The heterogeneity of tumour-associated macrophages contributes to the clinical outcomes and indications for immune checkpoint blockade in colorectal cancer patients
In this study, we aimed to know whether the extensive inter and intra heterogeneity of TAMs contributes to the clinical outcomes and indications for immune checkpoint blockade (ICB) in CRC. We used single-cell RNA sequencing (scRNA-Seq) data from 60 CRC patients and charactrized TAMs based on anatomic locations, tumor regions, stages, grades, metastatic status, MSS/MSI classification and pseudotemporal differentiation status. We then defined a catalog of 21 gene modules that determine macrophage status, and identified 7 of them as relevant to clinical outcomes and 11 as indications for ICB therapy. On this basis, we constr...
Source: Immunobiology - April 26, 2024 Category: Allergy & Immunology Authors: Junhui Tang Liang Ming Feiyu Qin Yan Qin Duo Wang Liuying Huang Yulin Cao Zhaohui Huang Yuan Yin Source Type: research
The heterogeneity of tumour-associated macrophages contributes to the clinical outcomes and indications for immune checkpoint blockade in colorectal cancer patients
In this study, we aimed to know whether the extensive inter and intra heterogeneity of TAMs contributes to the clinical outcomes and indications for immune checkpoint blockade (ICB) in CRC. We used single-cell RNA sequencing (scRNA-Seq) data from 60 CRC patients and charactrized TAMs based on anatomic locations, tumor regions, stages, grades, metastatic status, MSS/MSI classification and pseudotemporal differentiation status. We then defined a catalog of 21 gene modules that determine macrophage status, and identified 7 of them as relevant to clinical outcomes and 11 as indications for ICB therapy. On this basis, we constr...
Source: Immunobiology - April 26, 2024 Category: Allergy & Immunology Authors: Junhui Tang Liang Ming Feiyu Qin Yan Qin Duo Wang Liuying Huang Yulin Cao Zhaohui Huang Yuan Yin Source Type: research
The heterogeneity of tumour-associated macrophages contributes to the clinical outcomes and indications for immune checkpoint blockade in colorectal cancer patients
In this study, we aimed to know whether the extensive inter and intra heterogeneity of TAMs contributes to the clinical outcomes and indications for immune checkpoint blockade (ICB) in CRC. We used single-cell RNA sequencing (scRNA-Seq) data from 60 CRC patients and charactrized TAMs based on anatomic locations, tumor regions, stages, grades, metastatic status, MSS/MSI classification and pseudotemporal differentiation status. We then defined a catalog of 21 gene modules that determine macrophage status, and identified 7 of them as relevant to clinical outcomes and 11 as indications for ICB therapy. On this basis, we constr...
Source: Immunobiology - April 26, 2024 Category: Allergy & Immunology Authors: Junhui Tang Liang Ming Feiyu Qin Yan Qin Duo Wang Liuying Huang Yulin Cao Zhaohui Huang Yuan Yin Source Type: research
The heterogeneity of tumour-associated macrophages contributes to the clinical outcomes and indications for immune checkpoint blockade in colorectal cancer patients
In this study, we aimed to know whether the extensive inter and intra heterogeneity of TAMs contributes to the clinical outcomes and indications for immune checkpoint blockade (ICB) in CRC. We used single-cell RNA sequencing (scRNA-Seq) data from 60 CRC patients and charactrized TAMs based on anatomic locations, tumor regions, stages, grades, metastatic status, MSS/MSI classification and pseudotemporal differentiation status. We then defined a catalog of 21 gene modules that determine macrophage status, and identified 7 of them as relevant to clinical outcomes and 11 as indications for ICB therapy. On this basis, we constr...
Source: Immunobiology - April 26, 2024 Category: Allergy & Immunology Authors: Junhui Tang Liang Ming Feiyu Qin Yan Qin Duo Wang Liuying Huang Yulin Cao Zhaohui Huang Yuan Yin Source Type: research
The heterogeneity of tumour-associated macrophages contributes to the clinical outcomes and indications for immune checkpoint blockade in colorectal cancer patients
In this study, we aimed to know whether the extensive inter and intra heterogeneity of TAMs contributes to the clinical outcomes and indications for immune checkpoint blockade (ICB) in CRC. We used single-cell RNA sequencing (scRNA-Seq) data from 60 CRC patients and charactrized TAMs based on anatomic locations, tumor regions, stages, grades, metastatic status, MSS/MSI classification and pseudotemporal differentiation status. We then defined a catalog of 21 gene modules that determine macrophage status, and identified 7 of them as relevant to clinical outcomes and 11 as indications for ICB therapy. On this basis, we constr...
Source: Immunobiology - April 26, 2024 Category: Allergy & Immunology Authors: Junhui Tang Liang Ming Feiyu Qin Yan Qin Duo Wang Liuying Huang Yulin Cao Zhaohui Huang Yuan Yin Source Type: research
Association of neutrophil extracellular trap levels with Raynaud's phenomenon, glomerulonephritis and disease index score in SLE patients from Brazil
This study aimed to access possible associations between serum NETs levels with epidemiological, clinical, and serological data from a well-characterized SLE Brazilian patients' cohort. NET levels were evaluated in one hundred seventy serum samples of patients with Systemic Lupus Erythematosus (SLE) using an Immunoassay. Univariate and multivariate binary logistic regression used clinical patients' data as independent variables. Parametric and non-parametric tests compared log10 base serum NET levels transformed between patients' groups. SLE patients were also dichotomized into "High serum NET levels" and "Low serum NET le...
Source: Immunobiology - April 19, 2024 Category: Allergy & Immunology Authors: Eduardo Delabio Auer Val éria Bumiller-Bini Hoch Emiliano Borges da Silva Yohan Ricci Zonta Luciane Alarc ão Dias-Melicio Thelma Larocca Skare Vanessa F Picceli Iara Jos é Messias-Reason Angelica Beate Winter Boldt Source Type: research
Retraction notice to "In vitro anticholinergic drugs affect CD8+ peripheral blood T-cells apoptosis in COPD" [Immunobiology 217/3 (2012) 345-353]
Immunobiology. 2024 Apr 18:152800. doi: 10.1016/j.imbio.2024.152800. Online ahead of print.NO ABSTRACTPMID:38641460 | DOI:10.1016/j.imbio.2024.152800 (Source: Immunobiology)
Source: Immunobiology - April 19, 2024 Category: Allergy & Immunology Authors: Mirella Profita Loredana Riccobono Angela Marina Montalbano Anna Bonanno Maria Ferraro Giusy Daniela Albano Stefania Gerbino Paola Casarosa Michael Paul Pieper Mark Gjomarkaj Source Type: research
Association of neutrophil extracellular trap levels with Raynaud's phenomenon, glomerulonephritis and disease index score in SLE patients from Brazil
This study aimed to access possible associations between serum NETs levels with epidemiological, clinical, and serological data from a well-characterized SLE Brazilian patients' cohort. NET levels were evaluated in one hundred seventy serum samples of patients with Systemic Lupus Erythematosus (SLE) using an Immunoassay. Univariate and multivariate binary logistic regression used clinical patients' data as independent variables. Parametric and non-parametric tests compared log10 base serum NET levels transformed between patients' groups. SLE patients were also dichotomized into "High serum NET levels" and "Low serum NET le...
Source: Immunobiology - April 19, 2024 Category: Allergy & Immunology Authors: Eduardo Delabio Auer Val éria Bumiller-Bini Hoch Emiliano Borges da Silva Yohan Ricci Zonta Luciane Alarc ão Dias-Melicio Thelma Larocca Skare Vanessa F Picceli Iara Jos é Messias-Reason Angelica Beate Winter Boldt Source Type: research
Retraction notice to "In vitro anticholinergic drugs affect CD8+ peripheral blood T-cells apoptosis in COPD" [Immunobiology 217/3 (2012) 345-353]
Immunobiology. 2024 Apr 18:152800. doi: 10.1016/j.imbio.2024.152800. Online ahead of print.NO ABSTRACTPMID:38641460 | DOI:10.1016/j.imbio.2024.152800 (Source: Immunobiology)
Source: Immunobiology - April 19, 2024 Category: Allergy & Immunology Authors: Mirella Profita Loredana Riccobono Angela Marina Montalbano Anna Bonanno Maria Ferraro Giusy Daniela Albano Stefania Gerbino Paola Casarosa Michael Paul Pieper Mark Gjomarkaj Source Type: research
Association of neutrophil extracellular trap levels with Raynaud's phenomenon, glomerulonephritis and disease index score in SLE patients from Brazil
This study aimed to access possible associations between serum NETs levels with epidemiological, clinical, and serological data from a well-characterized SLE Brazilian patients' cohort. NET levels were evaluated in one hundred seventy serum samples of patients with Systemic Lupus Erythematosus (SLE) using an Immunoassay. Univariate and multivariate binary logistic regression used clinical patients' data as independent variables. Parametric and non-parametric tests compared log10 base serum NET levels transformed between patients' groups. SLE patients were also dichotomized into "High serum NET levels" and "Low serum NET le...
Source: Immunobiology - April 19, 2024 Category: Allergy & Immunology Authors: Eduardo Delabio Auer Val éria Bumiller-Bini Hoch Emiliano Borges da Silva Yohan Ricci Zonta Luciane Alarc ão Dias-Melicio Thelma Larocca Skare Vanessa F Picceli Iara Jos é Messias-Reason Angelica Beate Winter Boldt Source Type: research
Retraction notice to "In vitro anticholinergic drugs affect CD8+ peripheral blood T-cells apoptosis in COPD" [Immunobiology 217/3 (2012) 345-353]
Immunobiology. 2024 Apr 18:152800. doi: 10.1016/j.imbio.2024.152800. Online ahead of print.NO ABSTRACTPMID:38641460 | DOI:10.1016/j.imbio.2024.152800 (Source: Immunobiology)
Source: Immunobiology - April 19, 2024 Category: Allergy & Immunology Authors: Mirella Profita Loredana Riccobono Angela Marina Montalbano Anna Bonanno Maria Ferraro Giusy Daniela Albano Stefania Gerbino Paola Casarosa Michael Paul Pieper Mark Gjomarkaj Source Type: research
Association of neutrophil extracellular trap levels with Raynaud's phenomenon, glomerulonephritis and disease index score in SLE patients from Brazil
This study aimed to access possible associations between serum NETs levels with epidemiological, clinical, and serological data from a well-characterized SLE Brazilian patients' cohort. NET levels were evaluated in one hundred seventy serum samples of patients with Systemic Lupus Erythematosus (SLE) using an Immunoassay. Univariate and multivariate binary logistic regression used clinical patients' data as independent variables. Parametric and non-parametric tests compared log10 base serum NET levels transformed between patients' groups. SLE patients were also dichotomized into "High serum NET levels" and "Low serum NET le...
Source: Immunobiology - April 19, 2024 Category: Allergy & Immunology Authors: Eduardo Delabio Auer Val éria Bumiller-Bini Hoch Emiliano Borges da Silva Yohan Ricci Zonta Luciane Alarc ão Dias-Melicio Thelma Larocca Skare Vanessa F Picceli Iara Jos é Messias-Reason Angelica Beate Winter Boldt Source Type: research
Retraction notice to "In vitro anticholinergic drugs affect CD8+ peripheral blood T-cells apoptosis in COPD" [Immunobiology 217/3 (2012) 345-353]
Immunobiology. 2024 Apr 18:152800. doi: 10.1016/j.imbio.2024.152800. Online ahead of print.NO ABSTRACTPMID:38641460 | DOI:10.1016/j.imbio.2024.152800 (Source: Immunobiology)
Source: Immunobiology - April 19, 2024 Category: Allergy & Immunology Authors: Mirella Profita Loredana Riccobono Angela Marina Montalbano Anna Bonanno Maria Ferraro Giusy Daniela Albano Stefania Gerbino Paola Casarosa Michael Paul Pieper Mark Gjomarkaj Source Type: research
LncRNA SNHG1 overexpression alleviates osteoarthritis via activating PI3K/Akt signal pathway and suppressing autophagy
Immunobiology. 2024 Apr 6;229(3):152799. doi: 10.1016/j.imbio.2024.152799. Online ahead of print.ABSTRACTWe hereby intend to further explore and confirm the underlying mechanism of Small nucleolar RNA Host Gene 1 (SNHG1) in osteoarthritis (OA). For in vitro assays, OA was induced in primary chondrocytes with interleukin-1β (IL-1β) treatment; while for in vivo tests, OA model was established in mice using the destabilization of the medial meniscus (DMM) method. Cell viability and apoptosis were assessed with MTT and flow cytometry assays, respectively. Cartilage tissue was stained by Safranin-O/Fast Green Staining. The mR...
Source: Immunobiology - April 18, 2024 Category: Allergy & Immunology Authors: Qiushi Wang Jie Yang Rui Pan Zhengang Zha Source Type: research
LncRNA SNHG1 overexpression alleviates osteoarthritis via activating PI3K/Akt signal pathway and suppressing autophagy
Immunobiology. 2024 Apr 6;229(3):152799. doi: 10.1016/j.imbio.2024.152799. Online ahead of print.ABSTRACTWe hereby intend to further explore and confirm the underlying mechanism of Small nucleolar RNA Host Gene 1 (SNHG1) in osteoarthritis (OA). For in vitro assays, OA was induced in primary chondrocytes with interleukin-1β (IL-1β) treatment; while for in vivo tests, OA model was established in mice using the destabilization of the medial meniscus (DMM) method. Cell viability and apoptosis were assessed with MTT and flow cytometry assays, respectively. Cartilage tissue was stained by Safranin-O/Fast Green Staining. The mR...
Source: Immunobiology - April 18, 2024 Category: Allergy & Immunology Authors: Qiushi Wang Jie Yang Rui Pan Zhengang Zha Source Type: research
