Corrigendum
Hirano I, Collins MH, Assouline-Dayan Y, et al. RPC4046, a Monoclonal Antibody Against IL13, Reduces Histologic and Endoscopic Activity in Patients With Eosinophilic Esophagitis. Gastroenterology 2019;156:592–603.e10. (Source: Gastroenterology)
Source: Gastroenterology - May 4, 2024 Category: Gastroenterology Tags: Corrigendum Source Type: research
Risk of cancers proximal to the colon in fecal immunochemical test positive screenees in a colorectal cancer screening program
In more than half of the colorectal cancer (CRC) screening participants with a positive fecal immunochemical test (FIT) result, no advanced neoplasia (AN) is detected at colonoscopy. The positive FIT result could also be generated by cancers located proximal to the colon: upper gastrointestinal, oral cavity, nose and throat cancers. We evaluated screenees ’ risk of being diagnosed with a cancer proximal to the colon within the three years and compared risks between those with a positive versus those with a negative FIT. (Source: Gastroenterology)
Source: Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: W. de Klaver, M. van der Vlugt, M.C.W. Spaander, P.M. Bossuyt, E. Dekker Tags: Clinical - Alimentary Tract Source Type: research
Association of GLP-1 receptor agonists and hepatocellular carcinoma incidence and hepatic decompensation in patients with type 2 diabetes
Hepatocellular carcinoma (HCC) is a leading cause of cancer death. HCC is preventable with about 70 percent of HCC attributable to modifiable risk factors. Glucagon-like peptide-1 receptor agonists (GLP-1RAs), FDA-approved medications for treating type 2 diabetes mellitus (T2DM), have pleiotropic effects on counteracting risk factors for HCC. Here we evaluate the association of GLP-1RAs with incident HCC risk in a real-world population. (Source: Gastroenterology)
Source: Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Lindsey Wang, Nathan A. Berger, David C. Kaelber, Rong Xu Tags: Clinical - Liver Source Type: research
Empowering Tomorrow ’s Gastroenterologists and Their Patients:Integrating Motivational Interviewing into Fellowship Training
(Source: Gastroenterology)
Source: Gastroenterology - April 27, 2024 Category: Gastroenterology Authors: Media N. Ismael, Lisa J. Merlo Tags: Mentoring, Education, and Training Corner Source Type: research
Fecal microbiota transplantation for recurrent C. difficile infection can be the best therapeutic option in severely immunocompromised patients depending on a case-by-case assessment of the benefit/risk ratio
(Source: Gastroenterology)
Source: Gastroenterology - April 26, 2024 Category: Gastroenterology Authors: Nicolas BENECH, Nadim CASSIR, Tatiana GALPERINE, Laurent ALRIC, Julien SCANZI, Harry SOKOL, French Fecal Transplant Group (GFTF) Tags: Correspondence Source Type: research
“The OCEAN Study: Has Octreotide Quenched the Thirst for Angiodysplasia-Related Bleed?”
(Source: Gastroenterology)
Source: Gastroenterology - April 26, 2024 Category: Gastroenterology Authors: Avinash Tiwari Tags: Correspondence Source Type: research
Basket, Umbrella, and Platform Trials: The Potential for Master Protocol -Based Trials in Inflammatory Bowel Disease
(Source: Gastroenterology)
Source: Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Sailish Honap, Bruce E. Sands, Vipul Jairath, Silvio Danese, Eric Vicaut, Laurent Peyrin-Biroulet Tags: Commentary Source Type: research
A Curious Case of Colitis
(Source: Gastroenterology)
Source: Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Elida Voth, Amanda Johnson Tags: Electronic Gastro Curbside Consult Source Type: research
New Insights on Genes, Gluten, and Immunopathogenesis of Celiac Disease
Celiac disease (CeD) is a gluten-induced enteropathy that develops in genetically susceptible individuals upon consumption of cereal gluten proteins. It is a unique and complex immune disorder to study, as the driving antigen is known and the tissue targeted by the immune reaction can be interrogated. This review integrates findings gained from genetic, biochemical, and immunologic studies, which together have revealed mechanisms of gluten peptide modification and HLA binding, thereby enabling a maladapted anti-gluten immune response. (Source: Gastroenterology)
Source: Gastroenterology - April 24, 2024 Category: Gastroenterology Authors: Val érie Abadie, Arnold Han, Bana Jabri, Ludvig M. Sollid Tags: Invited 2024 13th Issue: Celiac Disease Source Type: research
Past, Present, and Future of Noninvasive Tests to Assess Gluten Exposure, Celiac Disease Activity, and End-Organ Damage
Although many biomarkers have been proposed, and several are in widespread clinical use, there is no single readout or combination of readouts that correlates tightly with gluten exposure, disease activity, or end-organ damage in treated patients with celiac disease. Challenges to developing and evaluating better biomarkers include significant interindividual variability-related to immune amplification of gluten exposure and how effects of immune activation are manifest. Furthermore, the current “gold standard” for assessment of end-organ damage, small intestinal biopsy, is itself highly imperfect, such that a marker t...
Source: Gastroenterology - April 24, 2024 Category: Gastroenterology Authors: Jocelyn A. Silvester, Luca Elli, Chaitan Khosla, Jason Tye-Din Tags: Invited 2024 13th Issue: Celiac Disease Source Type: research
Measuring post-colonoscopy colorectal cancers: Variations in methodology to address indicator timeliness and use in high-risk populations
(Source: Gastroenterology)
Source: Gastroenterology - April 24, 2024 Category: Gastroenterology Authors: Jill Tinmouth, Branson Chen, Yue Niu, Kyle Silveira, Linda Rabeneck, Catherine Dub é, Cancer Control and Evidence Integration PCCRC Method Working Group, Ontario Health, Cancer Control Tags: Research Letter Source Type: research
Real-world Stool-based mSDC2 Test Improved Detection of Advanced Colorectal Neoplasia for Colorectal Cancer Screening: A Prospective, Multicenter, Community-based Study.
(Source: Gastroenterology)
Source: Gastroenterology - April 24, 2024 Category: Gastroenterology Authors: Shengbing Zhao, Zixuan He, Xiangyu Sui, Song Zhang, Zhaoshen Li, Yu Bai, Community-based CRC Screening Study Group Tags: Research Letter Source Type: research
New insights on genes, gluten and immunopathogenesis of celiac disease
Celiac disease (CeD) is a gluten-induced enteropathy that develops in genetically susceptible individuals on consumption of cereal gluten proteins. It is a unique complex immune disorder to study as the driving antigen is known and the tissue targeted by the immune reaction can be interrogated. This review integrates findings gained from genetic, biochemical and immunological studies, which together have revealed mechanisms of gluten peptide modification and HLA binding thereby enabling a maladapted anti-gluten immune response. (Source: Gastroenterology)
Source: Gastroenterology - April 24, 2024 Category: Gastroenterology Authors: Val érie Abadie, Arnold Han, Bana Jabri, Ludvig M. Sollid Tags: Invited 2024 13th Issue: Celiac Disease Source Type: research
Past, present and future of non-invasive tests to assess gluten exposure, celiac disease activity, and end-organ damage
Although many biomarkers have been proposed and several are in widespread clinical use, there is no single readout or combination of readouts that correlates tightly with gluten exposure, disease activity or end-organ damage in treated celiac disease patients. Challenges to developing and evaluating better biomarkers include significant interindividual variability related to immune amplification of gluten exposure and how effects of immune activation are manifest. Furthermore, the current “gold standard” for assessment of end-organ damage, small intestinal biopsy, is itself highly imperfect, such that a marker that is ...
Source: Gastroenterology - April 24, 2024 Category: Gastroenterology Authors: Jocelyn A. Silvester, Luca Elli, Chaitan Khosla, Jason Tye-Din Tags: Invited 2024 13th Issue: Celiac Disease Source Type: research
The Economic Iceberg of Celiac Disease: More than the Cost of Gluten-Free Food
Celiac disease (CeD) is a chronic autoimmune disorder of global relevance, with the potential for acute and long-term complications. However, the economic burden of CeD is rarely considered and largely thought of as limited to the cost of gluten-free food. Fortunately, recent research has shed light on the various societal costs of CeD across the healthcare continuum.In this article, we summarize the current evidence on the economic impacts of CeD which suggest that the societal economic burden of CeD stretches beyond the cost of gluten-free food. (Source: Gastroenterology)
Source: Gastroenterology - April 24, 2024 Category: Gastroenterology Authors: Soran R. Bozorg, Anne Lee, Karl M årild, Joseph Murray Tags: Invited 2024 13th Issue: Celiac Disease Source Type: research
