Drug resistance in breast cancer is based on the mechanism of exocrine non-coding RNA
AbstractBreast cancer (BC) ranks first among female malignant tumors and involves hormonal changes and genetic as well as environmental risk factors. In recent years, with the improvement of medical treatment, a variety of therapeutic approaches for breast cancer have emerged and have strengthened to accommodate molecular diversity. However, the primary way to improve the effective treatment of breast cancer patients is to overcome treatment resistance. Recent studies have provided insights into the mechanisms of resistance to exosome effects in BC. Exosomes are membrane-bound vesicles secreted by both healthy and malignan...
Source: Hormones and Cancer - May 1, 2024 Category: Cancer & Oncology Source Type: research
Pan-cancer analysis of prognostic and immunological role of IL4I1 in human tumors: a bulk omics research and single cell sequencing validation
ConclusionIL4I1 may play a role as promoter of cancer and prognostic indicator in patients. High expression of IL4I1 is associated with the state of tumor immunosuppression and may contribute to tumor-associated macrophage invasion. Therefore, IL4I1 may be a new therapeutic target for the treatment and prognosis of patients with cancer. (Source: Hormones and Cancer)
Source: Hormones and Cancer - May 1, 2024 Category: Cancer & Oncology Source Type: research
The application of plant-exosome-like nanovesicles as improved drug delivery systems for cancer vaccines
AbstractThe use of cancer immunotherapeutics is currently increasing. Cancer vaccines, as a form of immunotherapy, are gaining much attention in the medical community since specific tumor-antigens can activate immune cells to induce an anti-tumor immune response. However, the delivery of cancer vaccines presents many issues for research scientists when designing cancer treatments and requires further investigation. Nanoparticles, synthetic liposomes, bacterial vectors, viral particles, and mammalian exosomes have delivered cancer vaccines. In contrast, the use of many of these nanotechnologies produces many issues of cytot...
Source: Hormones and Cancer - April 29, 2024 Category: Cancer & Oncology Source Type: research
Overexpression of SYNGAP1 suppresses the proliferation of rectal adenocarcinoma via Wnt/ β-Catenin signaling pathway
This study aimed to explore the expression and function of Ras GTPase-activating proteins in READ. In this study, we analyzed RNA sequencing data from 165 patients with READ and 789 normal tissue samples, identifying 5603 differentially expressed genes (DEGs), including 2937 upregulated genes and 2666 downregulated genes. Moreover, we also identified two dysregulated genes, RASA4 and SYNGAP1, among six Ras GTPase-activating proteins. High NF1 expression was associated with longer overall survival, while high SYNGAP1 expression showed a trend towards extended overall survival. Further analysis revealed the mutation frequenc...
Source: Hormones and Cancer - April 29, 2024 Category: Cancer & Oncology Source Type: research
The S100 family is a prognostic biomarker and correlated with immune cell infiltration in pan-cancer
ConclusionOur analysis demonstrated the role of S100 family in formation of TME diversity and complexity, enabling deeper cognition of TME infiltration characterization and the development of personalized immunotherapy strategies targeting S100 family for unique tumor types. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 29, 2024 Category: Cancer & Oncology Source Type: research
Anlotinib inhibits growth of human esophageal cancer TE-1 cells by negative regulating PI3K/Akt signaling pathway
This study aims to investigate its impact on esophageal cancer and the underlying mechanisms. Anlotiniband 5-fluorouracil + cisplatin (5-FU + DDP) was administered separately to human esophageal cancer TE- 1 cells tumor xenograft mouse models every 3 days. Tumor size and body weight were measured before each treatment and at the end of the experiment. In vitro studies were conducted using TE- 1 cells to exami ne the effects of Anlotinib. Cell viability, migration, proliferation, apoptosis, cell cycle, their regulatory proteins and the transcriptomic changes were analyzed. Anlotinib reduced tumor size, tumor weigh...
Source: Hormones and Cancer - April 27, 2024 Category: Cancer & Oncology Source Type: research
Stratification and prognostic evaluation of breast cancer subtypes defined by obesity-associated genes
Conclusion7 hub genes serve as excellent independent biomarkers for molecular diagnosis, and the neural network diagnostic model can accurately distinguish BRCA patients. In addition, based on the expression levels of these seven genes in BRCA patients, two subtypes can be reliably identified: BRCA subtype 1 and BRCA subtype 2, and these two subtypes showed significant differences in BRCA patient survival prognosis, proportion of immune cells, and expression levels of immune cells. Among them, patients with subtype 1 of BRCA had a poor prognosis. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 27, 2024 Category: Cancer & Oncology Source Type: research
AKR1B10 accelerates glycolysis through binding HK2 to promote the malignant progression of oral squamous cell carcinoma
ConclusionTo sum up, AKR1B10 could bind to HK2 to accelerate glycolysis, thereby facilitating the proliferation, migration, invasion and EMT of OSCC cells. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 26, 2024 Category: Cancer & Oncology Source Type: research
Comprehensive analysis and prognostic assessment of senescence-associated genes in bladder cancer
ConclusionsIn summation, our research emphasizes the prospective utility of risk assessments rooted in senescence-related gene signatures for enhancing BLCA clinical oversight. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 26, 2024 Category: Cancer & Oncology Source Type: research
An endothelial-related prognostic index for bladder cancer patients
ConclusionWe have effectively discerned pivotal genes from the endothelial cell perspective and constructed an EPI for BC patients, thereby offering promising prospects for precision medicine. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 25, 2024 Category: Cancer & Oncology Source Type: research
Case report: Mutation evolution in a patient with TdT positive high grade B cell lymphoma with MYC and BCL2 rearrangements following the treatment of concurrent follicular lymphoma and diffuse large B-cell lymphoma
ConclusionThis study reports a rare case of TdT positive “double hit” HGBL following the treatment of concurrent FL/DLBCL and highlights the mutation characteristics. Collectively, this study will help enrich the knowledge of TdT positive “double hit” HGBL transformed from FL/DLBCL. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 25, 2024 Category: Cancer & Oncology Source Type: research
Survival among treated tongue cancer patients: a single-center experience
ConclusionsIn tongue cancer patients, overall and specific survival were reduced in the presence of infiltrated resection margins. Lymphadenectomy in turn improved survival compared with patients in which this procedure was not carried out. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 23, 2024 Category: Cancer & Oncology Source Type: research
Comparison of clinicopathological and prognostic features of breast cancer patients younger than 40 years and older than 65 years
ConclusionTo our knowledge, no study directly compares these two groups. In our study, similar to many studies, more aggressive tumor features were found in young patients, but unlike many studies, mortality was found to be significantly higher in older patients. The presence of metastasis and poor ECOG PS were found to be the most influential factors in breast cancer-specific death risk. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 22, 2024 Category: Cancer & Oncology Source Type: research
HBO regulates the Warburg effect of hypoxic HCC cells through miR-103a-3p/TRIM35
ConclusionThese findings reveal that HBO regulates the Warburg effect of hypoxic HCC cells through miR-103a-3p/TRIM35 and inhibits tumor growth. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 20, 2024 Category: Cancer & Oncology Source Type: research
SLC35A2 expression is associated with HER2 expression in breast cancer
This study aimed to investigate the expression of SLC35A2 and clinicopathological variables in breast cancer patients. Immunohistochemical analysis of SLC35A2 protein was conductedon 40 adjacent non-neoplastic tissues and 320 breast cancer tissues. The study also assesed the association between SLC35A2 expression and breast cancer clinicopathological features of breast cancer, as well as its impact on overall survival. In comparison to adjacent non-neoplastic tissues, a significantly higher expression of SLC35A2 was observed in breast cancer tissues (P = 0.020), and this expression was found to be independently correla...
Source: Hormones and Cancer - April 19, 2024 Category: Cancer & Oncology Source Type: research
