis, Rattan Juneja Source Type: research

Diabetes and risk of acute coronary syndrome in callers with chest discomfort: Cross-sectional study in out-of-hours primary care
At out-of-hours primary care (OHS-PC), triage nurses are supported by a semi-automatic decision support tool, which is in the Netherlands the ‘Netherlands Triage Standard’ (NTS), to assist them in the complex process of telephone triage [1–3]. The triage nurse can choose out of 56 entrance complaints in the NTS system, one being ‘chest pain’. The NTS system displays hierarchically ordered triage questions, on average five, for c onsidering severity and thus urgency allocation which is a response time that ranges from U1 to U5. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 30, 2024 Category: Endocrinology Authors: Michelle Spek, Daphne C.A. Erkelens, Coralie van het Goor – van Wezep, Maarten van Smeden, Hester M. Den Ruijter, Loes T.C.M. Wouters, Roderick P. Venekamp, Frans H. Rutten, Dorien L. Zwart Source Type: research

IDF and IAPB release joint policy brief for the early diagnosis, treatment and prevention of diabetic retinopathy
The International Diabetes Federation (IDF) and The International Alliance for the Prevention of Blindness (IAPB) have launched a new policy brief that calls for a joint approach to prevent and manage vision loss in people living with diabetes by integrating diabetic retinopathy (DR) care into diabetes policies and national health plans. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 25, 2024 Category: Endocrinology Tags: International Diabetes Federation Source Type: research

Effect of proteinuria on the rapid kidney function decline in chronic kidney disease depends on the underlying disease: A post hoc analysis of the BRIGHTEN study
The rapidity of kidney function decline in patients with nephrosclerosis (NS) is less rapid than in those with diabetic kidney disease (DKD) presumably because of a relatively low level of proteinuria [1 –3]. Several studies demonstrated that chronic kidney disease (CKD) patients with NS undergo a favourable clinical course as compared with those with DKD [1–4]. The presence of diabetes and proteinuria, but not that of hypertension, were independent predictors for rapid kidney function decline i n Taiwanese CKD patients [5]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 25, 2024 Category: Endocrinology Authors: Tomohito Gohda, Maki Murakoshi, Yusuke Suzuki, Tatsuo Kagimura, Takashi Wada, Ichiei Narita Source Type: research

IDF/IAPB release joint policy brief for the early diagnosis, treatment and prevention of diabetic retinopathy
The International Diabetes Federation (IDF) and The International Alliance for the Prevention of Blindness (IAPB) have launched a new policy brief that calls for a joint approach to prevent and manage vision loss in people living with diabetes by integrating diabetic retinopathy (DR) care into diabetes policies and national health plans. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 25, 2024 Category: Endocrinology Tags: International Diabetes Federation Source Type: research

Association of 25-hydroxyvitamin D, lipoprotein-associated phospholipase A2 and asymptomatic coronary artery disease in patients with type 2 diabetes mellitus
To evaluate the relationship of 25-hydroxyvitamin D (25(OH)D), lipoprotein-associated phospholipase A2 (Lp-PLA2), and coronary artery disease (CAD) in type 2 diabetes mellitus (T2DM) patients with no history or symptoms of cardiovascular disease. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 24, 2024 Category: Endocrinology Authors: Qian Zhang, Qing-qing Zhang, Jiao-jiao He, Shu-qin Dong, Yu Lu Source Type: research

Are the cardiovascular properties of GLP-1 receptor agonists differentially modulated by sulfonylureas? insights from post-hoc analysis of EXSCEL
Cardiovascular outcome trials with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shown that they have cardiovascular benefits [1]. Likely mechanisms are multifactorial (e.g., weight loss) [2 –4] and may include a direct GLP-1 RA effect on the vasculature [5–8]. GLP-1 receptors are expressed in the human vasculature [9–11], but it is uncertain whether they are involved in mediating the vascular actions of GLP-1 RAs [6,8] Proposed mediators underlying GLP-1 RA vascular actions inclu de nitric oxide, hydrogen sulfide, and potassium channels, particularly KATP channels [7,12,13] as well as the endothelin pat...
Source: Diabetes Research and Clinical Practice - April 24, 2024 Category: Endocrinology Authors: Kim M. Gooding, Susanna Stevens, Yuliya Lokhnygina, Anna Giczewska, Angela C. Shore, Rury R. Holman Source Type: research

Associations of the obesity gene FTO variant with complications and comorbidities in patients with type 1 diabetes
The increasing prevalence of childhood overweight and obesity is a severe health problem worldwide that contributes to the development of various comorbidities [1]. Type 1 diabetes (T1D) patients are especially vulnerable to such complications since the intensive insulin therapy is associated with weight gain, abdominal obesity, dyslipidaemia, hypertension, and the presence of atherosclerosis development features in imaging [2]. Although clinical factors associated with the disease and its treatment as well as lifestyle elements have been widely studied, various genetic loci are also known to play important role in the obe...
Source: Diabetes Research and Clinical Practice - April 23, 2024 Category: Endocrinology Authors: Bartosz S łomiński, Maria Skrzypkowska, Małgorzata Myśliwiec, Piotr Trzonkowski Source Type: research

Role of nutritional therapy on dietary habits and glycemic control in insulin-treated kidney transplant patients with diabetes
To evaluate the effect of nutritional therapy on glycemic compensation and key cardio-renal risk markers in patients with diabetes and kidney transplant, on insulin treatment by Multiple Daily Injection (MDI) or Continuous Subcutaneous Insulin Infusion (CSII). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 22, 2024 Category: Endocrinology Authors: G. Clemente, N. Della Pia, A. Bramanti, L. Cerbara, G. Russo, P. De Rosa, V. Marotta, A. Tortora, M. Riccio, M. Vitale Source Type: research

The causal relationship between metabolic syndrome and its components and cardiovascular disease: A mendelian randomization study causal relationship between MetS and CVDs
To investigate the causal relationship between metabolic syndrome (MetS) and its components and 14 cardiovascular diseases using Mendelian randomization (MR). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 19, 2024 Category: Endocrinology Authors: Zejia Wu, Songyuan Luo, Dongqin Cai, Wenhui Lin, Xiaolu Hu, Ting Zhou, Xuxing Zhang, Yingqing Feng, Jianfang Luo Source Type: research

Intermittently scanned continuous glucose monitoring provides no benefit over structured self-monitoring of blood glucose in type 2 diabetes not on prandial insulin, in the context of diabetes self-management education: GLucose monitoring programme SingaporE (GLiMPSE)
We evaluated the impact of intermittently scanned continuous glucose monitoring(is-CGM)over self-monitoring of blood glucose(SMBG) in the context of diabetes self-management education (DSME) in sub-optimally controlled type 2 diabetes(T2D) in a multi-ethnicsetting. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 17, 2024 Category: Endocrinology Authors: Suresh Rama Chandran, Nabilah Rahman, Mihir Gandhi, Ngiap Chuan Tan, Ian K.Y. Phoon, Darren E.J. Seah, Ming Hann Cheah, Kathleen Sek, Daphne Su-Lyn Gardner Source Type: research

An 8-Week study on the effects of high and Moderate-Intensity interval exercises on mitochondrial MOTS-C changes and their relation to metabolic markers in male diabetic sand rats
This study explored the impact of high and moderate-intensity interval exercises on mitochondrial MOTS-C alterations and their correlation with metabolic markers in male diabetic sand rats. Thirty male sand rats were divided into six groups: control, MIIT, DM  + HIIT, DM + MIIT, DM, and HIIT (5 rats each). Diabetes was induced using a high-fat diet (HFD) combined with streptozotocin (STZ). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 16, 2024 Category: Endocrinology Authors: Sahar Parseh, Saeid Shakerian, Mohammad Reza Tabandeh, Abdolhamid Habibi Source Type: research