Neurological Deterioration in Wilson's Disease-Types, Etiology, Course, and Management
Discov Med. 2024 Apr;36(183):646-654. doi: 10.24976/Discov.Med.202436183.61.ABSTRACTWilson's disease (WD) is an inherited disorder of copper metabolism in which pathological copper accumulation, mainly in the liver and the brain, leads to hepatic and/or neuropsychiatric signs and symptoms. Chelators and zinc salts can successfully induce negative copper balance in many patients; however, neurological deterioration may still be observed. This phenomenon can be divided into: (1) early 'paradoxical' neurological deterioration, which usually develops in the first 6 months of anti-copper treatment and may be commonly related to...
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Tomasz Litwin Agnieszka Antos Jan Bembenek Anna Cz Onkowska Source Type: research
Incretins Beyond the Pancreas: Exploring the Impact of GIP and GLP-1/2 on Bone Remodeling
Discov Med. 2024 Apr;36(183):655-665. doi: 10.24976/Discov.Med.202436183.62.ABSTRACTIncretin hormones, such as glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 and 2 (GLP-1, 2), belong to the group of gastrointestinal hormones. Their actions occur through interaction with GIP and GLP-1/2 receptors, which are present in various target tissues. Apart from their well-established roles in pancreatic function and insulin regulation, incretins elicit significant effects that extend beyond the pancreas. Specifically, these hormones stimulate osteoblast differentiation and inhibit osteoclast activity,...
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Hejun Zhao Jie Sun Zhipeng Ren Source Type: research
Epithelial-Mesenchymal Transformation Promotes the Progression of Hepatocellular Carcinoma through NF- κB/MMP9 Axis
CONCLUSIONS: The NF-κB/MMP9 signaling axis serves as a pivotal regulator that fosters proliferation and impedes apoptosis in Huh7 cells by modulating the process of EMT.PMID:38665016 | DOI:10.24976/Discov.Med.202436183.63 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Jinsen Li Qingbin Cai Ziyue Wang Liangshi Wang Guangrun Yang Zhilong Zhang Na Ge Shunxin Hu Tian Bai Source Type: research
Changes and Significance of Central Carbon Metabolism before and after Metformin Treatment of Type 2 Diabetes Based on Mass Spectrometry
CONCLUSIONS: We employed HPIC-MS/MS to uncover alterations in CCM among individuals recently diagnosed with T2D before and after metformin treatment. The findings suggest that metformin may ameliorate the energy metabolism imbalance in T2D by reducing intermediates within the CCM pathway.PMID:38665017 | DOI:10.24976/Discov.Med.202436183.64 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Yang Shu Fujie Yang Weidong Li Lisha Li Qiongying Hu Daqian Xiong Source Type: research
Sleep Disorders in Patients with Severe COVID-19 Treated in the Intensive Care Unit: A Real-Life Descriptive Study in Vietnam
CONCLUSION: Sleep problems are highly prevalence among hospitalized patients with severe COVID-19 in the ICU. Healthcare providers should pay attention to sleep problems and their associated symptoms to initiate appropriate treatment to improve severe COVID-19 patients' health status and minimize the risk of death.PMID:38665018 | DOI:10.24976/Discov.Med.202436183.65 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Sy Duong-Quy Tram Tang-Thi-Thao Duc Huynh-Truong-Anh Huong Hoang-Thi-Xuan Toi Nguyen-Van Anh Nguyen-Tuan Tu Tran-Thi-Cam Khue Bui-Diem Quan Vu-Tran-Thien Si Tran-Duc Thu Nguyen-Ngoc-Phuong Vinh Nguyen-Nhu Thai Nguyen-Duy Source Type: research
Aminophylline Improves Ventilator-Induced Diaphragmatic Dysfunction by Targeting IGF-1-FOXO1-MURF1 Pathway
CONCLUSIONS: In this study, MV treatment induced symptoms of VIDD in rats, which were all effectively reversed by AP regulating the IGF-1-FOXO1-MURF1 pathway, demonstrating the potential of AP in ameliorating VIDD.PMID:38665019 | DOI:10.24976/Discov.Med.202436183.66 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Luyu Yang Xiaohong Jiang Jinhui Tan Shouzhi Fu Wankang Dian Source Type: research
Analgesic Mechanism of Dexmedetomidine and Esketamine in Rats with Spinal Cord Injury
CONCLUSIONS: Treatment using DEX combined with ESK improves the motor function, inhibits inflammation and astrocyte activity, and exerts analgesic effects on rats with SCI. These findings can serve as a reference for the selection of multi-modal analgesics.PMID:38665020 | DOI:10.24976/Discov.Med.202436183.67 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Huiting Zhao Zhuocheng Li Source Type: research
EZH2 Promotes Multiple Myeloma Progression via STAT3 Pathway Activation
CONCLUSIONS: The effect of EZH2 and STAT3 pathways on MM regulation was revealed and verified. EZH2 promoted the progression of MM cells by activating the STAT3 pathway. The EZH2 and STAT3 pathways could be potential targets for effective MM treatment.PMID:38665021 | DOI:10.24976/Discov.Med.202436183.68 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Yanyu Wang Jing Tian Dan Huang Yuan Gao Huan Lin Lejia Liu Aixin Wang Source Type: research
Visual Interpretation of Radiomics Features in Filtered Computed Tomography Images during the Portal Phase of Acute Pancreatitis
CONCLUSIONS: Various filtered images convey distinct physical significance and properties. The selection of the appropriate filtered image, contingent upon the characteristics of the Region of Interest (ROI), enables a more comprehensive capture of the heterogeneity of the disease.PMID:38665022 | DOI:10.24976/Discov.Med.202436183.69 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Wenjing He Mingyue Tang Xian Jiang Bo Xiao Jiayi Wei Yanmei Zhao Yuanzhong Zhu Xiaowen Chen Source Type: research
Investigating the Impact of First-Line Anti-Tuberculosis Drugs Encapsulated in a Eugenol-Based Nanoemulsion on Human Serum Albumin
CONCLUSIONS: From the results we could comprehend that the eugenol (EUG)-drug complex showed greater stability in HSA protein structure when compared to HSA interacting with isoniazid (INH), rifampicin (RIF), pyrazinamide (PYR), or ethambutol (ETH) alone or with EUG alone. Thus, inferring the potential of EUG-based drug-loaded formulations for a safer and efficient therapeutic use.PMID:38665023 | DOI:10.24976/Discov.Med.202436183.70 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Parvathy Mohan Menon Natarajan Chandrasekaran George Priya Doss C Source Type: research
Effect of Calcium Supplementation and TMEM16A Inhibition on Endoplasmic Reticulum Stress Induced by Dental Fluorosis in Mice
CONCLUSIONS: The supplementation of calcium or the inhibition of TMEM16A expression appears to mitigate the detrimental effects of fluorosis by suppressing endoplasmic reticulum stress. These findings hold implications for identifying potential therapeutic targets in addressing dental fluorosis.PMID:38665024 | DOI:10.24976/Discov.Med.202436183.71 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Yangyang Yu Fei Xia Rong Liu Yahui Yan Li Yin Source Type: research
Local Tumor Progression Predictive Model Based on MRI for Colorectal Cancer Liver Metastases after Radiofrequency Ablation
CONCLUSIONS: The semi-quantitative MRIAS 1MO criteria, used for post-RFA MRI appearance analysis, exhibited strong measurement reliability. Prediction models established based on overall MRIAS 1MO score (MRIS) and lesion diameter had good predictive performance for LTP in patients undergoing RFA for CRCLM treatment.PMID:38665025 | DOI:10.24976/Discov.Med.202436183.72 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Guangyuan Zhang Pei Liu Guangzhi Wang Xinhong He Lichao Xu Yaohui Wang Wentao Li Weijun Peng Source Type: research
Tropomyosin 2 Regulates Tumor Cell Proliferation, Immune Suppression, and Activation of the JNK Signaling Pathway in Colitis-Associated Cancer (CAC)
CONCLUSIONS: Our results demonstrated that TPM2 knockdown suppressed the proliferation of CAC IECs, enhanced immune suppression on CAC IECs, and inhibited the JNK signaling pathway within the framework of CAC. These findings suggest TPM2 can serve as a potential therapeutic target for CAC treatment.PMID:38665026 | DOI:10.24976/Discov.Med.202436183.73 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Aixi Sun Jian Ge Kaixin Ding Zhiyang Gao Yun Zhang Source Type: research
Tauroursodeoxycholic Acid Mitigates Oxidative Stress and Promotes Differentiation in High Salt-Stimulated Osteoblasts via NOX1 Mediated by PGC-1 α
CONCLUSIONS: TUDCA might protect against high salt-induced OP via modulation of NOX1 mediated by PGC-1α.PMID:38665027 | DOI:10.24976/Discov.Med.202436183.74 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Shuimei Lian Ting Wang Jiajin Li Qian Yang Chengliang Lu Source Type: research
Herbo-Mineral Medicine, Lithom Exhibits Anti-Nephrolithiasis Activity in Rat Model of Hyperoxaluria by Attenuating Calcium Oxalate Crystal Formation and Oxidative Stress
CONCLUSION: Taken together, Lithom could be a potential clinical-therapeutic alternative for management of nephrolithiasis.PMID:38665028 | DOI:10.24976/Discov.Med.202436183.75 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Acharya Balkrishna Sandeep Sinha Moumita Manik Anupam Pandey Madhulina Maity Rishabh Dev Anurag Varshney Source Type: research
