International Journal of Radiation Oncology * Biology * Physics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Reduced Risk of Severe Radiation-Induced Lymphopenia in Carbon Ion Radiation Therapy for Locally Advanced Pancreatic Cancer: A Comparative Analysis of Carbon Versus Photon Therapy
Radiation-induced lymphopenia (RIL) is associated with poor prognosis in patients with locally advanced pancreatic cancers. However, there are no reports comparing the effects of carbon ion radiation therapy (CIRT) and photon beam radiation therapy (RT) on the development of RIL. Differences in RIL after CIRT or photon beam RT and predictive factors for RIL in patients with locally advanced pancreatic cancer were investigated. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - May 7, 2024 Category: Radiology Authors: Gowoon Yang, Woong Sub Koom, Byung Min Lee, Tetsuro Isozaki, Makoto Shinoto, Shigeru Yamada, Jinsil Seong Tags: CLINICAL INVESTIGATION Source Type: research

The presence of extensive lymphovascular invasion (LVI) is associated with higher risks of local-regional recurrence compared to usual LVI in curatively treated breast cancer patients
We describe clinical outcomes in women with invasive breast cancer stratified by: 1) absence of LVI (neg), 2) LVI focal or suspicious (FS-LVI), 3) usual (non-extensive) LVI (LVI) and 4) extensive LVI (E-LVI).Materials/Methods: Between 12/2009 and 8/2021, 8837 patients with early-stage breast cancer were treated with curative intent and were evaluable. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - May 4, 2024 Category: Radiology Authors: Olufela Koleoso, Nicolas Toumbacaris, Edi Brogi, Zhigang Zhang, Lior Z Braunstein, Monica Morrow, Tracy-Ann Moo, Mahmoud El-Tamer, Catherine B. Marine, Simon N Powell, Atif J Khan Tags: Clinical Investigation Source Type: research

Application of Recombinant Human Superoxide Dismutase in Radical Concurrent Chemoradiotherapy for Cervical Cancer to Prevent and Treat Radiation-induced Acute Rectal Injury: A Multi-center, Randomized, Open-label, Prospective Trial
To evaluate the efficacy of recombinant human superoxide dismutase (rhSOD) enemas in radiation-induced acute rectal injury (RARI) in patients with locally advanced cervical cancer. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - May 3, 2024 Category: Radiology Authors: Jiawei Zhu, Xiaofan Li, Manni Huang, Hong Zhu, Yan Tan, Xia He, Zhihua Sun, Huijun Cheng, Fenghu Li, Ping Jiang, Hanmei Lou, Guihao Ke, Xinping Cao, Lihong Zhu, Peng Xie, Junfang Yan, Fuquan Zhang Source Type: research

Evaluation of radiation dose effect on lung function using iodine maps derived from dual-energy computed tomography
There is interest in using dual-energy computed tomography (DECT) to evaluate organ function before and after radiotherapy. The purpose of this study (trial identifier: XXXX) is to assess longitudinal changes in lung perfusion using iodine maps derived from DECT in lung cancer patients treated with conventional or stereotactic radiotherapy (RT). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - May 2, 2024 Category: Radiology Authors: Shen Zhang, Mika ël Simard, Andréanne Lapointe, Édith Filion, Marie-Pierre Campeau, Thi Trinh Thuc Vu, David Roberge, Jean-François Carrier, Danis Blais, Stéphane Bedwani, Houda Bahig Source Type: research

Intracellular oxygen transient quantification in vivo during Ultra-High Dose Rate (UHDR) FLASH radiotherapy
Large, rapid extracellular oxygen transients ( ΔpO2) have been measured in vivo during Ultra-High Dose Rate (UHDR) radiotherapy; however, it has been unclear if this matches intracellular oxygen levels. Here, the endogenously produced Protoporphyrin IX (PpIX) delayed fluorescence (DF) signal was measured as an intracellular in vivo oxygen senso r to quantify these transients, with direct comparison to extracellular pO2. Intracellular ΔpO2 is closer to the cellular DNA, the site of major radiobiological damage and therefore should help elucidate radiochemical mechanisms of the FLASH effect and potentially be translated to...
Source: International Journal of Radiation Oncology * Biology * Physics - May 2, 2024 Category: Radiology Authors: Arthur F. Petusseau, Megan Clark, Petr Bruza, David Gladstone, Brian W. Pogue Tags: Physics Contribution Source Type: research

Prognostic factors of mandibular osteoradionecrosis including accurate colocalization of avulsions and dosimetric dental mapping software, a case control study.
Osteoradionecrosis of the mandible (ORN) remains a significant complication in the intensity modulated radiotherapy (IMRT) era. Dental dose cannot be predicted from heterogeneous IMRT dose distributions; mandibular dose metrics cannot guide dentist avulsion decisions in high risk ORN situations. Using a mapping tool to report dental root dose, avulsions and ORN sites, we reexamined ORN risk factors in a case-control study. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 26, 2024 Category: Radiology Authors: Marion Renouf, Simon Auger, Lo ïc Campion, Grégory Delpon, Julie Longis, Cécile Dupas, Pauline Blery, Juliette Thariat, Mélanie Doré Tags: Clinical Investigation Source Type: research

Dose-effect Relationship of Kidney Function After Stereotactic Ablative Body Radiotherapy for Primary Renal Cell Carcinoma: Trog 15.03 Fastrack Ii
This study investigates the dose-effect relationship of kidney SABR with posttreatment renal function. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 26, 2024 Category: Radiology Authors: Mathieu Gaudreault, Nicholas Hardcastle, Price Jackson, Lachlan McIntosh, Braden Higgs, David Pryor, Mark Sidhom, Rachael Dykyj, Alisha Moore, Tomas Kron, Shankar Siva Tags: Clinical Investigation Source Type: research

Longitudinal assessment of tumor-infiltrating lymphocytes in primary breast cancer following neoadjuvant radiotherapy
Tumor-infiltrating lymphocytes (TILs) have prognostic significance in several cancers, including breast. Despite interest in combining radiotherapy with immunotherapy, little is known about the effect of radiotherapy itself on the tumor-immune microenvironment, including TILs. Here, we interrogated longitudinal dynamics of tumor-infiltrating and systemic lymphocytes in patient samples taken before, during, and after neoadjuvant radiotherapy (NART), from XXX and XXX breast clinical trials. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 25, 2024 Category: Radiology Authors: Miki Yoneyama, Konstantinos Zormpas-Petridis, Ruth Robinson, Faranak Sobhani, Elena Provenzano, Harriet Steel, Sara Lightowlers, Catherine Towns, Simon P. Castillo, Selvakumar Anbalagan, Tom Lund, Erik Wennerberg, Alan Melcher, Charlotte E. Coles, Ioannis Tags: Biology Contribution Source Type: research

Part-time training: levelling the playing field in Radiation Oncology
Despite decades of commitment to improving diversity in radiation oncology, the parameters remain stubbornly difficult to shift. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 18, 2024 Category: Radiology Authors: Farhannah Aly, Nicholas Bucknell, Liz Kenny, Fiona Hegi-Johnson Source Type: research

Salvage Stereotactic Radiosurgery for Recurrent WHO Grade 2 and 3 Meningiomas: A Multicenter Study (STORM)
The role of stereotactic radiosurgery (SRS) in the management of grade 2 and 3 meningiomas is not well elucidated. Unfortunately, local recurrence rates are high, and guidelines for management of recurrent disease are lacking. To address this knowledge gap, we conducted STORM, a multicenter retrospective cohort study of patients treated with primary SRS for recurrent grade 2 and 3 meningiomas. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 17, 2024 Category: Radiology Authors: Matthew Gallitto, Geoffrey Sedor, Albert Lee, Jared Pasetsky, Connor J Kinslow, Genesis De Los Santos, Derrick Obiri-Yeboah, Varun R Kshettry, Corbin A Helis, Michael D Chan, Thomas H Beckham, Susan L McGovern, Jennifer Matsui, Joshua D Palmer, Jonathan B Tags: Clinical Investigation Source Type: research

Putting the Brakes on Xerostomia in Oropharyngeal Cancer: Can Brachytherapy Be the Key?
There is no question as to the efficacy of brachytherapy in the management of de novo and recurrent head and neck cancers. It has been shown to contribute to both excellent oncologic outcomes in the upfront setting and durable local control and symptom relief in the recurrent setting.1-3 (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Shauna McVorran, Arash Naghavi, Philip Schaner Tags: Editorial Source Type: research

Put on Your Thinking Cap: A Fungating Scalp Mass
A 66-year-old farmer with a medical history significant for multiple squamous cell carcinomas and basal cell carcinomas presented with a large posterior scalp mass of 6-month duration (fig 1). His symptoms included headaches alone with no focal neurologic deficits. The patient continues to smoke half a pack per day with 20 pack-years. On examination, a large fixed fungating scalp mass with ulcerations was present with no palpable cervical lymphadenopathy. Magnetic resonance imaging of the head showed a 8.2- × 6.1-cm enhancing invasive scalp soft tissue mass lesion with extension through the bilateral parietal calvarium (f...
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Romy J. Megahed, Mausam A. Patel Tags: Gray Zones Source Type: research

The Crown Jewel: Checkpoint Inhibition in Unresectable Cutaneous Squamous Cell Carcinoma
This is a complex case1 requiring multidisciplinary assessment. Given his non-melanoma skin cancer history, consideration should be given to whether the biopsy is representative of the entire lesion. We would not recommend upfront surgery for this locally advanced cutaneous squamous cell carcinoma with likely transdural spread and parenchymal brain and posterior sagittal sinus involvement. The survival for these cases is poor,2 and resection of the posterior sagittal sinus carries a high risk of venous infarction. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Lachlan McDowell, Catherine Barnett Tags: Gray Zone Expert Opinion Source Type: research

Moving Toward Personalized Medicine in Gynecologic Cancers
This Oncology Scan will cover multiple key studies presented or published recently, which highlight recent advances in gynecologic malignancies, where the need for personalized treatment has never been more apparent. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Michelle Ludwig, Neil Taunk, Junzo Chino, Lara Hathout, Eric Leung, Emma Fields Tags: Oncology Scan Source Type: research

Off the Top of Our Head
The current standard of care for locally advanced cutaneous squamous cell carcinoma consists of upfront resection followed by adjuvant radiation in the presence of high-risk features. In this case, several factors make surgery less desirable. We do not know whether there is tumor involvement of the sagittal sinus. Invasion of the sagittal sinus would preclude upfront surgery. Additionally, the extent of resection would require a large reconstruction with free tissue transfer. In the setting of active smoking, there is significant concern for failure of a free flap reconstruction. (Source: International Journal of Radiation...
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Michael J. Jelinek, Nikhil Joshi Tags: Gray Zone Source Type: research