Germline NGS targeted analysis in adult patients with sporadic adrenocortical carcinoma
Adrenocortical carcinoma (ACC) is a rare cancer that arises sporadically or due to hereditary syndromes. Data on germline variants (GVs) in sporadic ACC are limited. Our aim was to characterize GVs of genes potentially related to adrenal diseases in 150 adult patients with sporadic ACC. (Source: European Journal of Cancer)
Source: European Journal of Cancer - April 25, 2024 Category: Cancer & Oncology Authors: Maria Scatolini, Salvatore Grisanti, Pasquale Tomaiuolo, Enrico Grosso, Vittoria Basile, Deborah Cosentini, Soraya Puglisi, Marta Lagan à, Paola Perotti, Laura Saba, Elisa Rossini, Flavia Palermo, Sandra Sigala, Marco Volante, Alfredo Berruti, Massimo Te Tags: Original Research Source Type: research
Real-world treatment patterns and medical costs of prostate cancer patients in Switzerland – a claims data analysis
Prostate cancer (PC) is the most prevalent cancer in men in Switzerland. However, evidence on the real-world health care use of PC patients is scarce. The aim of this study is to describe health care utilization, treatment patterns, and medical costs in PC patients over a period of five years (2014-2018). (Source: European Journal of Cancer)
Source: European Journal of Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Michael Stucki, Stephanie Dosch, Markus Gn ädinger, Sereina M. Graber, Carola A. Huber, Golda Lenzin, Räto T. Strebel, Daniel R. Zwahlen, Aurelius Omlin, Simon Wieser Tags: Original Research Source Type: research
COLUMBUS 7-year update: a randomized, open-label, phase III trial of encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF V600E/K-mutant melanoma
We report results from the 7-year analysis of COLUMBUS part 1 (NCT01909453) at 99.7 months (median duration between randomization and data cutoff). (Source: European Journal of Cancer)
Source: European Journal of Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Dirk Schadendorf, Reinhard Dummer, Keith T. Flaherty, Caroline Robert, Ana Arance, Jan Willem B. de Groot, Claus Garbe, Helen J. Gogas, Ralf Gutzmer, Ivana Krajsov á, Gabriella Liszkay, Carmen Loquai, Mario Mandalà, Naoya Yamazaki, Paola Queirolo, Carol Tags: Original Research Source Type: research
Skin cancers are the most frequent cancers in fair-skinned populations, but we can prevent them.
Cancers of the skin are the most commonly occurring cancers in humans. In fair-skinned populations, up to 95% of keratinocyte skin cancers and 70-95% of cutaneous melanomas are caused by ultraviolet radiation and are thus theoretically preventable. Currently, however, there is no comprehensive global advice on practical steps to be taken to reduce the toll of skin cancer. To address this gap, an expert working group comprising clinicians and researchers from Africa, America, Asia, Australia, and Europe, together with learned societies (European Association of Dermato-Oncology, Euromelanoma, Euroskin, European Union of Medi...
Source: European Journal of Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Claus Garbe, Ana-Maria Forsea, Teresa Amaral, Petr Arenberger, Philippe Autier, Marianne Berwick, Brigitta Boonen, Matilda Bylaite, Veronique del Marmol, Brigitte Dreno, Maria Concetta Fargnoli, Alan C. Geller, Adele C. Green, R üdiger Greinert, Axel Hau Tags: Current Perspective Source Type: research
Corrigendum to “Zotiraciclib (TG02) for newly diagnosed glioblastoma in the elderly or for recurrent glioblastoma: The EORTC 1608 STEAM trial” [Eur J Cancer 198 (2024) 113475]
The authors regret to advise of an error in Fig. 3A. By error, the survival curves shown were identical as in Fig. 3C. The corrected Fig. 3A is shown here:. (Source: European Journal of Cancer)
Source: European Journal of Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Emilie Le Rhun, Thierry Gorlia, J örg Felsberg, Joost Jongen, Claude-Alain Maurage, François Ducray, Dorothee Gramatzki, Peter Hau, Olivier L. Chinot, Matthias Preusser, Stephanie Cartalat, Patrick Roth, Martin van den Bent, Julia Furtner, Maike Collien Tags: Corrigendum Source Type: research
Application of blinatumomab, a bispecific anti-CD3/CD19 T-cell engager, in treating severe systemic sclerosis: A case study
Systemic sclerosis, a severe inflammatory autoimmune disease, shares a common thread with cancer through the underlying mechanism of inflammation. This inflammatory milieu not only drives the immune dysregulation characteristic of autoimmune diseases but also plays a pivotal role in the pathogenesis of cancer. Among the cellular components involved, B cells have emerged as key players in hematologic tumor and autoimmune disease, contributing to immune dysregulation and persistent tissue fibrosis in systemic sclerosis, as well as tumor progression and immune evasion in cancer. (Source: European Journal of Cancer)
Source: European Journal of Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Marion Subklewe, Giulia Magno, Christina Gebhardt, Veit B ücklein, Franziska Szelinski, Héctor Julián Rincón Arévalo, Hanel Gerulf Hänel, Thomas Dörner, Gerhard Zugmaier, Michael von Bergwelt-Baildon, Alla Skapenko, Hendrik Schulze-Koops Tags: Original Research Source Type: research
Incomplete DPYD haplotype B3 in a patient with locally advanced gastric cancer: reconsidering the 5-FU dosage strategy.
To the Editor: (Source: European Journal of Cancer)
Source: European Journal of Cancer - April 20, 2024 Category: Cancer & Oncology Authors: Sascha Dierks, S ören Matthias Buchholz, Alexander König, Torsten Liersch, Julie Schanz Tags: Letter to the Editor Source Type: research
Editorial Board
(Source: European Journal of Cancer)
Source: European Journal of Cancer - April 18, 2024 Category: Cancer & Oncology Source Type: research
European clinical practice guidelines for the definition, diagnosis, and treatment of oligometastatic esophagogastric cancer (OMEC-4).
The OligoMetastatic Esophagogastric Cancer (OMEC) project aims to provide clinical practice guidelines for the definition, diagnosis, and treatment of esophagogastric oligometastatic disease (OMD). (Source: European Journal of Cancer)
Source: European Journal of Cancer - April 16, 2024 Category: Cancer & Oncology Authors: Tiuri E. Kroese, Sebastiaan Bronzwaer, Peter S.N. van Rossum, Sebastian F. Schoppman, Pieter R.A.J. Deseyne, Eric van Cutsem, Karin Haustermans, Philippe Nafteux, Melissa Thomas, Radka Obermannova, Hanna R. Mortensen, Marianne Nordsmark, Per Pfeiffer, Ann Tags: Original Research Source Type: research
N0 neck trial: Does Intensification of Follow-up (ultrasound + Physical Examination) Influence Outcomes in Early-stage Oral Cancer?
We previously reported a survival benefit of elective neck dissection (END) over therapeutic neck dissection (TND) in patients with clinically node-negative early-stage oral cancer. We now report the results of the second question in the same study addressing the impact of adding neck ultrasound to physical examination during follow-up on outcomes. (Source: European Journal of Cancer)
Source: European Journal of Cancer - April 16, 2024 Category: Cancer & Oncology Authors: Richa Vaish, Rohini Hawaldar, Sudeep Gupta, Mitali Dandekar, Snehal Shah, Devendra Chaukar, Gouri Pantvaidya, Anuja Deshmukh, Pankaj Chaturvedi, Prathamesh Pai, Deepa Nair, Sudhir Nair, Meenakshi Thakur, Sarbani Ghosh-Laskar, JP Agarwal, Anil K D ’Cruz Tags: Clinical Trial Source Type: research
Impact of immunosuppressive agents on the management of immune-related adverse events of immune checkpoint blockers
Immune checkpoint blockers (ICBs) can induce immune-related adverse events (irAEs) whose management is based on expert opinion and may require the prescription of steroids and/or immunosuppressants (ISs). Recent data suggest that these treatments can reduce the effectiveness of ICBs. (Source: European Journal of Cancer)
Source: European Journal of Cancer - April 13, 2024 Category: Cancer & Oncology Authors: Pierre-Louis Cariou, C édric Pobel, Jean-Marie Michot, François-Xavier Danlos, Benjamin Besse, Franck Carbonnel, Xavier Mariette, Aurélien Marabelle, Sabine Messayke, Caroline Robert, Emilie Routier, Nicolas Noël, Olivier Lambotte Tags: Original Research Source Type: research
A selective anatomically based lymph node sampling can replace a side specific pelvic lymphadenectomy in endometrial cancer with failed sentinel node mapping.
To evaluate the locations of metastatic pelvic sentinel nodes (SLN) and the proportion of SLNs outside and within defined typical anatomical positions along the upper paracervical lymphatic pathway (UPP). (Source: European Journal of Cancer)
Source: European Journal of Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Michele Bollino, Barbara Geppert, Celine L önnerfors, Jan Persson Tags: Original Research Source Type: research
Expression of immune-related genes and breast cancer recurrence in women with ductal carcinoma in situ
Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer with highly variable clinical behavior, but risk stratification is still challenging. We sought to identify immune-related gene expression signatures of pure DCIS associated with different risks of breast cancer recurrence. (Source: European Journal of Cancer)
Source: European Journal of Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Elena Guerini-Rocco, Federica Bellerba, Alberto Concardi, Sergio Vincenzo Taormina, Giulio Cammarata, Caterina Fumagalli, Aliana Guerrieri-Gonzaga, Debora Macis, Eliza Del Fiol Manna, Emanuela Balladore, Maria Cannone, Paolo Veronesi, Nicola Fusco, Bernar Tags: Original Research Source Type: research
Composite event-free-survival as an endpoint in oncology drug evaluation: Review and guidance perspectives from the Haute Autorit é de Santé (HAS)
Clinical study reports should be improved in terms of reporting censoring, while stakeholders should be aware of this potential source of bias. At a minimum, sensitivity analysis that ignores intercurrent events should be requested. (Source: European Journal of Cancer)
Source: European Journal of Cancer - April 11, 2024 Category: Cancer & Oncology Authors: Etienne Lenglin é, Joachim Baba, Paul de Boissieu, Alexandre Beaufils, Alice Desbiolles, Thierno Diatta, Pierre Cochat, Sylvie Chevret Tags: Original Research Source Type: research
Unresectable biliary tract cancer: current and future systemic therapy
For decades, treatment of advanced biliary tract cancer (BTC) was confined to the use of chemotherapy. In recent years however, the number of therapeutic options available for patients with unresectable BTC have drastically increased, with immunotherapy and targeted treatment gradually joining the ranks of guideline-recommended treatment regimens.The aim of the present review is to summarise the current knowledge on unresectable BTC focusing on epidemiology, anatomical distribution and current strategies for systemic treatment. (Source: European Journal of Cancer)
Source: European Journal of Cancer - April 11, 2024 Category: Cancer & Oncology Authors: Danmei Zhang, Klara Dorman, C. Benedikt Westphalen, Michael Haas, Steffen Ormanns, Jens Neumann, Max Seidensticker, Jens Ricke, Enrico N. De Toni, Frederick Klauschen, Hana Alg ül, Timo Reisländer, Stefan Boeck, Volker Heinemann Tags: Review Source Type: research
