NLRP2 in health and disease
Immunology. 2023 Sep 22. doi: 10.1111/imm.13699. Online ahead of print.ABSTRACTNLR family pyrin domain containing 2 (NLRP2) is a novel member of the Nod-like receptor (NLR) family. However, our understanding of NLRP2 has long been ambiguous. NLRP2 may have a role in the innate immune response, but its 'specific' functions remain controversial. Although NLRP2 can initiate inflammasome and promote inflammation, it can also downregulate inflammatory signals. Additionally, NLRP2 has been reported to function in the reproductive system and shows high expression in the placenta. However, the exact role of NLRP2 in the reproducti...
Source: Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Tongtong Zhang Fei Xing Mingcui Qu Zhihu Yang Yafei Liu Yongchao Yao Na Xing Source Type: research
NLRP2 in health and disease
Immunology. 2023 Sep 22. doi: 10.1111/imm.13699. Online ahead of print.ABSTRACTNLR family pyrin domain containing 2 (NLRP2) is a novel member of the Nod-like receptor (NLR) family. However, our understanding of NLRP2 has long been ambiguous. NLRP2 may have a role in the innate immune response, but its 'specific' functions remain controversial. Although NLRP2 can initiate inflammasome and promote inflammation, it can also downregulate inflammatory signals. Additionally, NLRP2 has been reported to function in the reproductive system and shows high expression in the placenta. However, the exact role of NLRP2 in the reproducti...
Source: Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Tongtong Zhang Fei Xing Mingcui Qu Zhihu Yang Yafei Liu Yongchao Yao Na Xing Source Type: research
NLRP2 in health and disease
Immunology. 2023 Sep 22. doi: 10.1111/imm.13699. Online ahead of print.ABSTRACTNLR family pyrin domain containing 2 (NLRP2) is a novel member of the Nod-like receptor (NLR) family. However, our understanding of NLRP2 has long been ambiguous. NLRP2 may have a role in the innate immune response, but its 'specific' functions remain controversial. Although NLRP2 can initiate inflammasome and promote inflammation, it can also downregulate inflammatory signals. Additionally, NLRP2 has been reported to function in the reproductive system and shows high expression in the placenta. However, the exact role of NLRP2 in the reproducti...
Source: Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Tongtong Zhang Fei Xing Mingcui Qu Zhihu Yang Yafei Liu Yongchao Yao Na Xing Source Type: research
NLRP2 in health and disease
Immunology. 2023 Sep 22. doi: 10.1111/imm.13699. Online ahead of print.ABSTRACTNLR family pyrin domain containing 2 (NLRP2) is a novel member of the Nod-like receptor (NLR) family. However, our understanding of NLRP2 has long been ambiguous. NLRP2 may have a role in the innate immune response, but its 'specific' functions remain controversial. Although NLRP2 can initiate inflammasome and promote inflammation, it can also downregulate inflammatory signals. Additionally, NLRP2 has been reported to function in the reproductive system and shows high expression in the placenta. However, the exact role of NLRP2 in the reproducti...
Source: Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Tongtong Zhang Fei Xing Mingcui Qu Zhihu Yang Yafei Liu Yongchao Yao Na Xing Source Type: research
Transforming growth factor- β, Interleukin-23 and interleukin-1β modulate TH22 response during active multidrug-resistant tuberculosis
Immunology. 2023 Sep 16. doi: 10.1111/imm.13698. Online ahead of print.ABSTRACTWe previously reported that patients with multidrug-resistant tuberculosis (MDR-TB) showed low systemic and Mtb-induced Th22 responses associated to high sputum bacillary load and severe lung lesions suggesting that Th22 response could influence the ability of these patients to control bacillary growth and tissue damage. In MDR-TB patients, the percentage of IL-22+ cells inversely correlates with the proportion of senescent PD-1+ T cells. Herein, we aimed to evaluate the pathways involved on the regulation of systemic and Mtb-induced Th22 respon...
Source: Immunology - September 16, 2023 Category: Allergy & Immunology Authors: Bel én R Imperiale Ana Gamberale Noem í Yokobori Ana Garc ía Bruno Bartoletti Omar Aidar Beatriz L ópez Victor Cruz Pablo Gonz ález Montaner Domingo J Palmero Silvia de la Barrera Source Type: research
Transforming growth factor- β, Interleukin-23 and interleukin-1β modulate TH22 response during active multidrug-resistant tuberculosis
Immunology. 2023 Sep 16. doi: 10.1111/imm.13698. Online ahead of print.ABSTRACTWe previously reported that patients with multidrug-resistant tuberculosis (MDR-TB) showed low systemic and Mtb-induced Th22 responses associated to high sputum bacillary load and severe lung lesions suggesting that Th22 response could influence the ability of these patients to control bacillary growth and tissue damage. In MDR-TB patients, the percentage of IL-22+ cells inversely correlates with the proportion of senescent PD-1+ T cells. Herein, we aimed to evaluate the pathways involved on the regulation of systemic and Mtb-induced Th22 respon...
Source: Immunology - September 16, 2023 Category: Allergy & Immunology Authors: Bel én R Imperiale Ana Gamberale Noem í Yokobori Ana Garc ía Bruno Bartoletti Omar Aidar Beatriz L ópez Victor Cruz Pablo Gonz ález Montaner Domingo J Palmero Silvia de la Barrera Source Type: research
Transforming growth factor- β, Interleukin-23 and interleukin-1β modulate TH22 response during active multidrug-resistant tuberculosis
Immunology. 2023 Sep 16. doi: 10.1111/imm.13698. Online ahead of print.ABSTRACTWe previously reported that patients with multidrug-resistant tuberculosis (MDR-TB) showed low systemic and Mtb-induced Th22 responses associated to high sputum bacillary load and severe lung lesions suggesting that Th22 response could influence the ability of these patients to control bacillary growth and tissue damage. In MDR-TB patients, the percentage of IL-22+ cells inversely correlates with the proportion of senescent PD-1+ T cells. Herein, we aimed to evaluate the pathways involved on the regulation of systemic and Mtb-induced Th22 respon...
Source: Immunology - September 16, 2023 Category: Allergy & Immunology Authors: Bel én R Imperiale Ana Gamberale Noem í Yokobori Ana Garc ía Bruno Bartoletti Omar Aidar Beatriz L ópez Victor Cruz Pablo Gonz ález Montaner Domingo J Palmero Silvia de la Barrera Source Type: research
Transforming growth factor- β, Interleukin-23 and interleukin-1β modulate TH22 response during active multidrug-resistant tuberculosis
Immunology. 2023 Sep 16. doi: 10.1111/imm.13698. Online ahead of print.ABSTRACTWe previously reported that patients with multidrug-resistant tuberculosis (MDR-TB) showed low systemic and Mtb-induced Th22 responses associated to high sputum bacillary load and severe lung lesions suggesting that Th22 response could influence the ability of these patients to control bacillary growth and tissue damage. In MDR-TB patients, the percentage of IL-22+ cells inversely correlates with the proportion of senescent PD-1+ T cells. Herein, we aimed to evaluate the pathways involved on the regulation of systemic and Mtb-induced Th22 respon...
Source: Immunology - September 16, 2023 Category: Allergy & Immunology Authors: Bel én R Imperiale Ana Gamberale Noem í Yokobori Ana Garc ía Bruno Bartoletti Omar Aidar Beatriz L ópez Victor Cruz Pablo Gonz ález Montaner Domingo J Palmero Silvia de la Barrera Source Type: research
Transforming growth factor- β, Interleukin-23 and interleukin-1β modulate TH22 response during active multidrug-resistant tuberculosis
Immunology. 2023 Sep 16. doi: 10.1111/imm.13698. Online ahead of print.ABSTRACTWe previously reported that patients with multidrug-resistant tuberculosis (MDR-TB) showed low systemic and Mtb-induced Th22 responses associated to high sputum bacillary load and severe lung lesions suggesting that Th22 response could influence the ability of these patients to control bacillary growth and tissue damage. In MDR-TB patients, the percentage of IL-22+ cells inversely correlates with the proportion of senescent PD-1+ T cells. Herein, we aimed to evaluate the pathways involved on the regulation of systemic and Mtb-induced Th22 respon...
Source: Immunology - September 16, 2023 Category: Allergy & Immunology Authors: Bel én R Imperiale Ana Gamberale Noem í Yokobori Ana Garc ía Bruno Bartoletti Omar Aidar Beatriz L ópez Victor Cruz Pablo Gonz ález Montaner Domingo J Palmero Silvia de la Barrera Source Type: research
Advancements in Nipah virus treatment: Analysis of current progress in vaccines, antivirals, and therapeutics
Immunology. 2023 Sep 15. doi: 10.1111/imm.13695. Online ahead of print.ABSTRACTNipah virus (NiV) causes severe encephalitis in humans. Three NiV strains NiV-Malaysia (NiVM ), NiV Bangladesh (NiVB ), and NiV India (NiVI reported in 2019) have been circulating in South-Asian nations. Sporadic outbreak observed in South-East Asian countries but human to human transmission raises the concern about its pandemic potential. The presence of the viral genome in reservoir bats has further confirmed that NiV has spread to the African and Australian continents. NiV research activities have gained momentum to achieve specific preparedn...
Source: Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Gayatree Mishra Vishal Prajapat Debasis Nayak Source Type: research
Advancements in Nipah virus treatment: Analysis of current progress in vaccines, antivirals, and therapeutics
Immunology. 2023 Sep 15. doi: 10.1111/imm.13695. Online ahead of print.ABSTRACTNipah virus (NiV) causes severe encephalitis in humans. Three NiV strains NiV-Malaysia (NiVM ), NiV Bangladesh (NiVB ), and NiV India (NiVI reported in 2019) have been circulating in South-Asian nations. Sporadic outbreak observed in South-East Asian countries but human to human transmission raises the concern about its pandemic potential. The presence of the viral genome in reservoir bats has further confirmed that NiV has spread to the African and Australian continents. NiV research activities have gained momentum to achieve specific preparedn...
Source: Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Gayatree Mishra Vishal Prajapat Debasis Nayak Source Type: research
Serum vitamin D deficiency is associated with increased risk of γδ T cell exhaustion in HBV-infected patients
In this study, we found that the frequency of circulating Vδ2+ T cell and serum levels of vitamin 25(OH)D3 were significantly decreased in patients with HBV. And serum 25(OH)D3 levels in HBV-infected patients were negatively correlated with HBV DNA load and PD-1 expression on γδ T cells. Interestingly, 1α,25(OH)2 D3 alleviated the exhaustion phenotype of Vδ2 T cells in HBV-infected patients and promoted IFN-β expression in human cytotoxic Vδ2 T cells in vitro. Collectively, these findings demonstrate that vitamin D plays a pivotal role in reversing γδ T-cell exhaustion and is highly promising target for ameliorati...
Source: Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Ke Li Eying Lu Qian Wang Ruirong Xu Wenhui Yuan Ruan Wu Ligong Lu Peng Li Source Type: research
Macrophage memory: Types, mechanisms, and its role in health and disease
Immunology. 2023 Sep 13. doi: 10.1111/imm.13697. Online ahead of print.ABSTRACTOn the basis of the mechanisms of action and characteristics of immune effects, immunity is commonly categorized into innate and adaptive immunity. Adaptive immunity is associated with the response to non-self-entities and is characterized by high specificity and memory properties. In contrast, innate immunity has traditionally been considered devoid of memory characteristics. However, an increasing number of studies have sought to challenge this conventional immunological dogma and shown that innate immune cells exhibit a more robust and rapid ...
Source: Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Xu-Hui Fang Zhi-Jing Li Chun-Yan Liu Gil Mor Ai-Hua Liao Source Type: research
Serum vitamin D deficiency is associated with increased risk of γδ T cell exhaustion in HBV-infected patients
In this study, we found that the frequency of circulating Vδ2+ T cell and serum levels of vitamin 25(OH)D3 were significantly decreased in patients with HBV. And serum 25(OH)D3 levels in HBV-infected patients were negatively correlated with HBV DNA load and PD-1 expression on γδ T cells. Interestingly, 1α,25(OH)2 D3 alleviated the exhaustion phenotype of Vδ2 T cells in HBV-infected patients and promoted IFN-β expression in human cytotoxic Vδ2 T cells in vitro. Collectively, these findings demonstrate that vitamin D plays a pivotal role in reversing γδ T-cell exhaustion and is highly promising target for ameliorati...
Source: Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Ke Li Eying Lu Qian Wang Ruirong Xu Wenhui Yuan Ruan Wu Ligong Lu Peng Li Source Type: research
Macrophage memory: Types, mechanisms, and its role in health and disease
Immunology. 2023 Sep 13. doi: 10.1111/imm.13697. Online ahead of print.ABSTRACTOn the basis of the mechanisms of action and characteristics of immune effects, immunity is commonly categorized into innate and adaptive immunity. Adaptive immunity is associated with the response to non-self-entities and is characterized by high specificity and memory properties. In contrast, innate immunity has traditionally been considered devoid of memory characteristics. However, an increasing number of studies have sought to challenge this conventional immunological dogma and shown that innate immune cells exhibit a more robust and rapid ...
Source: Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Xu-Hui Fang Zhi-Jing Li Chun-Yan Liu Gil Mor Ai-Hua Liao Source Type: research
