Real-world clinical evidence of oral semaglutide on metabolic abnormalities in subjects with type 2 diabetes: a multicenter retrospective observational study (the Sapporo-Oral SEMA study)
This study was registered with the University Hospital Medical Information Network Center (UMIN000050583). Of 543 subjects who met the inclusion criteria, data for 434 subjects (age 55.5 ± 12.6 years; body mass index 29.6 ± 6.0 kg/m2) were analyzed. After a 6 months of observation period, semaglutide 3 mg, 7 mg, or 14 mg was used by 55 (12.7%), 241 (55.5%), and 138 (31.8%) of subjects, respectively. Both glycated hemoglobin and body weight significantly improved: 7.65 ± 1.11% to 6.88 ± 0.91% (p < 0.001) and 80.2 ± 19.2 kg to 77.6 ± 19.2 kg (p < 0.001), respectively. Efficacy was also confirmed in the subgroup s...
Source: Endocrine Journal - April 24, 2024 Category: Endocrinology Authors: Sho Furusawa Hiroshi Nomoto Chiho Oba-Yamamoto Jun Takeuchi Miki Ito Hiroyoshi Kurihara Shin Aoki Aika Miya Hiraku Kameda Akinobu Nakamura Tatsuya Atsumi Source Type: research
Lifelong cardiovascular care in Turner syndrome: two cases with review of literature
Endocr J. 2024 Apr 23. doi: 10.1507/endocrj.EJ24-0038. Online ahead of print.ABSTRACTCardiovascular disease is one of the most important complications in girls and women with Turner syndrome (TS). Although the latest international guideline provides useful suggestions for the management of cardiovascular diseases in TS, some unknown cardiac conditions warrant physicians' attention and awareness. Here, we have reported two adult cases wherein significant cardiovascular diseases were detected during the transition period. The first case patient was diagnosed with aortic crank deformity and left subclavian artery aneurysm at ...
Source: Endocrine Journal - April 24, 2024 Category: Endocrinology Authors: Shun Moriguchi Yuri Mukoyama Fumihiko Takizawa Atsushi Ogawa Tetsushi Ogawa Junko Ito Yukishige Yanagawa Chinatsu Komiyama Rieko Niitsu Tsuyoshi Isojima Source Type: research
Real-world clinical evidence of oral semaglutide on metabolic abnormalities in subjects with type 2 diabetes: a multicenter retrospective observational study (the Sapporo-Oral SEMA study)
This study was registered with the University Hospital Medical Information Network Center (UMIN000050583). Of 543 subjects who met the inclusion criteria, data for 434 subjects (age 55.5 ± 12.6 years; body mass index 29.6 ± 6.0 kg/m2) were analyzed. After a 6 months of observation period, semaglutide 3 mg, 7 mg, or 14 mg was used by 55 (12.7%), 241 (55.5%), and 138 (31.8%) of subjects, respectively. Both glycated hemoglobin and body weight significantly improved: 7.65 ± 1.11% to 6.88 ± 0.91% (p < 0.001) and 80.2 ± 19.2 kg to 77.6 ± 19.2 kg (p < 0.001), respectively. Efficacy was also confirmed in the subgroup s...
Source: Endocrine Journal - April 24, 2024 Category: Endocrinology Authors: Sho Furusawa Hiroshi Nomoto Chiho Oba-Yamamoto Jun Takeuchi Miki Ito Hiroyoshi Kurihara Shin Aoki Aika Miya Hiraku Kameda Akinobu Nakamura Tatsuya Atsumi Source Type: research
Lifelong cardiovascular care in Turner syndrome: two cases with review of literature
Endocr J. 2024 Apr 23. doi: 10.1507/endocrj.EJ24-0038. Online ahead of print.ABSTRACTCardiovascular disease is one of the most important complications in girls and women with Turner syndrome (TS). Although the latest international guideline provides useful suggestions for the management of cardiovascular diseases in TS, some unknown cardiac conditions warrant physicians' attention and awareness. Here, we have reported two adult cases wherein significant cardiovascular diseases were detected during the transition period. The first case patient was diagnosed with aortic crank deformity and left subclavian artery aneurysm at ...
Source: Endocrine Journal - April 24, 2024 Category: Endocrinology Authors: Shun Moriguchi Yuri Mukoyama Fumihiko Takizawa Atsushi Ogawa Tetsushi Ogawa Junko Ito Yukishige Yanagawa Chinatsu Komiyama Rieko Niitsu Tsuyoshi Isojima Source Type: research
Real-world clinical evidence of oral semaglutide on metabolic abnormalities in subjects with type 2 diabetes: a multicenter retrospective observational study (the Sapporo-Oral SEMA study)
This study was registered with the University Hospital Medical Information Network Center (UMIN000050583). Of 543 subjects who met the inclusion criteria, data for 434 subjects (age 55.5 ± 12.6 years; body mass index 29.6 ± 6.0 kg/m2) were analyzed. After a 6 months of observation period, semaglutide 3 mg, 7 mg, or 14 mg was used by 55 (12.7%), 241 (55.5%), and 138 (31.8%) of subjects, respectively. Both glycated hemoglobin and body weight significantly improved: 7.65 ± 1.11% to 6.88 ± 0.91% (p < 0.001) and 80.2 ± 19.2 kg to 77.6 ± 19.2 kg (p < 0.001), respectively. Efficacy was also confirmed in the subgroup s...
Source: Endocrine Journal - April 24, 2024 Category: Endocrinology Authors: Sho Furusawa Hiroshi Nomoto Chiho Oba-Yamamoto Jun Takeuchi Miki Ito Hiroyoshi Kurihara Shin Aoki Aika Miya Hiraku Kameda Akinobu Nakamura Tatsuya Atsumi Source Type: research
Lifelong cardiovascular care in Turner syndrome: two cases with review of literature
Endocr J. 2024 Apr 23. doi: 10.1507/endocrj.EJ24-0038. Online ahead of print.ABSTRACTCardiovascular disease is one of the most important complications in girls and women with Turner syndrome (TS). Although the latest international guideline provides useful suggestions for the management of cardiovascular diseases in TS, some unknown cardiac conditions warrant physicians' attention and awareness. Here, we have reported two adult cases wherein significant cardiovascular diseases were detected during the transition period. The first case patient was diagnosed with aortic crank deformity and left subclavian artery aneurysm at ...
Source: Endocrine Journal - April 24, 2024 Category: Endocrinology Authors: Shun Moriguchi Yuri Mukoyama Fumihiko Takizawa Atsushi Ogawa Tetsushi Ogawa Junko Ito Yukishige Yanagawa Chinatsu Komiyama Rieko Niitsu Tsuyoshi Isojima Source Type: research
Real-world clinical evidence of oral semaglutide on metabolic abnormalities in subjects with type 2 diabetes: a multicenter retrospective observational study (the Sapporo-Oral SEMA study)
This study was registered with the University Hospital Medical Information Network Center (UMIN000050583). Of 543 subjects who met the inclusion criteria, data for 434 subjects (age 55.5 ± 12.6 years; body mass index 29.6 ± 6.0 kg/m2) were analyzed. After a 6 months of observation period, semaglutide 3 mg, 7 mg, or 14 mg was used by 55 (12.7%), 241 (55.5%), and 138 (31.8%) of subjects, respectively. Both glycated hemoglobin and body weight significantly improved: 7.65 ± 1.11% to 6.88 ± 0.91% (p < 0.001) and 80.2 ± 19.2 kg to 77.6 ± 19.2 kg (p < 0.001), respectively. Efficacy was also confirmed in the subgroup s...
Source: Endocrine Journal - April 24, 2024 Category: Endocrinology Authors: Sho Furusawa Hiroshi Nomoto Chiho Oba-Yamamoto Jun Takeuchi Miki Ito Hiroyoshi Kurihara Shin Aoki Aika Miya Hiraku Kameda Akinobu Nakamura Tatsuya Atsumi Source Type: research
Lifelong cardiovascular care in Turner syndrome: two cases with review of literature
Endocr J. 2024 Apr 23. doi: 10.1507/endocrj.EJ24-0038. Online ahead of print.ABSTRACTCardiovascular disease is one of the most important complications in girls and women with Turner syndrome (TS). Although the latest international guideline provides useful suggestions for the management of cardiovascular diseases in TS, some unknown cardiac conditions warrant physicians' attention and awareness. Here, we have reported two adult cases wherein significant cardiovascular diseases were detected during the transition period. The first case patient was diagnosed with aortic crank deformity and left subclavian artery aneurysm at ...
Source: Endocrine Journal - April 24, 2024 Category: Endocrinology Authors: Shun Moriguchi Yuri Mukoyama Fumihiko Takizawa Atsushi Ogawa Tetsushi Ogawa Junko Ito Yukishige Yanagawa Chinatsu Komiyama Rieko Niitsu Tsuyoshi Isojima Source Type: research
Interleukin-17 prevents oxidative stress from damaging osteoblast formation by inhibiting autophagic degradation of metallothionein-2
In conclusion, IL-17A promotes ROS clearance by inhibiting autophagic degradation of MT-2, thereby protecting osteoblast formation from oxidative stress.PMID:38644219 | DOI:10.1507/endocrj.EJ24-0050 (Source: Endocrine Journal)
Source: Endocrine Journal - April 21, 2024 Category: Endocrinology Authors: Xueyan Ling Cuixia Wang Qin Feng Tao Zhang Source Type: research
Efficacy and safety of glucagon-like peptide-1 receptor agonists in the elderly versus non-elderly patients with type 2 diabetes mellitus: insights from a systematic review
In conclusion, while certain AEs leading to discontinuation may be more prevalent in older patients, GLP-1RAs are effective for weight loss and lead to decreased glucose concentrations with a low rate of complications in elderly patients.PMID:38644220 | DOI:10.1507/endocrj.EJ23-0384 (Source: Endocrine Journal)
Source: Endocrine Journal - April 21, 2024 Category: Endocrinology Authors: Yao Wang Jiangling Wang Qian Gong Haoming Wu Shuhao Yang Jufeng He Xulin Hu Tianfang Huang Source Type: research
Interleukin-17 prevents oxidative stress from damaging osteoblast formation by inhibiting autophagic degradation of metallothionein-2
In conclusion, IL-17A promotes ROS clearance by inhibiting autophagic degradation of MT-2, thereby protecting osteoblast formation from oxidative stress.PMID:38644219 | DOI:10.1507/endocrj.EJ24-0050 (Source: Endocrine Journal)
Source: Endocrine Journal - April 21, 2024 Category: Endocrinology Authors: Xueyan Ling Cuixia Wang Qin Feng Tao Zhang Source Type: research
Efficacy and safety of glucagon-like peptide-1 receptor agonists in the elderly versus non-elderly patients with type 2 diabetes mellitus: insights from a systematic review
In conclusion, while certain AEs leading to discontinuation may be more prevalent in older patients, GLP-1RAs are effective for weight loss and lead to decreased glucose concentrations with a low rate of complications in elderly patients.PMID:38644220 | DOI:10.1507/endocrj.EJ23-0384 (Source: Endocrine Journal)
Source: Endocrine Journal - April 21, 2024 Category: Endocrinology Authors: Yao Wang Jiangling Wang Qian Gong Haoming Wu Shuhao Yang Jufeng He Xulin Hu Tianfang Huang Source Type: research
An easy approach to ultrasonographic volumetry of the thyroid
Endocr J. 2024 Apr 11. doi: 10.1507/endocrj.EJ23-0606. Online ahead of print.ABSTRACTTo establish an easy way to perform volumetry of the thyroid gland using ultrasonography, we evaluated the accuracy of the products of the depth and width of the right thyroid lobe as indices of thyroid volume. The depth and width of both thyroid lobes were measured using ultrasonography before surgery in 193 patients with Graves' disease. The products were compared with the weight of the thyroid obtained from operative records. We also evaluated the depth and width of the right thyroid lobe in 312 subjects who presented without any thyroi...
Source: Endocrine Journal - April 10, 2024 Category: Endocrinology Authors: Tsukasa Murakami Naoyuki Higaki Yui Nishijima Junichi Tani Hitoshi Noguchi Manami Morisaki Misako Eto Yoshiko Tani Source Type: research
Changes in TgAb and TPOAb titers are greater in thyrotoxicosis than isolated hypothyroidism induced by PD-1 blockade
Endocr J. 2024 Apr 11. doi: 10.1507/endocrj.EJ23-0480. Online ahead of print.ABSTRACTAnti-thyroglobulin antibodies (TgAb) and/or anti-thyroid peroxidase antibodies (TPOAb) positivity at baseline is a risk marker for thyroid immune-related adverse events (thyroid-irAEs) in anti-programmed cell death-1 antibody (PD-1-Ab) treatment; however, it is unknown if TgAb and TPOAb titers are associated with clinical characteristics of thyroid-irAEs. Among 586 patients treated with PD-1-Ab at Nagoya University Hospital between 2 November 2015 and 30 September 2021, 57 patients developed thyroid-irAEs (thyrotoxicosis [n = 38]; hypothyr...
Source: Endocrine Journal - April 10, 2024 Category: Endocrinology Authors: Ayana Yamagami Shintaro Iwama Tomoko Kobayashi Xin Zhou Yoshinori Yasuda Takayuki Okuji Masaaki Ito Tetsushi Izuchi Masahiko Ando Takeshi Onoue Takashi Miyata Mariko Sugiyama Daisuke Hagiwara Hidetaka Suga Ryoichi Banno Hiroshi Arima Source Type: research
An easy approach to ultrasonographic volumetry of the thyroid
Endocr J. 2024 Apr 11. doi: 10.1507/endocrj.EJ23-0606. Online ahead of print.ABSTRACTTo establish an easy way to perform volumetry of the thyroid gland using ultrasonography, we evaluated the accuracy of the products of the depth and width of the right thyroid lobe as indices of thyroid volume. The depth and width of both thyroid lobes were measured using ultrasonography before surgery in 193 patients with Graves' disease. The products were compared with the weight of the thyroid obtained from operative records. We also evaluated the depth and width of the right thyroid lobe in 312 subjects who presented without any thyroi...
Source: Endocrine Journal - April 10, 2024 Category: Endocrinology Authors: Tsukasa Murakami Naoyuki Higaki Yui Nishijima Junichi Tani Hitoshi Noguchi Manami Morisaki Misako Eto Yoshiko Tani Source Type: research
