Pre-diagnostic plasma proteomics profile for hepatocellular carcinoma
CONCLUSION: However, the limited number of HCC cases in the cohorts necessitates caution in interpreting our findings, emphasizing the need for further validation in high-risk populations.PMID:38688524 | DOI:10.1093/jnci/djae079 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - April 30, 2024 Category: Genetics & Stem Cells Authors: Xinyuan Zhang Longgang Zhao Long H Ngo Simon T Dillon Xuesong Gu Michelle Lai Tracey G Simon Andrew T Chan Edward L Giovannucci Towia A Libermann Xuehong Zhang Source Type: research
Pre-diagnostic plasma proteomics profile for hepatocellular carcinoma
CONCLUSION: However, the limited number of HCC cases in the cohorts necessitates caution in interpreting our findings, emphasizing the need for further validation in high-risk populations.PMID:38688524 | DOI:10.1093/jnci/djae079 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - April 30, 2024 Category: Genetics & Stem Cells Authors: Xinyuan Zhang Longgang Zhao Long H Ngo Simon T Dillon Xuesong Gu Michelle Lai Tracey G Simon Andrew T Chan Edward L Giovannucci Towia A Libermann Xuehong Zhang Source Type: research
Graph neural networks-based prediction of drug gene association of P2X receptors in periodontal pain
In this study, 921 drug-gene interactions involving P2X receptors were accessed through https://www.probes-drugs.org/. These interactions underwent meticulous annotation, preprocessing, and subsequent utilization to train and assess GNNs. Furthermore, leveraging Cytoscape, the CytoHubba plugin, and other bioinformatics tools, gene expression networks were constructed to pinpoint hub genes within these interactions. Through analysis, SLC6A3, SLC6A2, FGF1, GRK2, and PLA2G2A were identified as central hub genes within the context of P2X receptor-mediated drug-gene interactions. Despite achieving a 65 percent accuracy rate, th...
Source: Genomics Proteomics ... - April 29, 2024 Category: Genetics & Stem Cells Authors: Pradeep Kumar Yadalam Prabhu Manickam Natarajan Seyed Ali Mosaddad Artak Heboyan Source Type: research
From flesh to bones: Multi-omics approaches in forensic science
Proteomics. 2024 Apr 29:e2200335. doi: 10.1002/pmic.202200335. Online ahead of print.ABSTRACTRecent advancements in omics techniques have revolutionised the study of biological systems, enabling the generation of high-throughput biomolecular data. These innovations have found diverse applications, ranging from personalised medicine to forensic sciences. While the investigation of multiple aspects of cells, tissues or entire organisms through the integration of various omics approaches (such as genomics, epigenomics, metagenomics, transcriptomics, proteomics and metabolomics) has already been established in fields like biom...
Source: Genomics Proteomics ... - April 29, 2024 Category: Genetics & Stem Cells Authors: Noemi Procopio Andrea Bonicelli Source Type: research
The TP53-activated E3 ligase RNF144B is a tumour suppressor that prevents genomic instability
CONCLUSIONS: Supported by clinical data, our study suggests that RNF144B plays a pivotal role in maintaining genomic stability during tumor suppression.PMID:38685100 | PMC:PMC11057071 | DOI:10.1186/s13046-024-03045-4 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - April 29, 2024 Category: Genetics & Stem Cells Authors: Etna Abad J érémy Sandoz Gerard Romero Ivan Zadra Julia Urgel-Solas Pablo Borredat Savvas Kourtis Laura Ortet Carlos M Mart ínez Donate Weghorn Sara Sdelci Ana Janic Source Type: research
Graph neural networks-based prediction of drug gene association of P2X receptors in periodontal pain
In this study, 921 drug-gene interactions involving P2X receptors were accessed through https://www.probes-drugs.org/. These interactions underwent meticulous annotation, preprocessing, and subsequent utilization to train and assess GNNs. Furthermore, leveraging Cytoscape, the CytoHubba plugin, and other bioinformatics tools, gene expression networks were constructed to pinpoint hub genes within these interactions. Through analysis, SLC6A3, SLC6A2, FGF1, GRK2, and PLA2G2A were identified as central hub genes within the context of P2X receptor-mediated drug-gene interactions. Despite achieving a 65 percent accuracy rate, th...
Source: Genomics Proteomics ... - April 29, 2024 Category: Genetics & Stem Cells Authors: Pradeep Kumar Yadalam Prabhu Manickam Natarajan Seyed Ali Mosaddad Artak Heboyan Source Type: research
From flesh to bones: Multi-omics approaches in forensic science
Proteomics. 2024 Apr 29:e2200335. doi: 10.1002/pmic.202200335. Online ahead of print.ABSTRACTRecent advancements in omics techniques have revolutionised the study of biological systems, enabling the generation of high-throughput biomolecular data. These innovations have found diverse applications, ranging from personalised medicine to forensic sciences. While the investigation of multiple aspects of cells, tissues or entire organisms through the integration of various omics approaches (such as genomics, epigenomics, metagenomics, transcriptomics, proteomics and metabolomics) has already been established in fields like biom...
Source: Genomics Proteomics ... - April 29, 2024 Category: Genetics & Stem Cells Authors: Noemi Procopio Andrea Bonicelli Source Type: research
The TP53-activated E3 ligase RNF144B is a tumour suppressor that prevents genomic instability
CONCLUSIONS: Supported by clinical data, our study suggests that RNF144B plays a pivotal role in maintaining genomic stability during tumor suppression.PMID:38685100 | DOI:10.1186/s13046-024-03045-4 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - April 29, 2024 Category: Genetics & Stem Cells Authors: Etna Abad J érémy Sandoz Gerard Romero Ivan Zadra Julia Urgel-Solas Pablo Borredat Savvas Kourtis Laura Ortet Carlos M Mart ínez Donate Weghorn Sara Sdelci Ana Janic Source Type: research
Targeting tumour markers in ovarian cancer treatment
Clin Chim Acta. 2024 Apr 23;559:119687. doi: 10.1016/j.cca.2024.119687. Online ahead of print.ABSTRACTOvarian cancers (OC) are the most common, lethal, and stage-dependent cancers at the global level, specifically in female patients. Targeted therapies involve the administration of drugs that specifically target the alterations in tumour cells responsible for their growth, proliferation, and metastasis, with the aim of treating particular patients. Presently, within the realm of gynaecological malignancies, specifically in breast and OCs, there exist various prospective therapeutic targets encompassing tumour-intrinsic sig...
Source: Genomics Proteomics ... - April 25, 2024 Category: Genetics & Stem Cells Authors: Subham Preetam Sagar Mondal Swati Priya Jutishna Bora Seema Ramniwas Sarvesh Rustagi Naeem F Qusty Saad Alghamdi Ahmad O Babalghith Abdullah Siddiqi Sumira Malik Source Type: research
Targeting tumour markers in ovarian cancer treatment
Clin Chim Acta. 2024 Apr 23;559:119687. doi: 10.1016/j.cca.2024.119687. Online ahead of print.ABSTRACTOvarian cancers (OC) are the most common, lethal, and stage-dependent cancers at the global level, specifically in female patients. Targeted therapies involve the administration of drugs that specifically target the alterations in tumour cells responsible for their growth, proliferation, and metastasis, with the aim of treating particular patients. Presently, within the realm of gynaecological malignancies, specifically in breast and OCs, there exist various prospective therapeutic targets encompassing tumour-intrinsic sig...
Source: Genomics Proteomics ... - April 25, 2024 Category: Genetics & Stem Cells Authors: Subham Preetam Sagar Mondal Swati Priya Jutishna Bora Seema Ramniwas Sarvesh Rustagi Naeem F Qusty Saad Alghamdi Ahmad O Babalghith Abdullah Siddiqi Sumira Malik Source Type: research
Targeting tumor markers in ovarian cancer treatment
Clin Chim Acta. 2024 Apr 23:119687. doi: 10.1016/j.cca.2024.119687. Online ahead of print.ABSTRACTOvarian cancers (OC) are the most common, lethal, and stage-dependent cancers at the global level, specifically in female patients. Targeted therapies involve the administration of drugs that specifically target the alterations in tumour cells responsible for their growth, proliferation, and metastasis, with the aim of treating particular patients. Presently, within the realm of gynaecological malignancies, specifically in breast and OCs, there exist various prospective therapeutic targets encompassing tumour-intrinsic signall...
Source: Genomics Proteomics ... - April 25, 2024 Category: Genetics & Stem Cells Authors: Subham Preetam Sagar Mondal Swati Priya Jutishna Bora Seema Ramaniwas Sarves Rastagi Naeem F Qusty Saad Alghamdi Ahmad O Babalghith Abdullah Siddiqi Sumira Malik Source Type: research
OmicNavigator: open-source software for the exploration, visualization, and archival of omic studies
CONCLUSIONS: OmicNavigator can be found at https://github.com/abbvie-external/OmicNavigator.PMID:38658834 | DOI:10.1186/s12859-024-05743-4 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - April 24, 2024 Category: Genetics & Stem Cells Authors: Terrence R Ernst John D Blischak Paul Nordlund Joe Dalen Justin Moore Akshay Bhamidipati Pankaj Dwivedi Joe LoGrasso Marco Rocha Curado Brett Warren Engelmann Source Type: research
OmicNavigator: open-source software for the exploration, visualization, and archival of omic studies
CONCLUSIONS: OmicNavigator can be found at https://github.com/abbvie-external/OmicNavigator.PMID:38658834 | DOI:10.1186/s12859-024-05743-4 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - April 24, 2024 Category: Genetics & Stem Cells Authors: Terrence R Ernst John D Blischak Paul Nordlund Joe Dalen Justin Moore Akshay Bhamidipati Pankaj Dwivedi Joe LoGrasso Marco Rocha Curado Brett Warren Engelmann Source Type: research
Bioinformatics pipeline for the systematic mining genomic and proteomic variation linked to rare diseases: The example of monogenic diabetes
PLoS One. 2024 Apr 18;19(4):e0300350. doi: 10.1371/journal.pone.0300350. eCollection 2024.ABSTRACTMonogenic diabetes is characterized as a group of diseases caused by rare variants in single genes. Like for other rare diseases, multiple genes have been linked to monogenic diabetes with different measures of pathogenicity, but the information on the genes and variants is not unified among different resources, making it challenging to process them informatically. We have developed an automated pipeline for collecting and harmonizing data on genetic variants linked to monogenic diabetes. Furthermore, we have translated varian...
Source: Genomics Proteomics ... - April 18, 2024 Category: Genetics & Stem Cells Authors: Ksenia G Kuznetsova Jakub Va šíček Dafni Skiadopoulou Janne Molnes Miriam Udler Stefan Johansson P ål Rasmus Njølstad Alisa Manning Marc Vaudel Source Type: research
Bioinformatics pipeline for the systematic mining genomic and proteomic variation linked to rare diseases: The example of monogenic diabetes
PLoS One. 2024 Apr 18;19(4):e0300350. doi: 10.1371/journal.pone.0300350. eCollection 2024.ABSTRACTMonogenic diabetes is characterized as a group of diseases caused by rare variants in single genes. Like for other rare diseases, multiple genes have been linked to monogenic diabetes with different measures of pathogenicity, but the information on the genes and variants is not unified among different resources, making it challenging to process them informatically. We have developed an automated pipeline for collecting and harmonizing data on genetic variants linked to monogenic diabetes. Furthermore, we have translated varian...
Source: Genomics Proteomics ... - April 18, 2024 Category: Genetics & Stem Cells Authors: Ksenia G Kuznetsova Jakub Va šíček Dafni Skiadopoulou Janne Molnes Miriam Udler Stefan Johansson P ål Rasmus Njølstad Alisa Manning Marc Vaudel Source Type: research
