Gastroblastoma with an ACTB-GLI1 gene fusion in a 39-year-old man
A 39-year-old man complained with intermittent reflux of acid for 6 months. Physical and laboratory tests showed no abnormalities. Gastroscopy showed a 3.0-cm submucosal mass at the gastric antrum (Fig. 1A). Ultrasound gastroscopy showed a submucosal lesion with mixed echo (Fig. 1B). Abdominal computed tomography (CT) revealed local thickening (2.7 cm in long-diameter) of the antrum wall (Fig. 1 C,D). The tumor was resected completely by endoscopic submucosal desertion (ESD). Under microscopy, the tumor was composed of mesenchymal cells which were spindle to ovoid shaped, without obvious atypia, and were arranged in a reti...
Source: Digestive and Liver Disease - April 30, 2024 Category: Gastroenterology Authors: Lei Huang, Die Hu, Hongjin Hua, Xinmin Si Tags: Image of the Month Source Type: research
Reduced bone mineral density is associated to post-TIPS survival of female patients with decompensated cirrhosis
Malnutrition is common in patients with cirrhosis, eventually leading to sarcopenia and loss of bone mass. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 27, 2024 Category: Gastroenterology Authors: Marlene Reincke, Jochen Seufert, Katharina Laubner, Maximilian Meyer-Steenbuck, Anna Dammer, Lukas Sturm, Robert Thimme, Dominik Bettinger, Michael Schultheiss Tags: Liver, Pancreas and Biliary Tract Source Type: research
Risk factors and a nomogram for predicting local recurrence in adult patients with early gastric cancer after endoscopic submucosal dissection
Endoscopic submucosal dissection (ESD) is an effective treatment method for early gastric cancers. The aim of this study was to evaluate the risk factors of recurrence for patients with early gastric cancer after ESD and construct a nomogram for predicting recurrence. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 26, 2024 Category: Gastroenterology Authors: Shaoya Li, Ainun Nahar, Qian Zhang, Jie Xing, Peng Li, Shutian Zhang, Xiujing Sun Tags: Oncology Source Type: research
Primary squamous cell carcinoma of the pancreas causing regional portal hypertension
A female patient presented with epigastric pain with black stools and laboratory results suggesting positive fecal occult blood and higher than normal CA199. Upper abdominal CT (Fig. 1a,b) and magnetic resonance (Fig. 1c) suggested the possibility of pancreatic cervical body occupying lesions, involving the portal vein, splenic vein and superior mesenteric vein. Ultrasound-guided puncture biopsy of pancreatic mass was performed, and invasive carcinoma was detected (Fig. 1d). Immunohistochemistry results: P40 (Fig. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 26, 2024 Category: Gastroenterology Authors: Jingzhi Zhang, Daocong Ren, Qingshun Meng Tags: Image of the Month Source Type: research
Full Title Page /Editorial Board
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 25, 2024 Category: Gastroenterology Source Type: research
Post-infectious ibs following Clostridioides difficile infection; role of microbiota and implications for treatment
Up to 25% of patients recovering from antibiotic-treated Clostridioides difficile infection (CDI) develop functional symptoms reminiscent of Post-Infectious Irritable Bowel Syndrome (PI-IBS). For patients with persistent symptoms following infection, a clinical dilemma arises as to whether to provide additional antibiotic treatment or to adopt a conservative symptom-based approach. Here, we review the literature on CDI-related PI-IBS and compare the findings with PI-IBS. We review proposed mechanisms, including the role of C. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 22, 2024 Category: Gastroenterology Authors: Dana Taghaddos, Zarwa Saqib, Xaiopeng Bai, Premysl Bercik, Stephen M. Collins Tags: Review Article Source Type: research
Assessing ChatGPT and perplexity AI performance
This study assessed ChatGPT 3.5 and Perplexity AI's performance in answering gastroenterology-related questions from the 2023 Italian national residency admissi on test (SSM23). The study contrasted the chatbots' performance and concordance with test results from prior years. The procedures comprised feeding SSM23 questions into the chatbots and calculating the sum of their scores and right answers. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 22, 2024 Category: Gastroenterology Authors: Hinpetch Daungsupawong, Viroj Wiwanitkit Tags: Correspondence Source Type: research
Gastritis cystica profunda presenting as an ulcerated lesion
A 57-year-old man was referred to our hospital due to repeated upper abdominal discomfort for more than 1 year. Endoscopy was performed 4 times in the past and gastric cancer was suspected, but biopsy showed inflammation. In our hospital, endoscopy showed a 2.5 cm diameter depressed lesion on the gastric angle (Fig. 1A) and magnifying narrow band imaging observed the central surface structure of the lesion disappeared (Fig. 1B). Endoscopic ultrasound (EUS) revealed a 0.8 × 0.7 cm anechoic area in the submucosa (Fig. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 22, 2024 Category: Gastroenterology Authors: Yang Li, Ruide Liu, Ziqiang Wang, Yi Mou Tags: Image of the Month Source Type: research
A case of refractory severe pyoderma gangrenosum successfully treated with upadacitinib
A 59-year-old woman affected by colonic Crohn's disease and perianal disease underwent colectomy and end ileostomy. Persistently active luminal disease was associated with severe pyoderma gangrenosum localized to the upper and lower limbs. Previous treatments with intravenous steroids and infliximab were not effective on pyoderma gangrenosum lesions. The image shows the evolution of a large and deep lesion localized on the right hand, after starting upadacitinib 45 mg once a day, with clear improvement and almost complete healing in 6 weeks of treatment (Fig. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 21, 2024 Category: Gastroenterology Authors: Marco Mendolaro, Enrico Morello, Paola Salacone, Rodolfo Rocca Tags: Image of the Month Source Type: research
Artificial intelligence-assisted colonoscopy to identify histologic remission and predict the outcomes of patients with ulcerative colitis: A systematic review
This systematic review evaluated the current status of AI-assisted colonoscopy to identify histologic remission and predict the clinical outcomes of patients with ulcerative colitis. The use of artificial intelligence (AI) has increased substantially across several medical fields, including gastrointestinal endoscopy. Evidence suggests that it may be helpful to predict histologic remission and relapse, which would be beneficial because current histological diagnosis is limited by the inconvenience of obtaining biopsies and the high cost and time-intensiveness of pathological diagnosis. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 21, 2024 Category: Gastroenterology Authors: Yasuharu Maeda, Shin-ei Kudo, Giovanni Santacroce, Noriyuki Ogata, Masashi Misawa, Marietta Iacucci Tags: Alimentary Tract Source Type: research
Author's reply: “Assessing ChatGPT and perplexity AI performance”
None. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 21, 2024 Category: Gastroenterology Authors: Raffaele Pellegrino, Antonietta Gerarda Gravina Tags: Correspondence Source Type: research
Comment on “Echopattern parameter as an aid to profile Crohn's disease patients”
With a great interest in its subject matter, we extensively reviewed and analyzed an interesting article that was recently published by your journal, entitled “Echopattern parameter as a tool for characterizing Crohn's disease patients' profiles [1]”, authored by Cristofaro et al. We commend the Authors for their innovative efforts. Their core findings suggest that the assessment of bowel wall echopattern enables the differentiation of various Crohn's Disease (CD) behaviors, particularly noting that a hypoechoic echopattern correlates with both clinical and ultrasonographic (US) markers of inflammation, as well as poor...
Source: Digestive and Liver Disease - April 19, 2024 Category: Gastroenterology Authors: Muhammad Rafay Shahzad Cheema, Mukarram Farooq, Urba Jalal, Maryum Shahzad Tags: Correspondence Source Type: research
Magnetic resonance imaging short protocols for intraductal papillary mucinous neoplasm (IPMN) surveillance: The time has come
To analyze the diagnostic performance of three short magnetic resonance imaging (MRI) protocols for the follow-up of pancratic intraductal papillary mucinous neoplasms (IPMN). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 13, 2024 Category: Gastroenterology Authors: Mirko D'Onofrio, Luca Geraci, Riccardo Lombardi De Robertis, Nicol ò Cardobi, Alberto Balduzzi, Luisa Tomaiuolo, Eda Bardhi, Niccolò Faccioli, Gregorio Aluffi, Giovanni Marchegiani, Roberto Salvia Tags: Liver, Pancreas and Biliary Tract Source Type: research
Oral Budesonide and low serum albumin levels at surgery are associated with a higher risk of postoperative intra-abdominal septic complications after primary ileocaecal resection for Crohn's disease: A retrospective analysis of 853 consecutive patients
The terminal ileum is the most frequent site of Crohn's Disease (CD) that necessitates surgery. Of the postoperative complications (POCs) associated with ileocaecal resection for CD, intra-abdominal septic complications (IASCs) include anastomotic leak, abscesses, and entero-cutaneous fistula.We aimed to identify predictors of IASCs and severe POCs (Clavien-Dindo ≥3) after primary ileocaecal resection for CD. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 13, 2024 Category: Gastroenterology Authors: Gerti Dajti, Stefano Cardelli, Giacomo Calini, Fernando Rizzello, Paolo Gionchetti, Maria Elena Flacco, Gilberto Poggioli, Matteo Rottoli Tags: Alimentary Tract Source Type: research
Whether and when to biopsy coeliac patients: A never-ending story
Coeliac disease (CD) is an autoimmune enteropathy that primarily affects the small intestine, causing mucosal inflammation and variable villous atrophy. It occurs in genetically predisposed subjects following the ingestion of gluten, a protein complex of cereals such as wheat, barley, rye, whose main fractions are prolamins (including gliadin) and gluten [1]. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 13, 2024 Category: Gastroenterology Authors: Salvatore Cucchiara, Beatrice Leter Tags: Editorial Source Type: research
