Long-term impact of intravascular ultrasound-guided for percutaneous coronary intervention on unprotected left main. The IMPACTUS-LM, an observational, multicentric study
The potential benefit on long term outcomes of Percutaneous Coronary Intervention (PCI) on Unprotected Left Main (ULM) driven by IntraVascular UltraSound (IVUS) remains to be defined. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 16, 2024 Category: Cardiology Authors: Francesco Bruno, Ovidio de Filippo, Andrea Sardone, Piera Capranzano, Federico Conrotto, Imad Sheiban, Federico Giacobbe, Claudio Laudani, Francesco Burzotta, Francesco Saia, Javier Escaned, Sergio Raposeiras Roubin, Massimo Mancone, Christian Templin, Al Source Type: research

10-year experience of utilizing a stress-first SPECT myocardial perfusion imaging
We report utilizing stress-first single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 16, 2024 Category: Cardiology Authors: Donghee Han, Mark C. Hyun, Robert J.H. Miller, Heidi Gransar, Piotr J. Slomka, Damini Dey, Sean W. Hayes, John D. Friedman, Louise E.J. Thomson, Daniel S. Berman, Alan Rozanski Source Type: research

82-rubidium positron emission tomography determined myocardial flow reserve and outcomes following cardiac revascularisation – A multicentre registry study
Finding patients with chronic coronary syndrome (CCS) whom revascularization could benefit, is complicated. Myocardial flow reserve (MFR), a measurement of myocardial perfusion, has proven prognostic value on survival and risk of major adverse cardiac events (MACE). We investigated if MFR identifies who may benefit from revascularization. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 16, 2024 Category: Cardiology Authors: M.H. Toftholm, S. H øjstrup, U. Talleruphuus, L. Marner, L. Bjerking, L. Jakobsen, E.H. Christiansen, K. Bouchelouche, S. Galatius, E. Prescott, K.W. Skak-Hansen Source Type: research

Copeptin for the differentiation of type 1 versus type 2 myocardial infarction or myocardial injury
This study aimed to investigate whether copeptin, a stress hormone produced in the hypothalamus, helps to differentiate between T1MI versus T2MI or injury. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 16, 2024 Category: Cardiology Authors: Mona Kassem, Pedro Lopez Ayala, Tijana Andric-Cancarevic, Milos Tajsic, Kris G. Vargas, Dimitri Bendik, Christoph Kaufmann, Johann Wojta, Christian Mueller, Kurt Huber Source Type: research

Concomitant transthyretin cardiac amyloidosis in patients undergoing TAVR for aortic stenosis: A systemic review and meta-analysis
Transcatheter aortic valve replacement (TAVR) is a successful treatment for aortic stenosis (AS) patients, and previous studies indicate favorable outcomes for those with concomitant aortic stenosis and transthyretin-associated cardiac amyloidosis (TTRCA-AS). However, the impact of TAVR on more adverse outcomes in TTRCA-AS patients compared to those with AS alone is still uncertain, with conflicting findings reported in the literature. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 15, 2024 Category: Cardiology Authors: Kaneez Fatima, Qazi Shurjeel Uddin, Zoaib Habib Tharwani, Muhammad Arham Bin Kashif, Syed Sarmad Javaid, Prince Kumar, Muhammad Twaha Zia, Maarij Javed, Malaika Saeed Butt, Zoraiz Asim Tags: Review Article Source Type: research

Can cuproptosis-related genes be involved in the pathogenesis of dilated cardiomyopathy?
Dilated cardiomyopathy (DCM) is a progressive, usually irreversible, disease that in mostly cases leads to heart failure. Notwithstanding its prevalence estimates worldwide are limited, it accounts for approximately 1:250 –400 and up to 1:2500 in the general population [1]. From a complex pathologic standpoint, dilated cardiomyopathy is generally designates an idiopathic immune process, gene mutations, systemic endocrine or autoimmune disorders, etc., leading to the left ventricular or biventricular dilation and sy stolic dysfunction [2]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 15, 2024 Category: Cardiology Tags: Editorial Source Type: research

Transcatheter bicaval valve system for the treatment of severe isolated tricuspid regurgitation. Features from a single-Centre experience
In this report, we present our experience with TricValve in a single center. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 15, 2024 Category: Cardiology Authors: Michele Di Mauro, Stefano Guarracini, Lorenzo Mazzocchetti, Donato Capuzzi, Lorenzo Salute, Massimo Di Marco, Roberto Lorusso, Antonio M. Calafiore Source Type: research

Editorial for the article: Hospitalization-based epidemiology of systemic and cardiac amyloidosis in the Veneto Region, Italy
Cardiac amyloidosis (CA) is a progressive infiltrative disease caused most commonly by the deposition of misfolded, cleaved and aggregated monoclonal immunoglobulin free light chain (AL) or transthyretin (ATTR) proteins in the myocardial extracellular space [1]. Recent advances in imaging techniques and the development of an algorithm for non-invasive confirmation of ATTR-CA [2] have transformed the diagnosis of this condition. Although it has been traditionally considered a rare and inexorably fatal condition, CA now is an increasingly recognized cause of heart failure (HF) and mortality worldwide [3]. (Source: Internatio...
Source: International Journal of Cardiology - February 15, 2024 Category: Cardiology Authors: Aldostefano Porcari, Marco Pozzan Tags: Editorial Source Type: research

Use of artificial intelligence and I-score for prediction of recurrence before catheter ablation of atrial fibrillation
This study aimed to predict the recurrence of AF after catheter ablation by using artificial intelligence (AI)-enabled pre-ablation computed tomography (PVCT) images and pre-ablation clinical data. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 13, 2024 Category: Cardiology Authors: Chih-Min Liu, Wei-Shiang Chen, Shih-Lin Chang, Yu-Cheng Hsieh, Yuan-Heng Hsu, Hao-Xiang Chang, Yenn-Jiang Lin, Li-Wei Lo, Yu-Feng Hu, Fa-Po Chung, Tze-Fan Chao, Ta-Chuan Tuan, Jo-Nan Liao, Chin-Yu Lin, Ting-Yung Chang, Ling Kuo, Cheng-I Wu, Mei-Han Wu, Ch Source Type: research

Long-term changes in cardiac remodelling in prevalent kidney graft recipients
Approximately 15% of kidney transplant (KT) recipients develop de novo heart failure after KT. There are scarce data reporting the long-term changes in cardiac structure and function among KT recipients. Despite the improvement in renal function, transplant-related complications as well as immunosuppressive therapy could have an impact on cardiac remodelling during follow-up. We aimed to describe the long-term changes in echocardiographic parameters in prevalent KT recipients and identify the clinical and laboratory factors associated with these changes. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 13, 2024 Category: Cardiology Authors: V. Panisset, N. Girerd, E. Bozec, Z. Lamiral, Q. d'Herve, L. Frimat, S. Girerd Source Type: research

Potential regulatory role of epigenetic modifications in aging-related heart failure
Heart failure (HF) is a serious clinical syndrome and a serious development or advanced stage of various heart diseases. Aging is an independent factor that causes pathological damage in cardiomyopathy and participates in the occurrence of HF at the molecular level by affecting mechanisms such as telomere shortening and mitochondrial dysfunction. Epigenetic changes have a significant impact on the aging process, and there is increasing evidence that genetic and epigenetic changes are key features of aging and aging-related diseases. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 13, 2024 Category: Cardiology Authors: Lin Lv, Qiuyu Chen, Jing Lu, Qi Zhao, HongYan Wang, JiaHao Li, KeYing Yuan, ZengXiang Dong Source Type: research

“The INOCA-IT: Rationale and design of a multicenter registry investigating ischemia in patients with non-obstructive coronary artery (INOCA) disease in Italy”
Ischemia with non-obstructive coronary artery (INOCA) disease is being progressively acknowledged as one of the pathophysiological mechanisms of chronic coronary syndrome (CCS) in an increasingly wide range of clinical pictures. Although the research has already begun to move towards a defined diagnostic pathway and a specific medical therapy for this disease, at present it remains a clinical challenge, especially if not thoroughly investigated. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 13, 2024 Category: Cardiology Authors: Giulia Ghizzoni, Antonio Maria Leone, Luigi di Serafino, Domenico Galante, Giovanni Esposito, Matteo Montorfano, Alaide Chieffo Source Type: research

Variable clinical expression of a novel FLNC truncating variant in a large family
This study reports two familial cases of SCD and the results of cascade screening of their large family. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 12, 2024 Category: Cardiology Authors: Orr Tomer, Smadar Horowitz-Cederboim, Dini Rivkin, Vardiella Meiner, Michael H. Gollob, Donna R. Zwas, Ronen Durst, Ayelet Shauer Source Type: research

Cost-effectiveness of transthyretin cardiac amyloidosis screening and treatment: A Dilemma for the clinician
Professor Claudio Rapezzi, a pioneer in the field of cardiac amyloidosis (CA), used to cite a William Osler's quote: “there are three phases to treatment: diagnosis, diagnosis, and diagnosis”. Until recently, when no disease-modifying treatments for transthyretin CA (ATTR-CA) were available, the clinical utility of conclusively diagnosing ATTR-CA might be questioned, as it required the invasive demonstration o f amyloid deposits within tissues, without a direct impact on patient management. Thanks to the advances in diagnosis and treatment of ATTR-CA, most patients are now diagnosed through a non-invasive approach, and...
Source: International Journal of Cardiology - February 12, 2024 Category: Cardiology Authors: Vincenzo Castiglione, Alberto Aimo, Giuseppe Vergaro Tags: Editorial Source Type: research

Impact of diabetes mellitus on clinical outcomes after first episode in-stent restenosis PCI: Results from a large registry
Diabetes mellitus (DM) is associated with a high rate of major adverse cardiac events (MACE) after de novo coronary artery percutaneous coronary intervention (PCI). Whether patients with DM undergoing PCI for in-stent restenosis (ISR) experience a similar heightened risk of MACE is not known. Hence, we sought to compare the clinical outcomes of patients with and without DM undergoing PCI for ISR. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 12, 2024 Category: Cardiology Authors: Richard Tanner, Serdar Farhan, Gennaro Giustino, Samantha Sartori, Yihan Feng, Amit Hooda, Manish Vinayak, George Dangas, Roxana Mehran, Annapoorna S. Kini, Samin K. Sharma Source Type: research