Higher infection risk for JAK inhibitors tofacitinib and baricitinib compared to subcutaneous biological DMARDs
CONCLUSION: In comparison to bDMARDs, JAKi are associated with a slightly higher infection risk and a higher risk of herpes zoster specifically. In older patients, infection IRs are higher but similar infection risks for JAKi and bDMARDs are observed. No differences in infection risk between tofacitinib and baricitinib were found. Key Points • Compared to bDMARDs, JAKi are associated with a slightly higher infection risk for all ages • An increased risk of herpes zoster in patients who use JAK inhibitors was confirmed • No significant differences in infection incidence were found between tofacitinib and baricitinib.P...
Source: Herpes - May 4, 2024 Category: Infectious Diseases Authors: M A A Opdam N den Broeder B J F van den Bemt K Mulder K M van de Wiel H van Ballegooijen R van Crevel A A den Broeder Source Type: research
Determinants of uptake of influenza, zoster and pneumococcal vaccines in patients with cardiovascular diseases
CONCLUSION: Influenza, pneumococcal and zoster vaccine uptake among cardiac patients was low. Encouraging physician recommendations for vaccination for cardiac patients under 65 years of age and addressing vaccination challenges among people from culturally and linguistically diverse backgrounds and pharmacy, workplace, and hospital vaccination may help increase vaccination uptake among cardiac patients.PMID:38704255 | DOI:10.1016/j.vaccine.2024.04.031 (Source: Herpes)
Source: Herpes - May 4, 2024 Category: Infectious Diseases Authors: Elizabeth Benedict Kpozehouen C Raina Macintyre Timothy C Tan Source Type: research
Herpes zoster in older adults: Impact on carbon footprint in the United States
Hum Vaccin Immunother. 2024 Dec 31;20(1):2335722. doi: 10.1080/21645515.2024.2335722. Epub 2024 May 3.ABSTRACTWe provide estimates for (I) annual herpes zoster (HZ) cases, (II) carbon costs related to healthcare utilization, and (III) annual carbon emissions due to HZ among ≥50 years of age (YOA) United States (US) population. We estimated the annual number of HZ cases in the US based on available incidence data and demographic data of individuals ≥50 YOA. Both the healthcare resource utilization (HCRU) associated with HZ cases and the unit carbon dioxide equivalent (i.e. CO2e) costs associated with each type of HCRU i...
Source: Herpes - May 3, 2024 Category: Infectious Diseases Authors: Desmond Curran Jacopo Bitetti Imogen Catterall Stephen Wincott Source Type: research
Prevalence and clinical markers of herpes simplex virus infection in oral lesions of bullous pemphigoid
CONCLUSION: HSV infection is common in BP oral lesions. The inconsistent activity between oral and skin lesions, absence of blister in oral lesions, pain for oral lesions, higher currently used glucocorticoid dosage, and higher 2-week AGC dosage in BP patients should alert physicians to HSV infection in oral lesions and treat them with 2-week famciclovir in time.PMID:38698862 | PMC:PMC11063318 | DOI:10.3389/fimmu.2024.1387503 (Source: Herpes)
Source: Herpes - May 3, 2024 Category: Infectious Diseases Authors: Hanmei Zhang Meiwen Yu Guirong Liang Suo Li Chenjing Zhao Ke Jing Suying Feng Source Type: research
Etrasimod for the Treatment of Ulcerative Colitis: Analysis of Infection Events From the ELEVATE UC Clinical Program
CONCLUSIONS: Patients receiving etrasimod demonstrated no increased risk of infection. The incidence of serious infections and herpes zoster was similar in each group. Among patients receiving etrasimod, no association between ALC <0.5 × 109/L and infection events was observed. Longer-term follow-up will further characterize the etrasimod safety profile.PMID:38700040 | DOI:10.1093/ecco-jcc/jjae060 (Source: Herpes)
Source: Herpes - May 3, 2024 Category: Infectious Diseases Authors: Miguel Regueiro Britta Siegmund Andres J Yarur Flavio Steinwurz Krisztina B Gecse Martina Goetsch Abhishek Bhattacharjee Joseph Wu Jesse Green Aoibhinn McDonnell Catherine Crosby Krisztina Lazin Diogo Branquinho Irene Modesto Maria T Abreu Source Type: research
Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients
CONCLUSIONS: Prophylaxis with antiviral medications reduces CMV disease and CMV-associated death, compared with placebo or no treatment, in solid organ transplant recipients. These data support the continued routine use of antiviral prophylaxis in CMV-positive recipients and CMV-negative recipients of CMV-positive organ transplants.PMID:38700045 | DOI:10.1002/14651858.CD003774.pub5 (Source: Herpes)
Source: Herpes - May 3, 2024 Category: Infectious Diseases Authors: Robin Wm Vernooij Mini Michael Maleeka Ladhani Angela C Webster Giovanni Fm Strippoli Jonathan C Craig Elisabeth M Hodson Source Type: research
Clinical characteristics of viral-associated Fuchs uveitis syndrome and Posner-Schlossman syndrome in a Chinese population
CONCLUSION: Our study identified 4 types of viral infection in FUS and 2 types of viral infection in PSS. Virus-associated patients are usually associated with more obvious clinical signs and poor visual prognosis.PMID:38700591 | DOI:10.1007/s00417-024-06502-0 (Source: Herpes)
Source: Herpes - May 3, 2024 Category: Infectious Diseases Authors: Hui Liu Yuxian Lai Yaning Liu Guannan Su Peizeng Yang Source Type: research
Etiological Diagnosis and Treatment Value of mNGS in Alveolar Lavage Fluid of Children with Severe Pneumonia
CONCLUSION: mNGS is a promising technique for detecting co-pathogens in mixed pediatric lung infections, with potential benefits in terms of speed and sensitivity.PMID:38702151 (Source: Herpes)
Source: Herpes - May 3, 2024 Category: Infectious Diseases Authors: Wei Chen Haoquan Zhou Source Type: research
Herpes zoster in older adults: Impact on carbon footprint in the United States
Hum Vaccin Immunother. 2024 Dec 31;20(1):2335722. doi: 10.1080/21645515.2024.2335722. Epub 2024 May 3.ABSTRACTWe provide estimates for (I) annual herpes zoster (HZ) cases, (II) carbon costs related to healthcare utilization, and (III) annual carbon emissions due to HZ among ≥50 years of age (YOA) United States (US) population. We estimated the annual number of HZ cases in the US based on available incidence data and demographic data of individuals ≥50 YOA. Both the healthcare resource utilization (HCRU) associated with HZ cases and the unit carbon dioxide equivalent (i.e. CO2e) costs associated with each type of HCRU i...
Source: Herpes - May 3, 2024 Category: Infectious Diseases Authors: Desmond Curran Jacopo Bitetti Imogen Catterall Stephen Wincott Source Type: research
Prevalence and clinical markers of herpes simplex virus infection in oral lesions of bullous pemphigoid
CONCLUSION: HSV infection is common in BP oral lesions. The inconsistent activity between oral and skin lesions, absence of blister in oral lesions, pain for oral lesions, higher currently used glucocorticoid dosage, and higher 2-week AGC dosage in BP patients should alert physicians to HSV infection in oral lesions and treat them with 2-week famciclovir in time.PMID:38698862 | PMC:PMC11063318 | DOI:10.3389/fimmu.2024.1387503 (Source: Herpes)
Source: Herpes - May 3, 2024 Category: Infectious Diseases Authors: Hanmei Zhang Meiwen Yu Guirong Liang Suo Li Chenjing Zhao Ke Jing Suying Feng Source Type: research
Etrasimod for the Treatment of Ulcerative Colitis: Analysis of Infection Events From the ELEVATE UC Clinical Program
CONCLUSIONS: Patients receiving etrasimod demonstrated no increased risk of infection. The incidence of serious infections and herpes zoster was similar in each group. Among patients receiving etrasimod, no association between ALC <0.5 × 109/L and infection events was observed. Longer-term follow-up will further characterize the etrasimod safety profile.PMID:38700040 | DOI:10.1093/ecco-jcc/jjae060 (Source: Herpes)
Source: Herpes - May 3, 2024 Category: Infectious Diseases Authors: Miguel Regueiro Britta Siegmund Andres J Yarur Flavio Steinwurz Krisztina B Gecse Martina Goetsch Abhishek Bhattacharjee Joseph Wu Jesse Green Aoibhinn McDonnell Catherine Crosby Krisztina Lazin Diogo Branquinho Irene Modesto Maria T Abreu Source Type: research
Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients
CONCLUSIONS: Prophylaxis with antiviral medications reduces CMV disease and CMV-associated death, compared with placebo or no treatment, in solid organ transplant recipients. These data support the continued routine use of antiviral prophylaxis in CMV-positive recipients and CMV-negative recipients of CMV-positive organ transplants.PMID:38700045 | DOI:10.1002/14651858.CD003774.pub5 (Source: Herpes)
Source: Herpes - May 3, 2024 Category: Infectious Diseases Authors: Robin Wm Vernooij Mini Michael Maleeka Ladhani Angela C Webster Giovanni Fm Strippoli Jonathan C Craig Elisabeth M Hodson Source Type: research
Clinical characteristics of viral-associated Fuchs uveitis syndrome and Posner-Schlossman syndrome in a Chinese population
CONCLUSION: Our study identified 4 types of viral infection in FUS and 2 types of viral infection in PSS. Virus-associated patients are usually associated with more obvious clinical signs and poor visual prognosis.PMID:38700591 | DOI:10.1007/s00417-024-06502-0 (Source: Herpes)
Source: Herpes - May 3, 2024 Category: Infectious Diseases Authors: Hui Liu Yuxian Lai Yaning Liu Guannan Su Peizeng Yang Source Type: research
The heterogeneous sensitivity of pediatric brain tumors to different oncolytic viruses is predicted by unique gene expression profiles
Mol Ther Oncol. 2024 Apr 15;32(2):200804. doi: 10.1016/j.omton.2024.200804. eCollection 2024 Jun 20.ABSTRACTDespite decades of research, the prognosis of high-grade pediatric brain tumors (PBTs) remains dismal; however, recent cases of favorable clinical responses were documented in clinical trials using oncolytic viruses (OVs). In the current study, we employed four different species of OVs: adenovirus Delta24-RGD, herpes simplex virus rQNestin34.5v1, reovirus R124, and the non-virulent Newcastle disease virus rNDV-F0-GFP against three entities of PBTs (high-grade gliomas, atypical teratoid/rhabdoid tumors, and ependymoma...
Source: Herpes - May 2, 2024 Category: Infectious Diseases Authors: Konstantinos Vazaios Εftychia Stavrakaki Lisette B Vogelezang Jie Ju Piotr Waranecki Dennis S Metselaar Micha ël H Meel Vera Kemp Bernadette G van den Hoogen Rob C Hoeben E Antonio Chiocca William F Goins Andrew Stubbs Yunlei Li Marta M Alonso Friso G C Source Type: research
Utilization of a Meningitis/Encephalitis PCR panel at the University Hospital Basel - a retrospective study to develop a diagnostic decision rule
CONCLUSION: The ME panel positivity rate at our institution was similar as previously published. Our results highlight the need for diagnostic-stewardship interventions when utilizing this assay by implementing a stepwise approach based on a limited number of clinical and laboratory features. This decision rule may improve the pretest probability of a positive test result, increase the quality of test utilization, and reduce costs.PMID:38695026 | PMC:PMC11061443 | DOI:10.3389/fmed.2024.1351903 (Source: Herpes)
Source: Herpes - May 2, 2024 Category: Infectious Diseases Authors: Andrea Erba Fabian C Franzeck Vladimira Hinic Adrian Egli Michael Osthoff Source Type: research
