Secondary Streptococcus pneumoniae infection increases morbidity and mortality during murine cryptococcosis
In conclusion, our results highlight the importance of more studies addressing coinfections and their consequences in the host, aiming to establish more effective therapeutical strategies.PMID:37814467 | DOI:10.1111/imm.13701 (Source: Immunology)
Source: Immunology - October 10, 2023 Category: Allergy & Immunology Authors: B árbara A Miranda Gustavo J C Freitas Victor A T Leoc ádio Marliete C Costa El úzia C P Emídio Noelly Q Ribeiro Paulo H F Carmo Ludmila Gouveia-Eufr ásio Josy Hubner Luciana P Tavares Raquel D N Arifa Camila B Brito Monique F Silva Mauro M Teixeira Source Type: research
Unlocking the role of the B7-H4 polymorphism in psoriasis: Insights into methotrexate treatment outcomes: A prospective cohort study
This study aims to investigate the effect of B7-H4 polymorphism on the efficacy of methotrexate (MTX) and its mechanism in psoriasis. Four single nucleotide polymorphisms of B7-H4 were genotyped in 310 psoriatic patients who received 12-week MTX. The protein expression of B7-H4 in platelets was characterized using immunofluorescence staining, confocal laser scanning microscopy, and flow cytometry techniques. We found that GG genotype carriers of B7-H4 rs1935780 had a lower Psoriasis Area and Severity Index (PASI) 75 response rate and higher weight (p = 0.0245) and body mass index (p = 0.0185) than AA and AG genotype carrie...
Source: Immunology - October 10, 2023 Category: Allergy & Immunology Authors: Bing Wang Zhicheng Wang Wenjing Yang Ling Han Qiong Huang Nikhil Yawalkar Zhenghua Zhang Yu Yao Kexiang Yan Source Type: research
Secondary Streptococcus pneumoniae infection increases morbidity and mortality during murine cryptococcosis
In conclusion, our results highlight the importance of more studies addressing coinfections and their consequences in the host, aiming to establish more effective therapeutical strategies.PMID:37814467 | DOI:10.1111/imm.13701 (Source: Immunology)
Source: Immunology - October 10, 2023 Category: Allergy & Immunology Authors: B árbara A Miranda Gustavo J C Freitas Victor A T Leoc ádio Marliete C Costa El úzia C P Emídio Noelly Q Ribeiro Paulo H F Carmo Ludmila Gouveia-Eufr ásio Josy Hubner Luciana P Tavares Raquel D N Arifa Camila B Brito Monique F Silva Mauro M Teixeira Source Type: research
A new, all-encompassing aetiology of type 1 diabetes
In conclusion, T1D is caused by a somatic mutation within the epitope-binding groove of an at-risk HLA gene that affects HLA-insulin-peptide-TCR complex binding affinity and initiates an autoimmune pathway. The nature of the peptide that binds to a mutated epitope-binding groove of an at-risk HLA gene determines the type of autoimmune disease that develops, that is, one at-risk HLA locus, multiple autoimmune diseases. Thus, T1D and AAIDs, and therefore common autoimmune diseases, share a similar somatic mutation-based aetiology.PMID:37772700 | DOI:10.1111/imm.13700 (Source: Immunology)
Source: Immunology - September 29, 2023 Category: Allergy & Immunology Authors: Piet C de Groen Source Type: research
A new, all-encompassing aetiology of type 1 diabetes
In conclusion, T1D is caused by a somatic mutation within the epitope-binding groove of an at-risk HLA gene that affects HLA-insulin-peptide-TCR complex binding affinity and initiates an autoimmune pathway. The nature of the peptide that binds to a mutated epitope-binding groove of an at-risk HLA gene determines the type of autoimmune disease that develops, that is, one at-risk HLA locus, multiple autoimmune diseases. Thus, T1D and AAIDs, and therefore common autoimmune diseases, share a similar somatic mutation-based aetiology.PMID:37772700 | DOI:10.1111/imm.13700 (Source: Immunology)
Source: Immunology - September 29, 2023 Category: Allergy & Immunology Authors: Piet C de Groen Source Type: research
A new, all-encompassing aetiology of type 1 diabetes
In conclusion, T1D is caused by a somatic mutation within the epitope-binding groove of an at-risk HLA gene that affects HLA-insulin-peptide-TCR complex binding affinity and initiates an autoimmune pathway. The nature of the peptide that binds to a mutated epitope-binding groove of an at-risk HLA gene determines the type of autoimmune disease that develops, that is, one at-risk HLA locus, multiple autoimmune diseases. Thus, T1D and AAIDs, and therefore common autoimmune diseases, share a similar somatic mutation-based aetiology.PMID:37772700 | DOI:10.1111/imm.13700 (Source: Immunology)
Source: Immunology - September 29, 2023 Category: Allergy & Immunology Authors: Piet C de Groen Source Type: research
A new, all-encompassing aetiology of type 1 diabetes
In conclusion, T1D is caused by a somatic mutation within the epitope-binding groove of an at-risk HLA gene that affects HLA-insulin-peptide-TCR complex binding affinity and initiates an autoimmune pathway. The nature of the peptide that binds to a mutated epitope-binding groove of an at-risk HLA gene determines the type of autoimmune disease that develops, that is, one at-risk HLA locus, multiple autoimmune diseases. Thus, T1D and AAIDs, and therefore common autoimmune diseases, share a similar somatic mutation-based aetiology.PMID:37772700 | DOI:10.1111/imm.13700 (Source: Immunology)
Source: Immunology - September 29, 2023 Category: Allergy & Immunology Authors: Piet C de Groen Source Type: research
A new, all-encompassing aetiology of type 1 diabetes
In conclusion, T1D is caused by a somatic mutation within the epitope-binding groove of an at-risk HLA gene that affects HLA-insulin-peptide-TCR complex binding affinity and initiates an autoimmune pathway. The nature of the peptide that binds to a mutated epitope-binding groove of an at-risk HLA gene determines the type of autoimmune disease that develops, that is, one at-risk HLA locus, multiple autoimmune diseases. Thus, T1D and AAIDs, and therefore common autoimmune diseases, share a similar somatic mutation-based aetiology.PMID:37772700 | DOI:10.1111/imm.13700 (Source: Immunology)
Source: Immunology - September 29, 2023 Category: Allergy & Immunology Authors: Piet C de Groen Source Type: research
A new, all-encompassing aetiology of type 1 diabetes
In conclusion, T1D is caused by a somatic mutation within the epitope-binding groove of an at-risk HLA gene that affects HLA-insulin-peptide-TCR complex binding affinity and initiates an autoimmune pathway. The nature of the peptide that binds to a mutated epitope-binding groove of an at-risk HLA gene determines the type of autoimmune disease that develops, that is, one at-risk HLA locus, multiple autoimmune diseases. Thus, T1D and AAIDs, and therefore common autoimmune diseases, share a similar somatic mutation-based aetiology.PMID:37772700 | DOI:10.1111/imm.13700 (Source: Immunology)
Source: Immunology - September 29, 2023 Category: Allergy & Immunology Authors: Piet C de Groen Source Type: research
A new, all-encompassing aetiology of type 1 diabetes
In conclusion, T1D is caused by a somatic mutation within the epitope-binding groove of an at-risk HLA gene that affects HLA-insulin-peptide-TCR complex binding affinity and initiates an autoimmune pathway. The nature of the peptide that binds to a mutated epitope-binding groove of an at-risk HLA gene determines the type of autoimmune disease that develops, that is, one at-risk HLA locus, multiple autoimmune diseases. Thus, T1D and AAIDs, and therefore common autoimmune diseases, share a similar somatic mutation-based aetiology.PMID:37772700 | DOI:10.1111/imm.13700 (Source: Immunology)
Source: Immunology - September 29, 2023 Category: Allergy & Immunology Authors: Piet C de Groen Source Type: research
A new, all-encompassing aetiology of type 1 diabetes
In conclusion, T1D is caused by a somatic mutation within the epitope-binding groove of an at-risk HLA gene that affects HLA-insulin-peptide-TCR complex binding affinity and initiates an autoimmune pathway. The nature of the peptide that binds to a mutated epitope-binding groove of an at-risk HLA gene determines the type of autoimmune disease that develops, that is, one at-risk HLA locus, multiple autoimmune diseases. Thus, T1D and AAIDs, and therefore common autoimmune diseases, share a similar somatic mutation-based aetiology.PMID:37772700 | DOI:10.1111/imm.13700 (Source: Immunology)
Source: Immunology - September 29, 2023 Category: Allergy & Immunology Authors: Piet C de Groen Source Type: research
A new, all-encompassing aetiology of type 1 diabetes
In conclusion, T1D is caused by a somatic mutation within the epitope-binding groove of an at-risk HLA gene that affects HLA-insulin-peptide-TCR complex binding affinity and initiates an autoimmune pathway. The nature of the peptide that binds to a mutated epitope-binding groove of an at-risk HLA gene determines the type of autoimmune disease that develops, that is, one at-risk HLA locus, multiple autoimmune diseases. Thus, T1D and AAIDs, and therefore common autoimmune diseases, share a similar somatic mutation-based aetiology.PMID:37772700 | DOI:10.1111/imm.13700 (Source: Immunology)
Source: Immunology - September 29, 2023 Category: Allergy & Immunology Authors: Piet C de Groen Source Type: research
Suppression of protein quality control system by TRIM30a sensitises tumour cells to NK cell-mediated immune surveillance
In this study, we find that overexpression of murine tripartite motif-containing protein 30a (TRIM30a) sensitises tumour cells to natural killer (NK) cells-mediated cytolysis. TRIM30a has no effect on tumour cell proliferation or apoptosis in vitro. However, TRIM30a-overexpressing tumour cells grow substantially slower than control tumour cells in immune-competent mice but not in NK-depleted mice. Mechanistically, TRIM30a overexpression impedes the clearance of misfolded protein and increases the production of reactive oxygen species induced by proteotoxic stress, implying that TRIM30a impairs protein quality control (PQC)...
Source: Immunology - September 27, 2023 Category: Allergy & Immunology Authors: Lukman O Afolabi Jiacheng Bi Liang Chen Xiaolu Yang Xiaochun Wan Source Type: research
Suppression of protein quality control system by TRIM30a sensitises tumour cells to NK cell-mediated immune surveillance
In this study, we find that overexpression of murine tripartite motif-containing protein 30a (TRIM30a) sensitises tumour cells to natural killer (NK) cells-mediated cytolysis. TRIM30a has no effect on tumour cell proliferation or apoptosis in vitro. However, TRIM30a-overexpressing tumour cells grow substantially slower than control tumour cells in immune-competent mice but not in NK-depleted mice. Mechanistically, TRIM30a overexpression impedes the clearance of misfolded protein and increases the production of reactive oxygen species induced by proteotoxic stress, implying that TRIM30a impairs protein quality control (PQC)...
Source: Immunology - September 27, 2023 Category: Allergy & Immunology Authors: Lukman O Afolabi Jiacheng Bi Liang Chen Xiaolu Yang Xiaochun Wan Source Type: research
NLRP2 in health and disease
Immunology. 2023 Sep 22. doi: 10.1111/imm.13699. Online ahead of print.ABSTRACTNLR family pyrin domain containing 2 (NLRP2) is a novel member of the Nod-like receptor (NLR) family. However, our understanding of NLRP2 has long been ambiguous. NLRP2 may have a role in the innate immune response, but its 'specific' functions remain controversial. Although NLRP2 can initiate inflammasome and promote inflammation, it can also downregulate inflammatory signals. Additionally, NLRP2 has been reported to function in the reproductive system and shows high expression in the placenta. However, the exact role of NLRP2 in the reproducti...
Source: Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Tongtong Zhang Fei Xing Mingcui Qu Zhihu Yang Yafei Liu Yongchao Yao Na Xing Source Type: research
