Low-risk delisting strategy in highly sensitized patients without donor offers included in exchange donation programs. One single-center experience
Hum Immunol. 2024 Apr 24:110806. doi: 10.1016/j.humimm.2024.110806. Online ahead of print.ABSTRACTDonor exchange programs were designed to allocate organs for highly sensitized (HS) patients. The allocation algorithm differs slightly among countries and includes different strategies to improve access to transplants in HS patients. However, many HS patients with a calculated panel reactive of antibodies (cPRA) of 100 % remain on the waiting list for a long time. Some allocation algorithms assume immunological risk, including Imlifidase treatment, to increase the chance of transplantation in very HS patients. Here, we descri...
Source: Human Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Alejandra Comins-Boo Juan Irure-Ventura Maria O Valentin Lara Belmar-Vega Covadonga L ópez Del Moral Cuesta Rosal ía Valero San Cecilio Emilio Rodrigo Calabia M ónica Renuncio-García Carolina Castro Hern ández Dzmitry Mikhalkovich Nerea Mota P érez Source Type: research
Low-risk delisting strategy in highly sensitized patients without donor offers included in exchange donation programs. One single-center experience
Hum Immunol. 2024 Apr 24:110806. doi: 10.1016/j.humimm.2024.110806. Online ahead of print.ABSTRACTDonor exchange programs were designed to allocate organs for highly sensitized (HS) patients. The allocation algorithm differs slightly among countries and includes different strategies to improve access to transplants in HS patients. However, many HS patients with a calculated panel reactive of antibodies (cPRA) of 100 % remain on the waiting list for a long time. Some allocation algorithms assume immunological risk, including Imlifidase treatment, to increase the chance of transplantation in very HS patients. Here, we descri...
Source: Human Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Alejandra Comins-Boo Juan Irure-Ventura Maria O Valentin Lara Belmar-Vega Covadonga L ópez Del Moral Cuesta Rosal ía Valero San Cecilio Emilio Rodrigo Calabia M ónica Renuncio-García Carolina Castro Hern ández Dzmitry Mikhalkovich Nerea Mota P érez Source Type: research
Low-risk delisting strategy in highly sensitized patients without donor offers included in exchange donation programs. One single-center experience
Hum Immunol. 2024 Apr 24:110806. doi: 10.1016/j.humimm.2024.110806. Online ahead of print.ABSTRACTDonor exchange programs were designed to allocate organs for highly sensitized (HS) patients. The allocation algorithm differs slightly among countries and includes different strategies to improve access to transplants in HS patients. However, many HS patients with a calculated panel reactive of antibodies (cPRA) of 100 % remain on the waiting list for a long time. Some allocation algorithms assume immunological risk, including Imlifidase treatment, to increase the chance of transplantation in very HS patients. Here, we descri...
Source: Human Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Alejandra Comins-Boo Juan Irure-Ventura Maria O Valentin Lara Belmar-Vega Covadonga L ópez Del Moral Cuesta Rosal ía Valero San Cecilio Emilio Rodrigo Calabia M ónica Renuncio-García Carolina Castro Hern ández Dzmitry Mikhalkovich Nerea Mota P érez Source Type: research
Low-risk delisting strategy in highly sensitized patients without donor offers included in exchange donation programs. One single-center experience
Hum Immunol. 2024 Apr 24:110806. doi: 10.1016/j.humimm.2024.110806. Online ahead of print.ABSTRACTDonor exchange programs were designed to allocate organs for highly sensitized (HS) patients. The allocation algorithm differs slightly among countries and includes different strategies to improve access to transplants in HS patients. However, many HS patients with a calculated panel reactive of antibodies (cPRA) of 100 % remain on the waiting list for a long time. Some allocation algorithms assume immunological risk, including Imlifidase treatment, to increase the chance of transplantation in very HS patients. Here, we descri...
Source: Human Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Alejandra Comins-Boo Juan Irure-Ventura Maria O Valentin Lara Belmar-Vega Covadonga L ópez Del Moral Cuesta Rosal ía Valero San Cecilio Emilio Rodrigo Calabia M ónica Renuncio-García Carolina Castro Hern ández Dzmitry Mikhalkovich Nerea Mota P érez Source Type: research
Multi-epitopevaccines, from design to expression; an in silico approach
Hum Immunol. 2024 Apr 23:110804. doi: 10.1016/j.humimm.2024.110804. Online ahead of print.ABSTRACTThe development of vaccines against a wide range of infectious diseases and pathogens often relies on multi-epitope strategies that can effectively stimulate both humoral and cellular immunity. Immunoinformatics tools play a pivotal role in designing such vaccines, enhancing immune response potential, and minimizing the risk of failure. This review presents a comprehensive overview of practical tools for epitope prediction and the associated immune responses. These immunoinformatics tools facilitate the selection of epitopes b...
Source: Human Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Behnam Mortazavi Ali Molaei Najaf Allahyari Fard Source Type: research
HLA-DRB1 and HLA-DQB1 genes in patients diagnosed with systemic lupus erythematosus in Guatemala
Hum Immunol. 2024 Apr 22:110803. doi: 10.1016/j.humimm.2024.110803. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is an autoimmune disorder that impacts connective tissue and can affect various organs and systems within the body. One important aspect of this disease is the role of the human leukocyte antigen (HLA) system, a protein complex that plays a role in the immune response. Specifically, the HLA-DRB1 and HLA-DQB1 genes have been implicated in the development of SLE. In order to better understand this relationship in the Guatemalan population, a study was conducted with the objective of characteriz...
Source: Human Immunology - April 23, 2024 Category: Allergy & Immunology Authors: Juan C Barrios-Men éndez C ésar Camilo Carías-Alvarado Lilian Isabel Cayax Francisco L ópez-Hun Adolfo Santizo Maynor A Herrera Diana Ira íz Hernández-Zaragoza Karla Escobar-Castro Source Type: research
Cretan HLA genetics supports its early Minoan culture as a link between North Africa and Europe
Hum Immunol. 2024 Apr 17:110799. doi: 10.1016/j.humimm.2024.110799. Online ahead of print.ABSTRACTHLA studies in Crete show that this population is related to North Africans and also Iberians. This may be a reflection of a common prehistoric first Europeans relationships with North Africans and drying Saharan emigration after 10,000 years BC; it may be specifically represented by a primitive and early cult to the bull in both Cretan (Minoan) and Iberian populations. In the present study, unrelated Cretans representing different Island parts have been studied for class II HLA-DRB1 and -DQB1 alleles. The most frequent ones w...
Source: Human Immunology - April 18, 2024 Category: Allergy & Immunology Authors: Antonio Arnaiz-Villena Ignacio Juarez Christian Vaquero-Yuste Tomas Lledo Jose Manuel Martin-Villa Fabio Suarez-Trujillo Source Type: research
Cretan HLA genetics supports its early Minoan culture as a link between North Africa and Europe
Hum Immunol. 2024 Apr 17:110799. doi: 10.1016/j.humimm.2024.110799. Online ahead of print.ABSTRACTHLA studies in Crete show that this population is related to North Africans and also Iberians. This may be a reflection of a common prehistoric first Europeans relationships with North Africans and drying Saharan emigration after 10,000 years BC; it may be specifically represented by a primitive and early cult to the bull in both Cretan (Minoan) and Iberian populations. In the present study, unrelated Cretans representing different Island parts have been studied for class II HLA-DRB1 and -DQB1 alleles. The most frequent ones w...
Source: Human Immunology - April 18, 2024 Category: Allergy & Immunology Authors: Antonio Arnaiz-Villena Ignacio Juarez Christian Vaquero-Yuste Tomas Lledo Jose Manuel Martin-Villa Fabio Suarez-Trujillo Source Type: research
Deregulated expression of autophagy genes; PIK3C3 and RAB7A in COVID-19 patients
CONCLUSIONS: The study showed reduction of PIK3C3 and RAB7A expressions in COVID-19 patients. However, further studies are recommended to clarify their roles in the disease pathogenies as autophagy genes.PMID:38609772 | DOI:10.1016/j.humimm.2024.110801 (Source: Human Immunology)
Source: Human Immunology - April 12, 2024 Category: Allergy & Immunology Authors: Mona Tahoun Ahmed S Sadaka Source Type: research
Deregulated expression of autophagy genes; PIK3C3 and RAB7A in COVID-19 patients
CONCLUSIONS: The study showed reduction of PIK3C3 and RAB7A expressions in COVID-19 patients. However, further studies are recommended to clarify their roles in the disease pathogenies as autophagy genes.PMID:38609772 | DOI:10.1016/j.humimm.2024.110801 (Source: Human Immunology)
Source: Human Immunology - April 12, 2024 Category: Allergy & Immunology Authors: Mona Tahoun Ahmed S Sadaka Source Type: research
Deregulated expression of autophagy genes; PIK3C3 and RAB7A in COVID-19 patients
CONCLUSIONS: The study showed reduction of PIK3C3 and RAB7A expressions in COVID-19 patients. However, further studies are recommended to clarify their roles in the disease pathogenies as autophagy genes.PMID:38609772 | DOI:10.1016/j.humimm.2024.110801 (Source: Human Immunology)
Source: Human Immunology - April 12, 2024 Category: Allergy & Immunology Authors: Mona Tahoun Ahmed S Sadaka Source Type: research
Deregulated expression of autophagy genes; PIK3C3 and RAB7A in COVID-19 patients
CONCLUSIONS: The study showed reduction of PIK3C3 and RAB7A expressions in COVID-19 patients. However, further studies are recommended to clarify their roles in the disease pathogenies as autophagy genes.PMID:38609772 | DOI:10.1016/j.humimm.2024.110801 (Source: Human Immunology)
Source: Human Immunology - April 12, 2024 Category: Allergy & Immunology Authors: Mona Tahoun Ahmed S Sadaka Source Type: research
Updates in induction immunosuppression regimens for intestinal transplantation
Hum Immunol. 2024 Apr 9:110800. doi: 10.1016/j.humimm.2024.110800. Online ahead of print.ABSTRACTIntestinal allografts are the most immunologically complex and carry the highest risk of rejection among solid organ transplantation, necessitating complex immunosuppressive management. We evaluated the latest information regarding induction immunosuppression, with an emphasis on established, novel, and emergent therapies. We also reviewed classic and novel induction immunosuppression strategies for highly sensitized recipients. Comparable progress has been made in intestinal transplantation clinical outcomes since the implemen...
Source: Human Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Johann Paulo Guzman Mohamed Maklad Mohammed Osman Ayat Elsherif Masato Fujiki Source Type: research
Updates in induction immunosuppression regimens for intestinal transplantation
Hum Immunol. 2024 Apr 9:110800. doi: 10.1016/j.humimm.2024.110800. Online ahead of print.ABSTRACTIntestinal allografts are the most immunologically complex and carry the highest risk of rejection among solid organ transplantation, necessitating complex immunosuppressive management. We evaluated the latest information regarding induction immunosuppression, with an emphasis on established, novel, and emergent therapies. We also reviewed classic and novel induction immunosuppression strategies for highly sensitized recipients. Comparable progress has been made in intestinal transplantation clinical outcomes since the implemen...
Source: Human Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Johann Paulo Guzman Mohamed Maklad Mohammed Osman Ayat Elsherif Masato Fujiki Source Type: research
Updates in induction immunosuppression regimens for intestinal transplantation
Hum Immunol. 2024 Apr 9:110800. doi: 10.1016/j.humimm.2024.110800. Online ahead of print.ABSTRACTIntestinal allografts are the most immunologically complex and carry the highest risk of rejection among solid organ transplantation, necessitating complex immunosuppressive management. We evaluated the latest information regarding induction immunosuppression, with an emphasis on established, novel, and emergent therapies. We also reviewed classic and novel induction immunosuppression strategies for highly sensitized recipients. Comparable progress has been made in intestinal transplantation clinical outcomes since the implemen...
Source: Human Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Johann Paulo Guzman Mohamed Maklad Mohammed Osman Ayat Elsherif Masato Fujiki Source Type: research
