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Enhanced osteogenic and ROS-scavenging MXene nanosheets incorporated gelatin-based nanocomposite hydrogels for critical-sized calvarial defect repair
Int J Biol Macromol. 2024 May 3;269(Pt 1):131914. doi: 10.1016/j.ijbiomac.2024.131914. Online ahead of print.ABSTRACTThe healing of critical-sized bone defects is a major challenge in the field of bone tissue engineering. Gelatin-related hydrogels have emerged as a potential solution due to their desirable properties. However, their limited osteogenic, mechanical, and reactive oxygen species (ROS)-scavenging capabilities have hindered their clinical application. To overcome this issue, we developed a biofunctional gelatin-Mxene nanocomposite hydrogel. Firstly, we prepared two-dimensional (2D) Ti3C2 MXene nanosheets using a...
Source: International Journal of Biological Macromolecules - May 4, 2024 Category: Biochemistry Authors: Jin Zhao Tiehua Wang Yuanchao Zhu Haotian Qin Junyu Qian Qichang Wang Peng Zhang Peng Liu Ao Xiong Nan Li Anjaneyulu Udduttula Sang-Ho Ye Deli Wang Hui Zeng Yingqi Chen Source Type: research

Efficacious bioconversion of alginate/cellulose to value-added oligosaccharides by alginate-degrading GH5 endoglucanase from Trichoderma asperellum
Int J Biol Macromol. 2024 May 2:131968. doi: 10.1016/j.ijbiomac.2024.131968. Online ahead of print.ABSTRACTEnzymatic degradation of lignocellulosic biomass provides an eco-friendly approach to produce value-added macromolecules, e.g., bioactive polysaccharides. A novel acidophilic GH5 β-1,4-endoglucanase (termed TaCel5) from Trichoderma asperellum ND-1 was efficiently expressed in Komagataella phaffii (~1.5-fold increase, 38.42 U/mL). TaCel5 displayed both endoglucanase (486.3 U/mg) and alginate lyase (359.5 U/mg) enzyme activities. It had optimal pH 3.0 and strong pH stability (exceed 86 % activity retained over pH range...
Source: International Journal of Biological Macromolecules - May 4, 2024 Category: Biochemistry Authors: Huan Zhuang Fengzhen Zheng Hengbin Zhang Jiaqiang Wang Jun Chen Source Type: research

Enhancing the nonlinear rheological property and digestibility of mung bean flour gels using controlled microwave treatments: Effect of starch debranching and protein denaturation
In conclusion, an industrial microwave treatment improved the gelling and digestive properties of MBF, and Lissajous curve has good adaptability in characterizing the viscoelasticity of gels under large deformations.PMID:38704060 | DOI:10.1016/j.ijbiomac.2024.132049 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - May 4, 2024 Category: Biochemistry Authors: Yue Gu Rong Xu Tongxun Liu David Julian McClements Xiujie Zhao Jinjin Wu Mouming Zhao Qiangzhong Zhao Source Type: research

Inhibition of protein misfolding and aggregation by steroidal quinoxalin-2(1H)-one and their molecular docking studies
Int J Biol Macromol. 2024 May 2:132020. doi: 10.1016/j.ijbiomac.2024.132020. Online ahead of print.ABSTRACTA series of D-ring fused 16-substituted steroidal quinoxalin-2(1H)-one attached to an electron-releasing (ER) or electron-withdrawing (EW) groups via steroidal oxoacetate intermediate were synthesized to investigate their protein aggregation inhibition potential using human lysozyme (HLZ). The influence of the type of substituent at the C-6 positions of the quinoxalin-2(1H)-one ring on the protein aggregation inhibition potential was observed, showing that the EW moiety improved the protein aggregation inhibition pote...
Source: International Journal of Biological Macromolecules - May 4, 2024 Category: Biochemistry Authors: Arfeen Iqbal Md Tauqir Alam Asna Khan Tabassum Siddiqui Abad Ali Source Type: research

Emerging trends and challenges in polysaccharide derived materials for wound care applications: A review
Int J Biol Macromol. 2024 May 2:132048. doi: 10.1016/j.ijbiomac.2024.132048. Online ahead of print.ABSTRACTPolysaccharides are favourable and promising biopolymers for wound care applications due to their abundant natural availability, low cost and excellent biocompatibility. They possess different functional groups, such as carboxylic, hydroxyl and amino, and can easily be modified to obtain the desirable properties and various forms. This review systematically analyses the recent progress in polysaccharides derived materials for wound care applications, emphasizing the most commonly used cellulose, chitosan, alginate, st...
Source: International Journal of Biological Macromolecules - May 4, 2024 Category: Biochemistry Authors: Muhammad Zubair Ajaz Hussain Sohail Shahzad Muhammad Arshad Aman Ullah Source Type: research

Fractionation of cassava pectins and their detailed structural analyses using various pectinolytic enzymes
In this study, we analyzed the pectin structure within the pulp of cassava. Cassava pectin, derived from cassava pulp treatment at 120 °C for 90 min, was separated into four fractions (CP-P, CP-SD1, CP-SD2F, and CP-SD2R) based on variations in water solubility, electrical properties, and molecular weights. Sugar composition analysis demonstrated an abundance of homogalacturonan (HG) in CP-P and CP-SD2F, rhamnogalacturonan I (RG-I) in CP-SD2R, and neutral sugars in CP-SD1. Because RG-I possesses a complex structure, we analyzed CP-SD2R using various pectinolytic enzymes. Galactose was the major sugar in CP-SD2R accounting ...
Source: International Journal of Biological Macromolecules - May 4, 2024 Category: Biochemistry Authors: Yuka Kotani Nozomu Shibata Meng-I Lin Masami Nakazawa Mitsuhiro Ueda Tatsuji Sakamoto Source Type: research

Cu-Tremella fuciformis polysaccharide-based tumor microenvironment-responsive injectable gels for cuproptosis-based synergistic osteosarcoma therapy
Int J Biol Macromol. 2024 May 2:132029. doi: 10.1016/j.ijbiomac.2024.132029. Online ahead of print.ABSTRACTCuproptosis affects osteosarcoma locally, and the exploitation of cuproptosis-related biomaterials for osteosarcoma treatment is still in its infancy. We designed and synthesized a novel injectable gel of Cu ion-coordinated Tremella fuciformis polysaccharide (TFP-Cu) for antiosteosarcoma therapy. This material has antitumor effects, the ability to stimulate immunity and promote bone formation, and a controlled Cu2+ release profile in smart response to tumor microenvironment stimulation. TFP-Cu can selectively inhibit ...
Source: International Journal of Biological Macromolecules - May 4, 2024 Category: Biochemistry Authors: Chao Xie Qili Sun Jingle Chen Bingsheng Yang Huiwen Lu Zhanpeng Liu Yucong Li Kai Li Bin Tang Lijun Lin Source Type: research

ICG-labeled PD-L1-antagonistic affibody dimer for tumor imaging and enhancement of tumor photothermal-immunotherapy
Int J Biol Macromol. 2024 May 2:132058. doi: 10.1016/j.ijbiomac.2024.132058. Online ahead of print.ABSTRACTIn clinical practice, tumor-targeting diagnosis and immunotherapy against programmed death ligand 1 (PD-L1) have a significant impact. In this research, a PD-L1-antagonistic affibody dimer (ZPD-L1) was successfully prepared through Escherichia coli expression system, and conjugated with the photosensitizer of ICG via N-hydroxysuccinimide (NHS) ester to develop a novel tumor-targeting agent (ICG-ZPD-L1) for both tumor imaging diagnosis and photothermal-immunotherapy simultaneously. In vitro, ZPD-L1 could specifically b...
Source: International Journal of Biological Macromolecules - May 4, 2024 Category: Biochemistry Authors: Dianlong Jia Shiqi Zhao Huimin Liu Xinyu Zhan Zhongxia Zhou Mingjia Lv Xiufeng Tang Wen Guo Hui Li Lilan Sun Yidong Zhong Baoqing Tian Dandan Yuan Xiaohui Tang Qing Fan Source Type: research

Inorganic catalase-powered nanomotors with hyaluronic acid coating for pneumonia therapy
Int J Biol Macromol. 2024 May 2:132028. doi: 10.1016/j.ijbiomac.2024.132028. Online ahead of print.ABSTRACTClinical therapy for widespread infections caused by Streptococcus pneumoniae (S. pneumoniae), such as community-acquired pneumonia, is highly challenging. As an important bacterial toxin, hydrogen peroxide (H2O2) secreted by S. pneumoniae can suppress the host's immune system and cause more severe disease. To address this problem, a hyaluronic acid (HA)-coated inorganic catalase-driven Janus nanomotor was developed, which can cleverly utilize and decompose H2O2 to reduce the burden of bacterial infection, and have ex...
Source: International Journal of Biological Macromolecules - May 4, 2024 Category: Biochemistry Authors: Jingru Shi Yu Wang Lingjiao Zhang Fei Wang Yu Miao Jialun Yang Liping Wang Shuo Shi Lili Ma Jinyou Duan Source Type: research

Emerging anticancer potential and mechanisms of snake venom toxins: A review
Int J Biol Macromol. 2024 May 2:131990. doi: 10.1016/j.ijbiomac.2024.131990. Online ahead of print.ABSTRACTAnimal-derived venom, like snake venom, has been proven to be valuable natural resources for the drug development. Previously, snake venom was mainly investigated in its pharmacological activities in regulating coagulation, vasodilation, and cardiovascular function, and several marketed cardiovascular drugs were successfully developed from snake venom. In recent years, snake venom fractions have been demonstrated with anticancer properties of inducing apoptotic and autophagic cell death, restraining proliferation, sup...
Source: International Journal of Biological Macromolecules - May 4, 2024 Category: Biochemistry Authors: Xijun Guo Yuanfeng Fu Junbo Peng Ying Fu Shuai Dong Ren-Bo Ding Xingzhu Qi Jiaolin Bao Source Type: research

A review on the enhancement of circular economy aspects focusing on nanocellulose composites
Int J Biol Macromol. 2024 May 2:132052. doi: 10.1016/j.ijbiomac.2024.132052. Online ahead of print.ABSTRACTResearchers are now focusing on using the circular economy model to manufacture nanocellulose composites due to growing environmental issues related to waste management. The circular economy model offers a sustainable solution to the problem by optimizing resource efficiency and waste management by reducing waste, maintaining value over time, minimizing the use of primary resources, and creating closed loops for goods, components, and materials. With the use of the circular economy model, waste, such as industrial, ag...
Source: International Journal of Biological Macromolecules - May 4, 2024 Category: Biochemistry Authors: Muhammad Adlan Azka Adib Adam S M Ridzuan S M Sapuan Abdul Habib Source Type: research

A review on structure-function mechanism and signaling pathway of serine/threonine protein PIM kinases as a therapeutic target
In conclusion, we provide insights into the benefits of degrading PIM kinases as opposed to blocking their catalytic activity to address the oncogenic potential of PIM kinases.PMID:38704069 | DOI:10.1016/j.ijbiomac.2024.132030 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - May 4, 2024 Category: Biochemistry Authors: Ajaya Kumar Rout Budheswar Dehury Satya Narayan Parida Sushree Swati Rout Rajkumar Jena Neha Kaushik Nagendra Kumar Kaushik Sukanta Kumar Pradhan Chita Ranjan Sahoo Ashok Kumar Singh Meenakshi Arya Bijay Kumar Behera Source Type: research

A novel sponge composite of chitosan-sodium tripolyphosphate-melamine for anionic dye Orange II removal
Int J Biol Macromol. 2024 May 2:132056. doi: 10.1016/j.ijbiomac.2024.132056. Online ahead of print.ABSTRACTSince the potential carcinogenic, toxic and non-degradable dyes trigger serious environmental contamination by improper treatment, developing novel adsorbents remains a major challenge. A novel high efficiency and biopolymer-based environmental-friendly adsorbent, chitosan‑sodium tripolyphosphate-melamine sponge (CTS-STPP-MS) composite, was prepared for Orange II removing with chitosan as raw material, sodium tripolyphosphate as cross-linking agent. The composite was carefully characterized by SEM, EDS, FT-IR and XP...
Source: International Journal of Biological Macromolecules - May 4, 2024 Category: Biochemistry Authors: Jiani Hu Kexin Chen Minghan Xiang Jianxiang Wei Yang Zeng Yan Qin Lingfan Zhang Wenqing Zhang Source Type: research

Effects of synergistic action on rheological and thermal properties of potato starch complexes co-gelatinized with caffeic acid and squash polysaccharides extracted with water and subcritical water
Int J Biol Macromol. 2024 May 2:131912. doi: 10.1016/j.ijbiomac.2024.131912. Online ahead of print.ABSTRACTIn order to broaden the application range of squash polysaccharide (WESP/SWESP) and caffeic acid (CAA) and improve the quality of potato starch (PS) products, the effects of WESP/SWESP and CAA on the gelatinization, rheology, thermodynamics, microstructure and in vitro digestion of PS were investigated. Meanwhile, the synergistic effect of WESP/SWESP and CAA on PS was further analyzed. Differently, due to WESP and SWESP had different monosaccharide composition and structure, they had different effects on the system. P...
Source: International Journal of Biological Macromolecules - May 4, 2024 Category: Biochemistry Authors: Yu Zhang Xunze Han Shanshan Diao Pengxinyi Xiao Shengtong Zhou Yiming Wang Bingjie Yang Jing Zhao Source Type: research

Discovery of a novel chemotype as DYRK1A inhibitors against Alzheimer's disease: Computational modeling and biological evaluation
Int J Biol Macromol. 2024 May 2:132024. doi: 10.1016/j.ijbiomac.2024.132024. Online ahead of print.ABSTRACTDual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) plays an essential role in Tau and Aβ pathology closely related to Alzheimer's disease (AD). Accumulative evidence has demonstrated DYRK1A inhibition is able to reduce the pathological features of AD. Nevertheless, there is no approved DYRK1A inhibitor for clinical use as anti-AD therapy. This is somewhat due to the lack of effective and safe chemotypes of DYRK1A inhibitors. To address this issue, we carried out in silico screening, in vitro assa...
Source: International Journal of Biological Macromolecules - May 4, 2024 Category: Biochemistry Authors: Nianzhuang Qiu Chenliang Qian Tingting Guo Yaling Wang Hongwei Jin Mingli Yao Mei Li Tianyang Guo Yuli Lv Xinxin Si Song Wu Hao Wang Xuehui Zhang Jie Xia Source Type: research