Immunology and Allergy Clinics of North America This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Chronic Spontaneous Urticaria
Chronic spontaneous urticaria (CSU) affects 0.5% to 1% of the general population and is often managed by allergy and immunology specialists. Guidelines have evolved over the past several decades with an emphasis on decreasing extensive screening laboratory testing as they are of low-yield and cost-ineffective. The utility of biomarkers remains under investigation but total immunoglobulin E may be helpful in determining specific endotypes and response to omalizumab. Antihistamines and omalizumab remain the primary therapeutic options for CSU, but an expanding body of evidence supports the use of immunosuppressants and anti-...
Source: Immunology and Allergy Clinics of North America - April 25, 2024 Category: Allergy & Immunology Authors: Shyam R. Joshi, Karen M. Anstey, David A. Khan Source Type: research

Emerging Therapeutics in Chronic Urticaria
Chronic urticaria (CU) is a common and long-lasting mast cell-mediated skin disease associated with psychiatric and autoimmune comorbidities, high economic costs, and considerable impact on quality of life. Available therapies show limited efficacy in many CU patients, which may be related to distinct underlying pathophysiology. Targeted and disease-modifying treatments with higher and broader efficacy are needed and are under development for CU. These novel drugs, small molecules, and monoclonal antibodies target mast cells and their receptors, signaling pathways, or mediators and other immune cells. In this article, the ...
Source: Immunology and Allergy Clinics of North America - April 23, 2024 Category: Allergy & Immunology Authors: Melba Mu ñoz, Emek Kocatürk, Marcus Maurer, Pavel Kolkhir Source Type: research

Current and Emerging Therapeutics in Hereditary Angioedema
Angioedema is characterized by transient movement of fluid from the vasculature into the interstitial space leading to subcutaneous or submucosal non-pitting edema. Current evidence suggests that most angioedema conditions can be grouped into 2 categories: mast cell-mediated (previously termed histaminergic) or bradykinin-mediated angioedema. Although effective therapies for mast cell-mediated angioedema have existed for decades, specific therapies for bradykinin-mediated angioedema have more recently been developed. In recent years, rigorous studies of these therapies in treating hereditary angioedema (HAE) have led to re...
Source: Immunology and Allergy Clinics of North America - April 21, 2024 Category: Allergy & Immunology Authors: Toan Do, Marc A. Riedl Source Type: research

Eosinophilic Gastrointestinal Diseases
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - April 3, 2024 Category: Allergy & Immunology Authors: Glenn T. Furuta, Dan Atkins Source Type: research

Copyright
ELSEVIER (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - April 3, 2024 Category: Allergy & Immunology Source Type: research

Contributors
ROHIT KATIAL, MD, FAAAAI, FACAAI, FACP (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - April 3, 2024 Category: Allergy & Immunology Source Type: research

Contents
Rohit Katial (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - April 3, 2024 Category: Allergy & Immunology Source Type: research

Forthcoming Issues
Updates in Urticaria/Angioedema (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - April 3, 2024 Category: Allergy & Immunology Source Type: research

Pathophysiology of Non-Esophageal Eosinophilic Gastrointestinal Disorders
Eosinophilic gastrointestinal disorder (EGID) is an umbrella term encompassing a group of chronic, immune-mediated disorders characterized by eosinophil-rich inflammation affecting one or more segments of the gastrointestinal tract. A recent consensus in nomenclature and emerging data made possible through multi-center consortia are beginning to unravel the molecular and cellular underpinnings of EGIDs below the esophagus. These emerging findings are revealing both overarching commonalities related to a food allergen-driven, chronic, Th2-mediated immune response as well as location-specific nuances in the pathophysiology o...
Source: Immunology and Allergy Clinics of North America - February 20, 2024 Category: Allergy & Immunology Authors: Julia L.M. Dunn, Lisa A. Spencer Source Type: research

Dietary Management of Eosinophilic Esophagitis
This article will focus on the rationale for dietary therapy in EoE and provide helpful tools for the implementation of dietary therapy in practice. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - February 19, 2024 Category: Allergy & Immunology Authors: Alfredo Lucendo, Marion Groetch, Nirmala Gonsalves Source Type: research

Embracing Diversity, Equity, Inclusion, and Accessibility in Eosinophilic Gastrointestinal Diseases
Eosinophilic gastrointestinal diseases (EGIDs) including eosinophilic esophagitis (EoE) are rare diseases in which eosinophils abnormally infiltrate the gastrointestinal tract. Because these are rare diseases, there is limited information regarding race and ethnicity in EGIDs and even less is known about the impact of socioeconomic factors. There is some evidence that access to care in rural settings may be affecting epidemiologic understanding of EGIDs in the pediatric populations. Future work should try to evaluate bias in research and strive for representation in clinical trials and medicine. (Source: Immunology and All...
Source: Immunology and Allergy Clinics of North America - February 19, 2024 Category: Allergy & Immunology Authors: Amanda B. Muir, Dominique D. Bailey, Pooja Mehta Source Type: research

Role of Mast Cells in Eosinophilic Gastrointestinal Diseases
Mast cells play a central role in the pathogenesis of eosinophilic gastrointestinal disorders (EGIDs), including eosinophilic esophagitis. Their interactions with immune and structural cells, involvement in tissue remodeling, and contribution to symptoms make them attractive targets for therapeutic intervention. More is being discovered regarding the intricate interplay of mast cells and eosinophils. Recent studies demonstrating that depletion of eosinophils is insufficient to improve symptoms of EGIDs have raised the question of whether other cells may play a role in symptomatology and pathogenesis of EGIDs. (Source: Immu...
Source: Immunology and Allergy Clinics of North America - February 19, 2024 Category: Allergy & Immunology Authors: Paneez Khoury, Joshua B. Wechsler Source Type: research

Associations of Eosinophilic Gastrointestinal Disorders with Other Gastrointestinal and Allergic Diseases
Eosinophilic gastrointestinal disorders (EGIDs) are becoming more common causing significant suffering and reduced quality of life. These conditions can affect different parts of the digestive system, either individually or in combination. Recognition of their link to allergic disorders or other gastrointestinal (GI) diseases has raised questions about their shared underlying mechanisms, which has had implications for diagnosis and management. The authors critically examine the current understanding of the connection between EGIDs and allergic conditions (ie, atopic dermatitis, allergic rhinitis, asthma, and food allergy) ...
Source: Immunology and Allergy Clinics of North America - February 19, 2024 Category: Allergy & Immunology Authors: Salvatore Oliva, Emily Clarke McGowan Source Type: research

The Relationship Between Eosinophilic Esophagitis and Immunotherapy
Immunotherapy is a treatment approach based on the principle of incremental allergen exposure to achieve desensitization. Recently, oral immunotherapy has been introduced as a treatment of IgE-mediated food allergy. Some patients receiving oral immunotherapy for food allergy may develop eosinophilic esophagitis. Here, we summarize the literature examining this association, its treatment, and outcomes and discuss possible explanations for this clinical phenomenon. We further identify potential associations with aeroallergen sensitivity and other forms of immunotherapy including subcutaneous immunotherapy and sublingual immu...
Source: Immunology and Allergy Clinics of North America - February 14, 2024 Category: Allergy & Immunology Authors: Bridget E. Wilson, Maria A. Sacta, Benjamin L. Wright, Jonathan Spergel, Nicole Wolfset Source Type: research

Histopathology of Eosinophilic Gastrointestinal Diseases Beyond Eosinophilic Esophagitis
Eosinophilic gastrointestinal diseases (EGID), such as eosinophilic gastritis (EoG), eosinophilic enteritis, and eosinophilic colitis (EoC), are chronic inflammatory conditions characterized by persistent gastrointestinal symptoms and elevated levels of activated eosinophils in the gastrointestinal tract. EoG and eosinophilic duodenitis (EoD) are strongly associated with food allergen triggers and TH2 inflammation, whereas EoC shows minimal transcriptomic overlap with other EGIDs. The level of expression of certain genes associated with TH2 immune response is associated with certain histopathologic findings of EoG, EoD, an...
Source: Immunology and Allergy Clinics of North America - February 14, 2024 Category: Allergy & Immunology Authors: Nicoleta C. Arva, Anas Bernieh, Oscar Lopez-Nunez, Maria Pletneva, Guang-Yu Yang, Margaret H. Collins Source Type: research