Inhibiting the IRAK4/NF- κB/NLRP3 signaling pathway can reduce pyroptosis in hippocampal neurons and seizure episodes in epilepsy
CONCLUSION: IRAK4 plays a key role in the pathological process of epilepsy, and its potential mechanism may be related to pyroptosis mediated by the NF-κB/NLRP3 signaling pathway. PF-06650833 has potential as a therapeutic agent for alleviating epilepsy.PMID:38685307 | DOI:10.1016/j.expneurol.2024.114794 (Source: Experimental Neurology)
Source: Experimental Neurology - April 30, 2024 Category: Neurology Authors: Ting Zhao Xuefei Zhang Xiaoxiao Cui Songxue Su Lei Li Yanan Chen Na Wang Lei Sun Jianyuan Zhao Jiewen Zhang Xiong Han Jing Cao Source Type: research
Dorsal dentate gyrus mediated enriched environment-induced anxiolytic and antidepressant effects in cortical infarcted mice
This study aimed to explore the effectiveness of EE on emotional disorders after cerebral ischemia and its underling mechanism. In this study, sensorimotor cortical infarction was induced by photothrombosis with stable infarct location and volume, resulting in motor dysfunction, anxiety and depression-like behaviors in mice, with decreased ALFF and ReHo values and decreased c-fos expression in the infarction area and adjacent regions. Seven days' EE treatment significantly improved motor function of contralateral forelimb and exhibited anxiolytic and antidepressant effects in infarcted mice. Compared to the mice housing in...
Source: Experimental Neurology - April 30, 2024 Category: Neurology Authors: Dan Huang Yunhui Fan Jingjun Zhang Qianfeng Wang Ming Ding Ruiqing Hou Kewei Yu Xiao Xiao Yi Wu Junfa Wu Source Type: research
Peripheral nervous system lymphatic vessels: A simple delivery route to promote nerve regeneration
Exp Neurol. 2024 Apr 28:114783. doi: 10.1016/j.expneurol.2024.114783. Online ahead of print.ABSTRACTThe structural and functional features of lymphatic vessels in the peripheral nervous system (pLVs) is still unclear. Here, we clarify the existence of pLVs in rats, PROX1-EGFP transgenic mice and human, and exhibit a clear three-dimensional structure for helping understand its structural features. Moreover, two specific phenotypes of lymphatics endothelial cells (Rnd1Hi LECs and Ccl21Hi LECs) in peripheral nerves are well characterized by single-cell sequencing. Subsequently, the ability of trans-lymphatic delivery to perip...
Source: Experimental Neurology - April 30, 2024 Category: Neurology Authors: Senrui Li Jiangnan Li Xiaoqi Yang Jinsheng Huang Shuai Feng Zhenjun Xie Ningning Yang Yuanyi Wang Nan Zhou Source Type: research
Elabela ameliorates neuronal pyroptosis and mitochondrial fission via APJ/ZBP1 signaling in ischemic stroke
Exp Neurol. 2024 Apr 26:114802. doi: 10.1016/j.expneurol.2024.114802. Online ahead of print.ABSTRACTPyroptosis signifies a significant form of programmed neuronal demise subsequent to ischemic stroke. In our prior investigations, we demonstrated that the Elabela (ELA)-Apelin receptor (APJ) axis alleviated neuronal death by improving collateral circulation and mitigating ferroptosis in a murine model of middle cerebral artery occlusion (MCAO). However, the connection between ELA and neuronal pyroptosis remains further elucidation. Here, we observed an upregulation of ELA and APJ expression in both murine brain specimens and...
Source: Experimental Neurology - April 28, 2024 Category: Neurology Authors: Nan Shen Lingqi Kong Xinyue Wang Yan Zhang Rui Li Chunrong Tao Guoping Wang Pengfei Xu Wei Hu Source Type: research
Hypothermia protects the integrity of corticospinal tracts and alleviates mitochondria injury after intracerebral hemorrhage in mice
In this study, we employed a chemogenetics approach to selectively activate bilateral warm-sensitive neurons in the preoptic areas to induce a hypothermia-like state. We then assessed effects of HT treatment on the integrity of CST and motor functional recovery after ICH. Our results showed that HT treatment significantly alleviated axonal degeneration around the hematoma and the CST axons at remote midbrain region, ultimately promoted skilled motor function recovery. Anterograde and retrograde tracing revealed that HT treatment protected the integrity of the CST over an extended period. Mechanistically, HT treatment preve...
Source: Experimental Neurology - April 28, 2024 Category: Neurology Authors: Eryi Sun Siyuan Lu Chuanyan Yang Zheng Li Yu Qian Yue Chen Siyuan Chen Xiaodong Ma Yan Deng Xiuhong Shan Bo Chen Source Type: research
Elabela ameliorates neuronal pyroptosis and mitochondrial fission via APJ/ZBP1 signaling in ischemic stroke
Exp Neurol. 2024 Apr 26:114802. doi: 10.1016/j.expneurol.2024.114802. Online ahead of print.ABSTRACTPyroptosis signifies a significant form of programmed neuronal demise subsequent to ischemic stroke. In our prior investigations, we demonstrated that the Elabela (ELA)-Apelin receptor (APJ) axis alleviated neuronal death by improving collateral circulation and mitigating ferroptosis in a murine model of middle cerebral artery occlusion (MCAO). However, the connection between ELA and neuronal pyroptosis remains further elucidation. Here, we observed an upregulation of ELA and APJ expression in both murine brain specimens and...
Source: Experimental Neurology - April 28, 2024 Category: Neurology Authors: Nan Shen Lingqi Kong Xinyue Wang Yan Zhang Rui Li Chunrong Tao Guoping Wang Pengfei Xu Wei Hu Source Type: research
Hypothermia protects the integrity of corticospinal tracts and alleviates mitochondria injury after intracerebral hemorrhage in mice
In this study, we employed a chemogenetics approach to selectively activate bilateral warm-sensitive neurons in the preoptic areas to induce a hypothermia-like state. We then assessed effects of HT treatment on the integrity of CST and motor functional recovery after ICH. Our results showed that HT treatment significantly alleviated axonal degeneration around the hematoma and the CST axons at remote midbrain region, ultimately promoted skilled motor function recovery. Anterograde and retrograde tracing revealed that HT treatment protected the integrity of the CST over an extended period. Mechanistically, HT treatment preve...
Source: Experimental Neurology - April 28, 2024 Category: Neurology Authors: Eryi Sun Siyuan Lu Chuanyan Yang Zheng Li Yu Qian Yue Chen Siyuan Chen Xiaodong Ma Yan Deng Xiuhong Shan Bo Chen Source Type: research
Dim light at night shifts microglia to a pro-inflammatory state after cerebral ischemia, altering stroke outcome in mice
This study provides supporting evidence that environmental lighting exacerbates ischemic injury and post-stroke mortality by a biological mechanism, that exposure to dLAN causes a fundamental shift of activated microglial phenotypes from beneficial to detrimental at an early time point after stroke, resulting in irreversible neuronal death.PMID:38677449 | DOI:10.1016/j.expneurol.2024.114796 (Source: Experimental Neurology)
Source: Experimental Neurology - April 27, 2024 Category: Neurology Authors: Jennifer A Liu William H Walker O Hecmarie Mel éndez-Fernández Jacob R Bumgarner Ning Zhang James C Walton Gordon P Meares A Courtney DeVries Randy J Nelson Source Type: research
Dim light at night shifts microglia to a pro-inflammatory state after cerebral ischemia, altering stroke outcome in mice
This study provides supporting evidence that environmental lighting exacerbates ischemic injury and post-stroke mortality by a biological mechanism, that exposure to dLAN causes a fundamental shift of activated microglial phenotypes from beneficial to detrimental at an early time point after stroke, resulting in irreversible neuronal death.PMID:38677449 | DOI:10.1016/j.expneurol.2024.114796 (Source: Experimental Neurology)
Source: Experimental Neurology - April 27, 2024 Category: Neurology Authors: Jennifer A Liu William H Walker O Hecmarie Mel éndez-Fernández Jacob R Bumgarner Ning Zhang James C Walton Gordon P Meares A Courtney DeVries Randy J Nelson Source Type: research
Galectin-3 absence alters lymphocytes populations dynamics behavior and promotes functional recovery after spinal cord injury in mice
In conclusion, GALNEG mice exhibited better functional recovery attributed to the milder pro-inflammatory influence, compensated by a higher quantity of T Reg and Th2 cells. These findings suggest that galectin-3 plays a crucial role in the immune response after spinal cord injury and could be a potential target for clinical therapeutic interventions.PMID:38670250 | DOI:10.1016/j.expneurol.2024.114785 (Source: Experimental Neurology)
Source: Experimental Neurology - April 26, 2024 Category: Neurology Authors: Caio Andrade Prins Felipe Leite de Oliveira Valeria de Mello Coelho Emanuela Bezerra Dos Santos Ribeiro Juliana Silva de Almeida Natalia Moraes Bechelli Silva Fernanda Martins Almeida Ana Maria Blanco Martinez Source Type: research
Adenylate kinase 4 promotes neuronal energy metabolism and mitophagy in early cerebral ischemia via Parkin/PKM2 pathway
In conclusion, our data demonstrate that AK4/ Parkin /PKM axis prevents cerebral ischemia damage via regulation of neuronal energy metabolism model and mitophagy. AK4 was a new target for intervention of early ischemic neuron injury.PMID:38670251 | DOI:10.1016/j.expneurol.2024.114798 (Source: Experimental Neurology)
Source: Experimental Neurology - April 26, 2024 Category: Neurology Authors: Yunxue Zhong Bingbing Jia Cong Xie Hu Linghui Zijun Liao Wenlan Liu Yuan Zhang Guodong Huang Source Type: research
STZ-induced diabetes exacerbates neurons ferroptosis after ischemic stroke by upregulating LCN2 in neutrophils
This study aimed to investigate the effect of streptozotocin (STZ)-induced diabetes on ferroptosis after stroke from the immune cell perspective, and to provide a theoretical foundation for the clinical management of ischemic stroke in patients with diabetes. The results revealed that STZ-induced diabetes not only facilitates the infiltration of neutrophils into the brain after stroke, but also upregulates the expression of lipocalin 2 (LCN2) in neutrophils. LCN2 promotes lipid peroxide accumulation by increasing intracellular ferrous ions, which intensify ferroptosis in major brain cell populations, especially neurons. Ou...
Source: Experimental Neurology - April 26, 2024 Category: Neurology Authors: Huan Wang Zhao Wang Yuxiao Gao Jingjing Wang Yujia Yuan Cong Zhang Xiangjian Zhang Source Type: research
An antioxidant and anti-ER stress combination therapy elevates phosphorylation of α-Syn at serine 129 and alleviates post-TBI PD-like pathology in a sex-specific manner in mice
We presently evaluated if curtailing oxidative stress and ER stress concomitantly using a combination of apocynin and tert-butylhydroquinone and salubrinal during the acute stage after TBI in mice reduces the severity of late-onset PD-like pathology. The effect of multiple low doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on post-TBI neurodegeneration was also evaluated. The combo therapy elevated the level of phosphorylation at serine 129 (pS129) of α-Syn in the pericontusional cortex of male mice at 72 h post-TBI. Motor and cognitive deficits induced by TBI lasted at least 3 months and the combo therapy c...
Source: Experimental Neurology - April 24, 2024 Category: Neurology Authors: Charles K Davis Saivenkateshkomal Bathula Soomin Jeong Vijay Arruri Jeongwoo Choi Shruti Subramanian Carlie M Ostrom Raghu Vemuganti Source Type: research
An antioxidant and anti-ER stress combination therapy elevates phosphorylation of α-Syn at serine 129 and alleviates post-TBI PD-like pathology in a sex-specific manner in mice
We presently evaluated if curtailing oxidative stress and ER stress concomitantly using a combination of apocynin and tert-butylhydroquinone and salubrinal during the acute stage after TBI in mice reduces the severity of late-onset PD-like pathology. The effect of multiple low doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on post-TBI neurodegeneration was also evaluated. The combo therapy elevated the level of phosphorylation at serine 129 (pS129) of α-Syn in the pericontusional cortex of male mice at 72 h post-TBI. Motor and cognitive deficits induced by TBI lasted at least 3 months and the combo therapy c...
Source: Experimental Neurology - April 24, 2024 Category: Neurology Authors: Charles K Davis Saivenkateshkomal Bathula Soomin Jeong Vijay Arruri Jeongwoo Choi Shruti Subramanian Carlie M Ostrom Raghu Vemuganti Source Type: research
An antioxidant and anti-ER stress combination therapy elevates phosphorylation of α-Syn at serine 129 and alleviates post-TBI PD-like pathology in a sex-specific manner in mice
We presently evaluated if curtailing oxidative stress and ER stress concomitantly using a combination of apocynin and tert-butylhydroquinone and salubrinal during the acute stage after TBI in mice reduces the severity of late-onset PD-like pathology. The effect of multiple low doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on post-TBI neurodegeneration was also evaluated. The combo therapy elevated the level of phosphorylation at serine 129 (pS129) of α-Syn in the pericontusional cortex of male mice at 72 h post-TBI. Motor and cognitive deficits induced by TBI lasted at least 3 months and the combo therapy c...
Source: Experimental Neurology - April 24, 2024 Category: Neurology Authors: Charles K Davis Saivenkateshkomal Bathula Soomin Jeong Vijay Arruri Jeongwoo Choi Shruti Subramanian Carlie M Ostrom Raghu Vemuganti Source Type: research
