International Journal of Clinical Chemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Evidence of ostarine cross-contamination via sweat in 2 athletes sharing the same neoprene hamstring sleeves. An original situation of drug transfer where the anti-doping rule violation was suspended by the sport authorities
Clin Chim Acta. 2024 Apr 24:119688. doi: 10.1016/j.cca.2024.119688. Online ahead of print.ABSTRACTThe presence of ostarine, a selective androgen receptor modulator (SARM) in an athlete's sample constitutes one of the most frequent anti-doping rules violation. It is possible to challenge this violation but it is the athlete who has to demonstrate he / she is innocent. The conditions to evidence no fault or negligence are mostly based on 2 points: 1. the athlete or his/her legal representative must present verified circumstances of contamination and the source of contamination must be identified; and 2. there must be verifie...
Source: International Journal of Clinical Chemistry - April 26, 2024 Category: Chemistry Authors: Pascal Kintz Laurie Gheddar Source Type: research

Precision medicine in colorectal cancer: Leveraging multi-omics, spatial omics, and artificial intelligence
Clin Chim Acta. 2024 Apr 23:119686. doi: 10.1016/j.cca.2024.119686. Online ahead of print.ABSTRACTColorectal cancer (CRC) is a leading cause of cancer-related deaths. Recent advancements in genomic technologies and analytical approaches have revolutionized CRC research, enabling precision medicine. This review highlights the integration of multi-omics, spatial omics, and artificial intelligence (AI) in advancing precision medicine for CRC. Multi-omics approaches have uncovered molecular mechanisms driving CRC progression, while spatial omics have provided insights into the spatial heterogeneity of gene expression in CRC ti...
Source: International Journal of Clinical Chemistry - April 25, 2024 Category: Chemistry Authors: Zishan Xu Wei Li Xiangyang Dong Yingying Chen Dan Zhang Jingnan Wang Lin Zhou Guoyang He Source Type: research

Biosensors for metastatic cancer cell detection
This article examines biosensors for metastatic cancer cells. It also studies metastatic cancer cells and the mechanism of metastasis. Finally, the function of biosensors and biomarkers in metastatic cancer cells is investigated.PMID:38663472 | DOI:10.1016/j.cca.2024.119685 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 25, 2024 Category: Chemistry Authors: Masoomeh Yari Kalashgrani Seyyed Mojtaba Mousavi Muhammad Hussnain Akmal Ahmad Gholami Navid Omidifar Wei-Hung Chiang Chin Wei Lai Md Ripaj Uddin Raed H Althomali Mohammed M Rahman Source Type: research

Targeting tumor markers in ovarian cancer treatment
Clin Chim Acta. 2024 Apr 23:119687. doi: 10.1016/j.cca.2024.119687. Online ahead of print.ABSTRACTOvarian cancers (OC) are the most common, lethal, and stage-dependent cancers at the global level, specifically in female patients. Targeted therapies involve the administration of drugs that specifically target the alterations in tumour cells responsible for their growth, proliferation, and metastasis, with the aim of treating particular patients. Presently, within the realm of gynaecological malignancies, specifically in breast and OCs, there exist various prospective therapeutic targets encompassing tumour-intrinsic signall...
Source: International Journal of Clinical Chemistry - April 25, 2024 Category: Chemistry Authors: Subham Preetam Sagar Mondal Swati Priya Jutishna Bora Seema Ramaniwas Sarves Rastagi Naeem F Qusty Saad Alghamdi Ahmad O Babalghith Abdullah Siddiqi Sumira Malik Source Type: research

CircRNAs in cancer therapy tolerance
Clin Chim Acta. 2024 Apr 20;558:119684. doi: 10.1016/j.cca.2024.119684. Online ahead of print.ABSTRACTThe rapidly expanding field of circular RNA (circ-RNA) research has opened new avenues in cancer diagnostics and treatment, highlighting the role of serum circRNAs as potential biomarkers for assessing tumor therapy resistance. This review comprehensively compiles existing knowledge regarding the biogenesis, function, and clinical relevance of circRNAs, emphasizing their stability, abundance, and cell type-specific expression profiles, which make them ideal candidates for noninvasive early biomarkers in cancer treatment. W...
Source: International Journal of Clinical Chemistry - April 22, 2024 Category: Chemistry Authors: Miao He Yunyan Pan Chongge You Hongwei Gao Source Type: research

Significance of immunoglobulins synthesis with central nervous system involvement in Neuro-Beh çet's disease
CONCLUSIONS: IgA index acts as a potential diagnostic indicator in differentiating NBD from NIND and CNS-IIDD. Excessive immunoglobulin production induced by CNS inflammation and demyelination might be latent immunopathogenesis of NBD.PMID:38643816 | DOI:10.1016/j.cca.2024.119681 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 21, 2024 Category: Chemistry Authors: Haoting Zhan Linlin Cheng Yeling Liu Honglin Xu Xinxin Feng Yongmei Liu Haolong Li Zhan Li Siyu Wang Haiqiang Jin Wenjie Zheng Hongjun Hao Yongzhe Li Source Type: research

Serum levels of IL-9 and IL-11 serve as predictors for the occurrence of early neurologic deterioration in patients with cerebral infarction
CONCLUSION: Serum IL-9 and IL-11 levels can predict the occurrence of END in patient with cerebral infarction and are correlated with serum BDNF levels.PMID:38643817 | DOI:10.1016/j.cca.2024.119683 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 21, 2024 Category: Chemistry Authors: Xianglin Guo Xiaoyan Zhu Shuai Zhou Xiaohong Dong Source Type: research

A benefit risk approach in cutoff determination for diagnostic tests
Clin Chim Acta. 2024 Apr 19:117887. doi: 10.1016/j.cca.2024.117887. Online ahead of print.ABSTRACTA crucial step in the design of a diagnostic test is determining the cutoff point, the threshold which separates a negative measurement from a positive one. The results of a diagnostic test have clinical consequences: only when disease is accurately detected, proper treatments be administered, and vice versa. Benefit-Risk (BR) analysis should be used to determine the optimal cutoff point that optimizes the consequence. Quantitative BR analysis requires measurable benefit and risk and a function, e.g., linear or ratio, to combi...
Source: International Journal of Clinical Chemistry - April 21, 2024 Category: Chemistry Authors: Jeng Mah Robert Magari Karen Kw Lo Nicole Winden Gang Xu Source Type: research

Elevated serum HE4 levels as a novel biomarker of disease severity and hepatic fibrosis in autoimmune hepatitis
CONCLUSIONS: Serum HE4 levels were found to be elevated in AIH-LC patients and exhibited a strong correlation with the severity of hepatic fibrosis, thus supporting their potential clinical value as a novel biomarker of disease severity and hepatic fibrosis in AIH.PMID:38643819 | DOI:10.1016/j.cca.2024.119682 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 21, 2024 Category: Chemistry Authors: Zhi Yu Caina Nian Wenmei Sun Xinhua Liu Xueyuan Nian Source Type: research

Guideline for diagnosis and management of congenital dysfibrinogenemia
CONCLUSIONS: The new CD diagnosis criteria and comprehensive treatment recommendations can effectively improve the diagnosis and treatment of CD.PMID:38642629 | DOI:10.1016/j.cca.2024.119680 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 20, 2024 Category: Chemistry Authors: Jie Yan Lin Liao Donghong Deng Weijie Zhou Peng Chen Liqun Xiang Meiling Luo Faquan Lin Source Type: research

Hook-effect in MAGLUMI immunoassay for serum anti-GAD antibodies in neurological disorders: When "wrong" matrix is the right choice
Clin Chim Acta. 2024 Apr 18;558:119679. doi: 10.1016/j.cca.2024.119679. Online ahead of print.ABSTRACTAntibodies against glutamic acid decarboxylase (anti-GAD) are a valuable diagnostic tool to detect severe autoimmune conditions as type 1 diabetes mellitus (T1DM) and anti-GAD related neurological disorders, having the latter more often anti-GAD concentrations in serum multiple times higher than in the former. Automated immunoassays, either with ELISA or chemiluminescent technology, are validated for diagnostic use in serum with analytical ranges suitable for T1DM diagnosis. In a patient presenting with a suspected autoimm...
Source: International Journal of Clinical Chemistry - April 20, 2024 Category: Chemistry Authors: G Musso M Zoccarato N Gallo M Plebani D Basso Source Type: research

Uterine fluid microRNAs in repeated implantation failure
Clin Chim Acta. 2024 Apr 17:119678. doi: 10.1016/j.cca.2024.119678. Online ahead of print.ABSTRACTRecurrent implantation failure (RIF) is a significant obstacle in assisted reproductive procedures, primarily because of compromised receptivity. As such, there is a need for a dependable and accurate clinical test to evaluate endometrial receptiveness, particularly during embryo transfer. MicroRNAs (miRNAs) have diverse functions in the processes of implantation and pregnancy. Dysregulation of miRNAs results in reproductive diseases such as recurrent implantation failure (RIF). The endometrium secretes several microRNAs (miRN...
Source: International Journal of Clinical Chemistry - April 19, 2024 Category: Chemistry Authors: Pourya Rokhsartalab Azar Mahdi Maleki Aghdam Sarmad Karimi Arian Haghtalab Sonia Sadeghpour Hassan Mellatyar Mortaza Taheri-Anganeh Hojat Ghasemnejad-Berenji Source Type: research

An up-conversion fluorescence lateral-flow immunoassay for rapid detection of Daratumumab in serum protein electrophoresis clinical samples
CONCLUSIONS: The performance of the up-conversion fluorescence LFA strip meets the purpose of clarifying DARA interference in SPEP results. It may be used as an independent and objective confirmation of the presence of DARA in clinical samples. The LFA strip offers a cost-effective rapid on-site test to check for DARA interference alongside standard SPEP equipment, which significantly improves the interpretation of ambiguous SPEP results involving DARA, and does not intervene the current SPEP workflow in clinical laboratory practice.PMID:38636694 | DOI:10.1016/j.cca.2024.119677 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 18, 2024 Category: Chemistry Authors: Yajing Liu Yanru Tao Priscilla S-W Yeung Mengyan Lu Jing Liu Fang Yu Run-Zhang Shi Ruben Yiqi Luo Source Type: research