Pegylated polymeric micelles of boswellic acid-selenium mitigates repetitive mild traumatic brain injury: Regulation of miR-155 and miR-146a/BDNF/ Klotho/Foxo3a cue
This study aims to explore the protective machinery of pegylated polymeric micelles of boswellic acid-selenium (PMBS) against secondary neuronal damage triggered by mild repetitive traumatic brain injury (RTBI). After PMBS characterization in terms of particle size, size distribution, zeta potential, and transmission electronic microscopy, the selected formula was used to investigate its potency against experimental RTBI. Five groups of rats were used; group 1 (control) and the other four groups were subjected to RTBI. Groups 2 was RTBI positive control, while 3, 4, and 5 received boswellic acid (BSA), selenium (SEL), and ...
Source: International Immunopharmacology - May 5, 2024 Category: Allergy & Immunology Authors: Amira A El-Gazar Soad Z El-Emam Shorouk M El-Sayyad Shereen S El-Mancy Sahar M Fayez Nermin M Sheta Asmaa K Al-Mokaddem Ghada M Ragab Source Type: research
Ferroptosis in antitumor therapy: Unraveling regulatory mechanisms and immunogenic potential
Int Immunopharmacol. 2024 May 4;134:112203. doi: 10.1016/j.intimp.2024.112203. Online ahead of print.ABSTRACTFerroptosis, a recently discovered form of non-apoptotic cell death, has the potential to revolutionize anti-tumor therapy. This review highlights the regulatory mechanisms and immunogenic properties of ferroptosis, and how it can enhance the effectiveness of radio and immunotherapies in overcoming tumor resistance. However, tumor metabolism and the impact of ferroptosis on the tumor microenvironment present challenges in completely realizing its therapeutic potential. A deeper understanding of the effects of ferrop...
Source: International Immunopharmacology - May 5, 2024 Category: Allergy & Immunology Authors: Ting Zhang Xiaoping Zeng Erming Zeng Hongmei Wang Source Type: research
Cornuside alleviates psoriasis-like skin lesions in mice by relieving inflammatory effects
Int Immunopharmacol. 2024 May 4;134:112183. doi: 10.1016/j.intimp.2024.112183. Online ahead of print.ABSTRACTPsoriasis is a chronic inflammatory skin disease substantially affecting the quality of life, with no complete cure owing to its complex pathogenesis. Cornuside, a major bioactive compound present in Cornus officinalis Sieb. et Zucc., which is a well-known traditional Chinese medicine with a variety of biological and pharmacological activities, such as anti-apoptotic, antioxidant, and anti-inflammatory properties. However, its effects on psoriasis remain unclear. Our preliminary analysis of network pharmacology show...
Source: International Immunopharmacology - May 5, 2024 Category: Allergy & Immunology Authors: Fenglian Yan Lin Wang Junfeng Zhang Zhihong Liu Bin Yu Wenbo Li Zhengran Guo Dongmei Shi Hui Zhang Huabao Xiong Source Type: research
Phage-delivered melittin for oral squamous cell Carcinoma: A potential therapeutic agent
Int Immunopharmacol. 2024 May 4:112163. doi: 10.1016/j.intimp.2024.112163. Online ahead of print.NO ABSTRACTPMID:38705763 | DOI:10.1016/j.intimp.2024.112163 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 5, 2024 Category: Allergy & Immunology Authors: Maheswaran Easwaran Fatma Abdelrahman Sivagnanavelmurugan Madasamy Baskar Venkidasamy Source Type: research
Current understanding on TREM-2 molecular biology and physiopathological functions
Int Immunopharmacol. 2024 May 3;134:112042. doi: 10.1016/j.intimp.2024.112042. Online ahead of print.ABSTRACTTriggering receptor expressed on myeloid cells 2 (TREM-2), a glycosylated receptor belonging to the immunoglobin superfamily and especially expressed in the myeloid cell lineage, is frequently explained as a reminiscent receptor for both adaptive and innate immunity regulation. TREM-2 is also acknowledged to influence NK cell differentiation via the PI3K and PLCγ signaling pathways, as well as the partial activation or direct inhibition of T cells. Additionally, TREM-2 overexpression is substantially linked to cell...
Source: International Immunopharmacology - May 4, 2024 Category: Allergy & Immunology Authors: Shiv Bharadwaj Yaroslava Groza Joanna M Mierzwicka Petr Mal ý Source Type: research
Shared biomarkers and mechanisms in idiopathic pulmonary fibrosis and non-small cell lung cancer
CONCLUSIONS: We revealed dysregulated extracellular matrix through aberrant expression of the relevant genes, which provided further understanding for the common molecular mechanisms predisposing the occurrence of both IPF and NSCLC.PMID:38703565 | DOI:10.1016/j.intimp.2024.112162 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 4, 2024 Category: Allergy & Immunology Authors: Xiaorui Ding Huarui Liu Qinghua Xu Tong Ji Ranxun Chen Zhengcheng Liu Jinghong Dai Source Type: research
Chemokine ‑ and chemokine receptor-based subtypes predict prognosis, immunotherapy and chemotherapy response in colorectal cancer patients
CONCLUSION: We first established robust prognostic subtypes based on chemokines and chemokine receptors, which could potentially serve as a novel biomarker for guiding individualized treatment in patients with CRC undergoing immunotherapy and chemotherapy.PMID:38703566 | DOI:10.1016/j.intimp.2024.112172 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 4, 2024 Category: Allergy & Immunology Authors: Wenjie Zhu Shimin Zhao Xiufeng Cheng Changlei Wu Zitao Liu Jun Huang Source Type: research
A novel vaccine strategy against Brucellosis using Brucella abortus multi-epitope OMPs vaccine based on Lactococcus lactis live bacterial vectors
This study evaluated the effectiveness of orally administering Lactococcus lactis (L. lactis) for producing the Brucella abortus multi-epitope OMPs peptide. A multi-epitope plasmid was generated through a reverse vaccinology method, and mice were administered the genetically modified L. lactis orally as a vaccine. The plasmid underwent digestion, synthesizing a 39 kDa-sized protein known as OMPs by the target group. The sera of mice that were administered the pNZ8124-OMPs-L. lactis vaccine exhibited a notable presence of IgG1 antibodies specific to outer membrane proteins (OMPs), heightened levels of interferon (IFN-λ) an...
Source: International Immunopharmacology - May 4, 2024 Category: Allergy & Immunology Authors: Tohid Piri-Gharaghie Ghazal Ghajari Golnoosh Rezaeizadeh Mohaned Adil Mohammed H Mahdi Source Type: research
Seipin is involved in oxygen-glucose deprivation/reoxygenation induced neuroinflammation by regulating the TLR3/TRAF3/NF- κB pathway
Int Immunopharmacol. 2024 May 3;134:112182. doi: 10.1016/j.intimp.2024.112182. Online ahead of print.ABSTRACTSeipin plays a crucial role in lipid metabolism and is involved in neurological disorders. However, the function and mechanism of action of seipin in acute ischemic stroke have not yet been elucidated. Here, we aimed to investigate the effect of seipin on neuroinflammation induced by oxygen-glucose deprivation/reoxygenation (OGD/R) and further explore the molecular mechanism by functional experiments. Our results revealed a significant decrease in seipin mRNA levels, accompanied by enhanced expression of TNF-α in p...
Source: International Immunopharmacology - May 4, 2024 Category: Allergy & Immunology Authors: Dongfen Guo Lele Hu Peng Xie Ping Sun Wenfeng Yu Source Type: research
New strategy to treat spinal cord injury: Nafamostat mesilate suppressed NLRP3-mediated pyroptosis during acute phase
In this study, we first determined the optimal dosage of NM for mice post-SCI (5 mg/kg/day). Subsequently, our RNA-seq findings revealed that NM has the potential to inhibit pyroptosis after SCI. These findings were further substantiated by subsequent Western blot (WB) and Immunofluorescence (IF) analyses in vivo. These results indicate that NM can alleviate NLRP3 (NOD-like receptor thermal protein domain associated protein 3)-mediated pyroptosis by modulating the NF-κB signaling pathway and reducing the protein expression levels of NIMA-related kinase 7 (NEK7) and cathepsin B (CTSB). In vitro experimental results support...
Source: International Immunopharmacology - May 4, 2024 Category: Allergy & Immunology Authors: Yongfu Lou Zonghao Li Han Zheng Zhongze Yuan Wenxiang Li Jianping Zhang Wenyuan Shen Yiming Gao Ning Ran Xiaohong Kong Shiqing Feng Source Type: research
Development of an immunoinflammatory indicator-related dynamic nomogram based on machine learning for the prediction of intravenous immunoglobulin-resistant Kawasaki disease patients
CONCLUSION: A web-based dynamic nomogram for IVIG resistance was constructed with good predictive performance, which can be used as a practical approach for early screening to assist physicians in personalizing the treatment of KD patients in Shanghai.PMID:38703570 | DOI:10.1016/j.intimp.2024.112194 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 4, 2024 Category: Allergy & Immunology Authors: Yue Wang Yinyin Cao Yang Li Fenhua Zhu Meifen Yuan Jin Xu Xiaojing Ma Jian Li Source Type: research
Rapid response in relapsed follicular lymphoma to novel anti-CD19 CAR-T therapy with pseudo-progression and cytomegalovirus infection: A case report
Int Immunopharmacol. 2024 May 3;134:112174. doi: 10.1016/j.intimp.2024.112174. Online ahead of print.ABSTRACTCD19-directed chimeric antigen receptor (CAR) T cell therapy has been shown to achieve a considerably durable response in patients with refractory or relapsed B cell non-Hodgkin lymphomas. Most of these CARs were generated by lentivirus. With the exception of Yescarta and Tecartus, few patients with relapsed-/refractory- lymphoma have been treated clinically with a CARs using retroviral vector (RV). Here, we reported a relapsed/refractory grade 2 follicular lymphoma patient with multiple chemotherapy failures, and w...
Source: International Immunopharmacology - May 4, 2024 Category: Allergy & Immunology Authors: Nan Zhong Qihong Ma Shiting Gong Yuanyuan Shi Lijun Zhao Danyu Wang Huanhuan Zhou Ning Liu Yuan Ye Jianxun Wang Liqiong Liu Zhi Guo Source Type: research
Mesenchymal stem cell-derived exosomes for management of prostate cancer: An updated view
Int Immunopharmacol. 2024 May 2;134:112171. doi: 10.1016/j.intimp.2024.112171. Online ahead of print.ABSTRACTProstate cancer represents the second most prevalent form of cancer found in males, and stands as the fifth primary contributor to cancer-induced mortality on a global scale. Research has shown that transplanted mesenchymal stem cells (MSCs) can migrate by homing to tumor sites in the body. In prostate cancer, researchers have explored the fact that MSC-based therapies (including genetically modified delivery vehicles or vectors) and MSC-derived exosomes are emerging as attractive options to improve the efficacy and...
Source: International Immunopharmacology - May 3, 2024 Category: Allergy & Immunology Authors: Fahimeh Lavi Arab Akram Hoseinzadeh Fatemeh Hafizi Fatemeh Sadat Mohammadi Farid Zeynali Melika Hadad Tehran Amirreza Rostami Source Type: research
cGAS/STING signaling pathway-mediated microglial activation in the PFC underlies chronic ethanol exposure-induced anxiety-like behaviors in mice
In this study, we initially confirmed that chronic ethanol exposure (CEE) induces anxiety-like behaviors in mice through open field test and elevated plus maze test. The cGAS/STING signaling pathway has been confirmed to exhibits a significant association with inflammatory signaling responses in both peripheral and central systems. Western blot analysis confirmed alterations in the cGAS/STING signaling pathway during CEE, including the upregulation of p-TBK1 and p-IRF3 proteins. Moreover, we observed microglial activation in the prefrontal cortex (PFC) of CEE mice, characterized by significant alterations in branching morp...
Source: International Immunopharmacology - May 3, 2024 Category: Allergy & Immunology Authors: Wei Zhao Shuang Zhao Ran Wei Ziqi Wang Fang Zhang Fangjiao Zong Han-Ting Zhang Source Type: research
Mesenchymal stem cell-derived exosomes for management of prostate cancer: An updated view
Int Immunopharmacol. 2024 May 2;134:112171. doi: 10.1016/j.intimp.2024.112171. Online ahead of print.ABSTRACTProstate cancer represents the second most prevalent form of cancer found in males, and stands as the fifth primary contributor to cancer-induced mortality on a global scale. Research has shown that transplanted mesenchymal stem cells (MSCs) can migrate by homing to tumor sites in the body. In prostate cancer, researchers have explored the fact that MSC-based therapies (including genetically modified delivery vehicles or vectors) and MSC-derived exosomes are emerging as attractive options to improve the efficacy and...
Source: International Immunopharmacology - May 3, 2024 Category: Allergy & Immunology Authors: Fahimeh Lavi Arab Akram Hoseinzadeh Fatemeh Hafizi Fatemeh Sadat Mohammadi Farid Zeynali Melika Hadad Tehran Amirreza Rostami Source Type: research
