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Anti-viral Effects of Pavetta indica Methanolic Extract and Acyclovir on Behavioral and Biochemical Parameters in Streptozotocin-induced Alzheimer's Disease in Rats
CONCLUSION: In a dose-dependent manner, acyclovir and Pavetta indica methanolic extract treatments abrogated the streptozotocin-induced behavioral and neurological abnormalities in rats. The potential therapeutic effects of PIME and acyclovir administration in intracerebroventricular-streptozotocin-treated rats may be attributed to its potential antiviral, antioxidant, and anti-inflammatory effects. The current study suggests that Pavetta indica methanolic extract and acyclovir are promising therapeutic targets against Alzheimer's disease.PMID:38685761 | DOI:10.2174/0118715303273145240110100341 (Source: Endocrine, Metaboli...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 30, 2024 Category: Endocrinology Authors: Deepak Kumar Govind Singh None Tarun Meenakshi Dhanawat Sumeet Gupta Mohamed A Morsy Anroop B Nair Asmaa I Matouk Source Type: research

An Overlooked Disease: Minimal Autonomous Cortisol Secretion (MACS). A Narrative Review
CONCLUSION: MACS is no longer considered an asymptomatic disorder; repeated hormonal and functional tests are crucial to prevent multiorgan damage.PMID:38686896 | DOI:10.2174/0118715303266569231129101847 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 30, 2024 Category: Endocrinology Authors: Stephanie Farah Leah Nasr Jocelyne Eid Fares Source Type: research

Role of Clinical Features, Pathogenic and Etiological Characteristics of Community-acquired Pneumonia with Type 2 Diabetes Mellitus in Early Diagnosis
CONCLUSION: Compared with those without diabetes, the infection rates of Klebsiella pneumoniae, Pseudomonas aeruginosa, and Candida albicans were higher in patients with combined CAP/T2D.PMID:38686909 | DOI:10.2174/0118715303273741231117060753 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 30, 2024 Category: Endocrinology Authors: Bai-Yi Liu Dan Zhang Zhu Fan Jing-Jing Jin Cai-Hong Li Rui-Nan Guo Xue-Juan Li Yan Huang Source Type: research

Anti-viral Effects of Pavetta indica Methanolic Extract and Acyclovir on Behavioral and Biochemical Parameters in Streptozotocin-induced Alzheimer's Disease in Rats
CONCLUSION: In a dose-dependent manner, acyclovir and Pavetta indica methanolic extract treatments abrogated the streptozotocin-induced behavioral and neurological abnormalities in rats. The potential therapeutic effects of PIME and acyclovir administration in intracerebroventricular-streptozotocin-treated rats may be attributed to its potential antiviral, antioxidant, and anti-inflammatory effects. The current study suggests that Pavetta indica methanolic extract and acyclovir are promising therapeutic targets against Alzheimer's disease.PMID:38685761 | DOI:10.2174/0118715303273145240110100341 (Source: Endocrine, Metaboli...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 30, 2024 Category: Drugs & Pharmacology Authors: Deepak Kumar Govind Singh None Tarun Meenakshi Dhanawat Sumeet Gupta Mohamed A Morsy Anroop B Nair Asmaa I Matouk Source Type: research

Effects of Metformin Therapy on Thyroid Volume and Functions in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A Single-center Prospective Study
CONCLUSION: Our results suggest that metformin treatment significantly reduces body weight, BMI, thyroid volume, and serum TSH, ALT, and Anti-TPO levels in patients with newly diagnosed T2DM. Moreover, serum TSH levels showed a significant decrease in non-obese subjects, while thyroid volume showed a significant decrease in obese subjects.PMID:38676519 | DOI:10.2174/0118715303307313240315162000 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Endocrinology Authors: Mehtap Evran Gizem Pire İsa Burak Güney Source Type: research

Phytochemicals, Herbal Extracts, and Dietary Supplements for Metabolic Disease Management
Endocr Metab Immune Disord Drug Targets. 2024 Apr 26. doi: 10.2174/0118715303287911240409055710. Online ahead of print.ABSTRACTComprehensive and effective care techniques have become essential due to the global epidemic dimensions of metabolic disorders, including diabetes, obesity, and cardiovascular ailments. Recent research highlights the potential of dietary supplements, herbal extracts, and phytochemicals in treating metabolic diseases. This abstract conveys the current state of the science in this field by highlighting these findings' underlying mechanisms and potential therapeutic applications. Plant-based diets con...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Endocrinology Authors: Praveen Halagali Aparna Inamdar Jagroop Singh Amit Anand Poulami Sadhu Rashmi Pathak Himanshu Sharma Deepak Biswas Source Type: research

SARS-Cov-2 Infection: A New Risk Factor for Pituitary Apoplexy?
CONCLUSION: Alongside known risk factors (hypertension, anticoagulation, pregnancy, surgery, etc.), COVID-19 infection might represent an emerging predisposing factor for PA onset. The two cases hereby presented are both significant: the first confirms the role of "classic" vascular predisposing factors for PA, while the second demonstrates that PA might arise also in young patients without known risk factors.PMID:38676521 | DOI:10.2174/0118715303315494240419060719 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Endocrinology Authors: Alberto Ragni Giulia Bendotti Emilia Biamonte Beatrice Cavigiolo Enrico Gabellieri Paola Leporati Edoardo Luigi Maria Mollero Marco Gallo Source Type: research

Acceleration of Wound Healing in Diabetic Rats through a Novel 3D Organo-Hydrogel Nanocomposite of Polydopamine/TiO2 Nanoparticles and Cu (PDA-TiO2@Cu)
CONCLUSION: The organo-hydrogel can be used for treating and decreasing the healing period of diabetic wounds.PMID:38676522 | DOI:10.2174/0118715303280532240415094718 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Endocrinology Authors: Sally A Elekhtiar Maha Mohamed Abo Gazia Azza I Helal Hala Mahfouz Nesma M El-Kemary Sherief Abd-Elsalam Samar Elksass Hend A Alkabes Maged El-Kemary Marwa M Abd-Elsalam Source Type: research

Post-surgical Persistent Hyperparathyroidism Successfully Treated with Parathyroid Radiofrequency Ablation: A Case Report
CONCLUSION: A minimally invasive technique for PHPT may represent a valid alternative to surgery, especially in patients with an elevated surgery-related risk. More studies are necessary to investigate the benefit of RFA as a first-line treatment in PHPT.PMID:38676523 | DOI:10.2174/0118715303308277240419062634 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Endocrinology Authors: Francesco Di Marco Claudio Cusini Anna Ferrulli Giovanni Mauri Livio Luzi Source Type: research

Effects of Metformin Therapy on Thyroid Volume and Functions in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A Single-center Prospective Study
CONCLUSION: Our results suggest that metformin treatment significantly reduces body weight, BMI, thyroid volume, and serum TSH, ALT, and Anti-TPO levels in patients with newly diagnosed T2DM. Moreover, serum TSH levels showed a significant decrease in non-obese subjects, while thyroid volume showed a significant decrease in obese subjects.PMID:38676519 | DOI:10.2174/0118715303307313240315162000 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Drugs & Pharmacology Authors: Mehtap Evran Gizem Pire İsa Burak Güney Source Type: research

Phytochemicals, Herbal Extracts, and Dietary Supplements for Metabolic Disease Management
Endocr Metab Immune Disord Drug Targets. 2024 Apr 26. doi: 10.2174/0118715303287911240409055710. Online ahead of print.ABSTRACTComprehensive and effective care techniques have become essential due to the global epidemic dimensions of metabolic disorders, including diabetes, obesity, and cardiovascular ailments. Recent research highlights the potential of dietary supplements, herbal extracts, and phytochemicals in treating metabolic diseases. This abstract conveys the current state of the science in this field by highlighting these findings' underlying mechanisms and potential therapeutic applications. Plant-based diets con...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Drugs & Pharmacology Authors: Praveen Halagali Aparna Inamdar Jagroop Singh Amit Anand Poulami Sadhu Rashmi Pathak Himanshu Sharma Deepak Biswas Source Type: research

SARS-Cov-2 Infection: A New Risk Factor for Pituitary Apoplexy?
CONCLUSION: Alongside known risk factors (hypertension, anticoagulation, pregnancy, surgery, etc.), COVID-19 infection might represent an emerging predisposing factor for PA onset. The two cases hereby presented are both significant: the first confirms the role of "classic" vascular predisposing factors for PA, while the second demonstrates that PA might arise also in young patients without known risk factors.PMID:38676521 | DOI:10.2174/0118715303315494240419060719 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Drugs & Pharmacology Authors: Alberto Ragni Giulia Bendotti Emilia Biamonte Beatrice Cavigiolo Enrico Gabellieri Paola Leporati Edoardo Luigi Maria Mollero Marco Gallo Source Type: research

Acceleration of Wound Healing in Diabetic Rats through a Novel 3D Organo-Hydrogel Nanocomposite of Polydopamine/TiO2 Nanoparticles and Cu (PDA-TiO2@Cu)
CONCLUSION: The organo-hydrogel can be used for treating and decreasing the healing period of diabetic wounds.PMID:38676522 | DOI:10.2174/0118715303280532240415094718 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Drugs & Pharmacology Authors: Sally A Elekhtiar Maha Mohamed Abo Gazia Azza I Helal Hala Mahfouz Nesma M El-Kemary Sherief Abd-Elsalam Samar Elksass Hend A Alkabes Maged El-Kemary Marwa M Abd-Elsalam Source Type: research

Post-surgical Persistent Hyperparathyroidism Successfully Treated with Parathyroid Radiofrequency Ablation: A Case Report
CONCLUSION: A minimally invasive technique for PHPT may represent a valid alternative to surgery, especially in patients with an elevated surgery-related risk. More studies are necessary to investigate the benefit of RFA as a first-line treatment in PHPT.PMID:38676523 | DOI:10.2174/0118715303308277240419062634 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Drugs & Pharmacology Authors: Francesco Di Marco Claudio Cusini Anna Ferrulli Giovanni Mauri Livio Luzi Source Type: research

Effects of Metformin Therapy on Thyroid Volume and Functions in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A Single-center Prospective Study
CONCLUSION: Our results suggest that metformin treatment significantly reduces body weight, BMI, thyroid volume, and serum TSH, ALT, and Anti-TPO levels in patients with newly diagnosed T2DM. Moreover, serum TSH levels showed a significant decrease in non-obese subjects, while thyroid volume showed a significant decrease in obese subjects.PMID:38676519 | DOI:10.2174/0118715303307313240315162000 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Endocrinology Authors: Mehtap Evran Gizem Pire İsa Burak Güney Source Type: research