FNA of Meningioma with Rhabdoid Features Presenting as a Lateral Neck Mass
We report a case of meningioma with rhabdoid features and BAP1 loss in a 26-year-old woman, presenting as a large neck mass along the carotid sheath. FNA biopsy of the mass demonstrated a highly cellular specimen with clusters of uniform, epithelioid cells with round to ovoid nuclei and moderate nuclear to cytoplasmic ratio. An extensive immunohistochemical panel performed on cell block sections showed that the tumor cells were weakly EMA positive, progesterone receptor was focally positive, and SSTR2A was diffuse and strongly positive. BAP1 immunohistochemistry showed a diffuse loss of expression in the tumor cells. After...
Source: Head and Neck Pathology - April 24, 2024 Category: Pathology Source Type: research
Molecular Aspects of Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma of the Salivary Gland
ConclusionsMolecular analysis is essential not only to improve the diagnosis and prognosis of the tumors but also to identify novel driver pathways in the precision medicine scenario. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - April 24, 2024 Category: Pathology Source Type: research
Extramammary Paget Disease of Oral Mucosa: Case Report with Literature Review
AbstractExtramammary Paget disease (EPMD) of the oral mucosa is an unusual and extremely rare condition, with fewer than ten cases documented. Here, we report a case of EMPD extensively involving oral mucosa and underlying salivary ducts in a 72-year-old male and review published clinical, histologic, immunophenotypic, and prognostic features of this rare entity. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - April 24, 2024 Category: Pathology Source Type: research
Recurrence of Glandular Odontogenic Cysts: A Systematic Review
ConclusionGOC has an aggressive behavior. Evidence was not conclusive to link any single or combination of histologic features to recurrence, and the strongest correlation for recurrence was the type of treatment. Since this is an uncommon cyst, more cases are needed. Follow-up should continue for at least five years, because recurrences were higher between years 3 and 5. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - April 18, 2024 Category: Pathology Source Type: research
Seven Steps to Financial Health
AbstractPhysicians and dentists have a very limited exposure to personal financial management and yet find themselves in the top 10% of earners in the United States of America. Education loans, practice expenses, and high standards of living obligate them to be good financial stewards to succeed financially. Anecdotal personal experience and review. The article establishes seven steps to implement as medical/dental students, interns, residents, or practicing doctors to move towards financial health and security. The steps include (1) saving enough; (2) good debt management; (3) being tax savvy; (4) obtaining the correct in...
Source: Head and Neck Pathology - April 18, 2024 Category: Pathology Source Type: research
Author Correction: Top IHC/ISH Hacks for and Molecular Surrogates of Poorly Differentiated Sinonasal Small Round Cell Tumors
(Source: Head and Neck Pathology)
Source: Head and Neck Pathology - April 18, 2024 Category: Pathology Source Type: research
Expression Profile of Circulating Exosomal microRNAs in Leukoplakia, Oral Submucous Fibrosis, and Combined Lesions of Leukoplakia and Oral Submucous Fibrosis
ConclusionPlasma circulating exosomal miRNAs miRNA 21, miRNA 145, and miRNA 184 expression could be a novel panel of plasma biomarkers to categorise case group (leukoplakia, OSMF, leukoplakia and OSMF) patients with a high risk of malignant transformation. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 27, 2024 Category: Pathology Source Type: research
Validation of the VisionArray ® Chip Assay for HPV DNA Testing in Histology Specimens of Oropharyngeal Squamous Cell Carcinoma
ConclusionsThe VisionArray ® HPV Chip assay can be recommended for high-risk HPV testing in FFPE tissue samples from OPSCC, providing both a fast and simultaneous genotyping for 41 clinically relevant HPV types. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 27, 2024 Category: Pathology Source Type: research
A Comparison of Clear Cell Sarcoma to Jaw and Salivary Tumors Bearing EWS Fusions
ConclusionGaining a better understanding of the similarities and differences between these three tumors may lead to a better understanding of each one. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 25, 2024 Category: Pathology Source Type: research
Reticular Myxoid Odontogenic Neoplasm with Novel STRN::ALK Fusion: Report of 2 Cases in 3-Year-Old Males
AbstractOdontogenic tumors represent a collection of entities ranging from hamartomas to destructive benign and malignant neoplasms. Occasionally, pathologists encounter gnathic lesions which clearly exhibit an odontogenic origin but do not fit within the confines of established diagnoses. Here, we describe two such odontogenic tumors, both affecting 3-year-old males. Each case presented as a destructive, radiolucent mandibular lesion composed of mesenchymal cells, some with unique multi-lobed nuclei, frequently arranged in a reticular pattern and supported by a myxoid stroma with focal laminations. Production of odontogen...
Source: Head and Neck Pathology - March 25, 2024 Category: Pathology Source Type: research
Proceedings of the 2024 North American Society of Head and Neck Pathology Companion Meeting, Baltimore, MD, March 24, 2024: Navigating Ancillary Studies in Basaloid/Blue Salivary Tumors
ConclusionsAlthough reported variability in their performance has perhaps limited their widespread adoption, these immunohistochemical studies can nevertheless be useful in supporting pathologic diagnoses, particularly when considered in more specific differentials or when used as a panel with other markers. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 25, 2024 Category: Pathology Source Type: research
Oncocytoid Salivary Tumors: Differential Diagnosis and Utility of Newly Described Immunohistochemistry
ConclusionOncocytoid salivary tumors may have overlapping morphologies, posing diagnostic challenges for pathologists. Recently described immunohistochemical markers may offer valuable tools for diagnosing and potentially guiding treatment options for these tumors. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 19, 2024 Category: Pathology Source Type: research
Xanthoma of the Jaw Bones: Cases Series and Review of Literature
ConclusionXJB is a rare lesion of unknown etiology, which may mimic other benign or reactive jaw lesions. Due to its rarity and the potential diagnostic challenges it presents, clinicians must remain vigilant and consider CXJ in their differential when assessing radiolucent jaw anomalies. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 19, 2024 Category: Pathology Source Type: research
Ten Ways to Improve Getting a Scientific Manuscript Accepted
ConclusionA discussion of relevant components in manuscript writing and journal submission to improve your chances of acceptance. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 19, 2024 Category: Pathology Source Type: research
BRAF p.V600E Mutational Status Does Not Correlate with Biological Behavior in Conventional Ameloblastomas: A Disease-Free Survival Analysis
ConclusionBRAF p.V600E mutation emerges as a prevalent molecular aberration in ameloblastomas. Nevertheless, it does not seem to significantly affect the tumor proliferative activity, CD138/syndecan-1-mediated cell adhesion, or disease-free survival outcomes. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 19, 2024 Category: Pathology Source Type: research
