Predicting factors and clinical outcome of biochemical incomplete response in middle eastern differentiated thyroid carcinoma
ConclusionTo achieve the fair efficacy of RAI therapy, early prediction of BIR before RAI ablation is desirable. Our finding of the clinico-pathological factors (high presTg level, LNM, delayed RAI therapy and male gender) could serve as easy and robust early predictors of BIR. In addition, DTC patients exhibiting BIR had a high risk of structural disease and hence personalized management approach would be preferable for BIR patients to ensure best clinical outcome. (Source: Endocrine)
Source: Endocrine - May 2, 2024 Category: Endocrinology Source Type: research
Response to the Letter to the Editor by Jorge Violante-Cumpa; Marina Norde & amp; Geloneze Geloneze “Fat-free mass index is a feasible predictor of insulin resistance in women with polycystic ovary syndrome: evidence from a cross-sectional study”
(Source: Endocrine)
Source: Endocrine - May 1, 2024 Category: Endocrinology Source Type: research
Differential ischemic stroke risk linked to novel subtypes of type 2 diabetes: insights from a Mendelian randomization analysis
ConclusionsOur study highlights distinct causal links between specific type 2 diabetes subtypes and ischemic stroke risks, emphasizing the importance of subtype-specific prevention and treatment strategies. (Source: Endocrine)
Source: Endocrine - April 30, 2024 Category: Endocrinology Source Type: research
Identification of potential targetable genes in papillary, follicular, and anaplastic thyroid carcinoma using bioinformatics analysis
ConclusionsThe findings unravel potential biomarkers and therapeutic targets of thyroid carcinomas. (Source: Endocrine)
Source: Endocrine - April 27, 2024 Category: Endocrinology Source Type: research
Clinical and radiographic characteristics of patients with non-functioning pituitary adenomas categorized according to their serum prolactin concentration: novel predictors of postoperative transient diabetes insipidus following surgery
ConclusionThe presence of a “stalk effect” was associated with a higher risk of postoperative transient diabetes insipidus, reflecting perioperative pituitary stalk dysfunction following NFPA surgery, especially in patients with serum prolactin concentrations ≥40 ng/mL and radiologic evidence of stalk deviation. (Source: Endocrine)
Source: Endocrine - April 25, 2024 Category: Endocrinology Source Type: research
Therapeutic patient education and treatment intensification of diabetes and hypertension in subjects with newly diagnosed type 2 diabetes mellitus: a longitudinal study
ConclusionsTPE, delivered as both individual and group sessions, represents an effective tool to reduce the need to intensify treatment of both diabetes and hypertension. Therefore, it can ensure better control of diabetes and hypertension with fewer medications. This could reduce adverse effects and costs and improve quality of life and medication taking in patients with type 2 diabetes. (Source: Endocrine)
Source: Endocrine - April 24, 2024 Category: Endocrinology Source Type: research
Efficacy, safety, and patient satisfaction of norditropin and sogroya in patients with growth hormone deficiency: a systematic review and meta-analysis of randomized controlled trials
ConclusionNorditropin and Sogroya showed comparable efficacy and safety profiles, except for the prevalence of rash in the Norditropin group, and Sogroya has higher satisfaction among adults. More high-quality studies with more patients are required to confirm these results. (Source: Endocrine)
Source: Endocrine - April 24, 2024 Category: Endocrinology Source Type: research
Effectiveness of prognostic nutritional index in predicting overall survival and evaluating immunotherapy response in anaplastic thyroid carcinoma
ConclusionPNI is an independent predictor of overall survival and holds the potential to serve as a valuable indicator for assessing and predicting immunotherapy efficacy in ATC patients. (Source: Endocrine)
Source: Endocrine - April 24, 2024 Category: Endocrinology Source Type: research
1,25(OH)2D3 inhibits pancreatic stellate cells activation and promotes insulin secretion in T2DM
ConclusionOur findings identify that PSCs activation contributes to islet fibrosis and β-cell dysfunction. 1,25(OH)2D3 exerts beneficial effects on T2DM potentially by inhibiting PSCs activation and inflammatory response, highlighting promising control strategies of T2DM by vitamin D.Graphical AbstractFig. 7 Molecular mechanism of 1,25(OH)2D3 in β cell damage following PSCs activation in T2DM mice. (Source: Endocrine)
Source: Endocrine - April 24, 2024 Category: Endocrinology Source Type: research
Efficacy, safety, and patient satisfaction of norditropin and sogroya in patients with growth hormone deficiency: a systematic review and meta-analysis of randomized controlled trials
ConclusionNorditropin and Sogroya showed comparable efficacy and safety profiles, except for the prevalence of rash in the Norditropin group, and Sogroya has higher satisfaction among adults. More high-quality studies with more patients are required to confirm these results. (Source: Endocrine)
Source: Endocrine - April 24, 2024 Category: Endocrinology Source Type: research
Effectiveness of prognostic nutritional index in predicting overall survival and evaluating immunotherapy response in anaplastic thyroid carcinoma
ConclusionPNI is an independent predictor of overall survival and holds the potential to serve as a valuable indicator for assessing and predicting immunotherapy efficacy in ATC patients. (Source: Endocrine)
Source: Endocrine - April 24, 2024 Category: Endocrinology Source Type: research
Therapeutic patient education and treatment intensification of diabetes and hypertension in subjects with newly diagnosed type 2 diabetes mellitus: a longitudinal study
ConclusionsTPE, delivered as both individual and group sessions, represents an effective tool to reduce the need to intensify treatment of both diabetes and hypertension. Therefore, it can ensure better control of diabetes and hypertension with fewer medications. This could reduce adverse effects and costs and improve quality of life and medication taking in patients with type 2 diabetes. (Source: Endocrine)
Source: Endocrine - April 24, 2024 Category: Endocrinology Source Type: research
1,25(OH)2D3 inhibits pancreatic stellate cells activation and promotes insulin secretion in T2DM
ConclusionOur findings identify that PSCs activation contributes to islet fibrosis and β-cell dysfunction. 1,25(OH)2D3 exerts beneficial effects on T2DM potentially by inhibiting PSCs activation and inflammatory response, highlighting promising control strategies of T2DM by vitamin D.Graphical AbstractFig. 7 Molecular mechanism of 1,25(OH)2D3 in β cell damage following PSCs activation in T2DM mice. (Source: Endocrine)
Source: Endocrine - April 24, 2024 Category: Endocrinology Source Type: research
No requirement of perioperative glucocorticoid replacement in patients with endogenous Cushing ’s syndrome – a pilot study
ConclusionPerioperative glucocorticoid replacement may be unnecessary in patients with central or adrenal CS undergoing curative surgery as first-line treatment. (Source: Endocrine)
Source: Endocrine - April 22, 2024 Category: Endocrinology Source Type: research
