Surgical training of gynecologic oncology fellows: Long-term trends and implications for future education
CONCLUSIONS: The experience of GO fellows has shifted toward increased use of MIS. While these trends in care are appropriate, they do not diminish the need in many patients for complex open procedures. These findings should help spur the development of innovative training to maintain the ability to provide these core, specialty-defining procedures safely.PMID:38696840 | DOI:10.1016/j.ygyno.2024.04.017 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 2, 2024 Category: Cancer & Oncology Authors: Mitchel Hoffman Victoria Dunsmore William Cliby Dennis Chi Stephanie Wheeler Daniel Clarke-Pearson Source Type: research
Antitumor immunity and prognosis value elicited by FAT3 and LRP1B co-mutation in endometrial cancer
CONCLUSIONS: In endometrial cancer, co-mutation of FAT3 and LRP1B not only leads to activation of the immune state, but also represents a subgroup with an improved prognosis, particularly in the MSI-H subtype.PMID:38696842 | DOI:10.1016/j.ygyno.2024.04.023 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 2, 2024 Category: Cancer & Oncology Authors: Zhansheng Jiang Mingyu Zhu Lu Zhang Haiyan Cui Richeng Jiang Yanfang Yang Source Type: research
Walking the tightrope: Fertility preservation among hereditary breast and ovarian Cancer syndrome Previvors
CONCLUSION: Patients with HBOC did not undergo expedited fertility treatment compared to control patients undergoing oocyte and embryo cryopreservation for non-infertility reasons. Patients diagnosed with BRCA1 had more oocytes retrieved compared to the control population which is possibly due to earlier age of presentation in the setting of recommended age of risk reducing surgery being age 35-40. When age matched, cycle outcomes did not differ between HBOC and control patients. Given the known cancer prevention benefit and recommendations for risk-reducing surgery, future studies should focus on guidelines for fertility ...
Source: Gynecologic Oncology - May 2, 2024 Category: Cancer & Oncology Authors: Sharonne Holtzman Lily McCarthy Samantha L Estevez Joseph A Lee Morgan F Baird Dmitry Gounko Alan B Copperman Stephanie V Blank Source Type: research
Mismatch repair deficiency and abnormal p53 expression has significant predictive value for progesterone resistance and endometrial tumorigenesis in patients with endometrial atypical hyperplasia receiving fertility-preserving treatment
CONCLUSIONS: EAH patients with MMR-d and p53abn have a significantly higher risk of disease relapse and progression. Thus, MMR-d and p53abn may be used as predictive biomarkers of progestin resistance and endometrial tumorigenesis in EAH.PMID:38691985 | DOI:10.1016/j.ygyno.2024.04.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 1, 2024 Category: Cancer & Oncology Authors: Hongfa Peng Jingjing Jiang Limeng Li Zengfang Hao Hongguang Lian Hui Du Wei Wang Source Type: research
Extended-duration antibiotics are not associated with a reduction in surgical site infection in patients with ovarian cancer undergoing cytoreductive surgery with large bowel resection
CONCLUSION(S): In this retrospective study of patients with advanced ovarian cancer undergoing CRS with LBR, extended post-operative ABX was not associated with reduced SSI, and prolonged administration of antibiotics should be avoided unless clinically indicated.PMID:38691986 | DOI:10.1016/j.ygyno.2024.04.003 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 1, 2024 Category: Cancer & Oncology Authors: Julia Chalif Laura M Chambers Meng Yao Michelle Kuznicki Robert DeBernardo Peter G Rose Chad M Michener Roberto Vargas Source Type: research
"Having cancer is very expensive": A qualitative study of patients with ovarian cancer and PARP inhibitor treatment
CONCLUSIONS: Patients identified cost, restrictive pharmacy benefits, and initial side effects as barriers to PARP-I usage. Having insurance and a supportive care team were identified as facilitators. Enhancing communication about PARP-I cost and side effects could improve patient experience and receipt of evidence-based maintenance therapy in ovarian cancer.PMID:38691987 | DOI:10.1016/j.ygyno.2024.04.018 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 1, 2024 Category: Cancer & Oncology Authors: Anna Jo Bodurtha Smith Caroline O'Brien Ashley Haggerty Emily M Ko Katharine A Rendle Source Type: research
Mismatch repair deficiency and abnormal p53 expression has significant predictive value for progesterone resistance and endometrial tumorigenesis in patients with endometrial atypical hyperplasia receiving fertility-preserving treatment
CONCLUSIONS: EAH patients with MMR-d and p53abn have a significantly higher risk of disease relapse and progression. Thus, MMR-d and p53abn may be used as predictive biomarkers of progestin resistance and endometrial tumorigenesis in EAH.PMID:38691985 | DOI:10.1016/j.ygyno.2024.04.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 1, 2024 Category: Cancer & Oncology Authors: Hongfa Peng Jingjing Jiang Limeng Li Zengfang Hao Hongguang Lian Hui Du Wei Wang Source Type: research
Extended-duration antibiotics are not associated with a reduction in surgical site infection in patients with ovarian cancer undergoing cytoreductive surgery with large bowel resection
CONCLUSION(S): In this retrospective study of patients with advanced ovarian cancer undergoing CRS with LBR, extended post-operative ABX was not associated with reduced SSI, and prolonged administration of antibiotics should be avoided unless clinically indicated.PMID:38691986 | DOI:10.1016/j.ygyno.2024.04.003 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 1, 2024 Category: Cancer & Oncology Authors: Julia Chalif Laura M Chambers Meng Yao Michelle Kuznicki Robert DeBernardo Peter G Rose Chad M Michener Roberto Vargas Source Type: research
"Having cancer is very expensive": A qualitative study of patients with ovarian cancer and PARP inhibitor treatment
CONCLUSIONS: Patients identified cost, restrictive pharmacy benefits, and initial side effects as barriers to PARP-I usage. Having insurance and a supportive care team were identified as facilitators. Enhancing communication about PARP-I cost and side effects could improve patient experience and receipt of evidence-based maintenance therapy in ovarian cancer.PMID:38691987 | DOI:10.1016/j.ygyno.2024.04.018 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 1, 2024 Category: Cancer & Oncology Authors: Anna Jo Bodurtha Smith Caroline O'Brien Ashley Haggerty Emily M Ko Katharine A Rendle Source Type: research
Effect of surgical volume on short-term outcomes of cytoreductive surgery for advanced-stage ovarian cancer: A population-based study from the Dutch Gynecological Oncology Audit
CONCLUSIONS: Our analyses do not support further centralization of iCRS for advanced-stage OC. High-volume was associated with higher complete pCRS, suggesting either a more accurate selection in these hospitals or a more aggressive approach. The higher completeness rates were at the expense of higher severe complications and prolonged admissions.PMID:38688188 | DOI:10.1016/j.ygyno.2024.04.002 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 30, 2024 Category: Cancer & Oncology Authors: M D Algera W J van Driel B F M Slangen M W J M Wouters R F P M Kruitwagen participants of the Dutch Gynecological Oncology Audit Collaborator Group Source Type: research
ChatGPT accurately performs genetic counseling for gynecologic cancers
CONCLUSION: ChatGPT accurately answers questions about genetic syndromes, genetic testing, and counseling in majority of the studied questions. These data suggest this powerful tool can be utilized as a patient resource for genetic counseling questions, though more data input from gynecologic oncologists would be needed to educate patients on genetic syndromes.PMID:38676973 | DOI:10.1016/j.ygyno.2024.04.006 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 27, 2024 Category: Cancer & Oncology Authors: Jharna M Patel Catherine E Hermann Whitfield B Growdon Emeline Aviki Marina Stasenko Source Type: research
ChatGPT accurately performs genetic counseling for gynecologic cancers
CONCLUSION: ChatGPT accurately answers questions about genetic syndromes, genetic testing, and counseling in majority of the studied questions. These data suggest this powerful tool can be utilized as a patient resource for genetic counseling questions, though more data input from gynecologic oncologists would be needed to educate patients on genetic syndromes.PMID:38676973 | DOI:10.1016/j.ygyno.2024.04.006 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 27, 2024 Category: Cancer & Oncology Authors: Jharna M Patel Catherine E Hermann Whitfield B Growdon Emeline Aviki Marina Stasenko Source Type: research
ChatGPT accurately performs genetic counseling for gynecologic cancers
CONCLUSION: ChatGPT accurately answers questions about genetic syndromes, genetic testing, and counseling in majority of the studied questions. These data suggest this powerful tool can be utilized as a patient resource for genetic counseling questions, though more data input from gynecologic oncologists would be needed to educate patients on genetic syndromes.PMID:38676973 | DOI:10.1016/j.ygyno.2024.04.006 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 27, 2024 Category: Cancer & Oncology Authors: Jharna M Patel Catherine E Hermann Whitfield B Growdon Emeline Aviki Marina Stasenko Source Type: research
Intermittent energy restriction inhibits tumor growth and enhances paclitaxel response in a transgenic mouse model of endometrial cancer
CONCLUSION: In Lkb1fl/flp53fl/fl mice, IER is generally more effective than LFD in promoting weight loss, inhibiting obesity-related endometrial tumor growth (particularly in combination with paclitaxel), and reversing detrimental obesity-related metabolic effects. These findings lay the foundation for further investigations of IER as an EC prevention and treatment strategies in overweight/obesity women.PMID:38669767 | DOI:10.1016/j.ygyno.2024.04.012 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Ziyi Zhao Jiandong Wang Weimin Kong Ziwei Fang Michael F Coleman Ginger L Milne Wesley C Burkett Meredith A Newton Olivia Lara Douglas Lee Boer Deng Xiaochang Shen Hongyan Suo Wenchuan Sun Stephen D Hursting Chunxiao Zhou Victoria L Bae-Jump Source Type: research
The activity advantage: Objective measurement of preoperative activity is associated with postoperative recovery and outcomes in patients undergoing surgery with gynecologic oncologists
CONCLUSION: Patients with high preoperative activity are associated with fewer postoperative complications and faster attainment of recovery milestones. Physical activity may be considered a modifiable risk factor for adverse postoperative outcomes.PMID:38669768 | DOI:10.1016/j.ygyno.2024.04.015 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Connor C Wang Allison Grubbs Olivia W Foley Sonya Bharadwa Brenda Vega Karl Bilimoria Emma L Barber Source Type: research
