Biophysics-inspired spike rate adaptation for computationally efficient phenomenological nerve modeling
This study introduces and evaluates the PHAST+ model, part of a computational framework designed to simulate the behavior of auditory nerve fibers in response to the electrical stimulation from a cochlear implant. PHAST+ incorporates a highly efficient method for calculating accommodation and adaptation, making it particularly suited for simulations over extended stimulus durations. The proposed method uses a leaky integrator inspired by classic biophysical nerve models. Through evaluation against single-fiber animal data, our findings demonstrate the model's effectiveness across various stimuli, including short pulse trai...
Source: Hearing Research - May 1, 2024 Category: Audiology Authors: Jacob de Nobel Savine S M Martens Jeroen J Briaire Thomas H W B äck Anna V Kononova Johan H M Frijns Source Type: research
Biophysics-inspired spike rate adaptation for computationally efficient phenomenological nerve modeling
This study introduces and evaluates the PHAST+ model, part of a computational framework designed to simulate the behavior of auditory nerve fibers in response to the electrical stimulation from a cochlear implant. PHAST+ incorporates a highly efficient method for calculating accommodation and adaptation, making it particularly suited for simulations over extended stimulus durations. The proposed method uses a leaky integrator inspired by classic biophysical nerve models. Through evaluation against single-fiber animal data, our findings demonstrate the model's effectiveness across various stimuli, including short pulse trai...
Source: Hearing Research - May 1, 2024 Category: Audiology Authors: Jacob de Nobel Savine S M Martens Jeroen J Briaire Thomas H W B äck Anna V Kononova Johan H M Frijns Source Type: research
Biophysics-inspired spike rate adaptation for computationally efficient phenomenological nerve modeling
This study introduces and evaluates the PHAST+ model, part of a computational framework designed to simulate the behavior of auditory nerve fibers in response to the electrical stimulation from a cochlear implant. PHAST+ incorporates a highly efficient method for calculating accommodation and adaptation, making it particularly suited for simulations over extended stimulus durations. The proposed method uses a leaky integrator inspired by classic biophysical nerve models. Through evaluation against single-fiber animal data, our findings demonstrate the model's effectiveness across various stimuli, including short pulse trai...
Source: Hearing Research - May 1, 2024 Category: Audiology Authors: Jacob de Nobel Savine S M Martens Jeroen J Briaire Thomas H W B äck Anna V Kononova Johan H M Frijns Source Type: research
Motor, somatosensory, and executive cortical areas elicit monosynaptic and polysynaptic neuronal activity in the auditory midbrain
Hear Res. 2024 Apr 16;447:109009. doi: 10.1016/j.heares.2024.109009. Online ahead of print.ABSTRACTWe recently reported that the central nucleus of the inferior colliculus (the auditory midbrain) is innervated by glutamatergic pyramidal cells originating not only in auditory cortex (AC), but also in multiple 'non-auditory' regions of the cerebral cortex. Here, in anaesthetised rats, we used optogenetics and electrical stimulation, combined with recording in the inferior colliculus to determine the functional influence of these descending connections. Specifically, we determined the extent of monosynaptic excitation and the...
Source: Hearing Research - April 26, 2024 Category: Audiology Authors: Sarah E Gartside Bas Mj Olthof Adrian Rees Source Type: research
Motor, somatosensory, and executive cortical areas elicit monosynaptic and polysynaptic neuronal activity in the auditory midbrain
Hear Res. 2024 Apr 16;447:109009. doi: 10.1016/j.heares.2024.109009. Online ahead of print.ABSTRACTWe recently reported that the central nucleus of the inferior colliculus (the auditory midbrain) is innervated by glutamatergic pyramidal cells originating not only in auditory cortex (AC), but also in multiple 'non-auditory' regions of the cerebral cortex. Here, in anaesthetised rats, we used optogenetics and electrical stimulation, combined with recording in the inferior colliculus to determine the functional influence of these descending connections. Specifically, we determined the extent of monosynaptic excitation and the...
Source: Hearing Research - April 26, 2024 Category: Audiology Authors: Sarah E Gartside Bas Mj Olthof Adrian Rees Source Type: research
Motor, somatosensory, and executive cortical areas elicit monosynaptic and polysynaptic neuronal activity in the auditory midbrain
Hear Res. 2024 Apr 16;447:109009. doi: 10.1016/j.heares.2024.109009. Online ahead of print.ABSTRACTWe recently reported that the central nucleus of the inferior colliculus (the auditory midbrain) is innervated by glutamatergic pyramidal cells originating not only in auditory cortex (AC), but also in multiple 'non-auditory' regions of the cerebral cortex. Here, in anaesthetised rats, we used optogenetics and electrical stimulation, combined with recording in the inferior colliculus to determine the functional influence of these descending connections. Specifically, we determined the extent of monosynaptic excitation and the...
Source: Hearing Research - April 26, 2024 Category: Audiology Authors: Sarah E Gartside Bas Mj Olthof Adrian Rees Source Type: research
Motor, somatosensory, and executive cortical areas elicit monosynaptic and polysynaptic neuronal activity in the auditory midbrain
Hear Res. 2024 Apr 16;447:109009. doi: 10.1016/j.heares.2024.109009. Online ahead of print.ABSTRACTWe recently reported that the central nucleus of the inferior colliculus (the auditory midbrain) is innervated by glutamatergic pyramidal cells originating not only in auditory cortex (AC), but also in multiple 'non-auditory' regions of the cerebral cortex. Here, in anaesthetised rats, we used optogenetics and electrical stimulation, combined with recording in the inferior colliculus to determine the functional influence of these descending connections. Specifically, we determined the extent of monosynaptic excitation and the...
Source: Hearing Research - April 26, 2024 Category: Audiology Authors: Sarah E Gartside Bas Mj Olthof Adrian Rees Source Type: research
Surface electrical stimulation of the auditory cortex preserves efferent medial olivocochlear neurons and reduces cochlear traits of age-related hearing loss
Hear Res. 2024 Apr 12;447:109008. doi: 10.1016/j.heares.2024.109008. Online ahead of print.ABSTRACTThe auditory cortex is the source of descending connections providing contextual feedback for auditory signal processing at almost all levels of the lemniscal auditory pathway. Such feedback is essential for cognitive processing. It is likely that corticofugal pathways are degraded with aging, becoming important players in age-related hearing loss and, by extension, in cognitive decline. We are testing the hypothesis that surface, epidural stimulation of the auditory cortex during aging may regulate the activity of corticofug...
Source: Hearing Research - April 18, 2024 Category: Audiology Authors: V Fuentes-Santamar ía Z Ben ítez-Maicán J C Alvarado I S Fern ández Del Campo M C Gabald ón-Ull M A Merch án J M Juiz Source Type: research
Surface electrical stimulation of the auditory cortex preserves efferent medial olivocochlear neurons and reduces cochlear traits of age-related hearing loss
Hear Res. 2024 Apr 12;447:109008. doi: 10.1016/j.heares.2024.109008. Online ahead of print.ABSTRACTThe auditory cortex is the source of descending connections providing contextual feedback for auditory signal processing at almost all levels of the lemniscal auditory pathway. Such feedback is essential for cognitive processing. It is likely that corticofugal pathways are degraded with aging, becoming important players in age-related hearing loss and, by extension, in cognitive decline. We are testing the hypothesis that surface, epidural stimulation of the auditory cortex during aging may regulate the activity of corticofug...
Source: Hearing Research - April 18, 2024 Category: Audiology Authors: V Fuentes-Santamar ía Z Ben ítez-Maicán J C Alvarado I S Fern ández Del Campo M C Gabald ón-Ull M A Merch án J M Juiz Source Type: research
Surface electrical stimulation of the auditory cortex preserves efferent medial olivocochlear neurons and reduces cochlear traits of age-related hearing loss
Hear Res. 2024 Apr 12;447:109008. doi: 10.1016/j.heares.2024.109008. Online ahead of print.ABSTRACTThe auditory cortex is the source of descending connections providing contextual feedback for auditory signal processing at almost all levels of the lemniscal auditory pathway. Such feedback is essential for cognitive processing. It is likely that corticofugal pathways are degraded with aging, becoming important players in age-related hearing loss and, by extension, in cognitive decline. We are testing the hypothesis that surface, epidural stimulation of the auditory cortex during aging may regulate the activity of corticofug...
Source: Hearing Research - April 18, 2024 Category: Audiology Authors: V Fuentes-Santamar ía Z Ben ítez-Maicán J C Alvarado I S Fern ández Del Campo M C Gabald ón-Ull M A Merch án J M Juiz Source Type: research
Surface electrical stimulation of the auditory cortex preserves efferent medial olivocochlear neurons and reduces cochlear traits of age-related hearing loss
Hear Res. 2024 Apr 12;447:109008. doi: 10.1016/j.heares.2024.109008. Online ahead of print.ABSTRACTThe auditory cortex is the source of descending connections providing contextual feedback for auditory signal processing at almost all levels of the lemniscal auditory pathway. Such feedback is essential for cognitive processing. It is likely that corticofugal pathways are degraded with aging, becoming important players in age-related hearing loss and, by extension, in cognitive decline. We are testing the hypothesis that surface, epidural stimulation of the auditory cortex during aging may regulate the activity of corticofug...
Source: Hearing Research - April 18, 2024 Category: Audiology Authors: V Fuentes-Santamar ía Z Ben ítez-Maicán J C Alvarado I S Fern ández Del Campo M C Gabald ón-Ull M A Merch án J M Juiz Source Type: research
Two are better than one: Differences in cortical EEG patterns during auditory and visual verbal working memory processing between Unilateral and Bilateral Cochlear Implanted children
The objective of this pioneering study was to identify electroencephalographic (EEG) marker pattern differences in visual and auditory VWM performances in CIs compared to NH peers and possible differences between unilateral cochlear implant (UCI) and bilateral cochlear implant (BCI) users. The main results revealed differences in theta and gamma EEG bands. Compared with hearing controls and BCIs, UCIs showed hypoactivation of theta in the frontal area during the most complex condition of the auditory task and a correlation of the same activation with VWM performance. Hypoactivation in theta was also observed, again for UCI...
Source: Hearing Research - April 12, 2024 Category: Audiology Authors: Bianca Maria Serena Inguscio Giulia Cartocci Nicolina Sciaraffa Maria Nicastri Ilaria Giallini Pietro Aric ò Antonio Greco Fabio Babiloni Patrizia Mancini Source Type: research
L-Ergothioneine slows the progression of age-related hearing loss in CBA/CaJ mice
Hear Res. 2024 Apr 2;446:109004. doi: 10.1016/j.heares.2024.109004. Online ahead of print.ABSTRACTThe naturally occurring amino acid, l-ergothioneine (EGT), has immense potential as a therapeutic, having shown promise in the treatment of other disease models, including neurological disorders. EGT is naturally uptaken into cells via its specific receptor, OCTN1, to be utilized by cells as an antioxidant and anti-inflammatory. In our current study, EGT was administered over a period of 6 months to 25-26-month-old CBA/CaJ mice as a possible treatment for age-related hearing loss (ARHL), since presbycusis has been linked to hi...
Source: Hearing Research - April 12, 2024 Category: Audiology Authors: Mark A Bauer Parveen Bazard Alejandro A Acosta Nidhi Bangalore Lina Elessaway Mark Thivierge Moksheta Chellani Xiaoxia Zhu Bo Ding Joseph P Walton Robert D Frisina Source Type: research
Two are better than one: Differences in cortical EEG patterns during auditory and visual verbal working memory processing between Unilateral and Bilateral Cochlear Implanted children
The objective of this pioneering study was to identify electroencephalographic (EEG) marker pattern differences in visual and auditory VWM performances in CIs compared to NH peers and possible differences between unilateral cochlear implant (UCI) and bilateral cochlear implant (BCI) users. The main results revealed differences in theta and gamma EEG bands. Compared with hearing controls and BCIs, UCIs showed hypoactivation of theta in the frontal area during the most complex condition of the auditory task and a correlation of the same activation with VWM performance. Hypoactivation in theta was also observed, again for UCI...
Source: Hearing Research - April 12, 2024 Category: Audiology Authors: Bianca Maria Serena Inguscio Giulia Cartocci Nicolina Sciaraffa Maria Nicastri Ilaria Giallini Pietro Aric ò Antonio Greco Fabio Babiloni Patrizia Mancini Source Type: research
L-Ergothioneine slows the progression of age-related hearing loss in CBA/CaJ mice
Hear Res. 2024 Apr 2;446:109004. doi: 10.1016/j.heares.2024.109004. Online ahead of print.ABSTRACTThe naturally occurring amino acid, l-ergothioneine (EGT), has immense potential as a therapeutic, having shown promise in the treatment of other disease models, including neurological disorders. EGT is naturally uptaken into cells via its specific receptor, OCTN1, to be utilized by cells as an antioxidant and anti-inflammatory. In our current study, EGT was administered over a period of 6 months to 25-26-month-old CBA/CaJ mice as a possible treatment for age-related hearing loss (ARHL), since presbycusis has been linked to hi...
Source: Hearing Research - April 12, 2024 Category: Audiology Authors: Mark A Bauer Parveen Bazard Alejandro A Acosta Nidhi Bangalore Lina Elessaway Mark Thivierge Moksheta Chellani Xiaoxia Zhu Bo Ding Joseph P Walton Robert D Frisina Source Type: research
