The relationship between muscle strength and epicardial fat in healthy adults
CONCLUSIONS: The relationship between epicardial fat and muscle strength is inverse and independent. Implementation of HGS measurement may be useful for the identification of subjects with excessive epicardial fat and cardiovascular risk. Measurement of epicardial fat could be helpful in the early detection of physical decline associated to ageing.PMID:38692441 | DOI:10.1016/j.exger.2024.112447 (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 1, 2024 Category: Geriatrics Authors: Klara Komici Leonardo Bencivenga Caterina Arganese Giuseppe Rengo Germano Guerra Source Type: research
TROP2 promotes PINK1-mediated mitophagy and apoptosis to accelerate the progression of senile chronic obstructive pulmonary disease by up-regulating DRP1 expression
In conclusion, TROP2 can be used as a new reference for COPD treatment.PMID:38685507 | DOI:10.1016/j.exger.2024.112441 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 30, 2024 Category: Geriatrics Authors: Yipu Zhao Zhengjie Wu Source Type: research
TROP2 promotes PINK1-mediated mitophagy and apoptosis to accelerate the progression of senile chronic obstructive pulmonary disease by up-regulating DRP1 expression
In conclusion, TROP2 can be used as a new reference for COPD treatment.PMID:38685507 | DOI:10.1016/j.exger.2024.112441 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 30, 2024 Category: Geriatrics Authors: Yipu Zhao Zhengjie Wu Source Type: research
Association between cognitive impairment and cardiovascular mortality in mature and older adults: A meta-analysis
CONCLUSIONS: Cognitive impairment is a significant predictor of cardiovascular mortality in mature and older adults from the general population. However, future studies are needed to evaluate the specific impact of cognitive impairment on different genders.PMID:38679351 | DOI:10.1016/j.exger.2024.112440 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 28, 2024 Category: Geriatrics Authors: Ze Fang Qiongfang Zhang Source Type: research
Oral frailty is associated with mortality independently of physical and psychological frailty among older adults
CONCLUSION: Oral frailty is associated with mortality independent of physical and psychological frailty in older adults. The Oral Frailty Index-8 may be useful for identifying individuals at high risk of mortality.PMID:38679352 | DOI:10.1016/j.exger.2024.112446 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 28, 2024 Category: Geriatrics Authors: Daiki Watanabe Tsukasa Yoshida Yuya Watanabe Keiichi Yokoyama Yosuke Yamada Takeshi Kikutani Mitsuyoshi Yoshida Motohiko Miyachi Misaka Kimura Source Type: research
Association between increased and decreased gut microbiota abundance and Parkinson's disease: A systematic review and subgroup meta-analysis
CONCLUSION: Patients in the PD cohort exhibited distinctive microbiota compositions compared to healthy individuals, with unique differential patterns in gut microbiome abundance at the phylum, family, and genus levels that may be associated wtih PD pathogenesis.PMID:38679353 | DOI:10.1016/j.exger.2024.112444 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 28, 2024 Category: Geriatrics Authors: Fusheng Bai Lin You Hongyan Lei Xinming Li Source Type: research
Association between cognitive impairment and cardiovascular mortality in mature and older adults: A meta-analysis
CONCLUSIONS: Cognitive impairment is a significant predictor of cardiovascular mortality in mature and older adults from the general population. However, future studies are needed to evaluate the specific impact of cognitive impairment on different genders.PMID:38679351 | DOI:10.1016/j.exger.2024.112440 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 28, 2024 Category: Geriatrics Authors: Ze Fang Qiongfang Zhang Source Type: research
Oral frailty is associated with mortality independently of physical and psychological frailty among older adults
CONCLUSION: Oral frailty is associated with mortality independent of physical and psychological frailty in older adults. The Oral Frailty Index-8 may be useful for identifying individuals at high risk of mortality.PMID:38679352 | DOI:10.1016/j.exger.2024.112446 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 28, 2024 Category: Geriatrics Authors: Daiki Watanabe Tsukasa Yoshida Yuya Watanabe Keiichi Yokoyama Yosuke Yamada Takeshi Kikutani Mitsuyoshi Yoshida Motohiko Miyachi Misaka Kimura Source Type: research
Association between increased and decreased gut microbiota abundance and Parkinson's disease: A systematic review and subgroup meta-analysis
CONCLUSION: Patients in the PD cohort exhibited distinctive microbiota compositions compared to healthy individuals, with unique differential patterns in gut microbiome abundance at the phylum, family, and genus levels that may be associated wtih PD pathogenesis.PMID:38679353 | DOI:10.1016/j.exger.2024.112444 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 28, 2024 Category: Geriatrics Authors: Fusheng Bai Lin You Hongyan Lei Xinming Li Source Type: research
Relationship between serum uric acid and sarcopenia in geriatric heart failure patients with preserved ejection fraction
CONCLUSIONS: In summary, the prevalence of sarcopenia is positively related to serum UA levels among the elderly diagnosed with HFpEF. Due to the cross-sectional nature of the study design, additional investigations are necessary to validate our findings and identify the optimal range for UA reduction.PMID:38670208 | DOI:10.1016/j.exger.2024.112445 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 26, 2024 Category: Geriatrics Authors: Miao Lu Yansong Li Yiting Pan Yinzhang Ding Kai Wang Di Xu Source Type: research
Relationship between serum uric acid and sarcopenia in geriatric heart failure patients with preserved ejection fraction
CONCLUSIONS: In summary, the prevalence of sarcopenia is positively related to serum UA levels among the elderly diagnosed with HFpEF. Due to the cross-sectional nature of the study design, additional investigations are necessary to validate our findings and identify the optimal range for UA reduction.PMID:38670208 | DOI:10.1016/j.exger.2024.112445 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 26, 2024 Category: Geriatrics Authors: Miao Lu Yansong Li Yiting Pan Yinzhang Ding Kai Wang Di Xu Source Type: research
Effects of moderate intensity training and lithium on spatial learning and memory in a rat model: The role of SIRT3 and PGC1- α expression levels and brain-derived neurotropic factor
In this study we investigated the potential synergistic effects of moderate interval training (MIT) and lithium on spatial learning and memory. Forty-two male Wistar males were classified into six groups including I: Control, II: 10 mg/kg/day IP lithium (Li10), III: MIT, IV: Li10 + MIT, V: 40 mg/kg/day IP lithium (Li40), and VI: Li40 + MIT. Then, the rats underwent Morris Water Maze (MWM) test to assess their spatial memory and learning ability. Brain-derived neurotrophic factor (BDNF) density was measured by enzyme-linked immunosorbent assay (ELISA), and the expression of PGC1 and SIRT3 were assessed via qRT-PCR. The resu...
Source: Experimental Gerontology - April 25, 2024 Category: Geriatrics Authors: Elham Shoghi Tahereh Safari Abolfazl Parsi-Moud Ilia Mirzaei Nahid Sepehri Rad Mohadeseh Chahkandi Source Type: research
Effects of moderate intensity training and lithium on spatial learning and memory in a rat model: The role of SIRT3 and PGC1- α expression levels and brain-derived neurotropic factor
In this study we investigated the potential synergistic effects of moderate interval training (MIT) and lithium on spatial learning and memory. Forty-two male Wistar males were classified into six groups including I: Control, II: 10 mg/kg/day IP lithium (Li10), III: MIT, IV: Li10 + MIT, V: 40 mg/kg/day IP lithium (Li40), and VI: Li40 + MIT. Then, the rats underwent Morris Water Maze (MWM) test to assess their spatial memory and learning ability. Brain-derived neurotrophic factor (BDNF) density was measured by enzyme-linked immunosorbent assay (ELISA), and the expression of PGC1 and SIRT3 were assessed via qRT-PCR. The resu...
Source: Experimental Gerontology - April 25, 2024 Category: Geriatrics Authors: Elham Shoghi Tahereh Safari Abolfazl Parsi-Moud Ilia Mirzaei Nahid Sepehri Rad Mohadeseh Chahkandi Source Type: research
Influence of age and sex on physical, cardiac electrical and functional alterations in progressive hyperoxia treatment: A time course study in a murine model
In this study, both young and aged mice (male and female) underwent 72 h of hyperoxia exposure and were monitored at 24-hour intervals for cardiac electrophysiological and functional parameters using ECG and electrocardiogram data. Our analysis showed that young male mice experienced significant weight loss as well as significant lung edema by 48 h. Although young male mice were highly susceptible to physical changes, they were resistant to early cardiac functional and electrophysiological changes compared to the other groups. Both young and aged female and aged males developed functional impairments by 24 h of hyperoxia e...
Source: Experimental Gerontology - April 18, 2024 Category: Geriatrics Authors: Yashwant Ayalasomayajula Anagha Hesaraghatta Neha Dantuluri Jenna Yassine Faizan Saleem Hussein Mansour Chayapatou Chayawatto Nishank Rangarajan Sashank Rangarajan Smrithi Krishnan Siva Kumar Panguluri Source Type: research
LncRNA NEAT1 promotes MPP+ induced injury of PC12 cells and accelerates the progression of Parkinson's disease in mice through FUS mediated inhibition of PI3K/AKT/mTOR signalling pathway
In conclusion, NEAT1 is involved in PD progression through FUS-mediated inhibition of the PI3K/AKT/mTOR signalling pathway.PMID:38636570 | DOI:10.1016/j.exger.2024.112436 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 18, 2024 Category: Geriatrics Authors: Yonghui Wang Zhuo Li Jiwen Li Chao Sun Source Type: research
