Microglial gp91phox-mediated neuroinflammation and ferroptosis contributes to learning and memory deficits in rotenone-treated mice
Free Radic Biol Med. 2024 Apr 30:S0891-5849(24)00427-1. doi: 10.1016/j.freeradbiomed.2024.04.240. Online ahead of print.ABSTRACTApart from dopaminergic neurotoxicity, exposure to rotenone, a commonly used insecticide in agriculture, also adversely affects hippocampal and cortical neurons, resulting in cognitive impairments in mice. We recently established a role of microglia-mediated neuroinflammation in rotenone-elicited deficits of cognition, yet the mechanisms remain elusive. Here, we investigated the involvement of NADPH oxidase 2 (NOX2) catalytic subunit gp91phox in rotenone-induced cognitive deficits and the associat...
Source: Free Radical Biology and Medicine - May 2, 2024 Category: Biology Authors: Lu Tian Peiyan Tang Jianing Liu Yiyang Liu Liyan Hou Jie Zhao Qingshan Wang Source Type: research
Interplay between Hypoxia Inducible Factor-1 and mitochondria in cardiac diseases
Free Radic Biol Med. 2024 Apr 30:S0891-5849(24)00426-X. doi: 10.1016/j.freeradbiomed.2024.04.239. Online ahead of print.ABSTRACTIschemic heart diseases and cardiomyopathies are characterized by hypoxia, energy starvation and mitochondrial dysfunction. HIF-1 acts as a cellular oxygen sensor, tuning the balance of metabolic and oxidative stress pathways to provide ATP and sustain cell survival. Acting on mitochondria, HIF-1 regulates different processes such as energy substrate utilization, oxidative phosphorylation and mitochondrial dynamics. In turn, mitochondrial homeostasis modifications impact HIF-1 activity. This under...
Source: Free Radical Biology and Medicine - May 2, 2024 Category: Biology Authors: Jeanne Mialet-Perez Elise Belaidi Source Type: research
A Role of ROS-dependent Defects in Mitochondrial Dynamic and Autophagy in Carbon Black Nanoparticle-mediated Myocardial Cell Damage
This study explored the mechanisms of CBNPs-mediated myocardial toxicity. CBNPs were given to mice through intra-tracheal instillation and it was demonstrated that the particles can be taken up into the cardiac tissue. Exposure to CBNPs induced cardiomyocyte inflammation and apoptosis. In combination with in vitro experiments, we showed that CBNPs increased the ROS and induced mitochondria fragmentation. Functionally, CBNPs-exposed cardiomyocyte exhibited depolarization of the mitochondrial membrane potential, release of cytochrome c, and activation of pro-apoptotic BAX, thereby initiating programmed cell death. On the oth...
Source: Free Radical Biology and Medicine - May 2, 2024 Category: Biology Authors: Zehua Xu Jing Li Bowen Su Hongying Gao Miaomiao Ren Yi Lin Heqing Shen Source Type: research
Terf2ip deficiency accelerate non-alcoholic steatohepatitis through regulating lipophagy and fatty acid oxidation via Sirt1/ AMPK pathway
CONCLUSIONS: These results revealed that Terf2ip played a protective role in the progression of NASH through regulating lipophagy and FAO by binding to Sirt1 promoter. Our findings provided a potential therapeutic target for the treatment of NASH.PMID:38697492 | DOI:10.1016/j.freeradbiomed.2024.04.238 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - May 2, 2024 Category: Biology Authors: Yirui Wang Shuochen Liu Ming Ni Yananlan Chen Ruixiang Chen Jifei Wang Wangjie Jiang Tao Zhou Shilong Fan Jiang Chang Xiao Xu Yaodong Zhang Yue Yu Xiangcheng Li Changxian Li Source Type: research
Targeted degradation of NDUFS1 by agrimol B promotes mitochondrial ROS accumulation and cytotoxic autophagy arrest in hepatocellular carcinoma
In conclusion, our study uncovers the anticancer mechanism of agrimol B in HCC involving the regulation of oxidative stress and autophagy, and suggests agrimol B as a potential therapeutic drug for HCC treatment.PMID:38697493 | DOI:10.1016/j.freeradbiomed.2024.04.242 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - May 2, 2024 Category: Biology Authors: Lixia Dong Li Luo Zihao Wang Shan Lian Mao Wang Xingyun Wu Jiawu Fan Yan Zeng Sijia Li Sinan Lv Yurong Yang Rong Chen Enhao Shen Wenyong Yang Changlong Li Kui Wang Source Type: research
Marine-derived antimicrobial peptide piscidin-1 triggers extrinsic and intrinsic apoptosis in oral squamous cell carcinoma through reactive oxygen species production and inhibits angiogenesis
Free Radic Biol Med. 2024 Apr 26;220:28-42. doi: 10.1016/j.freeradbiomed.2024.04.235. Online ahead of print.ABSTRACTCancer of the head and neck encompasses a wide range of cancers, including oral and oropharyngeal cancers. Oral cancer is often diagnosed at advanced stages and has a dismal prognosis. Piscidin-1, a marine antimicrobial peptide (AMP) containing approximately 22 amino acids, also exhibits significant anticancer properties. We investigated the possible anti-oral cancer effects of piscidin-1 and clarified the mechanisms underlying these effects. We treated the oral squamous cell carcinoma cell lines OC2 and SCC4...
Source: Free Radical Biology and Medicine - April 28, 2024 Category: Biology Authors: Fu-Ching Chiu Hsiao-Mei Kuo Chen-Ling Yu Padhmavathi Selvam I-Li Su Chung-Chih Tseng Chien-Han Yuan Zhi-Hong Wen Source Type: research
The NRF2 activator RTA-408 ameliorates chronic alcohol exposure-induced cognitive impairment and NLRP3 inflammasome activation by modulating impaired mitophagy initiation
CONCLUSION: Chronic alcohol exposure-induced impaired mitophagy initiation contributed to NLRP3 inflammasome activation and cognitive deficits, which could be alleviated by NRF2 activation via RTA-408.PMID:38679301 | DOI:10.1016/j.freeradbiomed.2024.04.236 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 28, 2024 Category: Biology Authors: Xinrou Lin Hongxuan Wang Lubin Zou Biying Yang Wanru Chen Xiaoming Rong Xiaoni Zhang Lei He Xiangpen Li Ying Peng Source Type: research
Marine-derived antimicrobial peptide piscidin-1 triggers extrinsic and intrinsic apoptosis in oral squamous cell carcinoma through reactive oxygen species production and inhibits angiogenesis
Free Radic Biol Med. 2024 Apr 26:S0891-5849(24)00422-2. doi: 10.1016/j.freeradbiomed.2024.04.235. Online ahead of print.ABSTRACTCancer of the head and neck encompasses a wide range of cancers, including oral and oropharyngeal cancers. Oral cancer is often diagnosed at advanced stages and has a dismal prognosis. Piscidin-1, a marine antimicrobial peptide (AMP) containing approximately 22 amino acids, also exhibits significant anticancer properties. We investigated the possible anti-oral cancer effects of piscidin-1 and clarified the mechanisms underlying these effects. We treated the oral squamous cell carcinoma cell lines ...
Source: Free Radical Biology and Medicine - April 28, 2024 Category: Biology Authors: Fu-Ching Chiu Hsiao-Mei Kuo Chen-Ling Yu Padhmavathi Selvam I-Li Su Chung-Chih Tseng Chien-Han Yuan Zhi-Hong Wen Source Type: research
The NRF2 activator RTA-408 ameliorates chronic alcohol exposure-induced cognitive impairment and NLRP3 inflammasome activation by modulating impaired mitophagy initiation
CONCLUSION: Chronic alcohol exposure-induced impaired mitophagy initiation contributed to NLRP3 inflammasome activation and cognitive deficits, which could be alleviated by NRF2 activation via RTA-408.PMID:38679301 | DOI:10.1016/j.freeradbiomed.2024.04.236 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 28, 2024 Category: Biology Authors: Xinrou Lin Hongxuan Wang Lubin Zou Biying Yang Wanru Chen Xiaoming Rong Xiaoni Zhang Lei He Xiangpen Li Ying Peng Source Type: research
Marine-derived antimicrobial peptide piscidin-1 triggers extrinsic and intrinsic apoptosis in oral squamous cell carcinoma through reactive oxygen species production and inhibits angiogenesis
Free Radic Biol Med. 2024 Apr 26:S0891-5849(24)00422-2. doi: 10.1016/j.freeradbiomed.2024.04.235. Online ahead of print.ABSTRACTCancer of the head and neck encompasses a wide range of cancers, including oral and oropharyngeal cancers. Oral cancer is often diagnosed at advanced stages and has a dismal prognosis. Piscidin-1, a marine antimicrobial peptide (AMP) containing approximately 22 amino acids, also exhibits significant anticancer properties. We investigated the possible anti-oral cancer effects of piscidin-1 and clarified the mechanisms underlying these effects. We treated the oral squamous cell carcinoma cell lines ...
Source: Free Radical Biology and Medicine - April 28, 2024 Category: Biology Authors: Fu-Ching Chiu Hsiao-Mei Kuo Chen-Ling Yu Padhmavathi Selvam I-Li Su Chung-Chih Tseng Chien-Han Yuan Zhi-Hong Wen Source Type: research
The NRF2 activator RTA-408 ameliorates chronic alcohol exposure-induced cognitive impairment and NLRP3 inflammasome activation by modulating impaired mitophagy initiation
CONCLUSION: Chronic alcohol exposure-induced impaired mitophagy initiation contributed to NLRP3 inflammasome activation and cognitive deficits, which could be alleviated by NRF2 activation via RTA-408.PMID:38679301 | DOI:10.1016/j.freeradbiomed.2024.04.236 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 28, 2024 Category: Biology Authors: Xinrou Lin Hongxuan Wang Lubin Zou Biying Yang Wanru Chen Xiaoming Rong Xiaoni Zhang Lei He Xiangpen Li Ying Peng Source Type: research
Corrigendum to "Menaquinone-4 attenuates ferroptosis by upregulating DHODH through activation of SIRT1 after subarachnoid hemorrhage" [Free Radic. Biol. Med. 210 (2024) 416-429]
Free Radic Biol Med. 2024 Apr 26;219:180-183. doi: 10.1016/j.freeradbiomed.2024.04.227. Online ahead of print.NO ABSTRACTPMID:38677202 | DOI:10.1016/j.freeradbiomed.2024.04.227 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 27, 2024 Category: Biology Authors: Jiatong Zhang Qi Zhu Zheng Peng Xiao-Jian Li Peng-Fei Ding Sen Gao Bin Sheng Yang Liu Yue Lu Zong Zhuang Chun-Hua Hang Wei Li Source Type: research
Mitochondrial Redox State, Bioenergetics, and Calcium Transport in Caloric Restriction: a Metabolic Nexus
Free Radic Biol Med. 2024 Apr 25:S0891-5849(24)00421-0. doi: 10.1016/j.freeradbiomed.2024.04.234. Online ahead of print.ABSTRACTMitochondria congregate central reactions in energy metabolism, many of which involve electron transfer. As such, they are expected to both respond to changes in nutrient supply and demand and also provide signals that integrate energy metabolism intracellularly. In this review, we discuss how mitochondrial bioenergetics and reactive oxygen species production is impacted by dietary interventions that change nutrient availability and impact on aging, such as calorie restriction. We also discuss how...
Source: Free Radical Biology and Medicine - April 27, 2024 Category: Biology Authors: Eloisa A Vilas-Boas Alicia J Kowaltowski Source Type: research
Human umbilical cord mesenchymal stem cells alleviate chemotherapy-induced premature ovarian insufficiency mouse model by suppressing ferritinophagy-mediated ferroptosis in granulosa cells
This study reveals that human umbilical cord-derived MSCs (hUC-MSCs) can protect ovarian granulosa cells (GCs) from cyclophosphamide (CTX)-induced ferroptosis, a form of cell death driven by iron accumulation. CTX, commonly used to induce POI animal model, triggered ferroptosis in GCs, while hUC-MSCs treatment mitigated this effect, both in vivo and in vitro. Further investigations using ferroptosis and autophagy inhibitors suggest that hUC-MSCs act by suppressing ferroptosis in GCs. Interestingly, hUC-MSCs activate a protective antioxidant pathway in GCs via NRF2, a stress-response regulator. Overall, our findings suggest...
Source: Free Radical Biology and Medicine - April 27, 2024 Category: Biology Authors: Wenjie Dai Bo Xu Liyang Ding Zhen Zhang Hong Yang Tiantian He Ling Liu Xiuying Pei Xufeng Fu Source Type: research
Exercise Epigenetics is fueled by cell Bioenergetics: Supporting role on Brain Plasticity and Cognition
Free Radic Biol Med. 2024 Apr 25:S0891-5849(24)00424-6. doi: 10.1016/j.freeradbiomed.2024.04.237. Online ahead of print.ABSTRACTExercise has the unique aptitude to benefit overall health of body and brain. Evidence indicates that the effects of exercise can be saved in the epigenome for considerable time to elevate the threshold for various diseases. The action of exercise on epigenetic regulation seems central to building an "epigenetic memory" to influence long-term brain function and behavior. As an intrinsic bioenergetic process, exercise engages the function of the mitochondria and redox pathways to impinge upon molec...
Source: Free Radical Biology and Medicine - April 27, 2024 Category: Biology Authors: Fernando Gomez-Pinilla Pavan Thapak Source Type: research
