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Neutrophils in pancreatic ductal adenocarcinoma: bridging preclinical insights to clinical prospects for improved therapeutic strategies
Expert Rev Clin Immunol. 2024 May 1. doi: 10.1080/1744666X.2024.2348605. Online ahead of print.ABSTRACTINTRODUCTION: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by a dismal five-year survival rate of less than 10%. Neutrophils are key components of the innate immune system, playing a pivotal role in the PDAC immune microenvironment.AREAS COVERED: This review provides a comprehensive survey of the pivotal involvement of neutrophils in the tumorigenesis and progression of PDAC. Furthermore, it synthesizes preclinical and clinical explorations aimed at targeting neutrophils within t...
Source: Expert Review of Clinical Immunology - May 1, 2024 Category: Allergy & Immunology Authors: Yi Jin Eric S Christenson Lei Zheng Keyu Li Source Type: research

How could our genetics impact COVID-19 vaccine response?
Expert Rev Clin Immunol. 2024 Apr 27:1-13. doi: 10.1080/1744666X.2024.2346584. Online ahead of print.ABSTRACTINTRODUCTION: The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has posed unprecedented global health challenges since its emergence in December 2019. The rapid availability of vaccines has been estimated to save millions of lives, but there is variation in how individuals respond to vaccines, influencing their effectiveness at an individual, and population level.AREAS COVERED: This review focuses on human genetic factors influencing the immune response and effectiveness of vaccines, highlighting the importance...
Source: Expert Review of Clinical Immunology - April 27, 2024 Category: Allergy & Immunology Authors: Keyi Zheng Amanda Y Chong Alexander J Mentzer Source Type: research

Exploring the relationship between house dust mites and asthma
Expert Rev Clin Immunol. 2024 Apr 23:1-4. doi: 10.1080/1744666X.2024.2346585. Online ahead of print.NO ABSTRACTPMID:38652085 | DOI:10.1080/1744666X.2024.2346585 (Source: Expert Review of Clinical Immunology)
Source: Expert Review of Clinical Immunology - April 23, 2024 Category: Allergy & Immunology Authors: Luis Caraballo Source Type: research

New Discoveries in the genetics and genomics of systemic juvenile idiopathic arthritis
Expert Rev Clin Immunol. 2024 Apr 20. doi: 10.1080/1744666X.2024.2345868. Online ahead of print.ABSTRACTINTRODUCTION: Systemic juvenile idiopathic arthritis (sJIA) is a severe inflammatory condition with onset in childhood. It is sporadic, but elements of its stereotypical innate immune responses are likely genetically encoded by both common variants with small effect sizes and rare variants with larger effects.AREAS COVERED: Genomic investigations have defined the unique genetic architecture of sJIA. Identification of the class II HLA locus as the strongest sJIA risk factor for the first time brought attention to T lympho...
Source: Expert Review of Clinical Immunology - April 20, 2024 Category: Allergy & Immunology Authors: Mariana Correia Marques Michael J Ombrello Grant S Schulert Source Type: research

The role of immune reconstitution in relapse after allogeneic hematopoietic stem cell transplantation
Expert Rev Clin Immunol. 2024 May;20(5):513-524. doi: 10.1080/1744666X.2023.2299728. Epub 2024 Jan 10.ABSTRACTINTRODUCTION: Leukemia relapse following stem cell transplantation remains a significant barrier to long-term remission. Timely and balanced immune recovery after transplantation is crucial for preventing leukemia relapse.AREAS COVERED: After an extensive literature search of PubMed and Web of Science through October 2023, we provide an overview of the dynamics of immune reconstitution and its role in controlling leukemia relapse. We also discuss strategies to promote immune reconstitution and reduce disease recurr...
Source: Expert Review of Clinical Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Xu-Ying Pei Xiao-Jun Huang Source Type: research