Psychiatric complications following SEEG-guided radiofrequency thermocoagulations in patients with drug-resistant epilepsy
Epilepsy Behav. 2024 Apr 26;156:109806. doi: 10.1016/j.yebeh.2024.109806. Online ahead of print.ABSTRACTSEEG-guided radiofrequency thermocoagulation (RF-TC) in the epileptogenic regions is a therapeutic option for patients with drug-resistant focal epilepsy who may have or not indication for epilepsy surgery. The most common adverse events of RF-TC are seizures, headaches, somatic pain, and sensory-motor deficits. If RF-TC could lead to psychiatric complications is unknown. In the present study, seven out of 164 patients (4.2 %) experienced psychiatric decompensation with or without memory deterioration after RF-TC of bila...
Source: Epilepsy and Behaviour - April 27, 2024 Category: Neurology Authors: Marianna Bregianni Francesca Pizzo Stanislas Lagarde Julia Makhalova Agnes Trebuchon Romain Carron Lisa Soncin Marie Arthuis Fabrice Bartolomei Source Type: research
Placebo response in patients with Dravet syndrome: Post-hoc analysis of two clinical trials
This study explored placebo response and its effects on safety, efficacy, and quality of life outcomes in patients with Dravet syndrome.METHODS: We performed exploratory post-hoc analyses of pooled data from placebo-treated patients from the GWPCARE 1B and GWPCARE 2 randomized controlled phase III trials, comparing cannabidiol and matched placebo in 2-18 year old Dravet syndrome patients. All patients had ≥4 convulsive seizures during a baseline period of 4 weeks.RESULTS: 124 Dravet syndrome-treated patients were included in the analysis (2-5 years: n = 35; 6-12 years: n = 52; 13-18 years: n = 37). Convulsive seizures we...
Source: Epilepsy and Behaviour - April 27, 2024 Category: Neurology Authors: Orrin Devinsky Kerry Hyland Rachael Loftus Charlotte Nortvedt Rima Nabbout Source Type: research
Construction and validation of an algorithm to separate focal and generalised epilepsy using clinical variables: A comparison of machine learning approaches
CONCLUSION: A clinical algorithm with eight variables is effective and accurate at separating focal from generalised epilepsy. It should be useful in resource-limited settings, by epilepsy-inexperienced doctors, to help determine epilepsy type and therefore optimal ASMs for individual patients, without the need for EEG or neuroimaging.PMID:38669972 | DOI:10.1016/j.yebeh.2024.109793 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - April 26, 2024 Category: Neurology Authors: Victor Patterson David H Glass Shambhu Kumar Sarah Misbah El-Sadig Inaam Mohamed Rahba El-Amin Mamta Singh Source Type: research
Quality of life in people with epilepsy: Associations with resilience, internalized stigma, and clinical factors in a low-income population
CONCLUSION: The QoL of PWE in a low-income context is strongly associated with their levels of resilience and internalized stigma. When addressing the social burden of epilepsy, resilience support should be increased in the care of PWE to reduce internalized stigma and improve the QoL.PMID:38669973 | DOI:10.1016/j.yebeh.2024.109801 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - April 26, 2024 Category: Neurology Authors: Florence P élissié Du Rausas Ignacio Lagger Pierre-Marie Preux Khadija Serghini Rousseau Oscar A Mart ínez Source Type: research
Second antiseizure medication monotherapy in patients with adult-onset epilepsy: A register-based analysis
Epilepsy Behav. 2024 Apr 25;155:109792. doi: 10.1016/j.yebeh.2024.109792. Online ahead of print.ABSTRACTOBJECTIVE: Revision of therapy is fundamental in epilepsy care, since only half of patients achieve seizure freedom and tolerate the first antiseizure medication (ASM). We studied the selection and retention of second antiseizure medication monotherapy in adults who discontinued treatment with one of the three most frequently prescribed first ASMs, and the impact of age or brain comorbidities.METHODS: Using Swedish national registers, we conducted a population-based, retrospective cohort study from 2007 to 2019 on patien...
Source: Epilepsy and Behaviour - April 26, 2024 Category: Neurology Authors: Konstantinos Polychronidis Samuel H åkansson Saman Hosseini Ashtiani Andr é Idegård David Larsson Johan Zelano Source Type: research
Comparison of minimally invasive to standard temporal lobectomy approaches to epilepsy surgery: Seizure relief and visual confrontation naming outcomes
Epilepsy Behav. 2024 Apr 24;155:109669. doi: 10.1016/j.yebeh.2024.109669. Online ahead of print.ABSTRACTThe purpose of this study was to systematically examine three different surgical approaches in treating left medial temporal lobe epilepsy (mTLE) (viz., subtemporal selective amygdalohippocampectomy [subSAH], stereotactic laser amygdalohippocampotomy [SLAH], and anterior temporal lobectomy [ATL]), to determine which procedures are most favorable in terms of visual confrontation naming and seizure relief outcome. This was a retrospective study of 33 adults with intractable mTLE who underwent left temporal lobe surgery at ...
Source: Epilepsy and Behaviour - April 25, 2024 Category: Neurology Authors: Karine Hageboutros Kelsey C Hewitt Gregory P Lee Aastha Bansal Cady Block Nigel P Pedersen Jon T Willie David W Loring Mike R Schoenberg Kris A Smith Cole A Giller Robert E Gross Daniel L Drane Source Type: research
Prevalence and genotypic associations of epilepsy in Prader-Willi Syndrome: A systematic review and meta-analysis
CONCLUSIONS: The prevalence of seizure disorders in PWS is higher than in the general population. In addition, deletions in 15q11-q13 may be associated with a higher risk of seizure disorders. Therefore, active screening for seizure disorders in PWS should improve the lives of these people. In addition, genotype could be used to stratify risk, even for epilepsy, although more studies or larger sample sizes are needed.PMID:38663143 | DOI:10.1016/j.yebeh.2024.109803 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - April 25, 2024 Category: Neurology Authors: Carlos Pascual-Morena Vicente Mart ínez-Vizcaíno Iv án Cavero-Redondo Celia Álvarez-Bueno Irene Mart ínez-García Eva Rodr íguez-Gutiérrez Iris Otero-Luis Andrea Del Saz-Lara Alicia Saz-Lara Source Type: research
Comparison of minimally invasive to standard temporal lobectomy approaches to epilepsy surgery: Seizure relief and visual confrontation naming outcomes
Epilepsy Behav. 2024 Apr 24;155:109669. doi: 10.1016/j.yebeh.2024.109669. Online ahead of print.ABSTRACTThe purpose of this study was to systematically examine three different surgical approaches in treating left medial temporal lobe epilepsy (mTLE) (viz., subtemporal selective amygdalohippocampectomy [subSAH], stereotactic laser amygdalohippocampotomy [SLAH], and anterior temporal lobectomy [ATL]), to determine which procedures are most favorable in terms of visual confrontation naming and seizure relief outcome. This was a retrospective study of 33 adults with intractable mTLE who underwent left temporal lobe surgery at ...
Source: Epilepsy and Behaviour - April 25, 2024 Category: Neurology Authors: Karine Hageboutros Kelsey C Hewitt Gregory P Lee Aastha Bansal Cady Block Nigel P Pedersen Jon T Willie David W Loring Mike R Schoenberg Kris A Smith Cole A Giller Robert E Gross Daniel L Drane Source Type: research
Prevalence and genotypic associations of epilepsy in Prader-Willi Syndrome: A systematic review and meta-analysis
CONCLUSIONS: The prevalence of seizure disorders in PWS is higher than in the general population. In addition, deletions in 15q11-q13 may be associated with a higher risk of seizure disorders. Therefore, active screening for seizure disorders in PWS should improve the lives of these people. In addition, genotype could be used to stratify risk, even for epilepsy, although more studies or larger sample sizes are needed.PMID:38663143 | DOI:10.1016/j.yebeh.2024.109803 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - April 25, 2024 Category: Neurology Authors: Carlos Pascual-Morena Vicente Mart ínez-Vizcaíno Iv án Cavero-Redondo Celia Álvarez-Bueno Irene Mart ínez-García Eva Rodr íguez-Gutiérrez Iris Otero-Luis Andrea Del Saz-Lara Alicia Saz-Lara Source Type: research
Evaluation of anti-seizure medications and their serum concentration with regard to cardiovascular risk parameters: A cross-sectional study
CONCLUSION: In our study, the majority of patients were children and adolescents. Regular monitoring of drug serum concentrations and metabolic parameters may be useful to select the safest drug in terms of cardiovascular disease risk. Randomized controlled trials on the long-term effects of anti-seizure treatment are needed.PMID:38657483 | DOI:10.1016/j.yebeh.2024.109802 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - April 24, 2024 Category: Neurology Authors: Merve Becit-Kizilkaya Seyma Oncu Halit Bugra Koca Dilek Cavusoglu Source Type: research
Cost-effectiveness analysis of HLA-B*15:02 screening before treatment of epilepsy in Indonesia
CONCLUSION: Calculation of the cost-effectiveness of lifetime epilepsy therapy in this study found that the initial screening strategy with the HLA-B*15:02 test was the most cost-effective.PMID:38657484 | DOI:10.1016/j.yebeh.2024.109787 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - April 24, 2024 Category: Neurology Authors: Eric Tanoto Herlyani Khosama Seilly Jehosua Sekplin A S Sekeon Winifred Karema Arthur H P Mawuntu Fima F L G Langi Lim Kheng Seang Source Type: research
Effect of prednisolone in a kindling model of epileptic seizures in rats on cytokine and intestinal microbiota diversity
This study aimed to evaluate the effects of prednisolone treatment on epileptic seizures and investigate the effect of this drug on the bacterial diversity of the intestinal microbiota and markers of inflammatory processes in intestinal tissue. We used Male Wistar rat littermates (n = 31, 90-day-old) divided into four groups: positive control treated with 2 mg/kg of diazepam (n = 6), negative control treated with 0.9 g% sodium chloride (n = 6), and the remaining two groups were subjected to treatment with prednisolone, with one receiving 1 mg/kg (n = 9) and the other 5 mg/kg (n = 10). All administrations were performed int...
Source: Epilepsy and Behaviour - April 24, 2024 Category: Neurology Authors: Amanda Muliterno Domingues Louren ço de Lima Gabriel de Lima Rosa Edson Fernando M üller Guzzo Rafael Bremm Padilha Milena Conci de Araujo Rodrigo Costa da Silva Adriana Simon Coitinho Sueli Teresinha Van Der Sand Source Type: research
Evaluation of anti-seizure medications and their serum concentration with regard to cardiovascular risk parameters: A cross-sectional study
CONCLUSION: In our study, the majority of patients were children and adolescents. Regular monitoring of drug serum concentrations and metabolic parameters may be useful to select the safest drug in terms of cardiovascular disease risk. Randomized controlled trials on the long-term effects of anti-seizure treatment are needed.PMID:38657483 | DOI:10.1016/j.yebeh.2024.109802 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - April 24, 2024 Category: Neurology Authors: Merve Becit-Kizilkaya Seyma Oncu Halit Bugra Koca Dilek Cavusoglu Source Type: research
Cost-effectiveness analysis of HLA-B*15:02 screening before treatment of epilepsy in Indonesia
CONCLUSION: Calculation of the cost-effectiveness of lifetime epilepsy therapy in this study found that the initial screening strategy with the HLA-B*15:02 test was the most cost-effective.PMID:38657484 | DOI:10.1016/j.yebeh.2024.109787 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - April 24, 2024 Category: Neurology Authors: Eric Tanoto Herlyani Khosama Seilly Jehosua Sekplin A S Sekeon Winifred Karema Arthur H P Mawuntu Fima F L G Langi Lim Kheng Seang Source Type: research
Effect of prednisolone in a kindling model of epileptic seizures in rats on cytokine and intestinal microbiota diversity
This study aimed to evaluate the effects of prednisolone treatment on epileptic seizures and investigate the effect of this drug on the bacterial diversity of the intestinal microbiota and markers of inflammatory processes in intestinal tissue. We used Male Wistar rat littermates (n = 31, 90-day-old) divided into four groups: positive control treated with 2 mg/kg of diazepam (n = 6), negative control treated with 0.9 g% sodium chloride (n = 6), and the remaining two groups were subjected to treatment with prednisolone, with one receiving 1 mg/kg (n = 9) and the other 5 mg/kg (n = 10). All administrations were performed int...
Source: Epilepsy and Behaviour - April 24, 2024 Category: Neurology Authors: Amanda Muliterno Domingues Louren ço de Lima Gabriel de Lima Rosa Edson Fernando M üller Guzzo Rafael Bremm Padilha Milena Conci de Araujo Rodrigo Costa da Silva Adriana Simon Coitinho Sueli Teresinha Van Der Sand Source Type: research
