FG-4592 protected haematopoietic system from ionising radiation in mice
Immunology. 2024 Apr 29. doi: 10.1111/imm.13797. Online ahead of print.ABSTRACTIonising radiation exposure can lead to acute haematopoietic radiation syndrome. Despite significant advancements in the field of radioprotection, no drugs with high efficacy and low toxicity have yet been approved by the Food and Drug Administration. FG-4592, as a proline hydroxylase inhibitor, may play an important role in radioprotection of the haematopoietic system. Mice were peritoneal injected with FG-4592 or normal saline. After irradiation, the survival time, body weight, peripheral blood cell and bone marrow cell (BMC) count, cell apopt...
Source: Immunology - April 30, 2024 Category: Allergy & Immunology Authors: Yuedong Wang Ying Cheng Pei Zhang Daqian Huang Xuanlu Zhai Zhenlan Feng Duo Fang Cong Liu Jicong Du Jianming Cai Source Type: research
FG-4592 protected haematopoietic system from ionising radiation in mice
Immunology. 2024 Apr 29. doi: 10.1111/imm.13797. Online ahead of print.ABSTRACTIonising radiation exposure can lead to acute haematopoietic radiation syndrome. Despite significant advancements in the field of radioprotection, no drugs with high efficacy and low toxicity have yet been approved by the Food and Drug Administration. FG-4592, as a proline hydroxylase inhibitor, may play an important role in radioprotection of the haematopoietic system. Mice were peritoneal injected with FG-4592 or normal saline. After irradiation, the survival time, body weight, peripheral blood cell and bone marrow cell (BMC) count, cell apopt...
Source: Immunology - April 30, 2024 Category: Allergy & Immunology Authors: Yuedong Wang Ying Cheng Pei Zhang Daqian Huang Xuanlu Zhai Zhenlan Feng Duo Fang Cong Liu Jicong Du Jianming Cai Source Type: research
FG-4592 protected haematopoietic system from ionising radiation in mice
Immunology. 2024 Apr 29. doi: 10.1111/imm.13797. Online ahead of print.ABSTRACTIonising radiation exposure can lead to acute haematopoietic radiation syndrome. Despite significant advancements in the field of radioprotection, no drugs with high efficacy and low toxicity have yet been approved by the Food and Drug Administration. FG-4592, as a proline hydroxylase inhibitor, may play an important role in radioprotection of the haematopoietic system. Mice were peritoneal injected with FG-4592 or normal saline. After irradiation, the survival time, body weight, peripheral blood cell and bone marrow cell (BMC) count, cell apopt...
Source: Immunology - April 30, 2024 Category: Allergy & Immunology Authors: Yuedong Wang Ying Cheng Pei Zhang Daqian Huang Xuanlu Zhai Zhenlan Feng Duo Fang Cong Liu Jicong Du Jianming Cai Source Type: research
FG-4592 protected haematopoietic system from ionising radiation in mice
Immunology. 2024 Apr 29. doi: 10.1111/imm.13797. Online ahead of print.ABSTRACTIonising radiation exposure can lead to acute haematopoietic radiation syndrome. Despite significant advancements in the field of radioprotection, no drugs with high efficacy and low toxicity have yet been approved by the Food and Drug Administration. FG-4592, as a proline hydroxylase inhibitor, may play an important role in radioprotection of the haematopoietic system. Mice were peritoneal injected with FG-4592 or normal saline. After irradiation, the survival time, body weight, peripheral blood cell and bone marrow cell (BMC) count, cell apopt...
Source: Immunology - April 30, 2024 Category: Allergy & Immunology Authors: Yuedong Wang Ying Cheng Pei Zhang Daqian Huang Xuanlu Zhai Zhenlan Feng Duo Fang Cong Liu Jicong Du Jianming Cai Source Type: research
FG-4592 protected haematopoietic system from ionising radiation in mice
Immunology. 2024 Apr 29. doi: 10.1111/imm.13797. Online ahead of print.ABSTRACTIonising radiation exposure can lead to acute haematopoietic radiation syndrome. Despite significant advancements in the field of radioprotection, no drugs with high efficacy and low toxicity have yet been approved by the Food and Drug Administration. FG-4592, as a proline hydroxylase inhibitor, may play an important role in radioprotection of the haematopoietic system. Mice were peritoneal injected with FG-4592 or normal saline. After irradiation, the survival time, body weight, peripheral blood cell and bone marrow cell (BMC) count, cell apopt...
Source: Immunology - April 30, 2024 Category: Allergy & Immunology Authors: Yuedong Wang Ying Cheng Pei Zhang Daqian Huang Xuanlu Zhai Zhenlan Feng Duo Fang Cong Liu Jicong Du Jianming Cai Source Type: research
Unravelling CD4 < sup > + < /sup > T cell diversity and tissue adaptation of Tregs in abdominal aortic aneurysms through single-cell sequencing
Immunology. 2024 Apr 18. doi: 10.1111/imm.13796. Online ahead of print.ABSTRACTImmune cell infiltration is a significant pathological process in abdominal aortic aneurysms (AAA). T cells, particularly CD4+ T cells, are essential immune cells responsible for substantial infiltration of the aorta. Regulatory T cells (Tregs) in AAA have been identified as tissue-specific; however, the time, location, and mechanism of acquiring the tissue-specific phenotype are still unknown. Using single-cell RNA sequencing (scRNA-seq) on CD4+ T cells from the AAA aorta and spleen, we discovered heterogeneity among CD4+ T cells and identified...
Source: Immunology - April 19, 2024 Category: Allergy & Immunology Authors: Luna Zhai Wangling Hu Jingyong Li Dan Li Ni Xia Tingting Tang Shaofang Nie Min Zhang Jiao Jiao Bingjie Lv Fen Yang Yuzhi Lu Lingfeng Zha Muyang Gu Xiajun Hu Shuang Wen Desheng Hu Li Zhang Weimin Wang Xiang Cheng Source Type: research
Unravelling CD4 < sup > + < /sup > T cell diversity and tissue adaptation of Tregs in abdominal aortic aneurysms through single-cell sequencing
Immunology. 2024 Apr 18. doi: 10.1111/imm.13796. Online ahead of print.ABSTRACTImmune cell infiltration is a significant pathological process in abdominal aortic aneurysms (AAA). T cells, particularly CD4+ T cells, are essential immune cells responsible for substantial infiltration of the aorta. Regulatory T cells (Tregs) in AAA have been identified as tissue-specific; however, the time, location, and mechanism of acquiring the tissue-specific phenotype are still unknown. Using single-cell RNA sequencing (scRNA-seq) on CD4+ T cells from the AAA aorta and spleen, we discovered heterogeneity among CD4+ T cells and identified...
Source: Immunology - April 19, 2024 Category: Allergy & Immunology Authors: Luna Zhai Wangling Hu Jingyong Li Dan Li Ni Xia Tingting Tang Shaofang Nie Min Zhang Jiao Jiao Bingjie Lv Fen Yang Yuzhi Lu Lingfeng Zha Muyang Gu Xiajun Hu Shuang Wen Desheng Hu Li Zhang Weimin Wang Xiang Cheng Source Type: research
Unravelling CD4 < sup > + < /sup > T cell diversity and tissue adaptation of Tregs in abdominal aortic aneurysms through single-cell sequencing
Immunology. 2024 Apr 18. doi: 10.1111/imm.13796. Online ahead of print.ABSTRACTImmune cell infiltration is a significant pathological process in abdominal aortic aneurysms (AAA). T cells, particularly CD4+ T cells, are essential immune cells responsible for substantial infiltration of the aorta. Regulatory T cells (Tregs) in AAA have been identified as tissue-specific; however, the time, location, and mechanism of acquiring the tissue-specific phenotype are still unknown. Using single-cell RNA sequencing (scRNA-seq) on CD4+ T cells from the AAA aorta and spleen, we discovered heterogeneity among CD4+ T cells and identified...
Source: Immunology - April 19, 2024 Category: Allergy & Immunology Authors: Luna Zhai Wangling Hu Jingyong Li Dan Li Ni Xia Tingting Tang Shaofang Nie Min Zhang Jiao Jiao Bingjie Lv Fen Yang Yuzhi Lu Lingfeng Zha Muyang Gu Xiajun Hu Shuang Wen Desheng Hu Li Zhang Weimin Wang Xiang Cheng Source Type: research
Unravelling CD4 < sup > + < /sup > T cell diversity and tissue adaptation of Tregs in abdominal aortic aneurysms through single-cell sequencing
Immunology. 2024 Apr 18. doi: 10.1111/imm.13796. Online ahead of print.ABSTRACTImmune cell infiltration is a significant pathological process in abdominal aortic aneurysms (AAA). T cells, particularly CD4+ T cells, are essential immune cells responsible for substantial infiltration of the aorta. Regulatory T cells (Tregs) in AAA have been identified as tissue-specific; however, the time, location, and mechanism of acquiring the tissue-specific phenotype are still unknown. Using single-cell RNA sequencing (scRNA-seq) on CD4+ T cells from the AAA aorta and spleen, we discovered heterogeneity among CD4+ T cells and identified...
Source: Immunology - April 19, 2024 Category: Allergy & Immunology Authors: Luna Zhai Wangling Hu Jingyong Li Dan Li Ni Xia Tingting Tang Shaofang Nie Min Zhang Jiao Jiao Bingjie Lv Fen Yang Yuzhi Lu Lingfeng Zha Muyang Gu Xiajun Hu Shuang Wen Desheng Hu Li Zhang Weimin Wang Xiang Cheng Source Type: research
Unravelling CD4 < sup > + < /sup > T cell diversity and tissue adaptation of Tregs in abdominal aortic aneurysms through single-cell sequencing
Immunology. 2024 Apr 18. doi: 10.1111/imm.13796. Online ahead of print.ABSTRACTImmune cell infiltration is a significant pathological process in abdominal aortic aneurysms (AAA). T cells, particularly CD4+ T cells, are essential immune cells responsible for substantial infiltration of the aorta. Regulatory T cells (Tregs) in AAA have been identified as tissue-specific; however, the time, location, and mechanism of acquiring the tissue-specific phenotype are still unknown. Using single-cell RNA sequencing (scRNA-seq) on CD4+ T cells from the AAA aorta and spleen, we discovered heterogeneity among CD4+ T cells and identified...
Source: Immunology - April 19, 2024 Category: Allergy & Immunology Authors: Luna Zhai Wangling Hu Jingyong Li Dan Li Ni Xia Tingting Tang Shaofang Nie Min Zhang Jiao Jiao Bingjie Lv Fen Yang Yuzhi Lu Lingfeng Zha Muyang Gu Xiajun Hu Shuang Wen Desheng Hu Li Zhang Weimin Wang Xiang Cheng Source Type: research
Unravelling CD4 < sup > + < /sup > T cell diversity and tissue adaptation of Tregs in abdominal aortic aneurysms through single-cell sequencing
Immunology. 2024 Apr 18. doi: 10.1111/imm.13796. Online ahead of print.ABSTRACTImmune cell infiltration is a significant pathological process in abdominal aortic aneurysms (AAA). T cells, particularly CD4+ T cells, are essential immune cells responsible for substantial infiltration of the aorta. Regulatory T cells (Tregs) in AAA have been identified as tissue-specific; however, the time, location, and mechanism of acquiring the tissue-specific phenotype are still unknown. Using single-cell RNA sequencing (scRNA-seq) on CD4+ T cells from the AAA aorta and spleen, we discovered heterogeneity among CD4+ T cells and identified...
Source: Immunology - April 19, 2024 Category: Allergy & Immunology Authors: Luna Zhai Wangling Hu Jingyong Li Dan Li Ni Xia Tingting Tang Shaofang Nie Min Zhang Jiao Jiao Bingjie Lv Fen Yang Yuzhi Lu Lingfeng Zha Muyang Gu Xiajun Hu Shuang Wen Desheng Hu Li Zhang Weimin Wang Xiang Cheng Source Type: research
Oligodeoxynucleotides containing CpG motifs (CpG-ODN) restores immune regulatory functions of airway macrophages of patients with asthma
In conclusion, the induction of IL-10 in macrophages of BALF in asthma patients was impaired, and it could be restored by exposure to CpG.PMID:38634546 | DOI:10.1111/imm.13792 (Source: Immunology)
Source: Immunology - April 18, 2024 Category: Allergy & Immunology Authors: Huanping Zhang Lihuan Wang Aizhi Zhang Xiangyu Wang Yun Liao Xiaoxue Chen Xuejie Xu Litao Yang Yu Liu Aifa Tang Pingchang Yang Source Type: research
TLR8-activating miR-146a-3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS
In this study, the pro-inflammatory roles of TLR7/TLR8-activating miRs were examined as mediators of FM inflammation in response to bacterial lipopolysaccharide (LPS) using an in vitro human FM explant system, an in vivo mouse model of pregnancy, and human clinical samples. Following LPS exposure, miR-146a-3p was significantly increased in both human FM explants and wild-type mouse FMs. Expression of miR-146a-3p was also significantly elevated in FMs from women with preterm birth and chorioamnionitis. FM IL-8 and inflammasome-mediated IL-1β production in response to LPS was dependent on miR-146a-3p and TLR8 downstream of ...
Source: Immunology - April 17, 2024 Category: Allergy & Immunology Authors: Hanah M Georges Caterina Cassin Mancy Tong Vikki M Abrahams Source Type: research
TLR8-activating miR-146a-3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS
In this study, the pro-inflammatory roles of TLR7/TLR8-activating miRs were examined as mediators of FM inflammation in response to bacterial lipopolysaccharide (LPS) using an in vitro human FM explant system, an in vivo mouse model of pregnancy, and human clinical samples. Following LPS exposure, miR-146a-3p was significantly increased in both human FM explants and wild-type mouse FMs. Expression of miR-146a-3p was also significantly elevated in FMs from women with preterm birth and chorioamnionitis. FM IL-8 and inflammasome-mediated IL-1β production in response to LPS was dependent on miR-146a-3p and TLR8 downstream of ...
Source: Immunology - April 17, 2024 Category: Allergy & Immunology Authors: Hanah M Georges Caterina Cassin Mancy Tong Vikki M Abrahams Source Type: research
Immunotherapy and the ovarian cancer microenvironment: Exploring potential strategies for enhanced treatment efficacy
Immunology. 2024 Apr 15. doi: 10.1111/imm.13793. Online ahead of print.ABSTRACTDespite progress in cancer immunotherapy, ovarian cancer (OC) prognosis continues to be disappointing. Recent studies have shed light on how not just tumour cells, but also the complex tumour microenvironment, contribute to this unfavourable outcome of OC immunotherapy. The complexities of the immune microenvironment categorize OC as a 'cold tumour'. Nonetheless, understanding the precise mechanisms through which the microenvironment influences the effectiveness of OC immunotherapy remains an ongoing scientific endeavour. This review primarily a...
Source: Immunology - April 15, 2024 Category: Allergy & Immunology Authors: Zhi-Bin Wang Xiu Zhang Chao Fang Xiao-Ting Liu Qian-Jin Liao Nayiyuan Wu Jing Wang Source Type: research
