Decoding long non ‑coding RNAs: Friends and foes in cancer development (Review)
Int J Oncol. 2024 Jun;64(6):61. doi: 10.3892/ijo.2024.5649. Epub 2024 May 2.ABSTRACTCancer remains a formidable adversary, challenging medical advancements with its dismal prognosis, low cure rates and high mortality rates. Within this intricate landscape, long non‑coding RNAs (lncRNAs) emerge as pivotal players, orchestrating proliferation and migration of cancer cells. Harnessing the potential of lncRNAs as therapeutic targets and prognostic markers holds immense promise. The present comprehensive review delved into the molecular mechanisms underlying the involvement of lncRNAs in the onset and progression of the top f...
Source: International Journal of Oncology - May 2, 2024 Category: Cancer & Oncology Authors: Hequn Song Joseph Adu-Amankwaah Qizhong Zhao Dongqi Yang Kuntao Liu Aisha Bushi Jinming Zhao Jinxiang Yuan Rubin Tan Source Type: research
Targeting tumor ‑associated macrophages: Critical players in tumor progression and therapeutic strategies (Review)
Int J Oncol. 2024 Jun;64(6):60. doi: 10.3892/ijo.2024.5648. Epub 2024 May 2.ABSTRACTTumor‑associated macrophages (TAMs) are essential components of the tumor microenvironment (TME) and display phenotypic heterogeneity and plasticity associated with the stimulation of bioactive molecules within the TME. TAMs predominantly exhibit tumor‑promoting phenotypes involved in tumor progression, such as tumor angiogenesis, metastasis, immunosuppression and resistance to therapies. In addition, TAMs have the potential to regulate the cytotoxic elimination and phagocytosis of cancer cells and interact with other immune cells to en...
Source: International Journal of Oncology - May 2, 2024 Category: Cancer & Oncology Authors: Pengfei Su Ou Li Kun Ke Zhichen Jiang Jianzhang Wu Yuanyu Wang Yiping Mou Weiwei Jin Source Type: research
Decoding long non ‑coding RNAs: Friends and foes in cancer development (Review)
Int J Oncol. 2024 Jun;64(6):61. doi: 10.3892/ijo.2024.5649. Epub 2024 May 2.ABSTRACTCancer remains a formidable adversary, challenging medical advancements with its dismal prognosis, low cure rates and high mortality rates. Within this intricate landscape, long non‑coding RNAs (lncRNAs) emerge as pivotal players, orchestrating proliferation and migration of cancer cells. Harnessing the potential of lncRNAs as therapeutic targets and prognostic markers holds immense promise. The present comprehensive review delved into the molecular mechanisms underlying the involvement of lncRNAs in the onset and progression of the top f...
Source: International Journal of Oncology - May 2, 2024 Category: Cancer & Oncology Authors: Hequn Song Joseph Adu-Amankwaah Qizhong Zhao Dongqi Yang Kuntao Liu Aisha Bushi Jinming Zhao Jinxiang Yuan Rubin Tan Source Type: research
Targeting tumor ‑associated macrophages: Critical players in tumor progression and therapeutic strategies (Review)
Int J Oncol. 2024 Jun;64(6):60. doi: 10.3892/ijo.2024.5648. Epub 2024 May 2.ABSTRACTTumor‑associated macrophages (TAMs) are essential components of the tumor microenvironment (TME) and display phenotypic heterogeneity and plasticity associated with the stimulation of bioactive molecules within the TME. TAMs predominantly exhibit tumor‑promoting phenotypes involved in tumor progression, such as tumor angiogenesis, metastasis, immunosuppression and resistance to therapies. In addition, TAMs have the potential to regulate the cytotoxic elimination and phagocytosis of cancer cells and interact with other immune cells to en...
Source: International Journal of Oncology - May 2, 2024 Category: Cancer & Oncology Authors: Pengfei Su Ou Li Kun Ke Zhichen Jiang Jianzhang Wu Yuanyu Wang Yiping Mou Weiwei Jin Source Type: research
Decoding long non ‑coding RNAs: Friends and foes in cancer development (Review)
Int J Oncol. 2024 Jun;64(6):61. doi: 10.3892/ijo.2024.5649. Epub 2024 May 2.ABSTRACTCancer remains a formidable adversary, challenging medical advancements with its dismal prognosis, low cure rates and high mortality rates. Within this intricate landscape, long non‑coding RNAs (lncRNAs) emerge as pivotal players, orchestrating proliferation and migration of cancer cells. Harnessing the potential of lncRNAs as therapeutic targets and prognostic markers holds immense promise. The present comprehensive review delved into the molecular mechanisms underlying the involvement of lncRNAs in the onset and progression of the top f...
Source: International Journal of Oncology - May 2, 2024 Category: Cancer & Oncology Authors: Hequn Song Joseph Adu-Amankwaah Qizhong Zhao Dongqi Yang Kuntao Liu Aisha Bushi Jinming Zhao Jinxiang Yuan Rubin Tan Source Type: research
Targeting tumor ‑associated macrophages: Critical players in tumor progression and therapeutic strategies (Review)
Int J Oncol. 2024 Jun;64(6):60. doi: 10.3892/ijo.2024.5648. Epub 2024 May 2.ABSTRACTTumor‑associated macrophages (TAMs) are essential components of the tumor microenvironment (TME) and display phenotypic heterogeneity and plasticity associated with the stimulation of bioactive molecules within the TME. TAMs predominantly exhibit tumor‑promoting phenotypes involved in tumor progression, such as tumor angiogenesis, metastasis, immunosuppression and resistance to therapies. In addition, TAMs have the potential to regulate the cytotoxic elimination and phagocytosis of cancer cells and interact with other immune cells to en...
Source: International Journal of Oncology - May 2, 2024 Category: Cancer & Oncology Authors: Pengfei Su Ou Li Kun Ke Zhichen Jiang Jianzhang Wu Yuanyu Wang Yiping Mou Weiwei Jin Source Type: research
S100 protein family: Emerging role and mechanism in digestive tract cancer (Review)
Int J Oncol. 2024 Jun;64(6):59. doi: 10.3892/ijo.2024.5647. Epub 2024 Apr 26.ABSTRACTDigestive tract cancer is one of the most common types of cancers globally, with ~4.8 million new cases and 3.4 million cancer‑associated deaths in 2018, accounting for 26% of cancer incidence and 35% of cancer‑related deaths worldwide. S100 protein family is involved in regulating cancer cell proliferation, angiogenesis, epithelial‑mesenchymal transition (EMT), metastasis, metabolism and immune microenvironment homeostasis. The critical role of S100 protein family in digestive tract cancer involves complicated mechanisms, such as ca...
Source: International Journal of Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Mingshuai Li Peng Cui Wenqing Dai Bo Cao Haobin Zhao Shuyu Jin Donghua Xu Youkui Shi Shushan Yan Source Type: research
S100 protein family: Emerging role and mechanism in digestive tract cancer (Review)
Int J Oncol. 2024 Jun;64(6):59. doi: 10.3892/ijo.2024.5647. Epub 2024 Apr 26.ABSTRACTDigestive tract cancer is one of the most common types of cancers globally, with ~4.8 million new cases and 3.4 million cancer‑associated deaths in 2018, accounting for 26% of cancer incidence and 35% of cancer‑related deaths worldwide. S100 protein family is involved in regulating cancer cell proliferation, angiogenesis, epithelial‑mesenchymal transition (EMT), metastasis, metabolism and immune microenvironment homeostasis. The critical role of S100 protein family in digestive tract cancer involves complicated mechanisms, such as ca...
Source: International Journal of Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Mingshuai Li Peng Cui Wenqing Dai Bo Cao Haobin Zhao Shuyu Jin Donghua Xu Youkui Shi Shushan Yan Source Type: research
S100 protein family: Emerging role and mechanism in digestive tract cancer (Review)
Int J Oncol. 2024 Jun;64(6):59. doi: 10.3892/ijo.2024.5647. Epub 2024 Apr 26.ABSTRACTDigestive tract cancer is one of the most common types of cancers globally, with ~4.8 million new cases and 3.4 million cancer‑associated deaths in 2018, accounting for 26% of cancer incidence and 35% of cancer‑related deaths worldwide. S100 protein family is involved in regulating cancer cell proliferation, angiogenesis, epithelial‑mesenchymal transition (EMT), metastasis, metabolism and immune microenvironment homeostasis. The critical role of S100 protein family in digestive tract cancer involves complicated mechanisms, such as ca...
Source: International Journal of Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Mingshuai Li Peng Cui Wenqing Dai Bo Cao Haobin Zhao Shuyu Jin Donghua Xu Youkui Shi Shushan Yan Source Type: research
S100 protein family: Emerging role and mechanism in digestive tract cancer (Review)
Int J Oncol. 2024 Jun;64(6):59. doi: 10.3892/ijo.2024.5647. Epub 2024 Apr 26.ABSTRACTDigestive tract cancer is one of the most common types of cancers globally, with ~4.8 million new cases and 3.4 million cancer‑associated deaths in 2018, accounting for 26% of cancer incidence and 35% of cancer‑related deaths worldwide. S100 protein family is involved in regulating cancer cell proliferation, angiogenesis, epithelial‑mesenchymal transition (EMT), metastasis, metabolism and immune microenvironment homeostasis. The critical role of S100 protein family in digestive tract cancer involves complicated mechanisms, such as ca...
Source: International Journal of Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Mingshuai Li Peng Cui Wenqing Dai Bo Cao Haobin Zhao Shuyu Jin Donghua Xu Youkui Shi Shushan Yan Source Type: research
S100 protein family: Emerging role and mechanism in digestive tract cancer (Review)
Int J Oncol. 2024 Jun;64(6):59. doi: 10.3892/ijo.2024.5647. Epub 2024 Apr 26.ABSTRACTDigestive tract cancer is one of the most common types of cancers globally, with ~4.8 million new cases and 3.4 million cancer‑associated deaths in 2018, accounting for 26% of cancer incidence and 35% of cancer‑related deaths worldwide. S100 protein family is involved in regulating cancer cell proliferation, angiogenesis, epithelial‑mesenchymal transition (EMT), metastasis, metabolism and immune microenvironment homeostasis. The critical role of S100 protein family in digestive tract cancer involves complicated mechanisms, such as ca...
Source: International Journal of Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Mingshuai Li Peng Cui Wenqing Dai Bo Cao Haobin Zhao Shuyu Jin Donghua Xu Youkui Shi Shushan Yan Source Type: research
RPL9 acts as an oncogene by shuttling miRNAs through exosomes in human hepatocellular carcinoma cells
Int J Oncol. 2024 Jun;64(6):58. doi: 10.3892/ijo.2024.5646. Epub 2024 Apr 19.ABSTRACTThe exosomal pathway is an essential mechanism that regulates the abnormal content of microRNAs (miRNAs) in hepatocellular carcinoma (HCC). The directional transport of miRNAs requires the assistance of RNA‑binding proteins (RBPs). The present study found that RBPs participate in the regulation of miRNA content through the exosomal pathway in HCC cells. First, differential protein expression profiles in the serum exosomes of patients with HCC and benign liver disease were detected using mass spectrometry. The results revealed that riboso...
Source: International Journal of Oncology - April 19, 2024 Category: Cancer & Oncology Authors: Ang Li Jiyan Xie Lihong Lv Zhihua Zheng Weibang Yang Wenfeng Zhuo Sijia Yang Diankui Cai Jinxin Duan Peiqing Liu Jun Min Jinxing Wei Source Type: research
RPL9 acts as an oncogene by shuttling miRNAs through exosomes in human hepatocellular carcinoma cells
Int J Oncol. 2024 Jun;64(6):58. doi: 10.3892/ijo.2024.5646. Epub 2024 Apr 19.ABSTRACTThe exosomal pathway is an essential mechanism that regulates the abnormal content of microRNAs (miRNAs) in hepatocellular carcinoma (HCC). The directional transport of miRNAs requires the assistance of RNA‑binding proteins (RBPs). The present study found that RBPs participate in the regulation of miRNA content through the exosomal pathway in HCC cells. First, differential protein expression profiles in the serum exosomes of patients with HCC and benign liver disease were detected using mass spectrometry. The results revealed that riboso...
Source: International Journal of Oncology - April 19, 2024 Category: Cancer & Oncology Authors: Ang Li Jiyan Xie Lihong Lv Zhihua Zheng Weibang Yang Wenfeng Zhuo Sijia Yang Diankui Cai Jinxin Duan Peiqing Liu Jun Min Jinxing Wei Source Type: research
Nuclear miRNAs as transcriptional regulators in processes related to various cancers (Review)
Int J Oncol. 2024 May;64(5):56. doi: 10.3892/ijo.2024.5644. Epub 2024 Apr 12.ABSTRACTMicroRNAs (miRNAs) are noncoding small nucleic acids that contain ~22 nucleotides and are considered to promote the degradation or inhibit the translation of mRNA by targeting its 3'‑untranslated region. However, growing evidence has revealed that nuclear miRNAs, combined with gene promoters or enhancers, are able to directly mediate gene transcription. These miRNAs exert a critical influence on cancer progression by affecting cell growth, migration and invasion. In this review, the direct regulation of gene expression by nuclear miRNAs ...
Source: International Journal of Oncology - April 12, 2024 Category: Cancer & Oncology Authors: Ziqiang Wang Yu Zhang Kun Li Source Type: research
Beyond self ‑eating: Emerging autophagy‑independent functions for the autophagy molecules in cancer (Review)
Int J Oncol. 2024 Jun;64(6):57. doi: 10.3892/ijo.2024.5645. Epub 2024 Apr 12.ABSTRACTAutophagy is a conserved catabolic process that controls organelle quality, removes misfolded or abnormally aggregated proteins and is part of the defense mechanisms against intracellular pathogens. Autophagy contributes to the suppression of tumor initiation by promoting genome stability, cellular integrity, redox balance and proteostasis. On the other hand, once a tumor is established, autophagy can support cancer cell survival and promote epithelial‑to‑mesenchymal transition. A growing number of molecules involved in autophagy have ...
Source: International Journal of Oncology - April 12, 2024 Category: Cancer & Oncology Authors: Giulia Tedesco Manuela Santarosa Roberta Maestro Source Type: research
