Novel polymorphisms in the octopamine receptor gene of amitraz resistant population of Rhipicephalus sanguineus sensu lato, in south India
Exp Parasitol. 2024 May 2:108763. doi: 10.1016/j.exppara.2024.108763. Online ahead of print.ABSTRACTThe brown dog tick or Rhipicephalus sanguineus sensu lato is an ixodid tick, responsible for the dissemination of pathogens that cause canine infectious diseases besides inflicting the direct effects of tick bite. The hot humid climate of Kerala, a south Indian state, is favorable for propagation of tick vectors and acaricides are the main stay of tick control. Though the resistance against synthetic pyrethroids is reported among these species, the status of amitraz resistance in R. sanguineus s. l. in the country is uncerta...
Source: Experimental Parasitology - May 4, 2024 Category: Parasitology Authors: Nikhat Reena Shaik Bindu Lakshmanan N Suresh Nair Amrutha Anand R Radhika K Syamala Source Type: research
Anthelmintic efficacy of an organic fraction from Guazuma ulmifolia leaves and evaluation of reactive oxidative stress on Haemonchus contortus
This study describes the anthelmintic efficacy of an organic fraction (EtOAc- F) from Guazuma ulmifolia leaves and evaluation of its reactive oxidative stress on Haemonchus contortus. The first step was to assess the anthelmintic effect of EtOAc-F at 0.0, 3.5, 7.0 and 14 mg kg of body weight (BW) in gerbil's (Meriones unguiculatus) artificially infected with H. contortus infective larvae (L3). The second step was to evaluate the preliminary toxicity after oral administration of the EtOAc-F in gerbils. Finally, the third step was to determine the relative expression of biomarkers as glutathione (GPx), catalase (CAT), and su...
Source: Experimental Parasitology - April 28, 2024 Category: Parasitology Authors: Guillermo Res éndiz-González Agust ín Olmedo-Juárez Roberto Gonz ález-Garduño Jorge Alberto Cortes Morales Manas és González Cortazar Ana Elvia S ánchez-Mendoza Mar ía Eugenia López-Arellano Cris óforo Mercado-Márquez Alejandro Lara-Bueno Ros Source Type: research
Design, in silico study, synthesis and evaluation of hybrid pyrazole substituted 1,3,5-triazine derivatives for antimalarial activity
CONCLUSION: Among the ten derivatives, compound 7J has considerable potential as an antimalarial agent, making it a viable contender for further refinement in the realm of pharmaceutical exploration, with the aim of mitigating the global malaria load.PMID:38679125 | DOI:10.1016/j.exppara.2024.108767 (Source: Experimental Parasitology)
Source: Experimental Parasitology - April 28, 2024 Category: Parasitology Authors: Pritom Borgohain Anshul Shakya Surajit Kumar Ghosh Neelutpal Gogoi Saurav Jyoti Patgiri Ipsita Pal Bhowmick Dibya Ranjan Bhattacharyya Udaya Pratap Singh Hans Raj Bhat Source Type: research
Comparison of extracellular vesicle isolation methods for the study of exosome cargo within Toxocara canis and Toxocara cati excretory secretory (TES) products
Exp Parasitol. 2024 Apr 27;261:108765. doi: 10.1016/j.exppara.2024.108765. Online ahead of print.ABSTRACTToxocara is a genus of nematodes, which infects a variety of hosts, principally dogs and cats, with potential zoonotic risks to humans. Toxocara spp. larvae are capable of migrating throughout the host tissues, eliciting eosinophilic and granulomatous reactions, while surviving for extended periods of time, unchanged, in the host. It is postulated that larvae are capable of altering the host's immune response through the release of excretory-secretory products, containing both proteins and extracellular vesicles (EVs). ...
Source: Experimental Parasitology - April 28, 2024 Category: Parasitology Authors: Timothy K Wu Janice L Liotta Dwight D Bowman Source Type: research
Anthelmintic efficacy of an organic fraction from Guazuma ulmifolia leaves and evaluation of reactive oxidative stress on Haemonchus contortus
This study describes the anthelmintic efficacy of an organic fraction (EtOAc- F) from Guazuma ulmifolia leaves and evaluation of its reactive oxidative stress on Haemonchus contortus. The first step was to assess the anthelmintic effect of EtOAc-F at 0.0, 3.5, 7.0 and 14 mg kg of body weight (BW) in gerbil's (Meriones unguiculatus) artificially infected with H. contortus infective larvae (L3). The second step was to evaluate the preliminary toxicity after oral administration of the EtOAc-F in gerbils. Finally, the third step was to determine the relative expression of biomarkers as glutathione (GPx), catalase (CAT), and su...
Source: Experimental Parasitology - April 28, 2024 Category: Parasitology Authors: Guillermo Res éndiz-González Agust ín Olmedo-Juárez Roberto Gonz ález-Garduño Jorge Alberto Cortes Morales Manas és González Cortazar Ana Elvia S ánchez-Mendoza Mar ía Eugenia López-Arellano Cris óforo Mercado-Márquez Alejandro Lara-Bueno Ros Source Type: research
Design, in silico study, synthesis and evaluation of hybrid pyrazole substituted 1,3,5-triazine derivatives for antimalarial activity
CONCLUSION: Among the ten derivatives, compound 7J has considerable potential as an antimalarial agent, making it a viable contender for further refinement in the realm of pharmaceutical exploration, with the aim of mitigating the global malaria load.PMID:38679125 | DOI:10.1016/j.exppara.2024.108767 (Source: Experimental Parasitology)
Source: Experimental Parasitology - April 28, 2024 Category: Parasitology Authors: Pritom Borgohain Anshul Shakya Surajit Kumar Ghosh Neelutpal Gogoi Saurav Jyoti Patgiri Ipsita Pal Bhowmick Dibya Ranjan Bhattacharyya Udaya Pratap Singh Hans Raj Bhat Source Type: research
Comparison of extracellular vesicle isolation methods for the study of exosome cargo within Toxocara canis and Toxocara cati excretory secretory (TES) products
Exp Parasitol. 2024 Apr 27;261:108765. doi: 10.1016/j.exppara.2024.108765. Online ahead of print.ABSTRACTToxocara is a genus of nematodes, which infects a variety of hosts, principally dogs and cats, with potential zoonotic risks to humans. Toxocara spp. larvae are capable of migrating throughout the host tissues, eliciting eosinophilic and granulomatous reactions, while surviving for extended periods of time, unchanged, in the host. It is postulated that larvae are capable of altering the host's immune response through the release of excretory-secretory products, containing both proteins and extracellular vesicles (EVs). ...
Source: Experimental Parasitology - April 28, 2024 Category: Parasitology Authors: Timothy K Wu Janice L Liotta Dwight D Bowman Source Type: research
Anthelmintic efficacy of an organic fraction from Guazuma ulmifolia leaves and evaluation of reactive oxidative stress on Haemonchus contortus
This study describes the anthelmintic efficacy of an organic fraction (EtOAc- F) from Guazuma ulmifolia leaves and evaluation of its reactive oxidative stress on Haemonchus contortus. The first step was to assess the anthelmintic effect of EtOAc-F at 0.0, 3.5, 7.0 and 14 mg kg of body weight (BW) in gerbil's (Meriones unguiculatus) artificially infected with H. contortus infective larvae (L3). The second step was to evaluate the preliminary toxicity after oral administration of the EtOAc-F in gerbils. Finally, the third step was to determine the relative expression of biomarkers as glutathione (GPx), catalase (CAT), and su...
Source: Experimental Parasitology - April 28, 2024 Category: Parasitology Authors: Guillermo Res éndiz-González Agust ín Olmedo-Juárez Roberto Gonz ález-Garduño Jorge Alberto Cortes Morales Manas és González Cortazar Ana Elvia S ánchez-Mendoza Mar ía Eugenia López-Arellano Cris óforo Mercado-Márquez Alejandro Lara-Bueno Ros Source Type: research
Design, in silico study, synthesis and evaluation of hybrid pyrazole substituted 1,3,5-triazine derivatives for antimalarial activity
CONCLUSION: Among the ten derivatives, compound 7J has considerable potential as an antimalarial agent, making it a viable contender for further refinement in the realm of pharmaceutical exploration, with the aim of mitigating the global malaria load.PMID:38679125 | DOI:10.1016/j.exppara.2024.108767 (Source: Experimental Parasitology)
Source: Experimental Parasitology - April 28, 2024 Category: Parasitology Authors: Pritom Borgohain Anshul Shakya Surajit Kumar Ghosh Neelutpal Gogoi Saurav Jyoti Patgiri Ipsita Pal Bhowmick Dibya Ranjan Bhattacharyya Udaya Pratap Singh Hans Raj Bhat Source Type: research
Comparison of extracellular vesicle isolation methods for the study of exosome cargo within Toxocara canis and Toxocara cati excretory secretory (TES) products
Exp Parasitol. 2024 Apr 27;261:108765. doi: 10.1016/j.exppara.2024.108765. Online ahead of print.ABSTRACTToxocara is a genus of nematodes, which infects a variety of hosts, principally dogs and cats, with potential zoonotic risks to humans. Toxocara spp. larvae are capable of migrating throughout the host tissues, eliciting eosinophilic and granulomatous reactions, while surviving for extended periods of time, unchanged, in the host. It is postulated that larvae are capable of altering the host's immune response through the release of excretory-secretory products, containing both proteins and extracellular vesicles (EVs). ...
Source: Experimental Parasitology - April 28, 2024 Category: Parasitology Authors: Timothy K Wu Janice L Liotta Dwight D Bowman Source Type: research
Anthelmintic efficacy of an organic fraction from Guazuma ulmifolia leaves and evaluation of reactive oxidative stress on Haemonchus contortus
This study describes the anthelmintic efficacy of an organic fraction (EtOAc- F) from Guazuma ulmifolia leaves and evaluation of its reactive oxidative stress on Haemonchus contortus. The first step was to assess the anthelmintic effect of EtOAc-F at 0.0, 3.5, 7.0 and 14 mg kg of body weight (BW) in gerbil's (Meriones unguiculatus) artificially infected with H. contortus infective larvae (L3). The second step was to evaluate the preliminary toxicity after oral administration of the EtOAc-F in gerbils. Finally, the third step was to determine the relative expression of biomarkers as glutathione (GPx), catalase (CAT), and su...
Source: Experimental Parasitology - April 28, 2024 Category: Parasitology Authors: Guillermo Res éndiz-González Agust ín Olmedo-Juárez Roberto Gonz ález-Garduño Jorge Alberto Cortes Morales Manas és González Cortazar Ana Elvia S ánchez-Mendoza Mar ía Eugenia López-Arellano Cris óforo Mercado-Márquez Alejandro Lara-Bueno Ros Source Type: research
Design, In silico study, Synthesis and Evaluation of Hybrid Pyrazole Substituted 1,3,5-Triazine Derivatives for Antimalarial Activity
CONCLUSION: Among the ten derivatives, compound 7J has considerable potential as an antimalarial agent, making it a viable contender for further refinement in the realm of pharmaceutical exploration, with the aim of mitigating the global malaria load.PMID:38679125 | DOI:10.1016/j.exppara.2024.108767 (Source: Experimental Parasitology)
Source: Experimental Parasitology - April 28, 2024 Category: Parasitology Authors: Pritom Borgohain Anshul Shakya Surajit Kumar Ghosh Neelutpal Gogoi Saurav Jyoti Patgiri Ipsita Pal Bhowmick Dibya Ranjan Bhattacharyya Udaya Pratap Singh Hans Raj Bhat Source Type: research
Comparison of Extracellular Vesicle Isolation Methods for the Study of Exosome Cargo within Toxocara canis and Toxocara cati Excretory Secretory (TES) Products
Exp Parasitol. 2024 Apr 26:108765. doi: 10.1016/j.exppara.2024.108765. Online ahead of print.ABSTRACTToxocara is a genus of nematodes, which infects a variety of hosts, principally dogs and cats, with potential zoonotic risks to humans. Toxocara spp. larvae are capable of migrating throughout the host tissues, eliciting eosinophilic and granulomatous reactions, while surviving for extended periods of time, unchanged, in the host. It is postulated that larvae are capable of altering the host's immune response through the release of excretory-secretory products, containing both proteins and extracellular vesicles (EVs). The ...
Source: Experimental Parasitology - April 28, 2024 Category: Parasitology Authors: Timothy K Wu Janice L Liotta Dwight D Bowman Source Type: research
Anthelmintic efficacy of an organic fraction from Guazuma ulmifolia leaves and evaluation of reactive oxidative stress on Haemonchus contortus
This study describes the anthelmintic efficacy of an organic fraction (EtOAc- F) from Guazuma ulmifolia leaves and evaluation of its reactive oxidative stress on Haemonchus contortus. The first step was to assess the anthelmintic effect of EtOAc-F at 0.0, 3.5, 7.0 and 14 mg kg of body weight (BW) in gerbil's (Meriones unguiculatus) artificially infected with H. contortus infective larvae (L3). The second step was to evaluate the preliminary toxicity after oral administration of the EtOAc-F in gerbils. Finally, the third step was to determine the relative expression of biomarkers as glutathione (GPx), catalase (CAT), and su...
Source: Experimental Parasitology - April 28, 2024 Category: Parasitology Authors: Guillermo Res éndiz-González Agust ín Olmedo-Juárez Roberto Gonz ález-Garduño Jorge Alberto Cortes Morales Manas és González Cortazar Ana Elvia S ánchez-Mendoza Mar ía Eugenia López-Arellano Cris óforo Mercado-Márquez Alejandro Lara-Bueno Ros Source Type: research
Design, In silico study, Synthesis and Evaluation of Hybrid Pyrazole Substituted 1,3,5-Triazine Derivatives for Antimalarial Activity
CONCLUSION: Among the ten derivatives, compound 7J has considerable potential as an antimalarial agent, making it a viable contender for further refinement in the realm of pharmaceutical exploration, with the aim of mitigating the global malaria load.PMID:38679125 | DOI:10.1016/j.exppara.2024.108767 (Source: Experimental Parasitology)
Source: Experimental Parasitology - April 28, 2024 Category: Parasitology Authors: Pritom Borgohain Anshul Shakya Surajit Kumar Ghosh Neelutpal Gogoi Saurav Jyoti Patgiri Ipsita Pal Bhowmick Dibya Ranjan Bhattacharyya Udaya Pratap Singh Hans Raj Bhat Source Type: research
