IL-1 signaling pathway, an important target for inflammation surrounding in myocardial infarction
This article reviews the complex series of responses after myocardial infarction, including the involvement of inflammatory cells and the role of cytokines and chemokines, focusing on the progression of the IL-1 family in myocardial infarction as well as the performance of current targeted therapy drugs in experiments. (Source: Inflammopharmacology)
Source: Inflammopharmacology - April 27, 2024 Category: Drugs & Pharmacology Source Type: research
The renoprotective activity of amikacin –gamma-amino butyric acid–chitosan nanoparticles: a comparative study
AbstractThe development of nanoparticles (NPs) with active components with upgraded stability, and prolonged release helps in enhanced tissue regeneration. In addition, NPs are feasible strategy to boost antibiotic effectiveness and reduce drug side effects. Our study focuses on the use of amikacin (AMK) and gamma amino butyric acid (GABA) unloaded combinations or loaded on chitosan nanoparticles (CSNPs) for kidney protection. The AMK –GABA–CSNPs were prepared with the ionic gelation method, the morphology was studied using transmission electron microscopy (TEM), zetasizer and the Fourier transform-infrared spectroscop...
Source: Inflammopharmacology - April 25, 2024 Category: Drugs & Pharmacology Source Type: research
Diosmetin attenuates fibromyalgia-like symptoms in a reserpine-induced model in mice
AbstractFibromyalgia is a potentially disabling idiopathic disease characterized by widespread chronic pain associated with comorbidities such as fatigue, anxiety, and depression. Current therapeutic approaches present adverse effects that limit adherence to therapy. Diosmetin, an aglycone of the flavonoid glycoside diosmin found in citrus fruits and the leaves ofOleaeuropaea L., has antinociceptive, anti-inflammatory, and antioxidant properties. Here, we investigated the effect of diosmetin on nociceptive behaviors and comorbidities in an experimental fibromyalgia model induced by reserpine in mice. To induce the experime...
Source: Inflammopharmacology - April 25, 2024 Category: Drugs & Pharmacology Source Type: research
Neuroinflammation and the role of epigenetic-based therapies for Huntington ’s disease management: the new paradigm
AbstractHuntington ’s disease (HD) is an inherited, autosomal, neurodegenerative ailment that affects the striatum of the brain. Despite its debilitating effect on its patients, there is no proven cure for HD management as of yet. Neuroinflammation, excitotoxicity, and environmental factors have been reported to inf luence the regulation of gene expression by modifying epigenetic mechanisms. Aside focusing on the etiology, changes in epigenetic mechanisms have become a crucial factor influencing the interaction between HTT protein and epigenetically transcribed genes involved in neuroinflammation and HD. This review pres...
Source: Inflammopharmacology - April 23, 2024 Category: Drugs & Pharmacology Source Type: research
Combined effect of pantoprazole and mesenchymal stem cells on experimentally induced gastric ulcer: implication of oxidative stress, inflammation and apoptosis pathways
This study aimed to investigate the possible alleviating effect of a combined treatment of pantoprazole (PANTO) and adipose tissue-derived mesenchymal stem cells (ADSCs) in comparison with each treatment alone on the healing process of the experimentally induced GU in rats, and to uncover the involved pathways. Rats were divided into five groups: (1) Control, (2) GU, (3) PANTO, (4) ADSCs and (5) ADSCs + PANTO. Markers of oxidative stress, inflammation and apoptosis were assessed. The current data indicated that PANTO-, ADSCs- and ADSCs + PANTO-treated groups showed significant drop (p < 0.05) in serum adva...
Source: Inflammopharmacology - April 23, 2024 Category: Drugs & Pharmacology Source Type: research
Molecular insights of Eucalyptol (1,8-Cineole) as an anti-arthritic agent: in vivo and in silico analysis of IL-17, IL-10, NF- κB, 5-LOX and COX-2
AbstractThe monoterpene oxide, Eucalyptol (1,8-Cineole), a primary component of eucalyptus oil, has been evaluated pharmacologically for anti-inflammatory and analgesic activity. Current research aimed to evaluate Eucalyptol ’s anti-arthritic potential in a Complete Freund’s adjuvant induced arthritis that resembles human rheumatoid arthritis. Polyarthritis developed after 0.1 mL CFA injection into the left hind footpad in rats. Oral administration of Eucalyptol at various doses (100, 200 and 400 mg/kg) significan tly reduced paw edema, body weight loss, 5-LOX, PGE2 and Anti-CCP levels. Real‐time PCR investigation ...
Source: Inflammopharmacology - April 22, 2024 Category: Drugs & Pharmacology Source Type: research
Efficacy and safety of proton pump inhibitors on cardiovascular events and inflammatory factors in patients with upper gastrointestinal bleeding undergoing dual antiplatelet therapy
ConclusionMelena was the most frequent clinical manifestation in UGIB patients. The use of PPIs did not increase the risk of CVEs, and different PPI drugs did not affect the occurrence of CVEs. Furthermore, PPIs lowered CRP and TNF- α levels in serum of these patients. (Source: Inflammopharmacology)
Source: Inflammopharmacology - April 20, 2024 Category: Drugs & Pharmacology Source Type: research
Therapeutic effects and mechanisms of isoxanthohumol on DSS-induced colitis: regulating T cell development, restoring gut microbiota, and improving metabolic disorders
AbstractUlcerative colitis (UC) is a severe hazard to human health. Since pathogenesis of UC is still unclear, current therapy for UC treatment is far from optimal. Isoxanthohumol (IXN), a prenylflavonoid from hops and beer, possesses anti-microbial, anti-oxidant, anti-inflammatory, and anti-angiogenic properties. However, the potential effects of IXN on the alleviation of colitis and the action of the mechanism is rarely studied. Here, we found that administration of IXN (60 mg/kg/day, gavage) significantly attenuated dextran sodium sulfate (DSS)-induced colitis, evidenced by reduced DAI scores and histological improvem...
Source: Inflammopharmacology - April 20, 2024 Category: Drugs & Pharmacology Source Type: research
Neuroprotective effect of Withania somnifera leaves extract nanoemulsion against penconazole-induced neurotoxicity in albino rats via modulating TGF- β1/Smad2 signaling pathway
In conclusion, WSLE NE markedly enhanced the permeability of plant extract constituents through the blood brain barrier to boost its neuroprotective effect against PEN-induced neurotoxicity. (Source: Inflammopharmacology)
Source: Inflammopharmacology - April 17, 2024 Category: Drugs & Pharmacology Source Type: research
Evaluating the docetaxel effect in an animal model of polyarthritis
ConclusionDTX reduces the progression and joint destruction in rats induced by Complete Freund ’s Adjuvant which may due to inhibition of PAD4, TNF-α, IL-1β, VEGF, and ACPA. Also, methotrexate exhibited anti PAD4 effect. (Source: Inflammopharmacology)
Source: Inflammopharmacology - April 15, 2024 Category: Drugs & Pharmacology Source Type: research
Impact of prior antihypertensive treatment on COVID-19 outcomes, by active ingredient
ConclusionThis large-scale real-world data study suggest thatenalapril andcandesartan are associated with a considerable reduction in risk of severe COVID19 outcomes. (Source: Inflammopharmacology)
Source: Inflammopharmacology - April 15, 2024 Category: Drugs & Pharmacology Source Type: research
Comparison of different sources of mesenchymal stem cells: focus on inflammatory bowel disease
This study comprehensively analyses MSC derived from multiple sources, including bone marrow, adipose tissue, umbilical cord, and other potential reservoirs. Core elements of this investigation include assessing differences in cell acquisition, immunomodulatory effects, and differentiation capabilities among these MSC sources, as well as comparing their clinical trial outcomes in IBD patients to their therapeutic efficacy in animal models. Through meticulous evaluation and comparative analysis, this thesis aims to elucidate disparities in the efficacy of different MSC sources for IBD treatment, thereby identifying the most...
Source: Inflammopharmacology - April 14, 2024 Category: Drugs & Pharmacology Source Type: research
Artemisia herba-alba: antioxidant capacity and efficacy in preventing chronic arthritis in vivo
This study investigated the hydroethanolic extract ofArtemisia herba-alba for its protective potential against arthritis hallmarks, oxidative stress, and lipid peroxidation in vitro. It also assessed its in vivo anti-arthritic activity. The phytochemical analysis identified various compounds within the extract, with high concentrations of polyphenols and flavonoids. These compounds are associated with numerous health benefits, makingA. herba-alba a potential source of valuable phytochemicals.A. herba-alba demonstrated a notable effect in body weight loss, paw edema, and arthritic severity. Histopathological examination rev...
Source: Inflammopharmacology - April 12, 2024 Category: Drugs & Pharmacology Source Type: research
Terminalia ferdinandiana Exell. extracts reduce pro-inflammatory cytokine and PGE2 secretion, decrease COX-2 expression and down-regulate cytosolic NF- κB levels
This study investigated the immune-modulatory and anti-inflammatory properties ofT. ferdinandiana fruit and leaf extracts by evaluating their inhibition of multiple pro- and anti-inflammatory cytokines and chemokines secretion in lipopolysaccharide (LPS)-stimulated and unstimulated RAW 264.7 macrophages using multiplex bead immunoassays and ELISA assays. The methanolic extracts were particularly good immune-modulators, significantly inhibiting the secretion of all the cytokines and chemokines tested. Indeed, the methanolic extracts completely inhibited IL-10, IFN- γ, IL-1β, IL-6, MCP-1, and MIP-2a secretion, and almost c...
Source: Inflammopharmacology - April 6, 2024 Category: Drugs & Pharmacology Source Type: research
Evaluation of efficacy and safety of glucosamine sulfate, chondroitin sulfate, and their combination regimen in the management of knee osteoarthritis: a systematic review and meta-analysis
ConclusionThis meta-analysis revealed that the CS (with decreased pain intensity and improvement in the physical function), and GS (with significant reduction in the joint space narrowing) have significant therapeutic benefits. However, their combination did not significantly improve the symptoms or modify the disease. This may be due to the limited trials that are available on the combination of the sulfate forms of the intervention. Hence, there is a scope for conducting multicentric randomised controlled trials to evaluate and conclude the therapeutic role of CS and GS combination in the management of KOA. (Source: Inflammopharmacology)
Source: Inflammopharmacology - April 6, 2024 Category: Drugs & Pharmacology Source Type: research
