KoCVAM-led Development of Phototoxicity Alternative Test Method using Reconstructed Human Epidermis model (KeraSkin ™)
Food Chem Toxicol. 2024 Apr 26:114698. doi: 10.1016/j.fct.2024.114698. Online ahead of print.ABSTRACTPhototoxicity is an acute toxic reaction induced by topical skin exposure to photoreactive chemicals followed by exposure to environmental light and thus chemicals that absorb UV are recommended to be evaluated for phototoxic potential. There are currently three internationally harmonized alternative test methods for phototoxicity. One of them is the in vitro Phototoxicity: RhE Phototoxicity test method (OECD TG498). Korean center for the Validation of Alternative Methods (KoCVAM) developed an in vitro phototoxicity test me...
Source: Food and Chemical Toxicology - April 28, 2024 Category: Food Science Authors: Nam-Hee Kang So-Hee Kim Joohwan Kim Source Type: research
KoCVAM-led Development of Phototoxicity Alternative Test Method using Reconstructed Human Epidermis model (KeraSkin ™)
Food Chem Toxicol. 2024 Apr 26:114698. doi: 10.1016/j.fct.2024.114698. Online ahead of print.ABSTRACTPhototoxicity is an acute toxic reaction induced by topical skin exposure to photoreactive chemicals followed by exposure to environmental light and thus chemicals that absorb UV are recommended to be evaluated for phototoxic potential. There are currently three internationally harmonized alternative test methods for phototoxicity. One of them is the in vitro Phototoxicity: RhE Phototoxicity test method (OECD TG498). Korean center for the Validation of Alternative Methods (KoCVAM) developed an in vitro phototoxicity test me...
Source: Food and Chemical Toxicology - April 28, 2024 Category: Food Science Authors: Nam-Hee Kang So-Hee Kim Joohwan Kim Source Type: research
Undifferentiated HepaRG cells show reduced sensitivity to the toxic effects of M8OI through a combination of CYP3A7-mediated oxidation and a reduced reliance on mitochondrial function
Food Chem Toxicol. 2024 Apr 25:114681. doi: 10.1016/j.fct.2024.114681. Online ahead of print.ABSTRACTThe methylimidazolium ionic liquid M8OI (1-octyl-3-methylimidazolium chloride, also known as [C8mim]Cl) has been detected in the environment and may represent a hazard trigger for the autoimmune liver disease primary biliary cholangitis, based in part on studies using a rat liver progenitor cell. The effect of M8OI on an equivalent human liver progenitor (undifferentiated HepaRG cells; u-HepaRG) was therefore examined. u-HepaRG cells were less sensitive (>20-fold) to the toxic effects of M8OI. The relative insensitivity ...
Source: Food and Chemical Toxicology - April 27, 2024 Category: Food Science Authors: Tarek M Abdelghany Shireen A Hedya Alex Charlton Fahad A Aljehani Khalid Alanazi Alaa A Budastour Larissa Marin Matthew C Wright Source Type: research
Lambda-cyhalothrin alters locomotion, mood and memory abilities in Swiss mice
In conclusion, LCT-treated female mice show an alteration in locomotor activity, mood state and memory abilities probably related to oxidative stress and altered neurotransmission.PMID:38677402 | DOI:10.1016/j.fct.2024.114680 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 27, 2024 Category: Food Science Authors: Assmaa Tali Nadra Lekouch Samir Ahboucha Source Type: research
Malondialdehyde levels and bioaccessibility in healthy diet bars: A gastrointestinal digestion model
This study aimed to determine the bioaccessibility level of MDA in diet bars sold as healthy snacks in the market using in vitro gastrointestinal digestive model. In our study, 28 different diet bar samples were bought from markets in Istanbul. MDA contents of the products were determined by the HPLC-FLD method. The investigation showed that diet bars had an average MDA concentration of 116.25 μg/100 g before digestion, while the average MDA concentration was 90.50 μg/100 g after in vitro digestion. In line with these data, the average MDA bioaccessibility of 28 diet bar samples was calculated as 77.3%. For this reason, ...
Source: Food and Chemical Toxicology - April 26, 2024 Category: Food Science Authors: K übra Demir Sultan Aslanhan Jale Çatak Elif Ede Çintesun Mustafa Yaman Ömer Faruk Mızrak Source Type: research
Malondialdehyde Levels and Bioaccessibility in Healthy Diet Bars: A Gastrointestinal Digestion Model
This study aimed to determine the bioaccessibility level of MDA in diet bars sold as healthy snacks in the market using in vitro gastrointestinal digestive model. In our study, 28 different diet bar samples were bought from markets in Istanbul. MDA contents of the products were determined by the HPLC-FLD method. The investigation showed that diet bars had an average MDA concentration of 116.25 μg/100 g before digestion, while the average MDA concentration was 90.50 μg/100 g after in vitro digestion. In line with these data, the average MDA bioaccessibility of 28 diet bar samples was calculated as 77.3%. For this reason, ...
Source: Food and Chemical Toxicology - April 26, 2024 Category: Food Science Authors: K übra Demir Sultan Aslanhan Jale Çatak Elif Ede Çintesun Mustafa Yaman Ömer Faruk Mızrak Source Type: research
Effects of Nanomolar Methylmercury on developing Human Neural Stem Cells and Zebrafish Embryo
This study shows that the ZF model was more susceptible than NSC to MeHg neurotoxicity. The combination of different models has improved the understanding of the underlying mechanisms of toxicity and possible compensatory mechanisms at the cellular and organismal level.PMID:38663761 | DOI:10.1016/j.fct.2024.114684 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 25, 2024 Category: Food Science Authors: M ónica Torres-Ruiz Mercedes de Alba Gonzalez Ana I Ca ñas Portilla Raquel Coronel Isabel Liste M ª Carmen González-Caballero Source Type: research
Identification of sensitive endpoints for the assessment of phthalates-induced reproductive and developmental toxicity: a literature mining study
Food Chem Toxicol. 2024 Apr 23:114686. doi: 10.1016/j.fct.2024.114686. Online ahead of print.ABSTRACTDibutyl phthalate (DBP) and di(2-ethylhexyl) phthalate (DEHP), two common types of phthalates, are known to cause reproductive and developmental toxicity in animals and humans. The reference doses (RfD) of DBP and DEHP should be determined by sensitive endpoints. We here aimed to identify sensitive endpoints for DBP- and DEHP-induced such toxicity using published literatures. By examining the impacts of maternal exposure to DBP or DEHP on anogenital distance (AGD) and semen quality of offspring, we discovered that DBP or DE...
Source: Food and Chemical Toxicology - April 25, 2024 Category: Food Science Authors: Kai Li Yiping Zhang Ludi Li Kanglong Cui Yingzi Li Chunying Li Yufei Dai Wusheng Xiao Qi Wang Source Type: research
Retinal toxicity of heavy metals and its involvement into retinal pathology
The objective of the present review is to discuss epidemiological evidence demonstrating the association between toxic metal (Cd, Pb, Hg, As, Sn, Ti, Tl) exposure and retinal pathology, along with the potential underlying molecular mechanisms. Epidemiological studies demonstrate that Cd, and to a lesser extent Pb exposure, are associated with age-related macular degeneration (AMD), while the existing evidence on the levels of these metals in patients with diabetic retinopathy is scarce. Epidemiological data on the association between other toxic metals and metalloids including mercury (Hg) and arsenic (As), are limited. Cl...
Source: Food and Chemical Toxicology - April 25, 2024 Category: Food Science Authors: Michael Aschner Anatoly V Skalny Monica M B Paoliello Margarita N Tinkova Airton C Martins Abel Santamaria Eunsook Lee Joao Bt Rocha Sandra Hp Farsky Alexey A Tinkov Source Type: research
Network toxicology and molecular docking for the toxicity analysis of food contaminants: A case of Aflatoxin B < sub > 1 < /sub >
Food Chem Toxicol. 2024 Apr 23:114687. doi: 10.1016/j.fct.2024.114687. Online ahead of print.ABSTRACTThe present study aims to promote network toxicology and molecular docking strategies for the efficient evaluation of the toxicity of food contaminants. With the example of liver injury induced by the food contaminant Aflatoxin B1(AFB1), this study effectively investigated the putative toxicity of food contaminants and the potentially molecular mechanisms. The study found that AFB1 regulates multiple signalling pathways by modulating core targets such as AKT1, BCL2, TNF, CASP3, SRC, and EGFR. These pathways encompass Pathwa...
Source: Food and Chemical Toxicology - April 25, 2024 Category: Food Science Authors: Zi-Yong Chu Xue-Jiao Zi Source Type: research
Effects of Nanomolar Methylmercury on developing Human Neural Stem Cells and Zebrafish Embryo
This study shows that the ZF model was more susceptible than NSC to MeHg neurotoxicity. The combination of different models has improved the understanding of the underlying mechanisms of toxicity and possible compensatory mechanisms at the cellular and organismal level.PMID:38663761 | DOI:10.1016/j.fct.2024.114684 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 25, 2024 Category: Food Science Authors: M ónica Torres-Ruiz Mercedes de Alba Gonzalez Ana I Ca ñas Portilla Raquel Coronel Isabel Liste M ª Carmen González-Caballero Source Type: research
Identification of sensitive endpoints for the assessment of phthalates-induced reproductive and developmental toxicity: a literature mining study
Food Chem Toxicol. 2024 Apr 23:114686. doi: 10.1016/j.fct.2024.114686. Online ahead of print.ABSTRACTDibutyl phthalate (DBP) and di(2-ethylhexyl) phthalate (DEHP), two common types of phthalates, are known to cause reproductive and developmental toxicity in animals and humans. The reference doses (RfD) of DBP and DEHP should be determined by sensitive endpoints. We here aimed to identify sensitive endpoints for DBP- and DEHP-induced such toxicity using published literatures. By examining the impacts of maternal exposure to DBP or DEHP on anogenital distance (AGD) and semen quality of offspring, we discovered that DBP or DE...
Source: Food and Chemical Toxicology - April 25, 2024 Category: Food Science Authors: Kai Li Yiping Zhang Ludi Li Kanglong Cui Yingzi Li Chunying Li Yufei Dai Wusheng Xiao Qi Wang Source Type: research
Retinal toxicity of heavy metals and its involvement into retinal pathology
The objective of the present review is to discuss epidemiological evidence demonstrating the association between toxic metal (Cd, Pb, Hg, As, Sn, Ti, Tl) exposure and retinal pathology, along with the potential underlying molecular mechanisms. Epidemiological studies demonstrate that Cd, and to a lesser extent Pb exposure, are associated with age-related macular degeneration (AMD), while the existing evidence on the levels of these metals in patients with diabetic retinopathy is scarce. Epidemiological data on the association between other toxic metals and metalloids including mercury (Hg) and arsenic (As), are limited. Cl...
Source: Food and Chemical Toxicology - April 25, 2024 Category: Food Science Authors: Michael Aschner Anatoly V Skalny Monica M B Paoliello Margarita N Tinkova Airton C Martins Abel Santamaria Eunsook Lee Joao Bt Rocha Sandra Hp Farsky Alexey A Tinkov Source Type: research
Network toxicology and molecular docking for the toxicity analysis of food contaminants: A case of Aflatoxin B < sub > 1 < /sub >
Food Chem Toxicol. 2024 Apr 23:114687. doi: 10.1016/j.fct.2024.114687. Online ahead of print.ABSTRACTThe present study aims to promote network toxicology and molecular docking strategies for the efficient evaluation of the toxicity of food contaminants. With the example of liver injury induced by the food contaminant Aflatoxin B1(AFB1), this study effectively investigated the putative toxicity of food contaminants and the potentially molecular mechanisms. The study found that AFB1 regulates multiple signalling pathways by modulating core targets such as AKT1, BCL2, TNF, CASP3, SRC, and EGFR. These pathways encompass Pathwa...
Source: Food and Chemical Toxicology - April 25, 2024 Category: Food Science Authors: Zi-Yong Chu Xue-Jiao Zi Source Type: research
Butylated hydroxyanisole induces vascular endothelial injury via TFEB-mediated degradation of GPX4 and FTH1
In conclusion, BHA degrades GPX4, xCT, and FTH1 through activation of the TFEB-mediated lysosomal pathway and promotes ferroptosis, ultimately leading to vascular endothelial cell injury.PMID:38657941 | DOI:10.1016/j.fct.2024.114682 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 24, 2024 Category: Food Science Authors: Yufei Zhan Yazhuo Zhang Source Type: research
