Prognostic value of a mandibular canal staging system for primary lesions in patients with lower gingival squamous cell carcinoma: a multicenter, retrospective study
ConclusionsSubsite-specific tumor classification should be used for patients with oral cancer, and our results suggest that mandibular canal tumor classification may be effective for patients with lower gingival carcinoma. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 2, 2024 Category: Cancer & Oncology Source Type: research

Therapeutic use of granulocyte colony-stimulating factor (G-CSF) in patients with febrile neutropenia: a comprehensive systematic review for clinical practice guidelines for the use of G-CSF 2022 from the Japan Society of Clinical Oncology
ConclusionA weak recommendation is made that G-CSF treatment not be administered to patients with febrile neutropenia during cancer chemotherapy. G-CSF treatment can be considered for patients at high risk. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 2, 2024 Category: Cancer & Oncology Source Type: research

Relationship between HER2-low status and efficacy of CDK4/6 inhibitors in advanced breast cancer: a real-world study
ConclusionsThe mPFS in the Her2-zero group was almost twice that of the Her2-low group, but the difference was not statistically significant. mPFS was significantly longer in the HER2-zero group compared to the HER2-low group in patients receiving ribociclib. More prospective studies are needed to understand the actual consequences of this biomarker. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 30, 2024 Category: Cancer & Oncology Source Type: research

PMDA regulatory update on approval and revision of the precautions for use of anticancer drugs; approval of elranatamab for multiple myeloma, CPX-351 for myeloid leukemia, inotuzumab ozogamicin for lymphoblastic leukemia, capivasertib for breast cancer, and zolbetuximab for gastric cancer in Japan
(Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 30, 2024 Category: Cancer & Oncology Source Type: research

Optimal surgical approach for mid-transverse colon cancer: a systematic review and meta-analysis
ConclusionDespite harvesting less LN, transverse colectomy has similar oncological outcomes to extended hemicolectomy for mid-transverse colon cancer. In addition to that, there was no significant difference in the incidence of complications between the two surgeries. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 29, 2024 Category: Cancer & Oncology Source Type: research

Impact of the serum creatinine and cystatin C ratio for prediction of sarcopenia and prognosis in biliary tract cancer
ConclusionsIn patients with biliary tract cancer, the Cr/CysC ratio showed weak correlation with sarcopenic indicators. However, the Cr/CysC ratio could be strong prognostic factor in biliary tract cancer. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 29, 2024 Category: Cancer & Oncology Source Type: research

The real-world data of immune-checkpoint inhibitor combination therapy for unresectable or metastatic esophageal cancer: a multi-institutional cohort study
ConclusionsImmune-checkpoint inhibitor combination therapy for esophageal cancer demonstrated comparable tumor response, safety, and long-term survival to previous randomized clinical trials. Patients with good performance status and low C-reactive protein levels may be suitable candidates for this treatment. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 28, 2024 Category: Cancer & Oncology Source Type: research

Availability of genome-matched therapy based on clinical practice
ConclusionThis study demonstrated the usefulness of CGP for patients with sarcoma and HNC in addition to lung cancer in clinical practice. Performing CGP at the front line has the potential to improve the availability of genome-matched therapy. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 26, 2024 Category: Cancer & Oncology Source Type: research

Significance of radiation therapy in the myxoid round-cell liposarcoma treatment regimen
ConclusionPreoperative radiation therapy for myxoid liposarcoma near vital organs is a good approach because even with a reduced dose of 40  Gy, significant tumor reduction and excellent results were achieved. Definitive radiation therapy is the recommended treatment for older patients with serious comorbidities or inoperable patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 24, 2024 Category: Cancer & Oncology Source Type: research

Short- and long-term post-nephrectomy outcomes for retroperitoneal liposarcoma from a high-volume sarcoma center: a propensity score matching analysis
ConclusionsRLPS resection with nephrectomy is related to a mild progression of renal impairment; however, dialysis is rare. En bloc nephrectomy for complete resection of RLPS is safe and improves local control. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research

Comparison between a single dose of PEG G-CSF and multiple doses of non-PEG G-CSF: a systematic review and meta-analysis from Clinical Practice Guidelines for the use of G-CSF 2022
ConclusionsA single dose of PEG G-CSF is strongly recommended over multiple-dose non-PEG G-CSF therapy for the primary prophylaxis of FN. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research

SlicerPIT: software development and implementation for planning and image-guided therapy in photoimmunotherapy
ConclusionSlicerPIT allows for detailed preoperative treatment planning and accurate puncture. It may be a valuable tool to improve the accuracy of photoimmunotherapy for deep lesions and improve patient outcomes. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research

Biomarker-oriented chemo-immunotherapy for advanced gastric cancer
AbstractThe biomarker-oriented chemo-immunotherapy is useful and promising in the development of new anticancer agents, since the responders can be enriched by selecting patients with biomarkers. Compared to colorectal and lung cancers, the development of biomarker-driven molecular-targeted therapeutics for gastric cancers has been straggled. However, several new biomarkers in gastric cancers have been discovered and clinical trials in enrichment design with certain biomarkers have been conducted. Therefore, there are currently several treatment options to treat gastric cancer patients based on individual biomarker-oriente...
Source: International Journal of Clinical Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research

Clinicopathological characteristics of Lynch-like syndrome
ConclusionsDistinguishing clinically between LS and LLS was challenging, but the incidence of neoplasms was higher in LS than in LLS, suggesting the need for different screening and surveillance methods for the two subtypes. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 20, 2024 Category: Cancer & Oncology Source Type: research

A Japanese multi-institutional phase II study of moderate hypofractionated intensity-modulated radiotherapy with image-guided technique for prostate cancer
ConclusionThe safety and efficacy of moderately hypofractionated IMRT with prostate-based image-guidance was confirmed among Japanese patients with prostate cancer. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 17, 2024 Category: Cancer & Oncology Source Type: research