Regulatory role of PDK1 via integrated gene analysis of mitochondria-immune response in periodontitis
Gene. 2024 Apr 22:148476. doi: 10.1016/j.gene.2024.148476. Online ahead of print.ABSTRACTAIMS: To investigate the association between mitochondrial events and immune response in periodontitis and related regulatory genes.MAIN METHODS: Gene expression profiles in gingival tissues were retrieved from the Gene Expression Omnibus. Mitochondria-immune response-related differentially expressed genes (MIR-DEGs) between the healthy and periodontitis samples were determined. WGCNA, GO, and KEGG were used to investigate the function and the enriched pathways of MIR-DEGs. The correlation between MIR-DEGs expression and clinical probi...
Source: Gene - April 24, 2024 Category: Genetics & Stem Cells Authors: Xiaoyu Sun Tong Wu Zhan Yang Shuhong Chen Zheyu Zhao Chaoming Hu Shengzhuang Wu Jiayu Wu Yixin Mao Jiefan Liu Chen Guo Gang Cao Xiangwei Xu Shengbin Huang Guang Liang Source Type: research
Comparative mitochondrial genomics of endemic Mexican vesper yellow bats genus Rhogeessa (Chiroptera: Vespertilionidae) and insights into internal relationships in the family Vespertilionidae
In this study, we assembled and annotated the mitochondrial genome of four species: R. aenea, R. genowaysi, R. mira, and R. parvula. We generated a phylomitogenomic hypothesis based on translated protein-coding genes for a total of 52 species in the family Vespertilionidae and examined the phylogenetic position of the genus Rhogeessa and species within the family. The AT-rich mitogenomes of R. aenea, R. genowaysi, R. mira, and R. parvula are 16,763, 16,781, 16,807, and 16,794 pb in length, respectively. Each studied mitogenome encodes 13 Protein Coding Genes (PCGs), 22 transfer RNA genes, and 2 rRNA genes, and contains a p...
Source: Gene - April 22, 2024 Category: Genetics & Stem Cells Authors: Anah í Martínez-Cárdenas Valeria Becerril Jorge Ortega Issachar L L ópez-Cuamatzi Joaqu ín Arroyo-Cabrales Iv án Díaz-Pacheco J Antonio Baeza Source Type: research
Identification of ferroptosis-related key genes associated with immune infiltration in sepsis by bioinformatics analysis and in vivo validation
CONCLUSION: MAPK14 and ACSL4 could become robustly reliable and promising biomarkers for sepsis by regulating ferroptosis through the NLRP3 pathway, which is mainly associated with T-cell infiltration.PMID:38649061 | DOI:10.1016/j.gene.2024.148482 (Source: Gene)
Source: Gene - April 22, 2024 Category: Genetics & Stem Cells Authors: Rui Shi Chunyun Bai Shibo Sun Fang Wang Chaozhong Li Chongyu Wang Lidan Hu Ziwen Zhao Qiuzhe Guo Guanhua Du Dan Xu Alex F Chen Weimin Yang Source Type: research
First characterization of major histocompatibility complex class II DRB3 diversity in cattle breeds raised in Egypt
In this study, we characterized BoLA-DRB3 in two local Egyptian populations and one foreign population using polymerase chain reaction-sequence-based typing (PCR-SBT) method. Fifty-four previously reported BoLA-DRB3 alleles and eight new alleles (BoLA-DRB3*005:08, *015:07, *016:03, *017:04, *020:02:02, *021:03, *164:01, and *165:01) were identified. Alignment analysis of the eight new alleles revealed 89.5-98.7 %, and 81.0-97.5 % nucleotide and amino acid identities, respectively, with the BoLA-DRB3 cDNA clone NR-1. Interestingly, BoLA-DRB3 in Egyptian cattle showed a high degree of allelic diversity in native (na = 28, hE...
Source: Gene - April 22, 2024 Category: Genetics & Stem Cells Authors: Rania Hamada Guillermo Giovambattista Samy Metwally Liushiqi Borjigin Meripet Polat Yamanaka Ryosuke Matsuura Alsagher O Ali Hassan Y A H Mahmoud Adel E A Mohamed Kyaw Kyaw Moe Shin-Nosuke Takeshima Satoshi Wada Yoko Aida Source Type: research
Comparative mitochondrial genomics of endemic Mexican vesper yellow bats genus Rhogeessa (Chiroptera: Vespertilionidae) and insights into internal relationships in the family Vespertilionidae
In this study, we assembled and annotated the mitochondrial genome of four species: R. aenea, R. genowaysi, R. mira, and R. parvula. We generated a phylomitogenomic hypothesis based on translated protein-coding genes for a total of 52 species in the family Vespertilionidae and examined the phylogenetic position of the genus Rhogeessa and species within the family. The AT-rich mitogenomes of R. aenea, R. genowaysi, R. mira, and R. parvula are 16,763, 16,781, 16,807, and 16,794 pb in length, respectively. Each studied mitogenome encodes 13 Protein Coding Genes (PCGs), 22 transfer RNA genes, and 2 rRNA genes, and contains a p...
Source: Gene - April 22, 2024 Category: Genetics & Stem Cells Authors: Anah í Martínez-Cárdenas Valeria Becerril Jorge Ortega Issachar L L ópez-Cuamatzi Joaqu ín Arroyo-Cabrales Iv án Díaz-Pacheco J Antonio Baeza Source Type: research
Identification of ferroptosis-related key genes associated with immune infiltration in sepsis by bioinformatics analysis and in vivo validation
CONCLUSION: MAPK14 and ACSL4 could become robustly reliable and promising biomarkers for sepsis by regulating ferroptosis through the NLRP3 pathway, which is mainly associated with T-cell infiltration.PMID:38649061 | DOI:10.1016/j.gene.2024.148482 (Source: Gene)
Source: Gene - April 22, 2024 Category: Genetics & Stem Cells Authors: Rui Shi Chunyun Bai Shibo Sun Fang Wang Chaozhong Li Chongyu Wang Lidan Hu Ziwen Zhao Qiuzhe Guo Guanhua Du Dan Xu Alex F Chen Weimin Yang Source Type: research
First characterization of major histocompatibility complex class II DRB3 diversity in cattle breeds raised in Egypt
In this study, we characterized BoLA-DRB3 in two local Egyptian populations and one foreign population using polymerase chain reaction-sequence-based typing (PCR-SBT) method. Fifty-four previously reported BoLA-DRB3 alleles and eight new alleles (BoLA-DRB3*005:08, *015:07, *016:03, *017:04, *020:02:02, *021:03, *164:01, and *165:01) were identified. Alignment analysis of the eight new alleles revealed 89.5-98.7 %, and 81.0-97.5 % nucleotide and amino acid identities, respectively, with the BoLA-DRB3 cDNA clone NR-1. Interestingly, BoLA-DRB3 in Egyptian cattle showed a high degree of allelic diversity in native (na = 28, hE...
Source: Gene - April 22, 2024 Category: Genetics & Stem Cells Authors: Rania Hamada Guillermo Giovambattista Samy Metwally Liushiqi Borjigin Meripet Polat Yamanaka Ryosuke Matsuura Alsagher O Ali Hassan Y A H Mahmoud Adel E A Mohamed Kyaw Kyaw Moe Shin-Nosuke Takeshima Satoshi Wada Yoko Aida Source Type: research
Genetic diversity in Leishmania infantum and Leishmania tropica isolates from human and canine hosts in northern Morocco
This study investigated nine provinces in northern Morocco and collected 275 skin scraping, 22 bone marrow aspirates, and 89 fine needle aspirations from suspected cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL) patients and potentially infected dogs. Molecular analysis using ITS1 RFLP PCR and RT-PCR revealed a higher prevalence of L. infantum (66.18 %; χ2 = 28.804; df = 1; P-value = 8.01e-08) than L. tropica in skin scraping, with L. infantum being the sole causative agent for both VL and canine leishmaniasis. L. infantum was predominantly found in most provinces, while L. tropica was relatively more dominan...
Source: Gene - April 20, 2024 Category: Genetics & Stem Cells Authors: Maryam Hakkour Bouabid Badaoui Sarah El Hamiani Khatat Hamid Sahibi Hajiba Fellah Abderrahim Sadak Faiza Sebti Source Type: research
Corrigendum to "Study of serum exosome miRNA as a biomarker for early onset adult ouclar myasthenia gravis" [Gene 896 (2024) 148034]
Gene. 2024 Apr 18;917:148440. doi: 10.1016/j.gene.2024.148440. Online ahead of print.NO ABSTRACTPMID:38640686 | DOI:10.1016/j.gene.2024.148440 (Source: Gene)
Source: Gene - April 19, 2024 Category: Genetics & Stem Cells Authors: Yajun Mu Xin Huang Yuanting Yang Ziqing Huang Jiaxin Chen Shiyin Li Yuying Dong Fangyuan Chen Rijia Zhang Jian Chen Huiyu Feng Qing Zhou Source Type: research
Different impact of short-term and long-term hindlimb disuse on bone homeostasis
In this study, we employed hindlimb-unloading mice models with different length of tail suspension to investigate if the bone loss was regulated by distinct factors under different duration of disuse. Our micro-CT results showed more significant decrease of bone mass in 6W (6-week) tail-suspension mice compared to the 1W (1-week) tail-suspension ones, as indicated by greater reduction of BV/TV, Tb.N, B.Ar/T.Ar and Ct.Th. RNA-sequencing results showed significant effects of hindlimb disuse on cell locomotion and immune system process which could cause bone loss.Real-time quantitative PCR results indicated a greater number o...
Source: Gene - April 19, 2024 Category: Genetics & Stem Cells Authors: Minhao Gao Chengji Dong Zhuliu Chen Renhao Jiang Peter Shaw Weiyang Gao Yuanna Sun Source Type: research
Noncoding RNAs in B cell non-Hodgkins lymphoma
Gene. 2024 Apr 16:148480. doi: 10.1016/j.gene.2024.148480. Online ahead of print.ABSTRACTB-cell non-Hodgkins lymphomas (BCNHLs) are a category of B-cell cancers that show heterogeneity. These blood disorders are derived from different levels of B-cell maturity. Among NHL cases, ∼80-90 % are derived from B-cells. Recent studies have demonstrated that noncoding RNAs (ncRNAs) contribute to almost all parts of mechanisms and are essential in tumorigenesis, including B-cell non-Hodgkins lymphomas. The study of ncRNA dysregulations in B-cell lymphoma unravels important mysteries in lymphoma's molecular etiology. It seems also ...
Source: Gene - April 18, 2024 Category: Genetics & Stem Cells Authors: Zahra Abedi Kichi Niloofar Dini Mahbubeh Rojhannezhad Zeinab Shirvani Farsani Source Type: research
Quail GHRL and LEAP2 gene cloning, polymorphism detection, phylogenetic analysis, tissue expression profiling and its association analysis with feed intake
This study cloned the entire qGHRL and qLEAP2 cDNA sequence in Chinese yellow quail (Coturnix japonica), including the 5' and 3' untranslated regions. Sanger sequencing analysis revealed no missense mutations in the coding region of qGHRL and qLEAP2. Subsequently, phylogenetic analysis and protein homology alignment were conducted on the qGHRL and qLEAP2 in major poultry species. The findings of this research indicated that the qGHRL and qLEAP2 sequences exhibit a high degree of similarity with those of chicken and turkey. Specifically, the N-terminal 6 amino acids of GHRL mature peptides and all the mature peptide sequenc...
Source: Gene - April 18, 2024 Category: Genetics & Stem Cells Authors: Xin Shu Ziwei Chen Xiaotong Zheng Guoying Hua Wuchao Zhuang Jilong Zhang Jianfei Chen Source Type: research
Construction of ceRNA network mediated by circRNAs screening from microarray and identification of novel biomarkers for myasthenia gravis
CONCLUSIONS: We found that circFRMD4, circPIGB and circNUP214 can be considered as valuable potential novel biomarkers for AchR + MG. CircFRMD4 participate in the development of AchR + MG via targeting binding with miR-145-5p.PMID:38631652 | DOI:10.1016/j.gene.2024.148463 (Source: Gene)
Source: Gene - April 17, 2024 Category: Genetics & Stem Cells Authors: Xiaotong Kong Tao Wu Hanlu Cai Zhimin Chen Yu Wang Ping He Peifang Liu Lei Li Shanshan Peng Fanfan Xu Jianjian Wang Huixue Zhang Lihua Wang Source Type: research
Genetic variants of ANRIL and coronary artery disease: Insights from a Turkish study population
CONCLUSIONS: In conclusion, selected ANRIL polymorphisms were associated with CAD presence/severity and CAD risk factors, T2DM, and hypertension. Notably, this study, the largest sample-sized study examining the effects of selected polymorphisms on CAD and its risk factors among Turkish individuals, supported the findings of previous studies conducted on different ethnicities.PMID:38631653 | DOI:10.1016/j.gene.2024.148475 (Source: Gene)
Source: Gene - April 17, 2024 Category: Genetics & Stem Cells Authors: Aybike Sena Ozuynuk-Ertugrul Cemre Buse Kirsan Aycan Fahri Erkan Berkay Ekici Evrim Komurcu-Bayrak Neslihan Coban Source Type: research
Construction of ceRNA network mediated by circRNAs screening from microarray and identification of novel biomarkers for myasthenia gravis
CONCLUSIONS: We found that circFRMD4, circPIGB and circNUP214 can be considered as valuable potential novel biomarkers for AchR + MG. CircFRMD4 participate in the development of AchR + MG via targeting binding with miR-145-5p.PMID:38631652 | DOI:10.1016/j.gene.2024.148463 (Source: Gene)
Source: Gene - April 17, 2024 Category: Genetics & Stem Cells Authors: Xiaotong Kong Tao Wu Hanlu Cai Zhimin Chen Yu Wang Ping He Peifang Liu Lei Li Shanshan Peng Fanfan Xu Jianjian Wang Huixue Zhang Lihua Wang Source Type: research
